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Quinacrine – The Winding Road from the Most Important Antimalarial of Its Time to an Indispensable Antiparasitic (Orphan) Drug of our Days
Get PDFQuinacrine, the main antimalarial drug during World War II, has had a chequered history that included the successful repurposing as an intrapleural sclerosant for the treatment of malignant pleural effusions, a non-surgical method of female sterilisation, and the use as an immunomodulatory drug in lupus erythematosus. While no longer used for these former indications, quinacrine (re)emerged as an indispensable second-line drug for the treatment of nitroimidazole-refractory Giardia duodenalis infections, and thus depicts an indispensable “orphan drug”
CHanalysis 2023 - Artificial Intelligence meets Analytical Excellence: Conference Report
No full textThe Growing Problem of the Spruce Bark Beetle: Chemical Education
No full textThe European spruce bark beetles release aggregation pheromones to trigger attack on Norway spruce trees; attracting beetles through the use of pheromone traps proves less effective than conventional forest management.
 
Büchi AG
Get PDFBüchi AG – büchiglasuster – leading Swiss manufacturer of reactor systems, pilot plants and process solutions for cGMP API synthesis – from lab through pilot plant/kilo lab to production scale
Ein Lernposter zum Aufbau von Reinstoffen
Get PDFPure chemical substances present a clearly defined area for teaching in which fundamental chemistry concepts can be treated didatically. However, the multitude of concepts involved can easily lead to misunderstandings. A graphical visualisation is presented that can help the students to understand the structure and the scope of the different concepts
Photochemical Upcycling/Modification of Polystyrene-based Plastic Waste
Get PDFThe escalating accumulation of plastic waste in landfills and marine environments has become a pressing concern to society. Among all plastic-based waste, polystyrenes are widely utilized as a commodity plastic and present very low recyclability. To improve this scenario, photocatalysis has recently become one of the viable techniques which can be performed under mild conditions. In this concise review, we have highlighted recent advancements in the valorization of polystyrene-based plastic waste by mainly focusing on the selective functionalization of the C–H bonds. This strategy clearly holds strong promise for the sustainable and efficient conversion of polystyrene-based waste and contributes to the reduction of waste and resource conservation
Swiss CAT+, a Data-driven Infrastructure for Accelerated Catalysts Discovery and Optimization
Get PDFThe Catalysis Hub – Swiss CAT+ is a new infrastructure project funded by ETH-domain, co-headed by EPFL and ETHZ. It offers the scientific community a unique integrated technology platform combining automated and high-throughput experimentation with advanced computational data analysis to accelerate the discoveries in the field of sustainable catalytic technologies. Divided into two hubs of expertise, homogeneous catalysis at EPFL and heterogeneous catalysis at ETHZ, the platform is open to academic and private research groups. Following a multi-year investment plan, both hubs have acquired and developed several high-end robotic platforms devoted to the synthesis, characterization, and testing of large numbers of molecular and solid catalysts. The hardware is associated with a fully digitalized experimental workflow and a specific data management strategy to support closed-loop experimentation and advanced computational data analysis