Multidisciplinary Digital Publishing Institute (Switzerland)
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Correlation Between Neurocognitive Function Changes and Cerebral Oximetry in Thoracic Surgery Patients
No full textBackground: Postoperative cognitive dysfunction (POCD) is a significant complication following thoracic surgery. One-lung ventilation (OLV) during these procedures can lead to cerebral desaturation, potentially contributing to POCD. This study investigated the correlation between intraoperative cerebral oximetry, measured by near-infrared spectroscopy (NIRS), and neurocognitive function changes in patients undergoing thoracic surgery. Methods: In this prospective, observational pilot study, 54 adult patients undergoing OLV for thoracic surgery were enrolled. Cerebral oxygen saturation (rScO2) was monitored continuously using NIRS. Patients were categorized into two groups: Group N (normal NIRS values) and Group D (decreased NIRS values, defined as a drop of ≥20% from baseline or an absolute value <50%). Neurocognitive function was assessed preoperatively, on the 3rd postoperative day, and at 3 months using the Addenbrooke’s Cognitive Examination-Revised (ACE-R) battery. The correlation between intraoperative rScO2 values, postoperative complications, and neurocognitive outcomes was analyzed. Results: A significant association was found between intraoperative cerebral desaturation and a decline in ACE-R scores. Group D showed a significant decrease in ACE-R scores on the 3rd postoperative day and at 3 months compared to their baseline, while Group N showed no significant change. The most pronounced decline in Group D was observed in the “Fluency” cognitive domain. Interestingly, there was a significant difference in ICU admission rates (p = 0.004) between the two groups, with more admissions in Group D, despite no significant difference in intraoperative hypotension or peripheral desaturation. Patients with pre-existing hypertension were more likely to experience cerebral desaturation. Conclusion: Intraoperative cerebral desaturation, as detected by NIRS, is a strong predictor of both early and late postoperative neurocognitive decline and increased postoperative morbidity in thoracic surgery patients. This underscores the value of NIRS as a sensitive monitoring tool to identify patients at risk and guide timely interventions. These findings suggest a need for further research, including larger randomized controlled trials, to confirm these associations and evaluate the impact of a protocol-driven NIRS intervention strategy on patient outcomes
The Marketplace’s Ambiences During the French Colonial Period in an Algerian Oasis: The ‘Al-Gh’deer’ Square in the Oasis of Sidi-Okba (Biskra, Algeria)
No full textThis study investigates the traditional life within Al-Gh’deer Market Square, which constitutes a fundamental component of the vernacular urban fabric of Sidi Okba’s old city from a sensorial perspective. This oasis, located in the southeast of Algeria, is currently severely degraded and requires urban and architectural preservation. However, the sensory experiences that once characterised traditional urban life have not yet been systematically explored. The aim of this study is to fill this gap by analysing the historical atmospheres depicted in various literary and iconographic sources created by French and European explorers who visited Algeria during the colonial period. This research highlights each component of the “Al-Gh’deer” market square, which had a sensory impact on writers and photographers during their visit to Sidi Okba. This impact is revealed through the different tangible and intangible signals generated by these components, which were then felt and described textually and/or visually by the travellers. To this end, the thematic content analysis is used as a research technique in order to analyse this textual corpus, whilst the image formatting and staging constitute the method used for the iconographic corpus study. The first method makes it possible to detect the most relayed ambiences by travellers. This is revealed by the identification and computation of the associated words and/or expressions within the considered textual corpus. The second technique consists of the extraction of the elements generating the physical signals that should create a sensory relationship with the people within the scene or looking at it. The identified ambiences among the two corpora are crossed in order to determine the most felt ones in the marketplace as well as the various components generating them. The outcomes of this research work would serve as a basis for revitalisation initiatives within the frame of socio-economic and cultural development projects
