16372 research outputs found
Sort by
Memcapacitor Emulator Based on Voltage Differencing Buffered Amplifiers
No full textThe advent of memristors has significantly increased research interest in memelements, leading to the development of various memcapacitor emulator circuits. In this study, we present a memcapacitor emulator circuit based on a fully balanced voltage differencing buffered amplifier (FB-VDBA), that demonstrates improved tunability and adaptability. The proposed emulator consists of two-stage configuration, where the second stage is a VDBA memristor. The VDBA memristor is transformed into a memcapacitor emulator, while the first stage acts as a VDBA active element circuit-based mutator. This memcapacitor emulator incorporates two VDBAs, two capacitors, and a resistor, enabling direct charge control through capacitor adjustments in the mutator stage. Furthermore, the emulator can operate across varying frequencies from 10 Hz to 10 kHz by modifying the capacitor in the memristor stage. Our results reveal that the emulator effectively supports an associative learning circuit, illustrating its potential for practical applications. The analysis of the non-ideal model is provided, highlighting the impact of parasitic impedances on circuit performance. Comprehensive PVT (Process, Voltage, and Temperature) analyses confirm the emulator's robustness under diverse conditions. The memcapacitor circuit demonstrated reliable performance with a +/- 10% variation in the VDBA supply voltages, as well as under extreme temperatures ranging from -50 degrees C to 100 degrees C. Simulations conducted using LTSpice with TSMC 0.18 mu m CMOS process parameters reveal precise time responses, voltage-charge relationships, and memory properties, emphasizing the circuit's suitability for advanced memory applications
Synthesis of novel benzofuran-4,7-quinones from 4,6-dimethoxybenzofurans specifically targeting breast and lung cancer cells
No full text4,6-Dimethoxy-2-phenylbenzofurans were synthesized from the one-pot reactions of 3,5-dimethoxyphenol and a range of alpha-bromoacetophenones. The dimethoxybenzofurans were then selectively formylated at C7 using Vilsmeier-Haack method to generate 4,6-dimethoxybenzofuran-7-carbaldehydes which have been effectively converted to 6-dimethoxybenzofuran-4,7-quinones by Dakin oxidation. The cytotoxic potentials of the targeted compounds in MDA-MB-231 breast cancer and A549 lung cancer cell lines were investigated and compared to the cytotoxicity profiles of normal breast and bronchial cells. 2-Phenylbenzofurans mostly targeted lung cancer cells whereas benzofuran-7-carbaldehydes were specifically cytotoxic for metastatic breast cancer cells. The targeted benzofuran derivatives were found to be the most effective compounds for lung and breast cancer. ADME analyses showed lethal doses of all compounds excluding benzofuran-4,7-quinones are around 4000 mg/kg.Scientific and Technological Research Council of Turkey (TUBITAK) [122Z598]; TUBITAKThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant Number 122Z598. The authors thank TUBITAK for their support. Authors thank Prof Zuelal ATLI SEKEROGLU (Ordu University, Department of Molecular Biology and Genetics, Tuerkiye) for providing a batch of BEAS-2B cells
Malaria in Turkey: A comprehensive analysis of diagnosis, treatment, and the impact of COVID-19, ten years after malaria elimination (2012–2023)
Full text linkBackground: The characteristics, diagnosis, and treatment stages of malaria in Turkey in the last ten years are not known except few case reports. We aimed to describe the details of the diagnosis and treatment practices of malaria cases in various hospitals across Turkey between 2012 and 2023 after the declaration of the elimination of malaria. Methods: We collected the patient data from 30 centers by using Qualtrics Survey Software. The patients were categorized according to the WHO Malaria Severe Disease Symptoms guidelines. Results: We detected 299 malaria cases. Of these patients, 23.7 % experienced misdiagnosis, with 77.5 % of misdiagnosed cases receiving antibiotics. Among the patients, 9 (3 %) had no travel history. Additionally, 28 (9.4 %) patients required admission to the intensive care unit (ICU) during hospitalization. There is a significant association between misdiagnosis and subsequent ICU admissions. Additionally, the duration between malaria diagnosis and the initiation of treatment significantly affected ICU admissions. Furthermore, the number of cases with severe malaria (according to WHO criteria) and ICU admissions increased after the COVID-19 period. In multivariate analysis, initial misdiagnosis was found to be associated with ICU admission (OR: 2.8, p < 0.05), while each day's treatment delays post-diagnosis increased ICU admissions (OR: 1.26, p < 0.05). Conclusion: Misdiagnosis is common which delays the treatment and is correlated with higher admissions to ICUs. Post-COVID-19, there was a notable increase in both ICU admissions and cases of severe malaria, suggesting an escalation in disease severity that warrants further investigation. The resurgence of rare malaria cases with no travel history to abroad highlights the necessity of continued vigilance for new malaria cases. Efforts to promptly treat upon diagnosis and improve diagnostic accuracy in Turkey, where malaria is uncommon, are crucial. Enhancing diagnostic methods and treatment strategies remains essential, especially in significant events like COVID-19. © 2025Koç University İşBank Infectious Diseases Cente
