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Ferroptosis in Myocardial Fibrosis: Mechanisms and Therapeutic Insights
No full textMyocardial fibrosis (MF) is a common pathological feature of diverse cardiac disorders and is a key driving factor of cardiac dysfunction. It is marked by excessive deposition of extracellular matrix (ECM) proteins, particularly collagen type I and III, and a prolonged activation of cardiac fibroblasts. However, the molecular drivers of this process remain undetermined. Ferroptosis is an iron-catalyzed, lipid-peroxidation-dependent mode of regulated cell death. Research indicates that ferroptosis is significantly involved in the onset and advancement of MF; consequently, developing therapies that selectively modulate ferroptosis presents a promising direction of treatment options. Therefore, this paper systematically discusses the mechanisms associated with ferroptosis to explore the link between ferroptosis and MF from multiple dimensions, including iron metabolism disorders, lipid peroxidation, imbalance of glutathione metabolism, and the dysregulated activation of ferroptosis regulatory pathways, to provide innovative perspectives for the study of the specific molecular mechanisms and treatment of MF. Method: By retrieving the literature on the mechanism of ferroptosis in MF published in PubMed and Web of Science databases from 2020 to July 2025, the mechanism of action was systematically analyzed and reviewed
Platform Governance and Digital Sustainability: A Systemic Functional Dependency Perspective
No full textThe governance of digital platforms is a key factor in sustainable business development. Nevertheless, the specific governance mechanisms through which platforms reconfigure virtual (e-commerce) and physical (logistics) systems, and whether these outcomes are equitable or sustainable, remain insufficiently examined. This research proposes an analytical framework, Systemic Functional Dependency, to elucidate how platform governance shapes the co-evolution of digital and physical activities in the platform economy. The analysis of China’s platform economy from 2013 to 2022 reveals a governance-induced bifurcation: Core regions build sustainable, synergistic business models (local e-com coef. = 0.204, p < 0.05). In contrast, peripheral regions face structural decoupling, where digital-led growth (22.63% CAGR) vastly outpaces the expansion of physical business capacity (6.46% CAGR). This imbalance, caused by a functional transition (32.21% CAGR in net-work-serving logistics vs. 2.44% in local-serving logistics), led to a structural breakpoint in 2017–2018. The findings advance digital business theory by linking platform governance to asymmetric outcomes. This leads to a functional lock-in for peripheral regions, which is a big problem for sustainability and shows how important it is to have governance frameworks right away
Impact of a History of COVID-19 Infection on Postoperative Complications in Spinal Surgery: A Nationwide Cohort Study
No full textBackground/Objectives: The postoperative implications of a history of coronavirus disease 2019 (COVID-19) in patients undergoing spinal surgery remain inadequately defined. This study investigated whether a history of COVID-19 is associated with increased postoperative complication risk and assessed how surgical timing after infection influences outcomes. Methods: Patients who underwent spinal surgery in 2020 were identified. Individuals with a confirmed history of COVID-19 were matched 1:3 by age and sex to uninfected controls. Patients were categorized by the interval between COVID-19 diagnosis and the index surgical date (≤1 month, >1–≤3 months, or >3–≤6 months). Postoperative pulmonary, cardiovascular, thromboembolic, infectious, and mortality outcomes were evaluated. Cumulative risks were estimated using Kaplan–Meier analysis, and adjusted hazard ratios (HRs) were determined using multivariable Cox proportional hazards models controlling for demographic and clinical factors. Results: Surgery performed ≤1 month after COVID-19 diagnosis was associated with significantly higher risks of pneumonia within 3 months (HR 3.91; p = 0.031) and 6 months postoperatively (HR 3.12; p = 0.049). Patients undergoing surgery >1–≤3 months after COVID-19 demonstrated increased risk of spinal and implant-related infections within 3 months (HR 2.12; p = 0.040), and this elevated risk persisted when surgery occurred >3–≤6 months after infection (HR 2.00; p = 0.022). No significant differences were observed in cardiovascular, thromboembolic, or mortality outcomes. Conclusions: A history of COVID-19 infection was associated with postoperative pneumonia and spinal and implant-related infections following spinal surgery. These findings suggest that prior COVID-19 infection may be a relevant consideration in perioperative risk assessment and surgical planning
