332 research outputs found
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Exploring the Therapeutic Potential of Barbaloin: A Wonder Constituent from Aloe Vera Plant
Full text linkThe aim of current study was to explore chemistry and therapeutic potential of barbaloin. A detailed literature review was carried out at various data bases such as PubMed, Elsevier, Springer, Wiley, Taylor & Francis, etc. The healing plant aloe emodin\u27s main compound is barbaloin (C21H22O9), anthrone\u27s C-glucoside. The Liliace family includes perennial succulent aloe vera. Barbaloin, a pale-yellow aloe vera powder, is a first-group glucoside of the alove emodin anthrone molecule. Barbaloin has anti-inflammatory, cathartic, antiviral, antibacterial, and antioxidant qualities that prevent cancer. Barbaloin also improves cardiovascular health, test perception, enzyme metabolism, and bioavailability. Barbaloin may help treat eczema, psoriasis, and burns. Barbaloin peaked three hours after oral dose. Molecular coupling studies have suggested these drugs may cure COVID-19. Many analytical methods exist for measuring aloin in aloe products. This paper summarizes the pharmacological properties, analytical method, chemical structure, extraction procedure, ethnomedicinal importance, and commercial value of barbaloin, which could be used to develop more effective and accessible formulations
Exploring the Correlation Between Medical Book Authors and Their Dedication
Full text linkTraining in medical sciences is considered one of the most challenging disciplines in higher education. India has one of the largest number of medical institutions in the world. Many initiatives are being taken to engage budding doctors. There has been phenomenal growth in medical literature to enrich students understanding and application of the knowledge in health care services. The authors of books on medical literature, are probably passionate experts keen to present the information in the best possible way for the readers. However, there is hardly any literature on what are the factors which inspires these works or who were the people who inspired them to bring out books in medical sciences. Authors dedication mentioned in their books is probably only source for us to understand, on who might have inspired them or enabled them. This study has explored these aspects as there is scarcity of literature in this area
Prevalence of Depression and Its Coping Strategies Among Rural and Urban Geriatric Population
Full text linkBackground: Aging is a natural process, and older age is a period in which most aspects of life require support from others. Globally, Depression is a serious public health concern among elderly populations. The aim of this study was to estimate the prevalence of depression and its coping strategies among geriatric population and to evaluate the association between socio-demographic factors and level of depression.
Methods: A cross-sectional study was conducted among 410 study participants in both rural and urban areas. Geriatric Depression Scale (GDS-15) was used to measure the depression and brief-COPE (28-items) scale was used to measure the coping strategies. Descriptive statistical measures like percentage, mean, median, and standard deviation has been applied. Chi-square tests/Fisher’s exact test were conducted to test the association between socio-demographic factors and level of depression.
Results: The study found 17.6% prevalence of depression among study participants. The study recorded the prevalence of depression was higher in rural area (19.1%) as compared to urban area (16.1%). The study observed problem focused coping was the most commonly used coping mechanisms whereas avoidant coping was the least commonly used coping mechanisms among the depressed geriatric population. The various factors associated with depression were age, marital status, types of family, living arrangement, occupation, and comorbid condition.
Conclusion: The prevalence of depression among the geriatric population was significantly high, more among in rural population as compared to urban population. Establishing accessible mental health service, including regular screening and counseling, can help to address this disparity.
Keywords: Geriatric, Prevalence, Depression, Coping Strategies, Socio-Demograph
Myocardial Infarction Trends Following COVID-19 Vaccination: A Retrospective Investigation From India
Full text linkBackground: The relationship between COVID-19 vaccination and the incidence of myocardial infarction remains a topic of debate. The study aimed to analyze the demographic, clinical, and outcome characteristics of MI patients post-vaccination in India, focusing on differences between Covishield and Covaxin recipients.
Methods: The retrospective observational study included 303 MI patients admitted to a tertiary care center. Data were collected on demographics, comorbidities, vaccination status, ICU admissions, and outcomes. The Charlson Comorbidity Index (CCI) was used to assess disease severity. Statistical analyses evaluated the associations between vaccination status, clinical parameters, and mortality.
Results: Among the study population, 74.3% were males, and 32.7% were aged 51–60 years, reflecting the typical Indian MI demographic. Covishield was the predominant vaccine received (80.9%), followed by Covaxin (15.2%), and 4.0% were unvaccinated. No significant differences were observed in CCI scores across vaccination groups. However, the mean CCI was significantly
higher in deceased patients than in survivors. ICU admission rates were higher in Covishield recipients (53.1%) than in Covaxin recipients (41.3%), but this difference was not statistically significant. Mortality rates were slightly higher in the Covishield group (11.1%) compared to the Covaxin group (8.9%), although this difference wasn\u27t significant. ICU management was associated with better survival rates compared to ward care.