Cluster Set vs. Traditional Set in Plyometric Training: Effect on the Athletic Performance of Youth Football Players
Full text linkAim: This study evaluated the effects of plyometric training with different set configurations on sprint speed, change of direction (COD), jump performance, and perceived exertion in youth football players. Method: Twenty-four U-19 players were randomized into three groups: Cluster Set (CLS, n = 8), Traditional Set (TRD, n = 8), and Control (CON, n = 8). CLS performed 8-10 sets of 2-3 repetitions, while TRD completed 2-3 sets of 8-10 repetitions in an 8-week plyometric program (2 sessions/week). The CON group did not train. Performance measures included 10 m, 20 m, and 30 m sprints, COD, Counter Movement Jump (CMJ), Reactive Strength Index (RSI), and Rate of Perceived Exertion (RPE). A repeated measures ANOVA analyzed group*time interactions. Results: Significant improvements were observed in CLS and TRD groups for sprints (10 m: f = 21.44; 20 m: f = 19.40; 30 m: f = 49.56; p 0.05). Conclusions: CLS and TRD plyometric training improved sprint speed, COD, and jump performance, with CLS showing slightly superior results and better fatigue management
Investigating Stability Problems in Solid Waste Landfills
Full text linkGünümüzün en acil çevresel sorunlarından biri, atıkların bertarafı, özellikle de düzenli depolama ile ilgilidir. Yanlış depolama yöntemleri nedeniyle yeraltı sularının kalitesi ciddi şekilde tehlikeye girmiştir. Vahşi depolama sahalarında insan sağlığı ve çevre kirliliğiyle ilgili problemler daha yaygındır. Bu düzensiz depolama sahaları birçok dezavantaja ve ciddi sağlık sorunlarına yol açmaktadır. Bu sebeple, daha önce depolama sahalarında meydana gelen şev göçmelerine neden olan vakalar incelenmiştir. Bu çalışmada, atık stabilitesinin değerlendirilmesine odaklanarak katı atık depolama alanlarıyla ilgili stabilite sorunları araştırılmaktadır. Çalışma, Hekimbaşı, Dona Juana, Gnojna Grora, Hiriya, Payatas ve Xerolakka gibi çeşitli düzenli depolama sahalarındaki şev göçmesi vakalarının analizini içermektedir. Plaxis 2D yazılımı kullanılarak, bu analizlerden elde edilen veriler titizlikle değerlendirilmiş ve en uygun düzenli depolama sahası yönetim stratejilerinin belirlenmesi amaçlanmıştır. Düzenli depolama sahalarındaki şev göçmeleri genellikle uygun olmayan depolama sahası tasarımı, günlük örtü serme ve atık sıkıştırma eksikliği, yetersiz atık ayrıştırma, yetersiz sızıntı suyu drenajı ve gaz tahliyesi ile aşırı şev açısı ve yüksekliğinden kaynaklanmaktadır. Bu koşullardan bir veya daha fazlasının varlığı saha stabilitesinde kayba neden olabilir. Mühendislik kontrollerinin yetersiz olduğu bu sahalarda duraysızlıklar yaşanmaktadır.One of today’s most pressing environmental issues is related to waste disposal, especially landfilling. The quality of groundwater has been seriously compromised due to improper storage methods. Problems related to human health and environmental pollution are more common in open dumps. These irregular disposal sites cause many disadvantages and serious health problems. For this reason, cases that caused slope failures in landfills have been examined. This study investigates stability issues related to solid waste landfills, focusing on the assessment of waste stability. The study includes analyses of slope failure cases in various landfills: Hekimbasi, Dona Juana, Gnojna Grora, Hiriya, Payatas, and Xerolakka. Using Plaxis 2D software, the data obtained from these analyses have been rigorously evaluated to determine the most appropriate landfill management strategies. Slope collapses in landfills are generally caused by unsuitable landfill design, lack of daily cover laying and waste compaction, inadequate waste segregation, insufficient leachate drainage and gas discharge, and excessive slope angle and height. The presence of one or more of these conditions can result in a decline in site stability. Instabilities are experienced in these areas where engineering controls are inadequate
Histopathological Evaluation of the Anterior Cruciate Ligament in Patients With Advanced Gonarthrosis
