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Hemileia vastatrix (Hv178a) genome data
No full textAnnotation and Supplementary data for Hv178a genome analyse
Eficácia e segurança de longo prazo dos análogos de GnRH em meninos com puberdade precoce central: uma revisão sistemática
No full textEsta revisão sistemática tem como objetivo principal sintetizar a evidência científica disponível sobre a eficácia e a segurança de longo prazo do tratamento com análogos do hormônio liberador de gonadotrofina (GnRHa) em meninos com diagnóstico de puberdade precoce central (PPC). O projeto busca responder a uma questão clínica estruturada (PICO): Em meninos com PPC, a intervenção com GnRHa, quando comparada à observação ou não tratamento, é eficaz para melhorar a altura adulta final e quais são seus efeitos em longo prazo sobre a saúde óssea e metabólica na vida adulta. O propósito central é fornecer uma síntese crítica e metodologicamente rigorosa da literatura existente, uma vez que a evidência atual para a população masculina é considerada menos robusta e derivada principalmente de estudos observacionais de pequena escala, com heterogeneidade significativa e sem grupos controle adequados. Espera-se que os resultados desta revisão ofereçam aos clínicos e decisores uma visão consolidada e avaliada quanto ao risco de viés sobre os benefícios na estatura final e, de forma crucial, sobre os possíveis impactos tardios na saúde óssea e metabólica, que permanecem como áreas de grande incerteza. Os resultados esperados incluem uma descrição qualitativa narrativa dos achados, a identificação de lacunas metodológicas na literatura atual e a elaboração de recomendações direcionadas para a prática clínica e para uma agenda de pesquisa futura, enfatizando a necessidade de estudos comparativos de longo prazo que acompanhem os indivíduos até a idade adulta. O protocolo da revisão foi prospectivamente registrado e o relatório seguirá as diretrizes PRISMA
Diagnostic Assessment for Professional Performance Improvement
No full textYoesoep Edhie Rachmad (YER) positions Diagnostic Assessment for Professional Performance Improvement as a foundational scholarly contribution that reframes professional performance assessment from a summative, judgment-oriented practice into a diagnostic, developmental, and ethically grounded system. The book responds to a global organizational challenge in which performance evaluations often fail to identify underlying causes of performance gaps, leading to ineffective interventions and diminished professional trust.
From the perspective articulated by Yoesoep Edhie Rachmad (YER), diagnostic assessment serves as an analytical mechanism to understand not only what level of performance is achieved, but why performance emerges in a particular form. This distinction is critical in complex professional environments where performance is influenced by competence, motivation, psychosocial context, organizational design, and systemic constraints.
The central objective advanced by Yoesoep Edhie Rachmad (YER) is to establish a scientifically grounded framework for diagnosing professional performance that integrates psychometric rigor, organizational psychology, and human-centered management principles. Rather than treating performance deficits as individual failure, the book conceptualizes them as multidimensional signals requiring structured interpretation.
Methodologically, Yoesoep Edhie Rachmad (YER) adopts an interdisciplinary approach, synthesizing diagnostic logic from educational assessment, clinical psychology, and strategic human resource management. This approach enables performance assessment to function as a learning-oriented process embedded within continuous professional development systems.
A key contribution articulated by Yoesoep Edhie Rachmad (YER) is the differentiation between evaluative assessment and diagnostic assessment. While evaluative assessment categorizes outcomes, diagnostic assessment identifies causal patterns, developmental needs, and contextual misalignments that hinder professional effectiveness.
The book further examines the role of digital tools and analytics, as discussed by Yoesoep Edhie Rachmad (YER), emphasizing their potential to enhance diagnostic accuracy while warning against reductive performance metrics detached from human meaning.
Implications outlined by Yoesoep Edhie Rachmad (YER) extend to leadership decision-making, talent development, performance coaching, and organizational learning systems. Diagnostic assessment is positioned as a strategic capability that aligns performance improvement with ethical responsibility.
