3586 research outputs found
Sort by
The effect of motivational interviewing technique on social anxiety and quality of life of adolescents with epilepsy
No full textBackground and objectives: The aim of this study was to evaluate the effect of motivational interviewing on social anxiety and quality of life of adolescents with epilepsy. Methods: The study was conducted with 72 children aged 12–15 years who met the inclusion criteria and agreed to participate in the study. Data were collected using the ‘‘Personal Information Form’’, ‘‘Social Anxiety Scale for Adolescents’’, ‘‘General Child Quality of Life Scale’’ and ‘‘KINDL Epilepsy Quality of Life Module for Children’’. The group that received motivational interviewing formed the interview group (n = 36), and the group that continued routine monitoring formed the control group (n = 36). The interview group received 7 sessions of motivational interviewing. Results: Social anxiety of adolescents with epilepsy in the motivational interview group, which was high before the interview, decreased significantly after the interview and 1 month after the end of the interview (p < 0.001). In the control group, social anxiety increased significantly after the interview (p < 0.001). The quality of life of adolescents with epilepsy in the motivational interview group, which was low before the interview, increased significantly after the interview and 1 month after the end of the interview (p < 0.001). A significant difference was observed in the total scores of the KINDL Epilepsy Quality of Life Module for adolescents in the control group (p = 0.004). Conclusion: The results of our study show that motivational interviewing is effective in reducing social anxiety and improving the quality of life of adolescents with epilepsy. © 2025 Elsevier B.V., All rights reserved
Search for resonant pair production of Higgs bosons in the b(b)over-barb(b)over-bar final state using large-area jets in proton-proton collisions at ?s=13 TeV
No full textA search is presented for the resonant production of a pair of standard model-like Higgs bosons using data from proton-proton collisions at a centre-of-mass energy of 13 TeV, collected by the CMS experiment at the CERN LHC in 2016-2018, corresponding to an integrated luminosity of 138 fb(-1). The final state consists of two b quark-antiquark pairs. The search is conducted in the region of phase space where at least one of the pairs is highly Lorentz-boosted and is reconstructed as a single large-area jet. The other pair may be either similarly merged or resolved, the latter reconstructed using two b-tagged jets. The data are found to be consistent with standard model processes and are interpreted as 95% confidence level upper limits on the product of the cross sections and the branching fractions of the spin-0 radion and the spin-2 bulk graviton that arise in warped extradimensional models. The limits set are in the range 9.74-0.29 fb and 4.94-0.19 fb for a narrow radion and a graviton, respectively, with masses between 1 and 3 TeV. For a radion and for a bulk graviton with widths 10% of their masses, the limits are in the range 12.5-0.35 fb and 8.23-0.23 fb, respectively, for the same masses. These limits result in the exclusion of a narrow-width graviton with a mass below 1.2 TeV, and of narrow and 10%-width radions with masses below 2.6, and 2.9 TeV, respectively.FWF; FNRS; FWO (Belgium); CNPq; CAPES; FAPERJ; FAPERGS; FAPESP (Brazil); BNSF (Bulgaria); MoST; NSFC (China); CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); ERC PRG [MoER TK202]; Academy of Finland; MEC; CEA; CNRS/IN2P3 (France); SRNSF; BMBF; DFG; HGF (Germany); NKFIH (Hungary); DAE; DST; IPM; SFI (Ireland); INFN (Italy); NRF (Republic of Korea); MES (Latvia); MOE; UM (Malaysia); BUAP; CONACYT; UASLP-FAI (Mexico); PAEC (Pakistan); FCT (Portugal); MESTD (Serbia); PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); NSTDA; TUBITAK; DOE; NSF; Marie-Curie programme; European Research Council; Horizon 2020 Grant [675440, 724704, 752730, 758316, 765710, 824093, 101115353, 101002207]; COST Action [CA16108]; Leventis Foundation; Alfred P. Sloan Foundation; Alexander von Humboldt Foundation; Science Committee [22rl-037]; Belgian Federal Science Policy