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住まいに対する今後の意向と空き家化の関係性に関する研究 ―長崎市を通して―
Get PDFThis paper clarifies the causes of the occurrence of vacant dwellings and problems in the process of inheritance and other home succession processes by ascertaining the state of determination of future housing intentions from a questionnaire survey targeting residents of residential areas in Nagasaki City. Although the mandatory inheritance registration that began in April this year has been acknowledged, it has not triggered people to think about their future plans for their dwellings, and many households are unable to inherit or dispose of their dwellings even if they wanted to, and have not thought about their plans. Although there has been a change in awareness of inheritance, the problem continues to remain because the inheritance mechanism has not changed. In rural areas, the problem is that heirs are difficult to assemble due to people moving out of the locality and that they cannot manage their inheritance even if they do inherit. Another major factor was found to be the low marketability of land and houses that are not tangentially connected to a road, as well as the low price of such land and houses. While it is easier to schedule a plot with a road access, in nature-friendly zones, the trend is that plots without a road access are more likely to be scheduled. It is thought that the less convenient and secure people feel in their current living situation, the more they feel threatened by inheritance and sale, and the more they take the initiative in making plans. Less than half of the households have thought about how to utilise their houses after inheritance, and it is thought that this kind of inheritance leads to a lack of management and is a factor in the occurrence of vacant houses.長崎大学大学院工学研究科研究報告, 55(104), pp.23-29; 2025departmental bulletin pape
移住者の定住促進における交流拠点の有用性に関する研究 -長崎県福江島と鹿児島県奄美大島を対象として-
Get PDFThe purpose of this study is to focus on coworking spaces as exchange hubs, to consider the usefulness of exchange hubs in promoting the settlement of migrants to remote islands, and to extract the functions necessary for them to become places for the formation of migrant communities. Furthermore, we clarify the functions of community managers at exchange hubs and their role in promoting the settlement of migrants. Using the Annual Report on Remote Island Statistics, we extracted the top 10 remote islands with positive social dynamics trends, and selected Fukue Island in Goto City, Nagasaki Prefecture, and Amami Oshima in Amami City, Kagoshima Prefecture as our target sites. On Fukue Island, many users visit the island to interact with other users and staff, and local residents and migrants have a relatively high level of awareness of interaction. On the other hand, on Amami Oshima, users have a low intention to interact, and facilities are simply used as a place to work. In addition, in facilities that provide multiple services, migrants gain connections with the community through their use of the facilities, and each facility functions as a place to build continuous relationships between migrants and the community. We believe that the exchange of information about daily life, such as where to live and what employment information to provide, accompanies everyday use of facilities such as eating and drinking and working, contributes to preventing isolation among migrants and promoting their relocation.長崎大学大学院工学研究科研究報告, 55(104), pp.65-71; 2025departmental bulletin pape
転用住宅を見据えた応急仮設住宅建設に関する研究 -令和2年7月豪雨を対象に-
