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European Chemical Society (EuChemS) Division of Chemistry and the Environment: EuChemS-DCE career award 2023 given to Prof. em. Walter Giger, Eawag/ETH Zurich
No full textAt ICCE 2023, held in Venice, Italy, Prof. em. Prof. Walter Giger received the 2023 EuChemS DCE Lifetime Achievement Award from the European Chemical Society, Division of Chemistry and the Environment (EuChemS DCE)
Geochemical Soil Atlas of Switzerland - Distribution of Toxic Elements
Get PDFChemical elements such as copper and molybdenum are essential for animal and human health but may become toxic at elevated concentrations depending on the exposure and intake rate. Other elements such as mercury pose a threat to human health at already low concentrations. The soil acts as the main source of these elements for plant uptake and is thus driving accumulation along the food chain. However, in Switzerland, no nationwide information on elemental distributions in soils has existed up to now. The geochemical soil atlas of Switzerland will fill this gap by presenting the concentration ranges and the spatial distribution of 20 elements in the topsoil. In this summary, we present the methodological approaches and some main findings of the atlas with a focus on toxic elements as well as elements that can be or are toxic at higher concentrations
Talent meets Industry – Industry Meets Talent: The Meet & Greet Event with the Alfred Werner Scholars on Novartis Campus
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The Rocky Road to a Digital Lab
Get PDFThe pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs). The development of smart manufacturing routes can be accelerated by utilizing digitalization, process analytical technology (PAT), and data-rich experimentation from an early stage. Here, we present the key aspects of implementing automated flow chemistry reactor platforms with real-time process analytics. Based on our experiences in this field, we aim to highlight the potential of these platforms to conduct self-optimization, automated reaction model building, dynamic experiments and to implement advanced process control strategie
Clinically Approved Antibiotics from 2010 to 2022
Get PDFThis review discusses small molecule antibiotics approved for clinical use in the time frame 2010-2022. This time span saw the approval of four synthetic antibiotics (bedaquiline, pretomanid, delafloxacin, tedizolid), nine natural product derivatives (ceftaroline fosamil, cefiderocol, plazomicin, omadacycline, eravacycline, sarecycline, lefamulin, dalbavancin, oritavancin), and one natural product (fidaxomicin)
Cold Ion-Molecule Chemistry: The Very Different Reactions of He⁺ with CO and NO
Get PDFThe ion-molecule reactions He+ + CO → He + C+ + O and He+ + NO → He + N+ + O have been measured at collision energies between 0 and kB · 10 K. Strong variations of the rate coefficients are observed below kB · 5 K. The rate of the He+ + CO reaction decreases by ~30% whereas that of the He+ + NO reaction increases by a factor of ~1.5. These observations are interpreted in the realm of an adiabatic-channel capture model as arising from interactions between the ion charge and the dipole and quadrupole moments of CO and NO. We show that the different low-energy behavior of these reactions originates from the closed- vs. open-shell electronic structures of CO and NO