The Role of Weight-Bearing Computed Tomography in the Assessment and Management of Charcot Foot Deformity: A Narrative Review
No full textCharcot neuro-osteoarthropathy (CNO) is a devastating complication of peripheral neuropathy, characterized by progressive bone and joint destruction that leads to severe foot deformity, ulceration, and a high risk of amputation. The management of CNO is predicated on an accurate understanding of its biomechanical instability, yet conventional imaging modalities like non-weight-bearing computed tomography (CT) and magnetic resonance imaging (MRI) fail to capture the true, load-dependent nature of the deformity. This review elucidates the paradigm shift facilitated by weight-bearing computed tomography (WBCT) in the diagnosis and management of CNO. A comprehensive narrative review of the literature was conducted to synthesize the pathophysiology of CNO, the limitations of conventional imaging, and the technological principles, clinical applications, and future directions of WBCT in CNO management. The review integrates findings on CNO pathophysiology, radiological assessment, and the debate surrounding weight-bearing protocols in conservative management. WBCT provides a three-dimensional, functional assessment of the Charcot foot under true physiological load, overcoming the critical limitations of non-weight-bearing imaging. It reveals the full extent of osseous collapse, unmasking hidden instabilities and enabling the use of novel quantitative 3D metrics for deformity characterization and risk stratification. Clinically, WBCT enhances the entire management pathway, from improving early diagnostic accuracy and informing surgical strategy with patient-specific instrumentation to enabling objective postoperative evaluation of reconstructive outcomes. WBCT is a promising technology that redefines the assessment of CNO from a static, morphological description to a dynamic, quantitative biomechanical analysis. Its integration into clinical practice offers the potential to improve diagnostic precision, optimize surgical planning, and ultimately enhance patient outcomes. The future synergy of WBCT with artificial intelligence holds promise for further advancing patient care, moving towards a predictive and prescriptive model for managing this complex condition
A Pilot Study for “In Vitro” Testing the Surface Conditioning Effects on CAD/CAM Hybrid Nanoceramic Adhesion
No full textBackground/Objectives: The clinical application of CAD/CAM restorative materials continues to evolve due to increasing demand for aesthetic, durable, and minimally invasive indirect restorations. Hybrid nanoceramics, such as Grandio disc (VOCO GmbH, Cuxhaven, Germany), are increasingly used in indirect restorative dentistry due to their favourable combination of mechanical strength, polishability, wear resistance, and bonding potential. One challenge associated with adhesive protocols for CAD/CAM materials lies in achieving durable bonds with resin cements. Extensive post-polymerization during fabrication reduces the number of unreacted monomers available for chemical interaction, thereby limiting the effectiveness of traditional adhesive strategies and necessitating specific surface conditioning approaches. This study aimed to evaluate, in a preliminary, non-inferential manner, the influence of several combined conditioning protocols on surface micromorphology, elemental composition, and descriptive SBS trends of a CAD/CAM hybrid nanoceramic. This work was designed as a preliminary pilot feasibility study. Due to the limited number of specimens (two discs per protocol, each providing two independent enamel bonding measurements), all bond strength outcomes were interpreted descriptively, without inferential statistical testing. This in vitro study investigated the effects of various surface conditioning protocols on the adhesive performance of CAD/CAM hybrid nanoceramics (Grandio disc, VOCO GmbH, Cuxhaven, Germany) to dental enamel. Hydrofluoric acid (HF) etching was performed to improve adhesion to indirect resin-based materials using two commercially available gels: 9.5% Porcelain Etchant (Bisco, Inc., Schaumburg, IL, USA) and 4.5% IPS Ceramic Etching Gel (Ivoclar Vivadent, Schaan, Liechtenstein), in combination with airborne-particle abrasion (APA), silanization, and universal adhesive application. HF may selectively dissolve the inorganic phase, while APA increases surface texture and micromechanical retention. However, existing literature reports inconsistent results regarding the optimal conditioning method for hybrid composites and nanoceramics, and the relationship between micromorphology, elemental surface changes, and adhesion remains insufficiently clarified. Methods: A total of ten composite specimens were subjected to five conditioning protocols combining airborne-particle