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Effects of Plyometric Training on Linear Sprint, Change-of-Direction, and Isokinetic Strength Performance in Male Basketball Players: A randomized controlled trial
No full textThis study examines the effects of an eight-week plyometric training program on physical performance in trained male basketball players. The study compares a plyometric training group with a control group to determine differences in linear sprint performance, change-of-direction ability, countermovement jump performance, and knee extensor and flexor isokinetic strength
CROSS-COUNTRY ANALYSIS OF SUSTAINABLE PRODUCTION PRACTICES AND CONSUMER ENGAGEMENT IN THE GLOBAL FASHION INDUSTRY
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Perceived maternal competence in mothers of children aged 0 to 3 years: a mapping of concepts, instruments and associated factors: scoping review protocol
No full textThis review will provide comprehensive mapping of evidence on maternal competence, supporting conceptual consolidation, refinement of assessment tools, and development of interventions to strengthen positive parenting and maternal-child care
Gender Discrimination, Organizational Climate, and Psychological Outcomes in Social Service Workers
No full textThis project involves the preregistration of a cross-sectional study examining the presence, forms, and correlates of gender discrimination among social service professionals in Italy. The study focuses on both subtle and overt forms of discrimination, organizational climate and reporting processes, and their associations with psychological and occupational outcomes such as burnout, engagement, self-efficacy, and resilience. The project aims to ensure transparency and methodological rigor through open science practices. The study includes the development and validation of a new exploratory questionnaire to investigate perceived gender discrimination in the workplace, with particular attention to subtle and everyday forms of discrimination
Meta-analysis of Bai Tou Weng Decoction in the Treatment of Ulcerative Colitis Animal Model
No full textThis meta-analysis project aims to systematically evaluate the therapeutic efficacy and potential mechanisms of Bai Tou Weng Decoction (BTWD) in rodent models of Ulcerative Colitis (UC). UC is a chronic, relapsing inflammatory bowel disease with a complex pathogenesis. BTWD, a classic traditional Chinese herbal formula composed of Pulsatilla chinensis (Bai Tou Weng), Coptis chinensis (Huang Lian), Phellodendron chinense (Huang Bai), and Fraxinus rhynchophylla (Qin Pi), has been extensively used in clinical practice and preclinical research for treating UC. However, existing animal studies report findings on diverse outcome measures with inconsistent effect sizes for the same indicators. This scattered evidence, coupled with uncertainties regarding its precise mechanisms of action, creates ambiguity and apparent contradiction regarding how BTWD ameliorates intestinal inflammation.
Preclinical research is crucial for deepening the understanding of drug efficacy and validating experimental hypotheses. Systematic review and meta-analysis of animal studies serve as powerful tools to synthesize fragmented evidence, enhance statistical power, and provide a more robust estimate of intervention effects. This study will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to conduct a systematic review and meta-analysis of controlled studies investigating BTWD in UC rodent models.
Primary Purpose:
The primary purpose is to quantitatively synthesize existing evidence from animal experiments to determine the overall effect of BTWD on key UC-related outcomes. This will provide a comprehensive assessment of its effectiveness in improving disease severity, histopathological damage, and modulating relevant biomarkers in preclinical settings.
Specific Objectives:
To assess the pooled effect of BTWD on clinical disease activity, primarily measured by the Disease Activity Index (DAI), in UC rodent models.
To evaluate the pooled effect of BTWD on colonic tissue damage through histopathological scoring.
To synthesize evidence on the impact of BTWD on secondary outcomes including body weight change, colon length, and levels of key inflammatory biomarkers (e.g., in serum or colon tissue, such as TNF-α, IL-1β, IL-6, MPO).
To explore potential sources of heterogeneity across studies (e.g., differences in rodent species, UC modeling methods, BTWD dosage, treatment duration) through subgroup analysis and meta-regression where feasible.
To critically appraise the methodological quality and risk of bias in the included studies using a tailored tool for animal research.
Methodology Overview:
We will perform a comprehensive literature search across major English (PubMed, Embase, Web of Science) and Chinese (WanFang, VIP, CNKI, CBM) databases from their inception to January 31, 2026. Eligible studies must be published animal experiments employing randomized design, using UC rodent models, and comparing a treatment group receiving oral gavage of the standard BTWD formula (only the four specified herbs) against a control group. Studies must report both DAI and histopathological score data. Review articles, in vitro studies, clinical trials, and studies combining BTWD with other therapies will be excluded. Two independent reviewers will screen studies, extract data (including study characteristics, animal details, intervention protocols, and all relevant outcomes), and assess risk of bias. Discrepancies will be resolved by consensus or consultation with a third reviewer. Statistical meta-analysis will be conducted using software such as RevMan or Stata, employing random-effects models to calculate standardized mean differences (SMD) or weighted mean differences (WMD) with 95% confidence intervals for continuous outcomes. Heterogeneity will be quantified using the I² statistic.
Expected Outcomes and Significance:
Evidence Synthesis: This will be the first systematic review and meta-analysis to provide a quantitative, pooled estimate of the efficacy of BTWD in UC animal models. The results are expected to confirm, with greater statistical confidence, whether BTWD effectively reduces DAI and improves histopathology, thereby strengthening the preclinical evidence base.
Mechanistic Insights: By synthesizing data on inflammatory biomarkers, the analysis may highlight consistent patterns of cytokine modulation (e.g., reduction of pro-inflammatory markers), offering clues about the dominant anti-inflammatory pathways engaged by BTWD.
Guidance for Future Research: The analysis will identify key gaps and inconsistencies in the existing literature. Findings regarding the influence of different modeling methods or dosing regimens can inform the design of more standardized and optimized future preclinical studies.
Foundation for Translation: A robust positive finding from animal-level evidence is a critical step in the translational pipeline. This work will help justify and guide subsequent high-quality clinical trials by identifying the most promising outcome measures and informing dose selection.
Contribution to Herbal Medicine Research: The project demonstrates a rigorous methodology for evaluating complex herbal formulations, contributing to the standardization and international recognition of evidence-based research in traditional medicine.
In summary, this project seeks to clarify the currently ambiguous and contradictory preclinical evidence regarding BTWD for UC. By providing a synthesized, quantitative assessment of its efficacy and exploring influencing factors, it aims to enhance the understanding of BTWD's therapeutic potential, inform future research directions, and ultimately contribute to the development of evidence-based complementary strategies for UC management
Scoping Review of Phytomedicines Investigated in Oral Squamous Cell Carcinoma: Mapping Evidence and Research Gaps
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ATAL FDP – Programme Design & Administration
No full textThis component contains administrative and academic planning documents related to the ATAL FDP, including programme structure, approvals, utility documentation, and coordination records.
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ATAL FDP – Academic Content & Expert Sessions
No full textThis component archives session abstracts, expert details, topic outlines, and academic content delivered during national and international expert sessions.
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