Conclusion: The study contributes to the growing body of evidence supporting the cardiovascular safety of COVID-19 vaccines. While vaccination wasn\u27t significantly associated with increased MI risk or mortality, higher comorbidity burdens were linked to worse outcomes
EVALUATION OF THE EFFICACY OF OUSHADHI TOOTH POWDER USING MICROBES ISOLATED FROM DENTAL PLAQUE AND ITS IMPLICATIONS IN GERIATRIC PATIENTS.
Full text linkThe oral cavity houses diverse microbial species influenced by various extrinsic and intrinsic factors, leading to biofilm formation and subsequent plaque build-up with caries evolution. Prevention strategies focusing on herbal ingredients and their efficacy in preventing dental plaque are essential to study. The mouth\u27s microflora acts as a natural barrier to pathogens, playing a crucial role in host defense. However, some microorganisms are opportunistic pathogens that can cause transient bacteremia and pyogenic infections. Hence, it is imperative to evaluate the efficacy of tooth powder in preventing bacterial adhesion using models that simulate biofilm formation in the oral environment. Additionally, antimicrobial sensitivity tests are performed to assess the effectiveness of ingredients present in tooth powder. These tests can help develop better oral healthcare products like herbal toothpaste, mouthwashes, and gargles. Improper oral health maintenance can lead to tooth and gum disease, which, if left untreated, can worsen chronic health conditions such as heart disease, arthritis, and diabetes. Maintaining oral health in the elderly presents unique challenges. This study aims to study the various parameters of an effective herbal toothpowder which contains mango leaves and suggest its form change to a mouthwash which may be better accepted. It is hoped that such a mouthwash will motivate geriatric patients to take an enthusiastic role in caring for their oral health holistically
Rates Of Appropriate Initiation Of Low Dose Aspirin Prophylaxis As Indicated By The Gestosis Score In Early Pregnancy: A Cross-Sectional Study
No full textIntroduction: Pre-clampsia is a multisystem disorder in pregnancy. Initiating Low Dose Aspirin (LDA) in early pregnancy is recommended to prevent development of pre-eclampsia in high-risk women. Gestosis score is a simple screening tool for predicting women at risk for developing pre-eclampsia. It can be done by any health care provider even in the periphery. This study highlights the degree of awareness amongst obstetric healthcare providers in prediction and prevention of pre-eclampsia and the rates of appropriate initiation of Aspirin.
Methodology: 134 pregnant women were included in the study. The parameters for calculating the GESTOSIS score were retrieved from the earliest antenatal records. Woman with score \u3e3 was considered high risk for developing pre-eclampsia. It was ascertained whether she was started on LDA. Rates of appropriate initiation of LDA based on the risk assessment, development of pre-eclampsia, its complications and obstetric outcome were correlated.
Results: Out of 134 women, 21 received LDA. 54 had high risk for development of pre-eclampsia as evidenced by the GESTOSIS score of \u3e 3 in early pregnancy. Out of these, 15 women (27.78%) were started on Aspirin. 31 women developed pre-eclampsia. 11 out of 31 cases were missed by the GESTOSIS score, giving NPV of 86.25%.
Discussion: This study documents the rates of appropriate initiation of LDA as assessed by the GESTOSIS score. The findings underscore the fact that risk factors for pre-eclampsia are not routinely assessed in the antenatal period and the initiation of LDA for those with high risk is not a routine practice
Evaluating The Role of Staff Nurses in Integrating Traditional and Alternative Medicine: Patients’ Perspectives From Rural Mysuru
No full textBackground: In rural India, nurses play a pivotal role as primary healthcare providers, due to limited physician availability. Their responsibilities often extend beyond routine care to include guiding patients in both modern and traditional healthcare approaches. However, there remains limited insight into how patients perceive this expanded role. This study aims to evaluate patients\u27 perspectives on the role of nursing staff as primary healthcare providers in South Indian rural hospitals.
Methods: A cross-sectional study was conducted over a three-month period in the rural and urban field practice areas of JSS Medical College. A total of 256 adult patients who had visited the hospital more than once, were surveyed using a pre-validated, semi-structured questionnaire. Data were analysed using SPSS version 26, with chi-square tests applied to assess associations between patient characteristics and satisfaction levels.
Results: Most patients (62.9%) recognized nurses as key contributors to their recovery, and 64.1% expressed satisfaction or high satisfaction with healthcare outcomes, following nursing care. However, gaps were reported in attentiveness (54.2% rated it neutral or poor), follow-up care (16.8% received it rarely or never), and communication of procedures (only 29.7% reported consistent explanation). Over 61% used traditional medicine alongside hospital treatment, yet only 35.1% felt supported by nurses in this integration. Significant associations were found between patient satisfaction and age, gender, and educational status (p \u3c 0.05), with younger, male, and less-educated patients reporting greater satisfaction.