abrasion with varying hydrofluoric acid (HF) concentrations and etching times. Bonding was performed using a dual-cure resin cement (BiFix QM) and evaluated by shear bond strength (SBS) testing. Surface morphology was examined through environmental scanning electron microscopy (ESEM), and elemental composition was analyzed via energy-dispersive X-ray spectroscopy (EDS). Results: indicated that dual treatment with HF and sandblasting showed descriptively higher SBS, with values ranging from 5.01 to 6.14 MPa, compared to 1.85 MPa in the sandblasting-only group. ESEM revealed that higher HF concentrations (10%) created more porous and irregular surfaces, while EDS indicated an increased fluorine presence trend and silicon reduction, indicating deeper chemical activation. However, extending HF exposure beyond 20 s did not further improve bonding, suggesting the importance of protocol optimization. Conclusions: The preliminary observations suggest a synergistic effect of mechanical and chemical conditioning on hybrid ceramic adhesion, but values should be interpreted qualitatively due to the pilot nature of the study. Manufacturer-recommended air abrasion alone may provide limited adhesion under high-stress conditions, although this requires confirmation in studies with larger sample sizes and ageing simulations. Future studies should address long-term durability and extend the comparison to other hybrid CAD/CAM materials and to other etching protocols
Chemical Composition of Extracts from Fruiting Bodies of Tinder Fungi and Their Effect on the Early Stages of Wheat Development
No full textOne of the global challenges is the deficit of food. Food production is highly dependent on the productivity of agricultural plants used by humans and livestock. Various chemical and natural compounds are used to stimulate plant growth and increase their resistance to stress. The aim of our study was to analyze the chemical composition of extracts of the most common Ural tinder fungi and their effect on the early stages of wheat growth. Water–alcohol extracts from five wood-destroying fungi contained biologically active compounds (BACs), such as phenolics, free amino acids and reducing sugars. F. pinicola was characterized by the smallest amount of extracted substances. F. fomentarius has the largest amount of phenolic compounds and sugars, and I. obliquus had the highest concentration of free amino acids. Qualitative analysis revealed alkaloids in P. betulinus, and anthraquinones in F. fomentarius. Saponins were found in all tested species, except F. fomentarius. The extracts stimulated the early stages of wheat development at concentrations of 1.0–0.2 g of fungal biomass per liter. Seed germination rate was comparable to the control samples or exceeded it, and the length of roots and shoots increased. Thus, extracts from fruiting bodies of studied fungi can be recommended for priming wheat seeds, and for biotechnological cultivation
In Vitro and In Vivo Evaluation of Nitroxoline as an Effective Antimicrobial Alternative to Poultry Production
No full textBackground: Antimicrobial resistance is a major global challenge that is exacerbated by extensive antibiotic use in livestock farming. Identifying effective alternatives to widely used human antibiotics in animal production is vital to safeguard vital human medicines and ensure sustainable food systems. Here we describe studies identifying nitroxoline (NTX) as a promising antimicrobial candidate for use in poultry production. Methods: The antibacterial activity and resistance potential of NTX were assessed in vitro. In vivo studies in chickens evaluated tolerance, therapeutic efficacy in Salmonella-infected birds, pharmacokinetics, tissue residue depletion, growth performance, and effects on caecal microbiota. NTX was administered in-feed at different dose levels. Pharmacokinetic parameters and withdrawal periods were determined, and caecal microbiota composition was analysed using ribosomal RNA 16S sequencing. Results: NTX exhibits potent broad-spectrum antibacterial activity in vitro and low levels of resistance. NTX is well-tolerated in chickens at 500 mg/kg in-feed for 7 days and substantially reduces liver bacterial loads at 100 mg/kg in Salmonella-infected chickens. Pharmacokinetic and residue analyses reveal NTX manifests rapid absorption and distribution, high oral bioavailability (86%), and efficient tissue clearance with a 17-day withdrawal period required for skin-plus-fat clearance. NTX supplementation is associated with increased weight gain and improved feed efficiency compared to the control group, with performance comparable to chlortetracycline. Microbiota analysis indicates modulation of caecal bacterial communities, including increased Faecalibacterium and Lactobacillus. Conclusions: These results indicate that NTX is a viable alternative to important human antibiotics widely deployed in poultry production, offering a potential approach to minimise antimicrobial resistance whilst maintaining animal health and food biosafety