Get PDFIn recent years, Japan has been hit by many disasters such as earthquakes and torrential rains, and temporary housing has been constructed to provide temporary housing for disaster victims. In particular, temporary wooden houses have been utilized as public housing for the victims to rebuild after the period of provision as temporary housing has ended. In the aftermath of the Heavy Rain Event on July 2020, Hitoyoshi City in Kumamoto Prefecture is planning to utilize temporary housing as a final safety net housing for victims who are unable to move into public disaster housing or who are unable to rebuild as originally envisioned. As for the changes from The 2016 Kumamoto earthquake, Hitoyoshi City has constructed all of its temporary housing in wooden structures, so that those who continue to live in the housing complex can live in the converted housing without having to move. In addition, since the laundry room was built indoors from the beginning of the construction of the temporary housing, no modification was necessary, and all the houses were equipped with slopes by repairing and constructing new slopes. In the future, it is necessary to consider the installation of wooden fixtures and fittings from the beginning of construction, taking into account the points that were useful in this disaster.長崎大学大学院工学研究科研究報告, 55(104), pp.72-77; 2025departmental bulletin pape
防災都市づくり計画の利点と課題に関する研究 －策定地域の取組みを踏まえて－
Get PDFJapan is a country prone to earthquakes, and in addition, due to climate change, damage from torrential rains is increasing. Local governments are promoting the development of disaster prevention and mitigation cities that assume the occurrence of various disasters, and the basic plans for this are Rocal Disaster Management Plans and Municipal Urban Master Plans. However, it cannot be said that these two plans are fully coordinated. Therefore, in the wake of the Great Hanshin-Awaji Earthquake, the ``Disaster Prevention Urban Plan'' was established as a way to connect both sides. However, Disaster Prevention Urban plans are not based on laws and regulations, and therefore only a few local governments have developed them. The purpose of this study is to clarify the benefits and challenges associated with the formulation of Disaster Prevention Urban plans by investigating the process behind the formulation by local governments that are formulating Disaster Prevention Urban plans, specific measures, and the situation of residents after formulation. Based on the results of this interview, it is necessary to fully assess disaster risk at the beginning of planning, determine target disasters, and reflect this in measures. It is also assumed that more coordinated plans can be created by involving both the Local Disaster Management Plan and Municipal Master Plan planners. It is inferred that not only the planning but also holding briefing sessions and support for citizens after the planning and after disaster prevention projects will lead to improved disaster prevention awareness.長崎大学大学院工学研究科研究報告, 55(104), pp.86-93; 2025departmental bulletin pape
Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective ultrasound cohort study
Get PDFObjectives: To evaluate the potential of clinical factors, ultrasound findings, serum autoantibodies, and serum cytokine and chemokine profiles as predictors of clinical outcomes in rheumatoid arthritis (RA). Patients and methods: We included 200 patients with RA treated with biological and targeted synthetic disease-modifying antirheumatic drugs in a prospective multicentre ultrasound cohort study. Their serum levels of multiple cytokines and chemokines, rheumatoid factors, and serum autoantibodies (anti-cyclic citrullinated peptide-2 (anti-CCP2) and anti-carbamylated protein antibodies) were measured at baseline, 3 months and 12 months. Results: Dimensionality reduction using 38 cytokines and chemokines demonstrated four distinct clusters that differed significantly regarding the frequencies of remission defined by clinical composite measures and ultrasound evaluations. Prominent differences in IL-1β, IL-5, IL-7, IL-10, IFNγ, GRO, IP-10, MCP-1 and MIP-1β characterised the between-cluster differences. Two distinct groups made of four clusters showed a significant difference in IgM-anti-CCP2 positivity. The least absolute shrinkage and selection operator regression of 38 cytokines and chemokines for Clinical Disease Activity Index (CDAI) remission at 12 months resulted in the selection of MIP-1β. Logistic regression using baseline levels of anti-citrullinated protein antibody, IgM-anti-CCP2 positivity, the CDAI, the total power Doppler score, the cluster by cytokines and chemokines, MIP-1β, methotrexate dose and mechanisms of action revealed that cluster by cytokines and chemokines was the sole significant factor for CDAI remission at 12 months. Conclusions: Specific patterns of cytokines and chemokines—no other clinical factors and autoantibody profiles—were important to distinguish patients with RA achieving remission at 12 months.RMD Open, 11(1), art. no. e005163; 2025journal articl
