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The level of nursing students' self-regulated learning and academic locus of control predicting self-confidence and anxiety in clinical decision-making
No full textAim: This study examined the extent to which nursing students' self-regulated learning and academic locus of control predict self-confidence and anxiety in clinical decision-making. Design: This study was a cross-sectional, descriptive, and correlational study. Methods: The study sample was 627 undergraduate nursing students. Data were collected with the Student Introductory Information Form, Self-Regulated Learning Scale for Clinical Nursing Practice, Academic Locus of Control Scale, and Nursing Anxiety and Self-Confidence with Clinical Decision-Making Scale (NASC-CDM). Multiple linear regression analysis evaluated the predictive level of the variables on the self-confidence and anxiety scale subscale scores in clinical decision-making. Results: The external locus of control and learning strategies significantly explain all sub-dimensions of the selfconfidence scale in clinical decision-making. The internal locus of control and learning strategies meaningfully explain the sub-dimensions of the anxiety scale in clinical decision-making using resources to obtain information, fully listening, and knowing and taking action. Conclusion: Self-regulated learning levels of nursing students affect clinical decision-making. It was determined that students with an internal locus of control had higher self-confidence in clinical decision-making and lower anxiety levels
Investigating the corrosion relationship and biomechanical effectiveness of Ti6Al4V screws Coated hBN and HA in triangular configuration for femoral neck fracture fixation using 3D modeling and numerical analysis
No full textThis study investigates the biomechanical behavior and corrosion resistance of Ti6Al4V screws coated with hexagonal boron nitride (hBN) and hydroxyapatite (HA) for femoral neck fracture fixation using a triangular configuration under axial loading. Utilizing 3D modeling software (Geomagic Studio and SolidWorks) and numerical analysis with AnsysWorkbench, the screws were designed and analyzed. The study aimed to determine the biomechanical effects and corrosion relationships of Ti6Al4V coated with hBN and HA. Comparative analysis revealed that Ti6Al4V-HA exhibited higher gap (0.036427), penetration (0.0028631), and sliding distance values (0.0024398) compared to Ti6Al4V-hBN (gap: 0.036196, penetration: 0.0028579, sliding distance: 0.0024300), indicating greater reactivity and corrosion potential. Conversely, Ti6Al4V-hBN demonstrated superior corrosion resistance. The findings suggest that hBN-coated Ti6Al4V screws provide improved stability and reduced stress concentration, which are critical for successful fracture fixation. Additionally, hBN coating effectively reduced the corrosion rate of Ti6Al4V in simulated body fluids, enhancing implant longevity and patient safety. However, further in vivo studies are necessary to validate these findings and assess long-term performance and biocompatibility. The study underscores the need to consider multiple factors in implant material selection to gain a comprehensive understanding of corrosion behavior. Overall, this research lays the groundwork for future advancements in orthopedic implant technology and has the potential to improve patient outcomes in fracture management
Observed and projected geographical and temporal changes in the Köppen-Geiger climate types in Türkiye
No full textThis study aimed at comparing the geographical and climatological changes in the spatial distributions and average elevations of Türkiye’s recent past (1961 − 1990) present (1991 − 2020) and projected future climate types in detail via the Köppen-Geiger (K-G) classification. The future K-G climate types were examined for the periods of 2041–2070 and 2071–2099 based on low (SSP1 − 2.6), medium (SSP2-4.5), and very high (SSP5-8.5) Shared Socioeconomic Pathways (SSP) scenarios. From 1961 − 1990 to 1991 − 2020, the mid-latitude semi-arid steppe (BSk), subtropical semi-arid steppe (BSh), and dry summer Mediterranean (Csa) climates expanded from 21.9% to 24.2%, 0.1% to 0.4%, and 28.9% to 31.8%, respectively. Conversely, the dry and warm summer cold (Dsb) climate decreased from 24% to 19.3%. Future projections, especially those under high emissions, reveal significant changes in the Dsb and Dfb (cold and humid with warm summer) climates. The main cold climate is expected to change toward drier and warmer cold