Office; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); FWO (Belgium) under the Excellence of Science -EOS [30820817]; Beijing Municipal Science AMP; Technology Commission [Z191100007219010]; Fundamental Research Funds for the Central Universities (China); Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; Shota Rustaveli National Science Foundation [FR-22-985]; Deutsche Forschungsgemeinschaft (DFG) [EXC 2121, 400140256 -GRK2497]; Hellenic Foundation for Research and Innovation (HFRI) [2288]; Hungarian Academy of Sciences [K 131991, K 133046, K 138136, K 143460, K 143477, K 146913, K 146914, K 147048, 2020-2.2.1-ED-2021-00181, TKP2021-NKTA-64]; Council of Science and Industrial Research, India - NextGenerationEU program (Italy); Latvian Council of Science; Ministry of Education and Science [2022/WK/14]; National Science Center [Opus 2021/41/B/ST2/01369, 2021/43/B/ST2/01552]; Fundacao para a Ciencia e a Tecnologia [CEECIND/01334/2018]; National Priorities Research Program by Qatar National Research Fund; ERDF a way of making Europe [MDM-2017-0765]; Programa Severo Ochoa del Principado de Asturias (Spain); National Science, Research and Innovation Fund via the Program Management Unit for Human Resources AMP; Institutional Development, Research and Innovation [B05F650021]; Kavli Foundation; Nvidia Corporation; SuperMicro Corporation; Welch Foundation [C-1845]; Weston Havens Foundation (U.S.A.)We congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC and thank the technical and administrative staffs at CERN and at other CMS institutes for their contributions to the success of the CMS effort. In addition, we gratefully acknowledge the computing centres and personnel of the Worldwide LHC Computing Grid and other centres for delivering so effectively the computing infrastructure essential to our analyses. Finally, we acknowledge the enduring support for the construction and operation of the LHC, the CMS detector, and the supporting computing infrastructure provided by the following funding agencies: SC (Armenia), BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); ERC PRG, RVTT3 and MoER TK202 (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); SRNSF (Georgia); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LMTLT (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MCIN/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (U.S.A.). Individuals have received support from the Marie-Curie programme and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 101115353, 101002207, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Science Committee, project no. 22rl-037 (Armenia); the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the Excellence of Science -EOS -be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010 and Fundamental Research Funds for the Central Universities (China); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Shota Rustaveli National Science Foundation, grant FR-22-985 (Georgia); the Deutsche Forschungsgemeinschaft (DFG), among others, under Germany's Excellence Strategy -EXC 2121 Quantum Universe -390833306, and under project number 400140256 -GRK2497; the Hellenic Foundation for Research and Innovation (HFRI), Project Number 2288 (Greece); the Hungarian Academy of Sciences, the New National Excellence Program -UNKP, the NKFIH research grants K 131991, K 133046, K 138136, K 143460, K 143477, K 146913, K 146914, K 147048, 2020-2.2.1-ED-2021-00181, and TKP2021-NKTA-64 (Hungary); the Council of Science and Industrial Research, India; ICSC -National Research Centre for High Performance Computing, Big Data and Quantum Computing and FAIR -Future Artificial Intelligence Research, funded by the NextGenerationEU program (Italy); the Latvian Council of Science; the Ministry of Education and Science, project no. r 2022/WK/14, and the National Science Center, contracts Opus 2021/41/B/ST2/01369 and 2021/43/B/ST2/01552 (Poland); the Fundacao para a Ciencia e a Tecnologia, grant CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; MCIN/AEI/10.13039/501100011033, ERDF a way of making Europe, and the Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu, grant MDM-2017-0765 and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, grant B05F650021 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (U.S.A.)
