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Towards Greener and More Cost-efficient Biosynthesis of Pharmaceuticals and Fragrance Molecules
Get PDFEnzymes are natural catalysts which are gaining momentum in chemical synthesis due to their exquisiteselectivity and their biodegradability. However, the cost-efficiency and the sustainability of the overall biocatalytic process must be enhanced to unlock completely the potential of enzymes for industrial applications. To reach this goal, enzyme immobilization and the integration into continuous flow reactors have been the cornerstone of our research. We showed key examples of the advantages of those tools for the biosynthesis of antivirals, anticancer drugs, and valuable fragrance molecules. By combining new strategies to immobilize biocatalysts, innovative bioengineering approaches, and process development, the performance of the reactions could be boosted up to 100-fold
Towards the Industrial Implementation of Mn-based Catalyst for the Hydrogenation of Ketones and Carboxylic Esters
Get PDFThere is a constant pressure in industry to move away from platinum group metals (PGM) and achieve more environmentally friendly and sustainable production processes in the future. Recently developed Mn-based catalysts offer an interesting opportunity to complement established catalysts based on Ru. In this article, recent achievements in the field are highlighted and recent achievements in the collaboration of Solvias AG with the group of Prof. M. Clarke towards the implementation of these catalysts on industrial scale are outlined
From C–H to C–N Bonds: Three Challenges, Three Catalysts, Three Solutions
Get PDFN-heterocycles are key building blocks for many pharmaceutical products. An efficient and sustainable method for the synthesis of this class of compounds consists of the recently established intramolecular C–H amination reaction. Development of new iron-based catalysts for this transformation is of paramount importance. Herein, three major challenges in this field are addressed: the accessibility of the catalyst, the lack of mechanisticunderstanding, and the limited activity and robustness of the catalyst. These challenges are tackled by threedifferent catalysts. The first catalyst is the commercially available FeI2, that shows good activities, but is limitedto substrates with activated C–H bonds. The Fe(HMDS)2 catalyst is used to perfom in-depth mechanistic studies, revealing key intermediates of the C–H amination reaction. The third catalyst, featuring mesoionic carbene ligands, displays unprecedented activities and aminates various C–H bonds
International Chemistry Olympiad 2024
Get PDFAt the International Chemistry Olympiad 2024 in Riyadh, Saudi Arabia, four outstanding students from Switzerland were awarded with one bronze medal and three honourable mentions. This report highlights the preparation of the Swiss delegation and some excerpts from the international competition. The International Chemistry Olympiad 2025 will take place in the United Arab Emirates. The registration for the corresponding national selection process closes at the end of September