climates. The current expansion of semi-arid steppe and Mediterranean climates and the contraction of the Dsb climate type can be seen as early indicators of the significant changes foreseen in future periods. As well, average elevations of climatic types will increase in both two future periods and two scenarios, especially in the very high scenarios. For example, under the very high scenario for the period of 2041 − 2070, the average elevations of the Cs, Cf, Ds, Df, and ET climates will increase by approximately 120 m, 220 m, 185 m, 290 m, and 1040 m, respectively. These results also show that the elevations and thicknesses of orographic-climatic vegetation layers may change; for example, the forest upper limit may be approximately 120–220 m higher in the future than in the present, for example, in humid temperate Black Sea forests. © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2025
Evaluation of the effects of HDAC activity in hydroxychloroquine applied human primary chondrocyte and nucleus pulposus cultures
No full textAIM: To evaluate the in vitro effects of hydroxychloroquine (HCQ) on histone deacetylase (HDAC) enzyme activity and interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-alpha) expressions. MATERIAL and METHODS: Primary cell cultures were prepared. Samples that did not receive any medication constituted the control group, while culture samples treated with HCQ served as the study group. The surface morphology of cells and the extracellular matrix (ECM) were evaluated by Giemsa staining and inverted light microscopy. Cell viability, proliferation, and cytotoxicity were determined by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium-bromide (MTT) analysis. The cultures were simultaneously stained with acridine orange (AO)/propidium iodide (PI) and viewed under fluorescence microscopy. HDAC enzyme activity and IL-6, IL-10, and TNF-alpha expression were evaluated using commercial enzyme-linked immunosorbent assay kits. The obtained data were analyzed using statistical methods. The alpha significance level was accepted as p<0.05. RESULTS: HCQ applied to cell cultures at the tested doses and durations showed cytotoxic effects on cell viability, proliferation, and cell or ECM morphology. It increased HDAC activity in chondrocytes and caused a proinflammatory response, indicated by an increase in TNF-alpha in the cells (p<0.05). CONCLUSION: The results of this study emphasized that the cytotoxic effect of HCQ increased HDAC activity; therefore, this proinflammatory response should be taken into consideration in the clinical use of HCQ
The effect of calorie restriction on testicular tissue during aging process
No full text[No abstract available]Gazi University Scientific Research Project Unit [TCD-2023-8842, 8842]This project was supported by Gazi University Scientific Research Project Unit (Project No: TCD-2023-8842/Project ID: 8842)
Biological variation of thyroid stimulating hormone, free triiodothyronine and free thyroxine in healthy subjects in Turkey
No full textIntroduction: Biological variation (BV) data are necessary for interpretation of test results and assessment of analytical performance. We aimed to determine the BV estimates for thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine(fT4) in healthy subjects in Turkey and compare them with the literature findings. Materials and methods: A total of 21 Turkish healthy volunteers (12 males and 9 females) were included in the study. Blood samples were collected once a week for five weeks, and the analysis was performed using the chemiluminescent immunoassay method on an Advia Centaur XP (Siemens Diagnostic, Tarrytown, USA). Analytical variation (CVA), within-subject BV (CVI) and between-subject BV (CVG) were calculated. Analytical goals, individuality index (II) and reference change value (RCV) were derived from these data. Statistical analysis was performed using BioVar: BV analysis tool v.1.0. Results: For TSH, fT3 and fT4, CVA (confidence interval, CI) were 3.3% (2.9 to 3.8), 1.7% (1.5 to 1.9) and 2.7% (2.4 to 3.1); CVI (CI) were 22.3% (19.3 to 26.3), 4.4% (3.8 to 5.3) and 5.1% (4.3 to 6.1); CVG (CI) were 26.6% (19.2 to 39.8), 9.2% (6.9 to 13.6) and 8.2% (6.1 to 12.1), respectively. For TSH, fT3 and fT4, desirable total errors were 27.1%, 6.2% and 6.6%; II values were calculated as 0.84, 0.48 and 0.61; and RCV% values (decrease; increase) were - 40.3;67.6, - 10.4;11.6 and - 12.7;14.5, respectively. Conclusions: Our study provides updated BV data for thyroid function tests (TFTs) in healthy subjects in Turkey. As TFTs have shown a high degree of individuality, RCV should be preferred rather than population-based reference ranges in the assessment of serum concentrations. Our BV estimates were compatible with European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) BV meta-analysis data obtained using different immunoassay methods in different populations. © by Croatian Society of Medical Biochemistry and Laboratory Medicine