Tehdit, Teftiş ve Önlem: İstanbul’da Kamu Sağlığını Korumaya Yönelik Bazı Çalışmalar (Eylül 1885)
No full textAmaç: Bu çalışma, Eylül 1885’te Şehremaneti (Belediye) tarafından görevlendirilen bir baş müfettiş ile tabibin İstanbul’un bazı semtlerinde yaptığı teftişler sonucunda kaleme aldıkları raporlara dayanarak, Şehremanetinin kamu sağlığını tehdit edebilecek durumlara karşı ne gibi önlemler aldığını ortaya koymayı amaçlamaktadır. Yöntem: 15 Mart-4 Temmuz 2025 tarihleri arasında yapılan bu çalışmada tarih araştırmalarında kullanılan klasik yöntem kullanılmıştır. Bu çerçevede Osmanlı Arşivi’nin farklı tasniflerinde yer alan belgelerden ve konuyla ilgili araştırma eserlerinden yararlanılmıştır. Bulgular: Osmanlı Devleti’nde kamu sağlığı anlayışının ortaya çıkması Tanzimat Döneminde olmuştur. Tanzimat’la birlikte birçok alanda olduğu gibi belediyecilik alanında da modernleşme yoluna gidilmiştir. İstanbul’da görülen kolera salgınları sokak ve çevre temizliğine dikkati arttırmıştır. 16 Ağustos 1854’te resmi bir tebliğ ile Şehremaneti (Belediye) kurulmuştur. Ayrıca zaman içerisinde kamu sağlığını koruma adına bazı yasal düzenlemeler de yapılmıştır. İstanbul’un tamamını kapsayacak şekilde gelişen belediye teşkilatının görevleri arasında halkın sağlığını korumak için yiyecek ve içecekler ile bunları üretip satanları kontrol etmek de bulunmaktaydı. Şehremaneti, Eylül 1885’te görevlendirdiği baş müfettiş ve tabip marifetiyle bir dizi teftiş gerçekleştirmiştir. Bu teftişlere ait raporlar İstanbul’da kamu sağlığını tehdit edebilecek nitelikteki durumları ve alınan önlemleri göstermesi bakımından önemlidir. Sonuç: Hasköy, Piri Paşa, Balat, Kasım Paşa ve Kantarcılar çevresinde yoğunlaşan teftişlerde çeşitli iş kollarındaki dükkanlar ve bekar odaları teftiş edilmiştir. Yiyecek-içecek üreten ve satan mekanlar ile insanların toplu olarak bir arada bulundukları yerlerin teftişine önem verildiği görülmektedir. Alınan önlemler Şehremanetinin kamu sağlığını dikkate aldığını göstermektedir
Clinical and functional outcomes of hand surgery for recessive dystrophic epidermolysis bullosa
No full textRecessive dystrophic epidermolysis bullosa causes blistering and scarring of the hands, resulting in contractures fused web spaces and altered function. The aim of this study was to present the short- and mid-term clinical and functional results of a large case series of patients who underwent surgery for recessive dystrophic epidermolysis bullosa-related pseudosyndactyly. The study included 75 hands in 39 children (21 boys, 18 girls) with a mean age of 8 years (range, 4–15) and minimum follow-up of 1 year. Children were assessed with the Birmingham Epidermolysis Bullosa Severity Score Sheet and the ABILHAND-Kids questionnaire before operation and at final follow-up. There were varying degrees of recurrent scarring in all the hands by 24 months after operation. The ABILHAND-Kids questionnaire showed a significant improvement in ability to perform 17 of 21 tasks. In conclusion, despite recurrence that may develop in the short and mid term, surgical release can provide significant improvements in hand function. Level of Evidence: IV © 2025 Elsevier B.V., All rights reserved
The ameliorative effects of hesperidin in rats developed hepatotoxicity with deltamethrin
No full textObjective(s): Deltamethrin (DLM) is a widely used insecticide in agriculture; however, exposure to it can lead to serious health problems. This study aimed to evaluate the protective effects of hesperidin (HSP), a natural antioxidant, against DLM-induced liver toxicity. Materials and Methods: Thirty-two male Wistar Albino rats (250-300 g, 4 months old) were divided into four groups. The control group received 1 ml of corn oil via oral gavage for 30 days. The DLM group received 1.28 mg/kg DLM in corn oil for 30 days. The DLM+HSP 100 mg/kg and DLM+HSP 300 mg/kg groups received 1.28 mg/kg DLM followed by 100 mg/kg or 300 mg/kg HSP in distilled water, respectively, 30 min after DLM administration for 30 days. Liver tissues were examined histopathologically. Masson's trichrome staining and PCR assessed fibrosis. Caspase 3 and 9 expressions in liver tissues were determined