Zorotic Online Library
Not a member yet
12224 research outputs found
Sort by
ENVIRONMENTAL POLLUTION: A SCIENTIFICO-PHILOSOPHICAL APPRAISAL
No full textEnvironmental pollution is indubitably one of the peculiar problems confronting the human society in recent times. Human conscious and non-conscious activity has not only hampered the progressivity and productivity of the natural environment, but has led to the pollution and destruction of same. One cannot but observe with dismay, that life in generality is greatly threatened if nothing is done urgently. Although the case of this problem can truly be traceable to certain non-human alterations in nature, yet predominantly, man stands as a peculiar precursor of environmental pollution. There is need to protect and nurture the environment for sustainable ecosystem
THE ROLE OF THE HISTORICAL MONUMENTS OF THE KASHKADARYA OASIS IN THE DEVELOPMENT OF TOURISM OF THE REPUBLIC OF UZBEKISTAN
No full textToday, the rich history of the Kashkadarya oasis region, the rare cultural and historical heritage that has been preserved to this day, is waiting for its fans like an undiscovered reserve. In this article, the history of many holy places, historical monuments of Kashkadarya region, their status today, and the role of Kashkadarya region in the development of the tourism industry of the Republic of Uzbekistan are detailed
PROGNOSTIC SIGNIFICANCE OF TP53 GENE MUTATIONS WITH ACUTE LEUKOSIS
No full textAcute leukemia is a malignant tumor of the hematopoietic system. It has a poor prognosis due to a number of complex features1. Based on the rate of development and cytogenetic analysis, leukemia has been classified into four main types 2: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML). Although research on leukemogenesis has been carried out for many years. The mechanisms underlying the development of this hematologic malignancy remain unclear. Multiple risk factors considered implicated in leukemia, and genetic factors such as constitutional genetic variation in components of DNA damage response pathways have become the subject of research. The TP53 protein functions by regulating cell cycle arrest, DNA repair, apoptosis and gene transcription to provide cellular responses to DNA damage. Frequent mutations and differential expression of TP53 in various types of cancer highlight the important role of p53. in carcinogenesis and tumor progression. Functional single nucleotide polymorphism (SNP) at codon 72 It was shown that the TP53 gene (rs1042522), encoding the transversion of G to C (Arg to Pro), is associated with interindividual differences in TP53 expression in malignant tumors, including leukemia. In addition, he has it was reported that the Arg72 variant induces apoptosis markedly better than the Pro72 variant. In addition, he has it was reported that the Arg72 variant induces apoptosis markedly better than the Pro72 variant. Thus, this genetic polymorphism holds promise as a potential biomarker for leukemia. To date, numerous studies have investigated the relationship between the Arg72Pro TP53 polymorphism and susceptibility to leukemia, but the effect of the Arg72Pro TP53 polymorphism on leukemia was still controversial
EXPRESSION OF ASTRONYMS IN UZBEKI THROUGH ZOOMORPHEMS
No full textThis scientific article is devoted to the issues of using the names of animals, birds, and insects in the representation of astronomy. The breadth of possibilities of lexical units denoting the names of animals in representing celestial bodies is considered. The difference between concept and understanding is explained. Attention is paid to the reflection of the " Heavenly bodies" concept in zoomorphic images
ROAD TRAFFIC SAFETY AND ITS IMPACT ON THE DEVELOPMENT OF MODERN ROAD-TRANSPORT EXPERTISE
No full textAn increase in the number of vehicles, as well as an increase in speed and intensity of traffic, makes the problem of road safety more urgent. The main indicator of good wheel contact with the road surface is the contact coefficient, which affects the stability and control of the car. The article examines the conditions and conditions that affect the value of the coefficient of adhesion of tires to the road surface. Studies were conducted for various vehicles with and without anti-lock braking system (ABS), as well as for summer and winter tires in dry and wet asphalt and concrete pavement conditions
DEVELOPMENT OF VALELOGIC PHYSICAL CULTURE OF FUTURE TEACHERS OF PHYSICAL CULTURE
No full textThe physical culture of the community members of a healthy lifestyle (STT) and special knowledge related to it is carried out mainly through the existing directions of the physical education process – general physical training (UJT), Professional Physical Training (KHJT), "sports training" and "mass volunteer sports" (Oks)
USE OF MEDICINAL PLANTS AS A PANACEA TO POULTRY PRODUCTION AND FOOD SECURITY: A REVIEW
No full textMedicinal plants remain the most untapped reservoir of potential therapeutic agents that can be exploited in reducing animal exposure to diseases. Some plants possess significant immune stimulatory, hepatoprotective, anti- inflammatory, antifungal, hypolipidemic and antioxidant activities due to the presence of phytochemicals. Phytochemicals or secondary metabolites are generally regarded as safe, effective, environmental freiendly and relatively cheap. Examples of phytochemicals includes; tannins, flavonoids, phenols, alkaloids, saponins and terpenoids. Concentrations of phytochemicals in plants vary from plant to plants, method of extraction, geographical locations, species and age of plants. Medicinal plants are capable of stimulating feed intake, enhancing growth performance, improving gastrointestinal morphology, immune modulator, nutrient utilization as well as modulating the fatty acid of meat. They are also recommended as one of the potential alternatives to antibiotics and to bridge the gap between food safety and livestock production
IN TURKISH DIDACTIC LITERATURE: TRADITION AND INNOVATION
No full textIn Turkish literature, which has a long and rich history, didactic or instructive works have a special position. The literary and educational heritage of Yusuf Khos Hajib, Ahmad Yugnaki, Ahmad Yassavi, Alisher Navoi, who are major representatives of Turkish didactic literature, are considered the most important monuments of literature in the spirit of pandnoma. In this article, Adib Ahmad Yugnaki's work "Hibat ul-haqayq" in the later period of pandnoma literature, the works created by Alisher Navoi, the issue of the influence of wisdom in the formation of ideas such as the perfect person, the just king, and the just society described in them, is highlighted
UZBEK THEATRICAL TERMS OF THE XVIII-XX CENTURIES
No full textEven in the XVIII-XIX centuries, there was no common name for all types of Uzbek theater. This article discusses some of the terms used in the Uzbek theater in the XVIII-XIX centuries, their etymological features and scope
CHANGES OF MITOCHONDRIAL FUNCTIONS IN DIFFERENT LIVER PATHOLOGIES (TOXIC HEPATITIS)
No full textAccording to the literature, mitochondrial dysfunction is the main cause of pathological conditions. Damage to the mitochondrial membrane leads to disease. For example, mitochondrial disorders in cells cause diabetes. Mitochondria are also affected by ischemia, hepatitis, and ischemic tissue reperfusion, which is manifested in the heart, brain, and kidneys. Mutations in mitochondrial proteins occur in a variety of pathological tissues; mitochondrial dysfunction is associated with all major neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and impaired motoneurons, often leading to sclerosis. Cardiac mitochondrial dysfunction can lead to cardiomyopathy. Mitochondrial dysfunction has been shown to play a key role in many organ system disorders during sepsis. Mitochondria are the main target in the onset of cell dysfunction