View from bibliometric framework of abdominal region traumatic injury in children
No full textÖZ Amaç: Çocukluk çağı abdominal bölge travmatik yaralanmaları hayati tehlike oluşturabilen ve aynı zamanda adli tıbbi öneme sahip ciddi yaralanmalardır. Dünya genelinde her gün 2000'den fazla çocuğun bu yaralanmalar sonucu hayatını kaybettiği belirtilmektedir. Bu çalışmada, Web of Science veritabanı kullanılarak yapılan çocukluk çağı abdominal bölge travmatik yaralanmalarına ilişkin çalışmalara bibliometrik çerçeveden bakılması amaçlanmaktadır. Yöntemler: Web of Science veritabanında "Child", "Children", "Pediatric", "Abdominal Trauma", "Abdominal Traumas", "Abdominal Injury" ve "Abdominal Injuries" anahtar sözcükleri kullanılarak bu sözcüklerin çalışma başlığında yer aldığı makaleler tespit edilmiş, bu makalelerin yazım dili, yayın yılı, yayınlandığı dergi, yazarları, yazar kurumları, çalışmaların yapıldığı ülke ve makalelere yapılan atıf sayısı gibi özellikleri incelenmiştir. Bulgular: Çalışma kapsamına alınan 285 makalenin 260’ının (%91,3) İngilizce dilinde yazıldığı, çalışmaların en sık Amerika Birleşik Devletleri, Türkiye ve Kanada’da yapıldığı, WoS kategorisine göre Cerrahi, Pediatri ve Acil Tıp kategorilerinin ön plana çıktığı belirlenmiştir. Sonuç: Bu çalışmada elde edilen veriler sayesinde ülkemizde ve diğer ülkelerde çocukluk çağı abdominal travmatik yaralanmaları ile ilgili yayınlanan makalelerin bibliyometrik değerlendirmesi ortaya konulmuştur. Çalışmamız bu alandaki araştırma verimliliğini ortaya koyan ilk çalışma niteliğindedir.ABSTRACT Objective: Childhood abdominal traumatic injuries are serious injuries that can be life-threatening and also have forensic medical importance. It is reported that more than 2000 children die every day worldwide as a result of these injuries. In this study, it is aimed to examine the studies on childhood abdominal traumatic injuries from a bibliometric framework using the Web of Science database. Material and Methods: Using the keywords "Child", "Children", "Pediatric", "Abdominal Trauma", "Abdominal Trauma", "Abdominal Traumas", "Abdominal Injury" and "Abdominal Injuries" in the Web of Science database, articles with these words in the title of the study were identified, and the characteristics of these articles such as language of writing, year of publication, journal, authors, author institutions, country of study and number of citations were examined. Results: It was determined that 260 (91.3%) of the 285 articles included in the study were written in English, the studies were most frequently conducted in the United States, Turkey and Canada, and the Surgery, Pediatrics and Emergency Medicine categories were prominent according to the WoS category. Conclusion: The bibliometric evaluation of articles published on childhood abdominal traumatic injuries in our country and other countries was revealed using to the data obtained in this study. Our study is the first of its kind to demonstrate research productivity in this field.Akdeniz Universit
Search for bottom quark associated production of the standard model Higgs boson in final states with leptons in proton-proton collisions at √s=13 TeV
No full textThis Letter presents the first search for bottom quark associated production of the standard model Higgs boson, in final states with leptons. Higgs boson decays to pairs of tau leptons and pairs of leptonically decaying W bosons are considered. The search is performed using data collected from 2016 to 2018 by the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb(-1). Upper limits at the 95% confidence level are placed on the signal strength for Higgs boson production in association with bottom quarks; the observed (expected) upper limit is 3.7 (6.1) times the standard model prediction.FWF (Austria); FNRS (Belgium); FWO (Belgium); CNPq (Brazil); CAPES (Brazil); FAPERJ (Brazil); FAPERGS (Brazil); FAPESP (Brazil); BNSF (Bulgaria); MoST (China); NSFC (China); CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER (Estonia); ERDF (Estonia); Academy of Finland (Finland); MEC (Finland); CEA (France); CNRS/IN2P3 (France); BMBF (Germany); DFG (Germany); HGF (Germany); NKFIH (Hungary); DAE (India); DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Republic of Korea); MES (Latvia); MOE (Malaysia); UM (Malaysia); BUAP (Mexico); CONACYT (Mexico); UASLP-FAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); FCT (Portugal); MESTD (Serbia); PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); NSTDA (Thailand); TUBITAK (Turkey); NASU (Ukraine); NSF (USA); Marie-Curie program (European Union); European Research Council (European Union); Horizon 2020 Grant (European Union) [675440, 724704, 752730, 758316, 765710, 824093, 884104]; COST Action (European Union) [CA16108]; Leventis Foundation; Alfred P. Sloan Foundation; Alexander von Humboldt Foundation; Belgian Federal Science Policy Office; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); FWO (Belgium) under the Excellence of Science - EOS - be.h project [30820817]; Beijing Municipal Science & Technology Commission [Z191100007219010]; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; Hellenic Foundation for Research and Innovation (HFRI) (Greece) [2288]; Deutsche Forschungsgemeinschaft (DFG) [EXC 2121, 390833306, 400140256 - GRK2497]; Hungarian Academy of Sciences (Hungary); Council of Science and Industrial Research, India; Latvian Council of Science; National Science Center (Poland) [Opus 2021/41/B/ST2/01369, 2021/43/B/ST2/01552]; National Priorities Research Program by Qatar National Research Fund; MCIN/AEI, ERDF a way of making Europe; Programa Severo Ochoa del Principado de Asturias (Spain); Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation (Thailand) [B05F650021]; Kavli Foundation; Nvidia Corporation; SuperMicro Corporation; Welch Foundation [C-1845]; Weston Havens Foundation (USA); BMBWF (Austria); MES (Bulgaria); CERN; CAS (China); MINCIENCIAS (Colombia); MSES (Croatia); ERC PUT (Estonia); HIP (Finland); GSRI (Greece); MSIP (Republic of Korea); LAS (Lithuania); CINVESTAV (Mexico); LNS (Mexico); SEP (Mexico); MOS (Montenegro); MES (Poland); NSC (Poland); MCIN/AEI (Spain); MST (Taipei); MHESI (Thailand); TENMAK (Turkey); STFC (United Kingdom); DOE (USA); F.R.S.-FNRS (Belgium); New National Excellence Program - UNKP (Hungary); NKFIH (Hungary) [K 124845, K 124850, K 128713, K 128786, K 129058, K 131991, K 133046, K 138136, K 143460, K 143477, 2020-2.2.1-ED-2021-00181, TKP2021-NKTA-64]; Ministry of Education and Science [2022/WK/14]; Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu (Spain) [MDM-2017-0765]We congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC and thank the technical and administrative staffs at CERN and at other CMS institutes for their contributions to the success of the CMS effort. In addition, we gratefully acknowledge the computing centers and personnel of the Worldwide LHC Computing Grid and other centers for delivering so effectively the computing infrastructure essential to our analyses. Finally, we acknowledge the enduring support for the construction and operation of the LHC, the CMS detector, and the supporting computing infrastructure provided by the following funding agencies: BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); MoER, ERC PUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MCIN/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (U.S.A.). Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 884104, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the Excellence of Science - EOS - be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Hellenic Foundation for Research and Innovation (HFRI), Project Number 2288 (Greece); the Deutsche Forschungsgemeinschaft (DFG), under Germany's Excellence Strategy - EXC 2121 Quantum Universe -390833306, and under project number 400140256 - GRK2497; the Hungarian Academy of Sciences, the New National Excellence Program - UNKP, the NKFIH research grants K 124845, K 124850, K 128713, K 128786, K 129058, K 131991, K 133046, K 138136, K 143460, K 143477, 2020-2.2.1-ED-2021-00181, and TKP2021-NKTA-64 (Hungary); the Council of Science and Industrial Research, India; the Latvian Council of Science; the Ministry of Education and Science, project no. 2022/WK/14, and the National Science Center, contracts Opus 2021/41/B/ST2/01369 and 2021/43/B/ST2/01552 (Poland); the Fundacao para a Ciencia e a Tecnologia, grant CEECIND/01334/2018 (Portugal); MCIN/AEI/10.13039/501100011033, ERDF a way of making Europe, and the Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu, grant MDM-2017-0765 and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, grant B05F650021 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (U.S.A.)