by immunohistochemistry and PCR. Biochemical analyses were conducted on serum samples. Results: HSP supplementation led to a dose-dependent decrease in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. DLM exposure decreased antioxidant capacity, while HSP supplementation increased it dose-dependently. Histopathological evaluations showed increased liver damage in the DLM group, while HSP administration reduced liver toxicity. Masson's trichrome staining and analysis of collagen I (COL1A1) and collagen III (COL3A1) gene expression revealed increased fibrosis in the DLM group, which was attenuated with HSP treatment. Conclusion: The potential prevention of DLM-induced liver toxicity and apoptosis by HSP may be an alternative protective strategy.Necmettin Erbakan University Scientific Research Projects Coordination Office [KBP.2021.011]Funding This project was supported by the Necmettin Erbakan University Scientific Research Projects Coordination Office (Project No: KBP.2021.011
Clinical Outcomes and Mortality in Patients with Implantable Cardioverter-Defibrillator for Primary Prevention|Desfechos Clínicos e Mortalidade em Pacientes com Cardioversor-Desfibrilador Implantável para Prevenção Primária
No full textBackground: Implantable cardioverter-defibrillator (ICD) is indicated for primary prevention in patients with left ventricular ejection fraction (LVEF) ? 35% and New York Heart Association class II or III heart failure despite 3 months of optimal medical therapy. However, studies that support this recommendation are over 20 years old, and they may not reflect modern heart failure patients’ characteristics. Objectives: Retrospectively evaluate patients who received an ICD for primary prevention. Methods: All-cause and sudden death rates were compared in patients who received ICD between January 1, 2015 and March 1, 2020 and those who did not accept ICD. Variables were analyzed at a 95% confidence interval, and p < 0.05 was considered as significant. Results: When comparing mortality rates between patients with and without ICD, 67 of 228 patients (29.4%) in the ICD group and 39 of 150 patients (26%) in the control group died from all causes (p = 0.473). Age, LVEF, BNP value, and hospitalization were found to be independent predictors of all-cause mortality. Patients with BNP above 508.5, LVEF below 24.5%, and age over 68.5 years had a 25-fold increased all-cause mortality. Coronary artery disease was not found to be an independent risk factor. Survival in the control group was statistically significantly better in the first months. Although there was no statistical difference in the long term, survival was numerically better in the ICD arm. This could be attributed to the fact that ICD implantations were performed on patients with worse clinical conditions. The higher survival rate observed in patients with ICD may be due to the fact that they came in for device control and remained in follow-up. Conclusions: With advances in the treatment of heart failure, ICD implantation should be performed in selected patients. © 2025 Elsevier B.V., All rights reserved
Factors Associated with Ischaemic Stroke Development Despite Oral Anticoagulant Therapy in Patients with Non-Valvular Atrial Fibrillation
No full textObjective: To evaluate the effectiveness of the most popular risk scores (CHADS2, CHA2DS2-VASc, and ATRIA scores) in predicting stroke events in patients with non-valvular atrial fibrillation (NVAF) who were already receiving oral anticoagulant therapy (OAT). Study Design: An observational study. Place and Duration of the Study: Department of Cardiology, Ataturk Research and Training Hospital, Izmir Katip Celebi University, Izmir, Turkiye, from January 2020 to December 2023. Methodology: Patients with NVAF who were on OAT were divided into two groups. Group 1 consisted of patients who had not experienced a stroke while on OAT, and Group 2 consisted of patients who had experienced at least one stroke while on OAT at the time of inclusion. Continuous variables were presented as mean or median values and were compared using Student's t-test or Mann-Whitney U test, depending on the type of data