Full text linkIntroduction: Knee osteoarthritis is a degenerative disease of the knee joint that leads to progressive loss of articular cartilage. There is only limited information in the literature on the degeneration of the anterior cruciate ligament (ACL) in patients with gonarthrosis. In this study, ACL samples excised during the surgery of patients undergoing total knee replacement (TKR) in 2019-2020 were evaluated histopathologically. The present study aims to investigate the relationship between the degeneration of the ACL and the stage of gonarthrosis. Methods: Direct X-rays of 47 patients undergoing knee arthroplasty were evaluated and stratified into two groups: Stage 3 (Group 1) and Stage 4 (Group 2). ACL samples were examined histopathologically. Staining was performed with hematoxylin-eosin (H&E), Alcian blue, and Masson's trichrome. The degree of degeneration was determined according to the Movin score and Bonar score. Based on these scores, the statistical significance of the relationship between the stage of gonarthrosis and histopathological examination results was evaluated. Results: When Group 1 patients were graded according to total Movin scores, the result was mild degeneration in 72.7% of the patients, while the corresponding rates were 76% in Group 2. None of the patients had a score reflecting severe degeneration. The total Bonar scores showed mild degeneration in 68.2% of Group 1 patients. In Group 2, the scores showed mild degeneration in 52% of the patients. No statistically significant difference was found between the groups in either scoring. Conclusion: It was determined that comparable degeneration occurred in the ACL with the progression of the stage of gonarthrosis
Differential loss of PRUNE2 in colorectal adenocarcinoma tissues
No full textColorectal cancer is of the most prevalent and deadliest cancer in the world. Cumulative evidence suggests that PRUNE is a tumor suppressor gene and plays a significant role in the development and progression of human cancers. However, its role during colorectal cancer development remains elusive. In the present study, we aimed to determine the role of PRUNE2 and its diagnostic significance in colorectal cancer. A total of 70 patients with colorectal cancer and 30 control subjects were included in the present study. All patients were confirmed to be colorectal adenocarcinoma. PRUNE2, P53, and PCNA immunoreactivity of patients were determined using standard immunohistochemistry staining techniques. Notably, PRUNE2 was identified to be significantly downregulated in colorectal cancer patients compared to the control group (p < 0.0001). Almost no immunoreactivity was observed in tumor samples compared to healthy colon tissues, where significant immunoreactivity was observed. Also, both P53 and PCNA were significantly higher in patients with colorectal cancer (p < 0.0001). Overall, our results suggest that PRUNE is a reliable and robust biomarker for the differential diagnosis of colorectal cancer and can be used for future diagnostic applications together with other immunological biomarkers such as PCNA. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2025
İRLANDA'DA KITLIK VE OSMANLI YARDIMI
No full textIn this study, it is aimed to examine the emergence of the potato famine in Ireland between 1845 and 1852, its development process, its effects, the socio-economic and political problems experienced during the famine, and the reflections of immigration from the country on the relevant literature sources and the British and Irish press of the period. On the other hand, the study deals with the Ottoman Sultan Abdulmecid's inability to remain insensitive to the famine in Ireland and the aid he provided to Ireland on behalf of the Ottoman Empire. Acting with the understanding of tolerance in the founding philosophy of the Ottoman Empire and as a result of the aid he provided to Ireland, the Irish people's gratitude to Sultan Abdülmecid is proven with the documents in the Prime Ministry Ottoman Archives, the Sultan sending grain-laden ships to Drogheda Port in Ireland, and In this context, it is aimed to evaluate its impact on the relations between the two countries.Bu çalışmada, İrlanda’da 1845-1852 yılları arasında yaşanan patates kıtlığının ortaya çıkışı, gelişim süreci, etkileri, kıtlık süresince yaşanan sosyo-ekonomik, politik sorunlar ile ülkeden yapılan göçlerin ilgili literatür kaynakları ve dönemin İngiliz ve İrlanda basınına yansımalarının incelenmesi amaçlanmaktadır. Diğer taraftan çalışmada, Osmanlı Devleti Sultanı Abdülmecid’in İrlanda’da yaşanan kıtlığa karşı duyarsız kalamayışı ve Osmanlı Devleti adına İrlanda’ya yaptığı yardımlar ele alınmaktadır. Osmanlı Devleti’nin kuruluş felsefesindeki hoşgörü anlayışı ile hareket ederek İrlanda’ya yaptığı yardımlar sonucunda, İrlandalıların Sultan Abdülmecid’e şükranlarını sunmalarının Başbakanlık Osmanlı Arşivi’nde bulunan belgelerle kanıtlanması ayrıca, Sultanın İrlanda’nın Drogheda Limanı’na tahıl yüklü gemiler göndermesi ve bu bağlamda iki ülke arasındaki ilişkilere etkisinin değerlendirilmesi amaçlanmaktadır
