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Chemistry 4.0: How the Digital Revolution is Changing Chemical Research: Medicinal Chemistry and Chemical Biology Highlights
No full text125th Anniversary of the School of Engineering and Architecture of Fribourg (HEIA-FR): Chimia Report/Company News
No full textThis year, on the 14th of January 2021 the School of Engineering and Architecture (HEIA-FR) celebrated its 125th anniversary. To celebrate, many interactive events are organized from February to September 2021
Questions for Classroom Response Systems and Teaching Instrumental Element Analysis
Get PDFAsking students questions is a central, although understudied and underappreciated, ingredient of teaching. Formative questioning provides many opportunities for teachers and students, e.g. to practice skills and receive feedback. Among other approaches, classroom response systems
(CRSs), which run on the mobile electronic devices of students, facilitate such active engagement of students in the lecture hall. This paper presents an overview on questions for teaching with a focus on questions for CRSs and provides considerations and brief guidelines for the development
of multiple-choice questions. Examples from a mid-sized analytical chemistry lecture illustrate additional challenges and different probes for potential misconceptions. Moreover, limitations of valid interpretation of students\u27 responses are emphasized. This leads to a discussion of the value
of incorporating prompts for justifications into questions
From Sugar to Nutritional Products – Product Form Development
Get PDFThe formulation of active ingredients into emulsion- and suspension-based delivery systems offers a wide range of opportunities to produce stable and highly bioavailable product forms for their later application in human and animal nutrition. Recent trends in product form development have focused on using renewable and naturally-derived raw materials to meet the increasing consumer demand on sustainable value chains and nutritional products with ‘clean labelling’. Therefore, we reviewed chemical fundamentals and application examples of plant-derived protective hydrocolloids with highly potent emulsifying capacity, in particular, modified starches, pectin, and lignosulfonates, for the formulation of vitamins, carotenoids, and other active ingredient
Use of Renewable Resources Towards the Sustainable Production of Crop Protection Agents
Get PDFToday, the production of food accounts for roughly one quarter of the anthropogenic greenhouse gas emissions. Since the 1970s, thanks to substantial research and development, the overall yield output in farm fields has increased by ca. 60%, while the net use of crop protection agents per square meter of farm field has been reduced by more than 90%. The development of modern crop protection agents remains an important need as new pests, diseases and weeds continue to affect crops. The vast majority of these effective solutions are manufactured using raw materials that ultimately come from fossil resources. In this article, we are touring within the agrochemical landscape to provide the reader with an overview of concrete examples on how in this industrial field, renewable and sustainable raw materials have been used to produce active ingredients. We are also discussing the opportunities for future development as well as some of the challenges and needs that are emerging
Flipper Probes for the Community
Get PDFThis article describes four fluorescent membrane tension probes that have been designed, synthesized, evaluated, commercialized and applied to current biology challenges in the context of the NCCR Chemical Biology. Their names are Flipper-TR©, ER Flipper-TR©, Lyso Flipper-TR© and Mito Flipper-TR©, they are available from Spirochrome
Chemical-Biology-derived in vivo Sensors: Past, Present, and Future
Get PDFTo understand the complex biochemistry and biophysics of biological systems, one needs to be able to monitor local concentrations of molecules, physical properties of macromolecular assemblies and activation status of signaling pathways, in real time, within single cells, and at high spatio-temporal resolution. Here we look at the tools that have been / are being / need to be provided by chemical biology to address these challenges. In particular, we highlight the utility of molecular probes that help to better measure mechanical forces and flux through key signalling pathways. Chemical biology can be used to both build biosensors to visualize, but also actuators to perturb biological processes. An emergent theme is the possibility to multiplex measurements of multiple cellular processes. Advances in microscopy automation now allow us to acquire datasets for 1000’s of cells. This produces high dimensional datasets that require computer vision approaches that automate image analysis. The high dimensionality of these datasets are often not immediately accessible to human intuition, and, similarly to ‘omics technologies, require statistical approaches for their exploitation. The field of biosensor imaging is therefore experiencing a multidisciplinary transition that will enable it to realize its full potential as a tool to provide a deeper appreciation of cell physiology