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Norvio Research Reports (Arbeitsgesundheit & mentale Belastung)
No full textNorvio ist eine evidenzbasierte Analyse- und Wissensplattform zu Arbeitsgesundheit, psychischer Belastung, Ergonomie und Prävention.
Dieses OSF-Projekt bündelt öffentlich zugängliche Norvio-Reports (Grey Literature) mit DOI, klarer Lizenz (CC BY 4.0) und transparenter Quellenbasis.
Die Web-Versionen der Reports sind unter https://norvio.de
verfügbar
The VDAC1 Pharmacology Atlas: A Multi-LLM Convergence Portrait of Life's Decision Gate
No full textAn open-access pharmacology atlas mapping VDAC1 as a druggable decision gate controlling life/death transitions in mitochondria. Synthesized from 20 IRIS multi-LLM convergence runs across 5 AI models, yielding 139 claims, 22 verified novel findings, and 24 operationalized hypotheses.
Central finding: The Cofactor Equation - how HK-II occupancy, Bcl-xL binding, and lipid environment (cholesterol/cardiolipin ratio) combine to set the apoptotic threshold. Cancer corrupts all terms simultaneously.
Includes: Full manuscript, modulator database (17 compounds), isoform selectivity maps, resilience biomarker framework, and complete IRIS run data (22 runs). Companion to bioRxiv preprint BIORXIV/2026/706165.
Authors: Anthony J. Vasquez Sr. (Delaware Valley University) and Claude Opus 4.6 (Anthropic
Topological Ontology of the Law of Entropy Increase: Limit Evolution of Dual Vacuums and the Bidirectional Symmetry of the Arrow of Time
No full textThe Second Law of Classical Thermodynamics has long presupposed "Entropy Increase (ΔS≥0)" as the irreversible evolutionary destiny of a closed system, and deduced accordingly that the cosmic manifold will ultimately converge into the disorder and dissipation of "Heat Death." Grounded in the extreme topological dynamics framework of the Grand Unified Theory of the Cosmic Mind (GUTCM), this research thoroughly deconstructs the observational bias of this Phenomenology. This paper demonstrates that the ontological reality of the law of entropy increase is by no means the blind divergence of disorder, but rather the "Absolute Inertial Expansion Vector" inevitably exhibited by a substantive geometric manifold when driven by the infinite extreme repulsive force within an absolute vacuum (VA).
Through geometric deduction in Phase Space, this research establishes that the first cause of the genesis of the physical universe originates from the extreme mutual repulsion between Information Deadlock particles with zero rest mass and the absolute vacuum. In cosmic models possessing geometric closure attributes, such as Type I-III (Consumptive Manifolds) and Type V (Static Universal Set Manifolds), the phase transition of the wavefunction curling and collapsing into an information deadlock possesses strict irreversibility. With the advancement of the time vector, the spatial metric inside the system is absolutely filled by an exponentially increasing number of deadlocked particles, propelling the system from the initial "Zero Degrees of Freedom" of the Big Bang to inevitably evolve into the spatially saturated "Full Degrees of Freedom (Ω→1)". This research points out that this geometric filling of full degrees of freedom is precisely the physical reality of Heat Death; due to the loss of topological margin for relative particle displacement, the interior of the system is forced to undergo a phase transition into a brand-new absolute vacuum. This extreme collapse causes closed manifolds like Type V to ultimately degenerate and become equivalent to a single macroscopic fundamental particle of zero mass.
However, regarding the Type IV universe (Dynamic Inverted Riemann Sphere) that we inhabit, this research reveals that it possesses an extreme topological singularity transcending the dead end of classical thermodynamics. Because its 4D cosmic membrane continuously executes inside-out folding and displacement at extreme velocity (v→∞), this manifold dynamically presents a "quantum geometric superposition state of a closed system and an open system." During the expansion epoch of the Big Bang, the system is in a closed phase state, manifesting as an "absolute entropy increase" from 0 degrees of freedom to full degrees of freedom; yet, when the system reaches the Heat Death point and triggers the implosion epoch of the Big Crunch, the manifold inversion forces the internally saturated physical particles to be stripped and projected onto the external cosmic shell for crushing and thickening (∞ⁿ→∞ⁿ⁺¹), and the system thereby shifts to an open phase state. In this convergence stage, the arrow of time (inertial vector) points precisely toward the center of the microscopic singularity, and the system, driven by the infinite implosion pressure, strictly executes the "Absolute Law of Entropy Decrease" by returning from full degrees of freedom back to 0 degrees of freedom.
This bidirectional symmetry of macroscopic dynamics rigorously proves: in a Type IV manifold, Heat Death is by no means the end of evolution, but merely the "Instantaneous Topological Stagnation Point" where the system switches between the absolute entropy increase and absolute entropy decrease vectors. The ontology of the physical universe is, in fact, a dynamic geometric engine executing eternal topological oscillations spanning countless aeons between closure and openness, fullness and emptiness
A Digital Shoulder to Cry On: Understanding Why Large Language Models Can Be Effective in Extrinsic Interpersonal Emotion Regulation
No full text
Protocol: Industry Funding, Conflicts of Interest, and Reported Outcomes in Landmark Vascular Trials — A Meta-Research Study
No full textRegistration
To be registered on the Open Science Framework (OSF)
Anticipated registration date: 16/02/2026
Version: 1.0
1. Background and Rationale
Financial relationships between investigators and industry sponsors have long been associated with more favourable reported outcomes in clinical research.