Traveling Together, Traveling Alone: Experiences of Violence and Danger for Migrating Children and Families in the US–Mexico Borderlands
No full textDecisions to migrate are based on individual and family assessments of risk and opportunity, shaped by economic conditions, risks and experiences of violence, resources, and networks, which interact with personal factors and opportunity. During the journey, migrating people may encounter threats to their safety and wellbeing from both human and natural hazards. This study drew on survey data from 305 Mexican and Central American participants who migrated into the US between 2013 and 2022 alone or with families and children. Respondents provided demographic data and answered questions about stressors that prompted their migration, dangerous experiences encountered on their journey, sources of support, and what they wished they had known. Factors that influenced migration included economic stressors such as loss of job and poverty, witnessing or experiencing interpersonal violence or state violence such as kidnapping or threats to self or family, and environmental factors such as natural disasters. Approximately a third of participants traveled with their children, parents or siblings. Younger migrants and migrating people traveling with children reported significantly higher likelihood of encountering dangers during migration. Implications for supporting migrating children and families who have encountered violence and trauma are discussed, as well as limitations of the research
Single Machine Scheduling Problems: Standard Settings and Properties, Polynomially Solvable Cases, Complexity and Approximability
No full textSince the publication of the first scheduling paper in 1954, a huge number of works dealing with different types of single machine problems have appeared. They addressed many heuristics and enumerative procedures, complexity results or structural properties of certain problems. Regarding surveys, often particular subjects like special objective functions were discussed or more general scheduling problems were surveyed, in which a substantial part was devoted to single machine problems. In this paper, we focus on standard settings, basic structural properties of these settings, polynomial algorithms and complexity and approximation issues, which have not been reviewed so far, and suggest some future work in this area
Immunotherapy of Canine Leishmaniasis by Vaccination with Singlet Oxygen-Inactivated Leishmania infantum
No full textBackground: Canine leishmaniasis is notoriously difficult to manage by chemotherapy alone, necessitating the consideration of supplemental or alternative treatment. Evidence is presented to support the feasibility of immunotherapy of diseased dogs through vaccination. Methods: The vaccine format used consisted of cultured promastigotes of Leishmania infantum, which were rapidly and completely killed by intracellularly generated singlet oxygen. A total of 33 owned dogs of different breeds and ages diagnosed positive for leishmaniasis were enrolled and divided into three groups for treatments as follows: (1) immunotherapy alone (9 dogs); (2) immunotherapy after chemotherapy (14 dogs); and (3) chemotherapy alone (10 dogs). All dogs in Groups 1 and 2 received intradermally three identical dosages of the vaccine format mentioned at the same schedules. The outcomes were assessed for one year at a post-treatment interval of 2–4 months by determining lymph node parasite loads and clinical scores based on established methodologies. Results: Spaghetti plots of the values for parasite loads obtained revealed that they scattered widely over time with a significant decline by 8–12 months post-treatment in all three groups. Sankey plots of clinical scores in stacked bars also showed that they followed erratic patterns of flow over time, albeit toward lower levels in all cases. Ordinal logistic regression analysis of clinical scores indicated that, while the odds for the emergence of severe clinical symptoms declined in all three groups, the lowest risk was associated with Group 2 dogs treated with immunotherapy after chemotherapy. The evidence presented thus suggests that immunotherapy of the diseased dogs with the vaccine format diminished their parasite loads and improved their clinical scores, especially when applied after chemotherapy. Dogs in Groups 1 and 2 that received immunotherapy, on average, lived twice as long as those in Group 3 that received chemotherapy alone. The risk of death estimated by analysis of the clinical scores using the Cox proportional hazard model was also found to be lower for Groups 1–2 dogs receiving immunotherapy than those in Group 3 receiving chemotherapy alone. Conclusions: Post-therapeutic survival time thus may be an additional parameter suitable to assess treatment efficacy by vaccination. In vitro approaches to mitigate some limitations of this study were proposed for future investigation