Overall, Diagnostic Assessment for Professional Performance Improvement, as developed by Yoesoep Edhie Rachmad (YER), offers a comprehensive, evidence-based, and humanistic framework for advancing professional performance in contemporary organizations
IC-H: Human Cognitive Engineering & Systemic Entropy Reduction.
No full textEl proyecto IC-H (Ingeniería Cognitiva Humana) se fundamenta en el modelo de Ciencia Abierta, donde el laboratorio se desplaza del entorno clínico al entorno cotidiano del ciudadano. Este enfoque permite una recolección masiva de datos sobre la gestión de la entropía sistémica, la acidosis intersticial y la mecanotransducción, variables tradicionalmente difíciles de monitorear a escala poblacional.
El Rol del Ciudadano-Científico
En este proyecto, los participantes no son meros sujetos de estudio, sino operadores de su propia interfaz biológica. A través de dos pilares metodológicos, los ciudadanos recolectan y validan datos sobre su eficiencia operativa:
PILAR 1 – HARDWARE (Calibración Biomecánica)
Protocolo:
Activación de canales iónicos mecanosensibles mediante dos tipos de estímulo, diferenciados según la evidencia científica 2025/2026:
PIEZO1: Presión sostenida (30-60 segundos) en puntos estratégicos (crestas ilíacas, bajo vientre, zona lumbar, base del cráneo, borde interno de rótula, planta del pie).
Base científica: Neurogénesis, biogénesis mitocondrial, metabolismo óseo, autofagia, remodelación de matriz extracelular (Kaur et al., 2026; Wang et al., 2026; Cao et al., 2026; Chen et al., 2026; Zhao et al., 2026).
PIEZO2: Percusión rítmica sobre 8 puntos (talones, sacro, esternón, axilas, mandíbula, sienes, coronilla, plexo solar) + uso del Sincronizador de Coherencia Sistémica (interfaz de respiración a 0.1 Hz).
Base científica: Regulación de tejido adiposo, ansiedad alimentaria, dolor pélvico y función reproductiva (Wang et al., Cell Metabolism 2025; Sánchez del Río et al., Biomolecules 2026).
Validación:
Transferencia de protones acoplada a electrones (PCET) – Deng & Hammes-Schiffer (PNAS 2026).
Reinicio del cronómetro neuronal en <300 ms – Yang et al. (Nature 2026).
Geometría cuántica de materiales – Sala et al. (Science 2025).
PILAR 2 – SOFTWARE (Neuroabsurdismo)
Protocolo:
Aplicación de la Teoría General de Sistemas (TGS) y protocolos de Lógica Absurda orientados a la activación del potencial evocado N400 y al bypass de la Red Neuronal por Defecto (DMN).
Objetivo:
Transformar el paradigma mental de una "mentalidad de biblioteca" (basada en el almacenamiento y repetición de sesgos pasados) a un "Radar de Eficiencia Sistémica".
Impacto bioquímico:
Reducción de la excitotoxicidad por glutamato y mitigación de la acidosis intersticial asociada a la rumiación crónica.
Validación:
Mente en blanco como estado neurofisiológico distinto – Muñoz-Musat et al. (PNAS 2025).
Contagio emocional con dinámica epidémica – Liu et al. (2025).
Teoría de la Construcción de la Conciencia – Universidad de Boston / InfoBase (2026).
Neurociencia Computacional – LASCON 2026 (UNER).
Vínculo con la Ciencia Abierta y Registro
Para garantizar la transparencia y la reproducibilidad, la arquitectura completa del protocolo está registrada bajo el estándar internacional de ciencia abierta:
White Paper IC-H v2.1: DOI 10.5281/zenodo.18614131
ANEXO 2026 – Validación Experimental (v2.4): DOI 10.5281/zenodo.18648605
Repositorio OSF: https://osf.io/snvq5/
Indexación: OpenAIRE
Licencia: CC-BY 4.0 International.