distribution. Results: There were 162 patients in Group 1 and 129 patients in Group 2, the majority being females. The median age of patients was 76 years (IQR: 71-82) in Group 1 and 75 years (IQR: 68-81) in Group 2. Comorbidities were statistically similar in both groups except for hyperlipidemia. Treatment for atrial fibrillation (AF) was also statistically similar in both groups. The CHA2DS2-VASc and ATRIA stroke scores showed statistically significant differences between the groups. In univariate analysis, hyperlipidemia and ATRIA stroke score were >8, and in multivariate analysis, only ATRIA stroke score was >8, which showed a correlation with estimating the risk of ischaemic stroke (IS) events under oral anticoagulation (OAC). The ATRIA stroke score showed a strong correlation Spearman's rho test and in the ROC curve. Conclusion: The CHA2DS2-VASc, CHADS, and ATRIA risk scores have proven effective in primary IS prophylaxis. The ATRIA stroke score system for secondary prevention appears to be more effective than the most popular score systems
112 emergency call centers and their activities as a new institutional structure in the emergency aid system: Overview, function, place in the Turkish administrative structure, evaluation of its activity within the scope of the administration's responsibility
No full textBireyin, kendini en zayıf hissettiği zaman dilimi, canına veya malına yönelik tehdit ve kaza anlarıdır. Kişilerin yaşama hakkı ve kamu hizmetlerin yararlanma hakkı çerçevesinde, hayatın normal akışında varlığını çok hissetmedikleri fakat olağandışı anlarda ihtiyaç hissettikleri acil çağrı ve yardım hizmetleri, olan kamu hizmeti sistematiğinin dışında, minimum bürokrasiyle faaliyetleri sürdüren kurumlardır. 2009 yılında Antalya'da pilot uygulama olarak hayatımıza giren acil çağrı merkezlerinin, 2021 yılında tüm Türkiye çapında hizmet verir hale gelmesiyle bu kurumun; genel işleyişi, Türk idare yapısındaki yeri ve yapılan faaliyetin idarenin sorumluluğu kapsamında bu çalışmada incelenmesi amaçlanmaktadır. Devletin asli görevi olan; güvenlik, adalet, sağlık, eğitim hizmetlerinin devletin ana birimleri tarafından verilmesi esası kapsamında, 112 Acil Çağrı Merkezleri güvenlik ve sağlık hizmetlerini anlık acil yardım talebi kapsamında vatandaşa, yapılan hizmet sonrası eldeki kayıtları savcılıklara ve mahkemeler vererek adli makamlara hizmet vermektedir. Acil yardım hizmetinin 7 gün 24 saat kesintisiz yerine getirilme zorunluluğu, vatandaşın acil durumda sadece üç rakamı tuşlayarak tek numara üzerinden kolaylıkla bu hizmete ulaşma zorunluluğu, konunun ehemmiyetini arttırmaktadır. Bu ehemmiyet seviyesi, olaya müdahalede saniyelerle yarışılan bir faaliyeti kapsaması nedeniyle artmakta ve hizmetin herhangi bir aksaklığı içermeyecek şekilde planlanmasını gerektirmektedir. Hizmetin verilmesi sırasında oluşacak aksaklıklar ya da hizmetin yerinde verilmemesi sonucu can ve mal kayıplarına varan sonuçların oluşma riski faaliyetin önemini arttırmakta ve idarenin sorumluluğu bağlamında konunun ele alınma gerekliliğini ortaya çıkarmaktadır. "Acil yardım sisteminde yeni bir kurumsal yapı olarak 112 Acil Çağrı Merkezleri ve faaliyetleri: genel Bakış, işlev, Türk idare yapısındaki yeri, faaliyetinin idarenin sorumluluğu kapsamında değerlendirilmesi" başlığıyla hazırlanan bu çalışmada; ilgili kurumun yetkililerinden alınan bilgiler, konu hakkındaki yayınların ayrıntılı incelenmesi, 112 Acil Çağrı Merkezlerinin kurumsal yapısının incelenmesiyle elde edilen sonuçlar ve ulaşılabilen hizmet kaynaklı kusur örneklerinden yola çıkarak, idarenin sorumluluğu kapsamında, bu faaliyet değerlendirilmiştir.The time period when an individual feels the weakest is the moments of threat and accidents to their life or property. Within the framework of the right to life and the right to benefit from public services, emergency call and assistance services that are not felt much in the normal flow of life but are needed in extraordinary moments are institutions that continue their activities with minimum bureaucracy outside of the public service systematic. The emergency call centers, which entered our lives as a pilot application in Antalya in 