Tensor-Train-Based Elastic Wavefield Decomposition in VTI Media
No full textElastic wavefield decomposition into quasi-compressional (qP) and quasi-shear-vertical (qSV) modes is essential for elastic imaging and inversion in VTI media, but becomes computationally expensive when polarization vectors vary strongly in space. I propose a tensor-train (TT) representation of mixed-domain decomposition projectors, constructed via TT-cross with a single user-specified tolerance and applied efficiently using FFT-based operations. A residual-orthogonal strategy extracts qSV from the residual wavefield after qP removal to suppress mode leakage. The method is implemented in Python/PyTorch with GPU acceleration. Numerical experiments on three 2D VTI models (a two-layer benchmark, a BP 2007 benchmark subset, and an Overthrust-based structurally complex model) demonstrate reconstruction errors of 0.094–0.89% for TT, compared to 1.67–6.44% for a conventional CUR low-rank approach (4–46× improvement), with consistently lower cross-talk and near-unity energy ratios. Time-domain receiver traces further confirm that TT yields smaller reconstruction residual spikes and reduced cross-mode leakage than CUR. Runtime tests show that CUR can be faster on smaller grids, whereas TT with GPU acceleration becomes competitive and can outperform CUR for larger models. The TT representation scales linearly with tensor Od Ns r2—enabling practical extension to higher-dimensional projector tensors where conven-tional methods become impractical
Implications of Land Use and Land Cover Changes in the Transformation of Agrifood Landscapes in Mountain Regions: The Case of the Southern Slopes of Sierra Nevada, Spain
No full textSince the mid-20th century, the landscapes of Mediterranean mountain regions have undergone a significant transformation, linked to the socioeconomic changes caused by the opening up of these regions to the market economy. This prompted a rural exodus, the abandoning of farmland and the reduction in livestock, so activating various reforestation processes. In parallel, the “green revolution” promoted the modernization of agrifood systems, so contributing to the decline of traditional ways of farming in mountain areas. The farms on which traditional polyculture and agroforestry are still carried out today are important agrobiodiversity reserves. In this research, we monitor the dynamics of land use and cover and the changes in the structure of the agrifood landscapes on the southern slopes of Sierra Nevada (Spain) by comparing maps from 1956, 1984, 2007 and 2020. The results reveal a sharp decline in cultivated land, from 39.19% to 21.54%, and an expansion of natural covers, especially Mediterranean forest, driven by the abandonment of farmland and reforestation policies. Today, the landscape is composed of a more fragmented, less cohesive mosaic of agroecosystems. These changes indicate a reduction in agrobiodiversity at a landscape level, in line with the tendency observed at farm level in the study area
Effect of Inaudible Binaural Beats Stimulation Timing and Task Performance Level on Visuospatial Working Memory
No full textThis study aimed to investigate the effect of inaudible-frequency binaural beats (BB), excluding the influence of audible sound, on visuospatial working memory performance (VSWMP). In particular, the effects were examined in relation to the stimulation timing of the stimulus and the task performance level of participants. Thirty adults in their 20 s (20 males, 25.7 ± 1.8 years; 10 females, 24.3 ± 1.6 years) participated in the experiment. A 10 Hz BB stimulus was generated by simultaneously presenting 18,000 Hz and 18,010 Hz tones to the left and right ears, respectively. The experiment employed a within-participant design consisting of a rest phase (5 min) and a task phase (5 min), with four BB stimulation conditions: Control (no BB), Exp1 (BB during both rest and task phases), Exp2 (BB during rest only), and Exp3 (BB during task only). VSWMP was assessed using corrected hit rate and reaction time in a 3-back task. Results indicated that all BB conditions (Exp1, Exp2, Exp3) significantly improved VSWMP compared to the Control condition, regardless of the stimulation timing. When participants were grouped based on task performance level into high- and low-performing groups (HPG, LPG), significant improvements in VSWMP were particularly evident in the LPG across all BB conditions compared to the Control. Notably, in Exp3, LPG participants demonstrated VSWMP comparable to that of the HPG. In conclusion, while BB stimulation enhances VSWMP regardless of its stimulation timing, its effectiveness may vary depending on the task performance level