Conclusion: While nurses are recognized as crucial to recovery and rural care delivery, inconsistencies in communication, follow-up, and support for traditional medicine reveal critical areas for improvement. Strengthening nurse-training in culturally sensitive communication and integrative practices could enhance satisfaction and health outcomes in rural India
Recent Trends in Medical Education to Sustain an Effective Practice - A Systematic Review
Full text linkLearning processes in medical practices in medicinal schools put more emphasis on the hard sciences than they do on developing soft skills like empathy and communication. For this reason, the medical humanities emerged to provide a different take on the creative process. Medical ethics, the doctor-patient relationship, clinical research, mental illness, and professionalism are just a few of the topics that have been utilized to discuss in medical school. A strong connection between classroom learning and clinical experience is crucial for medical school graduates. Students graduating from a medical program are expected to have experience with patient care, clinical procedures, and theoretical understanding. These expectations are not reaching the level in classical or conventional teaching pedagogies of medical education. The recent approaches practiced in medical education provide greater outcomes with expertise and knowledge. This review focuses on the merits and demerits of conventional teaching methods practiced in medical education over the advantages achieved through modern technologies like e-learning and digital learning that have been implemented to produce medical professionals having profound knowledge in respective fields in a safe and convenient environment
Study of Maternal and Fetal Outcomes in Pregnancy Complicated by Thyroid Disorders
No full textBackground:
Thyroid disorders, particularly hypothyroidism, are common during pregnancy and can significantly impact both maternal and fetal outcomes. Despite advancements in screening and treatment, thyroid dysfunction in pregnancy often remains underdiagnosed, especially in low-resource settings. This study aimed to evaluate the prevalence, outcomes and effective management strategies of thyroid dysfunction during pregnancy.
Objectives: To evaluate the prevalence and outcomes of thyroid dysfunction, including both hypothyroidism and hyperthyroidism, during pregnancy, and their associated maternal and fetal complications.
Methods: This prospective observational study included 281 pregnant women with thyroid disorders attending antenatal care at JSS Hospital, Mysuru, from August 2022 to January 2024. Thyroid function was assessed in each trimester, and maternal and fetal outcomes were documented. Statistical analyses included descriptive statistics and Friedman’s test to evaluate changes in thyroid function parameters across trimesters.
Results: The mean age of participants was 27.95 years (N=281, 27.95±3.91). The majority of participants were diagnosed with hypothyroidism (N=277, 98.6%) and only 4 (1.4%) had hyperthyroidism. Thyroid dysfunction was newly diagnosed during pregnancy in 166 (N=166, 59.1%) of the cases. Thyroid function tests revealed a significant decrease in TSH and an increase in free T3 (fT3) and free T4 (fT4) levels across trimesters, indicating effective management of hypothyroidism. Maternal complications were observed in 98 (N=98, 34.9%) participants, with preeclampsia (N=23, 8.2%) and anemia (N=19, 6.8%) being the most common. Fetal complications occurred in 47 (N=47, 16.7%) pregnancies, with fetal distress (N=20, 7.2%) being the most frequent. Anti-TPO positivity was present in 181 (N=181, 64.4%) hypothyroid patients, and it was associated with higher rates of maternal (N=77, 42.5%) and fetal complications (N=39, 21.5%).
Conclusion: The findings emphasize the need for universal thyroid screening early in pregnancy to detect undiagnosed thyroid dysfunction and ensure timely intervention. Despite effective management, considerable maternal and fetal complications persist, highlighting the importance of individualized care, trimester-specific monitoring, and multidisciplinary collaboration to optimize pregnancy outcomes
Lymphoma Chronicles: Insights from a Distinct Hodgkin\u27s Lymphoma Case Report
Full text linkHodgkin lymphoma (HL) is a kind of lymphatic malignancy distinguished by the presence of Reed-Sternberg cells. It often manifests as painless lymphadenopathy and systemic symptoms (B symptoms and can affect a variety of lymphoid tissues. The causes of HL are complicated and include genetic predisposition, environmental conditions and viral infections, particularly the Epstein-Barr virus (EBV). The diagnosis is primarily based on histological evaluation of lymph node samples, with immunophenotyping assisting classification. Herein, we report a case of classical Hodgkin’s lymphoma (HL) in an otherwise healthy 31-year-old male who had a mass per abdomen for a year and recently noticed a swelling in his left axilla. On ultrasound, abdominal lymphadenopathy and splenomegaly with multiple ill-defined hypoechoic lesions were identified. Lymph node biopsy revealed Erythroid hyperplasia with trilineage hematopoiesis, leading to a diagnosis of Hodgkins lymphoma