Enantio- and Diastereoselective Synthesis of Tricyclic Lactones Bearing Three Quaternary Stereocenters
No full textThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © 2025 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.5c01607.Journal of Organic Chemistry, 90(37), pp.13311-13314; 2025journal articl
Sustained humoral immunity in the patients recovered from severe fever with thrombocytopenia syndrome
Get PDFBackground: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease with a mortality rate of 10–30%; however, effective vaccines and therapies for this disease have not yet been developed. Understanding the long-term immune response of recovered individuals is critical for vaccine development and treatment. In this study, we conducted an epidemiological investigation of antibody and memory B cell trends in individuals with SFTS. Methods:Peripheral blood mononuclear cells (PBMCs) and plasma were collected from 16 survivors of SFTS and five healthy controls. SFTS virus (SFTSV)-specific humoral immune responses were assessed using enzyme-linked immunosorbent assay (ELISA), biolayer interferometry (BLI), neutralization assays, and flow cytometry. Results: SFTSV Gn-specific IgG was detected in plasma samples from all patients using ELISA and BLI. All patient plasma samples also presented neutralizing activity against SFTSV infection, and the IC₅₀ values were correlated with ELISA OD values (ρ = 0.700, P = 0.003 and BLI signals (ρ = 0.818, P = 0.0002). Neutralizing antibodies and SFTSV Gn-specific memory B cells were detected in samples from patients up to 6.7 years post-infection. Conclusion: SFTSV-specific humoral immunity, including neutralizing antibodies and memory B cells, can persist in the majority of recovered patients, including those as late as 6.7 years post-infection. This information will be useful for the development of vaccines and antiviral therapies using antibodies against SFTS.Tropical Medicine and Health, 53(1), art. no. 127; 2025journal articl
Methyl α-d-Tagatopyranoside
Get PDFd-Tagatose, classified as a rare sugar, exhibits notable biological activities, including its function as a low-calorie sweetener. The three-dimensional configuration of carbohydrates is crucial for elucidating their functional properties. Numerous studies have reported the X-ray crystallographic structures of d-tagatose and its derivatives bearing a free anomeric hydroxy group. However, there are no reports on the X-ray crystallographic structure of d-tagatosides featuring a glycosidic linkage at the anomeric position. In this study, we synthesized methyl α-d-tagatopyranoside from d-tagatose and successfully determined its X-ray crystallographic structure, revealing its 5C2 conformation.MolBank, 2025(3), art. no. M2046; 2025journal articl
「能力に応じ」る「ひとし」い教育とは何か―ケイパビリティ、発達、そして教育―
Get PDF本論文は、「教育の機会均等」を定めた日本国憲法26条・教育基本法4条における「能力」をケイパビリティとして解釈することを試みたものである。制定当初、「能力に応」じ、「ひとしく」という文言は、「能力」を基準とした選抜を正当化するものとして解釈された。1970年代の教育法学においては、「能力」を変化するものと捉えたうえで「一人びとりの子どもの能力発達のしかたに応じて全員に能力発達を可能ならしめるような教育」との解釈が提示され、障害児教育を念頭に置きつつ「能力」に応じた教育の個別化が目指された。潜在能力とも訳されるケイパビリティは、ある人が何かを行ったり何かになったりする実質的自由を意味する概念であり、ケイパビリティ・アプローチはこうした自由をすべての個人に保障することを目指すものである。ケイパビリティは「基礎的ケイパビリティ」・「内的ケイパビリティ」・「結合的ケイパビリティ」の３つに分けられるが、こうした概念区分は「能力」形成における社会環境の影響を位置づけ、個人の内的属性としてのみ捉えられていた「能力」概念を刷新するものである。また、ケイパビリティ・アプローチにおいては「発達」は実質的自由が拡大するプロセスと理解される。このことは、「基礎的ケイパビリティ」・「内的ケイパビリティ」に基づいた自由を行使しうる「結合的ケイパビリティ」―環境と「結合」し「機能」を発揮するケイパビリティ―の形成を「子どもの権利」保障の内実とすることを要請する。「教育の機会均等」条項における「能力」をケイパビリティとして解釈することは、「能力」の発現を可能とする環境の条件整備を憲法・教育基本法が保障すべき教育の内容として位置づけるのである。本論文は「九州地区国立大学教育系・文系研究論文集」Vol.12,No.1に査読を経て受理された。九州地区国立大学教育系・文系研究論文集, 12(1), No.4; 2025journal articl
Integrated Risk Assessment of Road Slope Failures Considering Slope Stability, Landslide Motion and Traffic Losses
Get PDF長崎大学学位論文 [学位記番号]博（工）甲第162号 [学位授与年月日]令和7年9月19日(2025-09-19)thesi