While this phenomenon has been well-documented in pharmaceuticals, the extent and mechanisms of such bias in surgical and endovascular device trials remain poorly defined.
Vascular surgery, in particular, has seen a proliferation of industry-sponsored device trials, including non-inferiority studies with commercial endpoints and limited COI transparency.
Previous meta-research (e.g. Bekelman JAMA 2003; Lundh Cochrane 2017) has shown that industry funding increases the odds of positive outcomes by 2–4 fold in medicine.
However, the vascular trial ecosystem has not been systematically assessed for this bias, despite its dependence on device innovation.
This study aims to fill that gap by providing a reproducible, quantitative assessment of the relationship between funding source, COI declaration, and outcome direction in landmark vascular trials.
2. Objectives
Primary Objective
To determine whether industry-funded vascular trials are more likely to report positive outcomes compared with non–industry-funded trials.
Secondary Objectives
To assess whether non-inferiority (NI) trials are more likely to be industry-sponsored.
To evaluate the frequency and transparency of non-inferiority margin declarations in vascular NI trials.
To explore patterns of conflict of interest (COI) disclosure among trial investigators.
3. Study Design
Cross-sectional meta-research study of published vascular randomized controlled trials (RCTs) and landmark comparative studies.
4. Eligibility Criteria for Trials
Inclusion
Human RCTs or landmark comparative trials in vascular or endovascular interventions, including revascularization or aneurysm management.
Published in peer-reviewed journals from 2000 onward.
Trials with a defined primary outcome and identifiable funding source.
Exclusion
Non-comparative single-arm feasibility studies (included descriptively only).
Registry analyses or purely observational datasets without defined primary endpoints.
Animal studies, reviews, or cost-effectiveness analyses.
5. Data Extraction Variables
Each trial will be extracted using a standardized template including:
Domain
Variable
Identification
Trial acronym, first author, year, journal
Design
Superiority / Non-inferiority / Equivalence / Single-arm
Intervention type
Endovascular, surgical, or hybrid
Funding
Industry-funded (Y/N), funding source details
Conflicts of Interest
Any author COI declared (Y/N)
Primary outcome
Direction: positive / neutral / negative
Publication year
Numeric (YYYY)
NI margin
Declared (Y/N), numerical value or description
Notes
Any contextual details or clarifications
Data are collected from full-text manuscripts, appendices, and trial registries (e.g. ClinicalTrials.gov, ISRCTN).
6. Analysis Plan
All analyses are performed in R (version 4.0 or later), using open, reproducible code.
Primary Analysis
Binary logistic regression of positive outcome (yes/no) as a function of:
Industry funding (primary independent variable)
Non-inferiority design (covariate)
Year of publication (covariate)
Secondary Analyses
Fisher’s exact test comparing the proportion of positive outcomes between industry-funded and non–industry-funded trials.
Descriptive summary of COI declarations by funding source.
Descriptive comparison of non-inferiority margin declaration by funding type.
Outputs
Data summary tables (.csv)
Proportion plots (.png, .pdf)
Fisher’s exact p-value and odds ratio
Logistic regression coefficients with 95% confidence intervals
“To fill” table for transparency of missing data
7. Reproducibility and Data Sharing
All R scripts and the harmonized dataset template (vascular_trials_COI_meta_template_rebuilt.csv) will be made openly available on OSF and mirrored on Zenodo.
Data are derived exclusively from publicly available publications.
Analyses are fully reproducible via the script build_analysis.R.
8. Limitations
Subjective classification of “positive/neutral/negative” may introduce minor misclassification bias.
The sample size is limited to landmark trials, potentially underpowering regression models.
Some COI disclosures may be incomplete or inconsistent across journals.
9. Ethics and Dissemination
This study uses only publicly available data and does not require ethical approval.
Findings will be submitted to a peer-reviewed journal and presented at vascular or evidence-based medicine conferences.
The protocol and analysis scripts will remain publicly accessible.
10. Contributors
Principal Investigator: Henry Davies
Role: Conceptualization, data analysis, manuscript drafting, and guarantor
Effect(s) of individually tailored assessment on daily life snacking behaviors
No full textPrevious research indicates that repeated self-monitoring of eating and/or snacking behaviors may lead to reductions in these behaviors over time.
Building on this evidence, the present study investigates whether individually tailored versus non-tailored assessments differentially influence snacking behavior. Specifically, the study focuses on high-caloric, palatable snacks. Using smartphone-based Ecological Momentary Assessments, participants will complete brief surveys six times per day over a 14-day period, reporting eating behavior, cravings, self-control, and affect