A Gastronomic Product Analysis with All Aspects: The Case of Mersin Tantuni
Full text linkBu çalışma, Mersin iline özgü tantuni yemeğinin tarihsel kökenlerini, yapım süreçlerini ve tüketim alışkanlıklarını incelemeyi amaçlamaktadır. Tantuni, Mersin mutfağının öne çıkan yemeklerinden biri olup, genellikle dana eti, soğan, domates ve baharatlarla hazırlanmaktadır. Çalışma betimsel fenomenolojik bir yaklaşımla gerçekleştirilmiş ve veri toplama aracı olarak yarı yapılandırılmış derinlemesine görüşmeler kullanılmıştır. Katılımcılar, Mersin'de tantuni ustası olarak çalışan bireylerden seçilmiştir. Araştırmanın bulguları, tantuninin kökeninin Mersin'e dayandığını ve tarihsel olarak yaklaşık 60-70 yıl öncesine kadar uzandığını göstermektedir. Tantuni, her öğünde ve mevsimde tüketilebilen pratik ve uygun fiyatlı bir yemek olarak tanımlanmıştır. Yapımında kullanılan etin kalitesi ve pişirme teknikleri, tantuninin lezzetini ve kalitesini belirleyen temel unsurlar olarak öne çıkmaktadır. Tantuninin, Mersin mutfağının ve kültürel kimliğinin ayrılmaz bir parçası olduğu vurgulanmaktadır. Bu araştırma, tantuni yemeğinin Mersin'in gastronomik mirasındaki önemini ve yerel kültür içindeki rolünü ortaya koymaktadır. Tantuninin yapım süreçleri ve tüketim alışkanlıkları, Mersin mutfağının zenginliğini ve çeşitliliğini yansıtmakta olup, bu geleneksel yemeğin korunması ve tanıtılması açısından önemli veriler sunmaktadır. Gelecekte yapılacak araştırmalar, tantuninin farklı coğrafi bölgelerdeki varyasyonlarını ve bu yemeğin gastronomi turizmi üzerindeki etkilerini inceleyerek, Mersin'in gastronomik mirasını daha geniş bir perspektifle değerlendirebilir.The aim of this study is to explore the historical roots, preparation phases and consumption behaviors of tantuni dish, being a local dish for Mersin city. A good Mersin cuisine offer: Tantuni is mostly served as a wrap with beef, onions, tomatoes and various spices. A basic Descriptive Phenomenology according to GILOZI (2015) was adopted doing semi-structured in-depth interviews as data collection method. The study group consisted of tantuni masters in Mersin. The research findings, touting Mersin as a birthplace for Tantuni and dating the food industry to be around 60–70 years old historically. Tantuni is praised for being a convenient, inexpensive food that can be eaten at all meals and every season. The type of the meat you got and how it was prepared are really significant in tantuni; these two aspects affect both thereal, taste and quality level of your dish. The promotion also uses the phrasing “tantuni is within Mersin cuisine-cultural heritage”. Through this work, the reflector of tantuni in Mersin's culinary heritage and place in local culture mainly addressed. In addition, The preparation steps and consumption are also indicators of the cultural richness and diversity of Mersin cuisine which making tantuni leaves valuable trails for documentation to be used in the protection and improvement of this tradition. Further studies can extend investigating the gastronomic heritage of Mersin in a more holistic approach by seeking locality changes of tantuni (different geographical regions) and level of impact on gastronomic tourism
Evaluation of Prenatal and Perinatal Risk Factors in Autism Spectrum Disorder According to Disease Severity
Full text linkAim: This study was conducted to investigate prenatal and perinatal characteristics among the risk factors in Autism Spectrum Disorder (ASD) according to disease severity. Materials and Methods: One hundred twenty-eight children in the ASD group and 100 children in the control group were included in the study. Prenatal and perinatal characteristics of the ASD and control groups were retrospectively evaluated using the Socio-demographic and Research Data Form. The ASD group was divided into two groups, mild-moderate ASD and severe ASD, according to the Childhood Autism Rating Scale scores. Results: Paternal age and history of hypoxia/asphyxia during pregnancy were found to be statistically significantly higher in the severe ASD group compared to both the mild-moderate ASD group and the control group. The rate of paternal smoking during pregnancy, preterm labor, and difficult delivery history were statistically higher in both ASD groups compared to the control group. Conclusion: This study shows that prenatal and perinatal factors are more prevalent in individuals diagnosed with ASD compared to the control group. It also found that the presence of certain factors, such as paternal age and history of hypoxia/asphyxia, was associated with more severe ASD symptoms. Our findings suggest that the identification and management of potential risk factors in the prenatal and perinatal periods may influence the severity of the disease in ASD