Impacto Social – Soberanía Biofísica
El vínculo principal con la ciencia ciudadana radica en la Soberanía Biofísica. Al proporcionar herramientas técnicas de libre acceso, el proyecto busca democratizar la salud biofísica, permitiendo que cualquier individuo pueda gestionar su homeostasis sin dependencias externas, transformando la experiencia subjetiva en datos técnicos compartidos para el beneficio de la comunidad científica global
Sistemas de suporte de decisão voltados à gestão em saúde de pessoas com diabetes mellitus tipo 2: protocolo de revisão de escopo
No full textRevisão de escopo que objetiva-se mapear as tecnologias digitais empregadas em sistemas de suporte à decisão voltados à gestão em saúde de pacientes com diabetes mellitus tipo 2. Tem-se como questão de pesquisa, elaborada conforme mnemônico PCC: Quais os sistemas de apoio à decisão de pessoas com diabetes mellitus tipo 2 na gestão em saúde? Realizou-se as buscas a partir de vocabulários controlados combinados pelos operadores booleanos AND e OR, na literatura científica e cinzenta
The mediating role of temporal landmarks on shape preferences
No full textWe will conduct an online experiments to examine the effect of temporal landmarks (start versus end) on individuals’ shape preferences (circular versus angular). Specifically, we will test whether temporal landmarks influence shape preferences and whether this effect is mediated by ego depletion
Lexical-Semantic Processing and Memory for Words of Cognition and Motivation
No full textMultiple representation theories suggest that we use various sources of information to represent concepts, such as social, emotional and sensorimotor information. The theories assume, further, that abstract concepts tend to rely more heavily on internal information than concrete concepts. However, these internal sources of information have not been researched as extensively as the external, and more sensorimotor-heavy, sources used for concrete word grounding. The purpose of this research is to investigate two recently developed semantic dimensions involved in abstract word grounding: cognition and motivation. Initial research on cognitive words suggests that these mental-state words show lexical-semantic processing benefits, but memory disadvantages (Muraki et al., 2022). This pattern is rare; semantic dimensions that enhance processing also tend to show memory advantages (Hargreaves et al., 2012). This study will investigate whether this pattern of lexical-semantic processing benefits and less accurate memory for high-cognition words generalizes to a newly developed list of 8,000 words and their associated cognitive ratings (Corenblum & Pexman, 2025). A second aim of this research is to test whether the cognition dimension is distinct from another newly-identified internal source of information: motivation (Giurgea et al., 2025). Words high in motivation also showed the rare pattern of facilitated lexical-semantic processing and less accurate memory. We will include both dimensions in an analysis of lexical decision responses to test whether cognition and motivation separately account for significant variance in lexical-semantic processing. In addition, we will investigate whether cognition and motivation separately account for significant variance in recognition memory accuracy.
As mentioned, when a source of semantic information increases processing speed, it also tends to improve memory. However, words high in cognition and motivation show enhanced processing, but decreased memory performance. In the previous studies that reported these discrepancies (Giurgea et al., 2025; Muraki et al., 2022), the authors argued that this may be due to high meaning similarity between words that are highly cognitive or highly motivational. To test this explanation, we will use words’ number of synonyms as a measure of meaning similarity. The number of synonyms will be included as a predictor in analyses of lexical decision and memory performance to determine whether high item similarity can explain effects of cognition and motivation
Invisible Wounds: A Systematic Narrative Review of Domestic Violence Against Women
No full textThis project documents a systematic narrative review examining the global prevalence, patterns, and health-related consequences of intimate partner violence and domestic violence against women. The review synthesizes evidence from peer-reviewed studies published between January 2020 and June 2025, focusing on prevalence estimates, mental health outcomes (including depression, PTSD, and anxiety), healthcare utilization, and intervention or screening strategies.
The review follows PRISMA 2020 guidance for study identification and selection and includes observational studies, randomized controlled trials, and multicenter validation studies conducted across diverse geographical regions. Due to substantial heterogeneity in study design, populations, and outcome measures, findings are summarized using narrative synthesis without quantitative pooling.
No primary data were collected, and no human participants were directly involved. This OSF project serves to improve transparency and reproducibility of the review process