Development and Laboratory Validation of a Real-Time Quantitative PCR Assay for Rapid Detection and Quantification of Heterocapsa bohaiensis
No full textHeterocapsa bohaiensis is an emerging harmful dinoflagellate increasingly reported from coastal regions of the Pacific. However, an available molecular assay offering rapid and sensitive detection is still lacking. This study developed a SYBR Green real-time quantitative PCR (qPCR) assay for the identification and quantification of H. bohaiensis. Species-specific primers (F: 5′-CCATCGAACCAGAACTCCGT-3′; R: 5′-AGTGTAGTGCACCGCATGTC-3′) were designed and the assay was optimized and evaluated using laboratory cultures for specificity, sensitivity, and quantitative performance. Primer screening and melt-curve analysis confirmed that the selected primer pair produced a single, specific amplification peak for H. bohaiensis, with no cross-reactivity observed in non-target species (Chlorella pyrenoidosa, Phaeocystis globosa, Skeletonema costatum, Alexandrium tamarense) or mixed algal communities. The standard curve displayed strong linearity (R2 = 0.9868) and a high amplification efficiency (102.5%). The limit of detection (LOD) was approximately 2–3 cells per reaction, as determined from 24 replicates of 5-cell equivalents and verified at ~2.7-cell equivalents. This sensitivity was comparable to or exceeded that reported for assays targeting other HABs forming dinoflagellates. Quantitative results derived from the qPCR assay closely matched microscopic cell counts, with a relative error of 10.79%, falling within the acceptable threshold for phytoplankton surveys. In summary, this study established and validates a species-specific qPCR assay for H. bohaiensis under controlled laboratory conditions. The method shows strong potential for incorporation into HAB monitoring programs, early-warning systems, and future ecological investigations of this emerging species
Encryption for Industrial Control Systems: A Survey of Application-Level and Network-Level Approaches in Smart Grids
No full textIndustrial Control Systems (ICS) are fundamental to the operation, monitoring, and automation of critical infrastructure in sectors such as energy, water utilities, manufacturing, transportation, and oil and gas. According to the Purdue Model, ICS encompasses tightly coupled OT and IT layers, becoming increasingly interconnected. Smart grids represent a critical class of ICS; thus, this survey examines encryption and relevant protocols in smart grid communications, with findings extendable to other ICS. Encryption techniques implemented at both the protocol and network layers are among the most effective cybersecurity strategies for protecting communications in increasingly interconnected ICS environments. This paper provides a comprehensive survey of encryption practices within the smart grid as the primary ICS application domain, focusing on protocol-level solutions (e.g., DNP3, IEC 60870-5-104, IEC 61850, ICCP/TASE.2, Modbus, OPC UA, and MQTT) and network-level mechanisms (e.g., VPNs, IPsec, and MACsec). We evaluate these technologies in terms of security, performance, and deployability in legacy and heterogeneous systems that include renewable energy resources. Key implementation challenges are explored, including real-time operational constraints, cryptographic key management, interoperability across platforms, and alignment with NERC CIP, IEC 62351, and IEC 62443. The survey highlights emerging trends such as lightweight Transport Layer Security (TLS) for constrained devices, post-quantum cryptography, and Zero Trust architectures. Our goal is to provide a practical resource for building resilient smart grid security frameworks, with takeaways that generalize to other ICS
Targeting Ferroptosis to Restore Salivary Gland Homeostasis in an Obesity Model