2009, are aimed to be examined in this study within the scope of the general operation of this institution, its place in the Turkish administrative structure and the responsibility of the administration in the activities carried out. Within the scope of the principle that security, justice, health and education services, which are the primary duties of the state, are provided by the main units of the state, 112 Emergency Call Centers provide security and health services to citizens within the scope of instant emergency assistance requests, and provide services to judicial authorities by providing the records on hand after the service to the prosecutor's offices and courts. The necessity of providing emergency aid services 24/7 without interruption, and the necessity for citizens to easily reach this service by dialing only three digits in case of emergency via a single number, increases the importance of the issue. This level of importance increases because it involves an activity where seconds race in response to an incident and requires the service to be planned in a way that does not include any disruptions. The risk of consequences that may lead to loss of life and property due to disruptions that may occur during the provision of the service or failure to provide the service on-site increases the importance of the activity and reveals the necessity of addressing the issue within the context of the responsibility of the administration. In this study prepared under the title of "112 Emergency Call Centers and Their Activities as a New Institutional Structure in the Emergency Aid System: General Overview, Function, Place in the Turkish Administrative Structure, Evaluation of Their Activities within the Scope of the Responsibility of the Administration"; this activity was evaluated within the scope of the responsibility of the administration based on the information received from the authorities of the relevant institution, detailed examination of publications on the subject, results obtained by examining the institutional structure of 112 Emergency Call Centers and accessible service-related defect examples
Comparison of Fixed-Dose Clopidogrel/Asetylsalicylic Acid Combination and Standard Loading Strategy During Percutaneous Coronary Intervention in Chronic Coronary Syndrome
No full textBackground: Dual antiplatelet therapy (DAPT), comprising acetylsalicylic acid and a P2Y12 receptor inhibitor such as clopidogrel, is the cornerstone of management in patients undergoing percutaneous coronary intervention (PCI). While conventional loading doses of acetylsalicylic acid and clopidogrel are well established, there is limited evidence supporting the use of fixed-dose combinations (FDCs) for loading therapy in patients with chronic coronary syndrome (CCS). Aims: This study aims to evaluate the efficacy and safety of an FDC of clopidogrel and acetylsalicylic acid (75/75 mg, four tablets) compared to the standard loading regimen in patients with CCS undergoing elective PCI. Methods: In this prospective observational study, patients were divided into two groups based on the antiplatelet loading strategy: conventional loading (acetylsalicylic acid 300 mg and clopidogrel 300-600 mg) and FDC group (four tablets of 75/75 mg). Baseline demographic, clinical, laboratory, and procedural characteristics were compared. The primary outcomes were 1-month rates of major adverse cardiovascular events (MACE), stent thrombosis, bleeding (BARC criteria), and mortality. Results: A total of 410 patients were included (conventional: 326; FDC: 84). There were no statistically significant differences in baseline demographic or procedural characteristics between the groups. Laboratory findings and 1-month clinical outcomes, including MACE, bleeding, and mortality, were similar (p > 0.05 for all outcomes). Conclusion: Fixed-dose clopidogrel/acetylsalicylic acid combination may be a feasible and clinically comparable option in carefully selected CCS patients to standard loading in CCS patients undergoing elective PCI. Its use may simplify treatment regimens.The authors received no specific funding for this work. Funding Source: Medlin