Glyphosate impairs both structure and function of GABAergic synapses in hippocampal neurons
No full textGlyphosate (Gly) is a broad-spectrum herbicide responsible for the inhibition of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase known to be expressed exclusively in plants and not in animals. For decades Gly has been thought to be ineffective in mammals, including humans, until it was demonstrated that rodents treated with the Gly-based herbicide Roundup showed reduced content of neurotransmitters (e.g., serotonin, dopamine, norepinephrine, and acetylcholine), increased oxidative stress in the brain associated with anxiety and depression-like behaviors and learning and memory deficits. Despite compelling evidence pointing to a neurotoxic effect of Gly, an in-depth functional description of its effects on synaptic transmission is still lacking. To investigate the synaptic alterations dependent on Gly administration we performed whole-cell patch-clamp recordings and immunocytochemistry on mouse primary cultured hippocampal neurons. Our findings reveal that 30 min incubation of Gly at the acceptable daily intake dose severely impaired inhibitory GABAergic synapses. Further analysis pointed out that Gly decreased the number of postsynaptic GABAA receptors and reduced the amplitude of evoked inhibitory postsynaptic currents, the readily releasable pool size available for synchronous release and the quantal size. Finally, a decreased number of release sites has been observed. Consistently, morphological analyses showed that the density of both pre- and post-synaptic inhibitory compartments decorating pyramidal cell dendrites was reduced by Gly. In conclusion, our experiments define for the first time the effects induced by Gly on GABAergic synapses, and reveal that Gly significantly impairs both pre- and postsynaptic mechanisms.FSE REACT-EU ProgramPhD scholarship from the FSE REACT-EU Program
Photoluminescence properties and structural analysis of Tb3+-doped K3Gd (BO2)6: A first study on negative thermal quenching
No full textIn this study, Tb3+-doped K3Gd(BO2)6 phosphors were synthesized using the microwave-assisted sol-gel method to explore their photoluminescence (PL) properties and thermal stability. XRD and Rietveld refinement confirmed the incorporation of Tb3+ions, without secondary phases. PL analysis revealed a strong green emission near 542 nm, attributed to the 5 D 4 -> 7 F 5 transition of Tb3+ions. An optimal Tb3+concentration of 3 wt% was identified, beyond which concentration quenching significantly reduced luminescence intensity. Radiative energy transfer, occurring via reabsorption, was observed at lower concentrations, facilitating efficient energy migration. Conversely, at higher concentrations, non-radiative processes such as cross-relaxation dominated. Remarkably, negative thermal quenching (NTQ) was observed up to 470 K, with an activation energy of 0.96 eV. Additionally, Na+ co- doping introduced lattice distortions that enhanced energy transfer between Tb3+ions and improved luminescence efficiency. The chromaticity diagram highlighted a shift towards the yellow-green region with increasing the Tb3+concentration, demonstrating tunable emission properties for solid-state lighting applications.Turkish Scientific Research Council [223M036, TUBITAK-1001]; Izmir Bakimath;ray University Scientific Research Projects Coordination Unit [HZP.2024.008]This study was supported by the Turkish Scientific Research Council with the project numbered 223M036 within the scope of theTUBITAK-1001 project. This work was also supported by Izmir Bak & imath;rcay University Scientific Research Projects Coordination Unit, under grant number HZP.2024.008