No full textObesity is a systemic metabolic disorder that is known to impair various organ systems; however, its precise impact on salivary gland homeostasis remains unclear. Recent studies have implicated ferroptosis—an iron-dependent form of regulated cell death characterized by lipid peroxidation and oxidative stress—in glandular dysfunction. In this study, we used leptin-deficient (ob/ob) mice to elucidate the role of ferroptosis in obesity-associated salivary gland pathology. The protective effects of ferroptosis inhibition were evaluated by administering ferrostatin-1 (a lipid reactive oxygen species [ROS] scavenger) and deferoxamine (an iron chelator) for an 8-week period. Obese mice exhibited significantly increased body weight, food intake, and hyperglycemia. These systemic changes are accompanied by profound histological alterations in the salivary glands, including lipid droplet accumulation, acinar atrophy, and mitochondrial ultrastructural damage. These alterations correlate with the hallmarks of ferroptotic injury, including increased ROS levels (p < 0.001), elevated malondialdehyde levels (p < 0.01), suppressed glutathione peroxidase 4 activity (p < 0.01), and iron overload (p < 0.001). Salivary gland fibrosis, inflammation, and secretory dysfunction were evident, characterized by the upregulation of TGF-β (p < 0.01) and Collagen I (p < 0.05), reduced expression of aquaporin-5 and amylase, and dysregulated levels of autophagy-related markers (LC3B and p62). Treatment with either ferrostatin-1 or deferoxamine significantly mitigated these pathologies; however, the degree of efficacy varied depending on the specific parameters that were examined. Thus, our findings implicate ferroptosis as a critical contributor to salivary gland dysfunction in obesity and suggest that pharmacological inhibition of this pathway represents a viable therapeutic strategy for preserving glandular integrity under metabolic stress
Cyclic Fatigue Resistance and Phase Transformation Behavior of SlimShaper and SlimShaper PRO NiTi Instruments: A Mechanical and Thermal Analysis
No full textObjectives: This study compared the cyclic fatigue resistance and the mechanical, thermal, and metallurgical characteristics of SlimShaper® and SlimShaper PRO® instruments. Both sequences include three instruments (ZS1–ZS3) with identical geometries, although SlimShaper PRO features an apically modified thermal treatment. Methods: Cyclic fatigue tests were performed using a standardized metallic guide with a 45° curvature, on six instruments of each sequence type. Fractured segments were measured, and fracture surfaces were analyzed using optical microscopy and Scanning Electron Microscopy (SEM). Elemental composition was assessed by Energy-dispersive Spectroscopy (EDS), while Differential Scanning Calorimetry (DSC) was used to determine transformation temperatures and enthalpy. Results: ZS1 and ZS1 PRO exhibited comparable cyclic fatigue resistance, whereas ZS2 and ZS3 showed significantly higher resistance than their PRO counterparts. SlimShaper PRO® instruments fractured with segments approximately 0.5–1 mm longer. EDS confirmed that both instruments were made of NiTi, with minor differences in surface composition, while DSC demonstrated similar enthalpy values but distinct transformation ranges. At room temperature (27 °C), SlimShaper® ZS2 remained predominantly martensitic, whereas ZS2 PRO could be partially austenitic, explaining its observed reduced fatigue resistance. The results of the DSC allowed to deduce the microstructure and thus the fatigue behavior at the temperature of the oral cavity. Conclusions: SlimShaper ZS2 and ZS3 showed significantly greater cyclic fatigue resistance than their PRO counterparts, while DSC analysis revealed distinct differences in phase transformation behavior that explain their mechanical performance
The Long-Term Effects of COVID-19 Stress on Mental Health and Identity Among College Students
No full textThe COVID-19 pandemic had widespread psychological effects, prompting research into long-term impacts on mental health and identity development. This retrospective study examined how pandemic-related stress affected obsessive–compulsive symptoms (OCS) and generalized anxiety symptoms across three timepoints, prior to the pandemic (2019–February 2020), during the height of the pandemic (March 2020–2022), and the present (within the past month), and how changes in these symptoms relates to identity. The sample consisted of undergraduate students (N = 476) who completed an anonymous online survey battery. Indices of psychological “damage” and “recovery” showed although OCS levels returned to baseline in the current period, anxiety levels remained elevated. COVID-related stress predicted higher OCS and anxiety symptoms across timepoints. Greater symptom damage was associated with more identity disturbance, while recovery from anxiety was related to reduced identity disturbance. Recovery from OCS was uniquely related to higher identity consolidation. These findings suggest the psychological toll of the pandemic extends beyond clinical symptoms, impacting foundations of identity. Although some psychological recovery has occurred, lingering anxiety symptoms may continue to affect developmental outcomes. Further research is needed to understand mechanisms that support long-term recovery and identity formation in the wake of large-scale stressors like the COVID-19 pandemic