Proceedings in Obstetrics and Gynecology
Not a member yet
462 research outputs found
Sort by
Division of Reproductive Endocrinology and Infertility
Get PDFThe Reproductive Endocrinology Division at the University of Iowa now consists of six staff physicians at the University of Iowa and one who is at our Quad Cities outreach office along with one physician assistant and two fellows in training. We remain very active clinically and are proud of our highly successful IVF Program with one of the highest rates of single embryo transfer with IVF in the country while continuing to maintain outstanding pregnancy rates. The Division also supports an emphasis on fertility preservation and a Pediatric and Adolescent Gynecology Clinic
Preeclampsia and diuresis criteria: our experience at the University of Iowa Hospitals and Clinics
Get PDFPreeclampsia is a multisystem disorder that complicates approximately 5-8% of pregnancies. It is known that the clinical manifestations of preeclampsia are a result of widespread vasoconstriction. It is therefore thought that the onset of diuresis may signal a reversal of this vasoconstriction, and thus resolution of the disease. This retrospective cohort study was conducted at the University of Iowa Hospitals and Clinics (UIHC) to validate our diuresis criteria and determine if there was a trend for diuresis that was dependent on the type of preeclampsia. This study suggests that the diuresis curves for those women with mild preeclampsia and severe preeclampsia do not vary significantly after the first 5 hours We were able to separate the women with severe preeclampsia into two groups, one of which would have met our diuresis criteria prior to 24 hours and the other of which would not have met diuresis criteria at 24 hours post-delivery
Knockdown of MTDH increases drug sensitivity to HDAC inhibitor and TRAIL combination treatment in endometrial cancer cells
Get PDFUnderstanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy
Positron emission tomography in detection of metastatic leiomyosarcoma in a postoperative patient: a case report
Get PDFIn leiomyosarcoma (LMS) abnormal vaginal bleeding is the most common reported symptom in patients (56%), followed by pelvic mass (54%), and pain (22%). LMS is often hard to diagnosis on a uterine biopsy because it does not originate in the endometrium and may not invade into the cavity. Non-specific symptoms as well as difficulty in diagnosis being made by biopsy, means that many LMS tumors are often mistaken for fibroids preoperatively. To our knowledge this is the only reported case of FDG-PET being used in the postoperative evaluation of a patient with LMS and a suspicious lung mass. Our case shows there may be a place for PET scans in the post-op surveillance of LMS. This method would be ideally suited, considering the metastatic spread pattern of LMS
Division of Urogynecology and Reconstructive Pelvic Surgery
Get PDFThe Division of Urogynecology and Reconstructive Pelvic Surgery at the University of Iowa includes Drs. Catherine Bradley a fellowship trained urogynecologist and a nurse practitioner with advanced clinical training, Diane Elas, ARNP. UIHC Urogynecology clinics focus on the outpatient evaluation and management of female pelvic floor disorders, including urinary incontinence, pelvic organ prolapse, and other urinary and defecatory disorders. Outpatient diagnostic testing is available, including urodynamic tests and cystourethroscopy. We offer a wide spectrum of clinical care for pelvic floor disorders, including nonsurgical (e.g. pessaries and behavioral therapies) and surgical therapies. Clinic-based procedures (such as transurethral bulking injections and intra-detrusor botulinum toxin injections) are offered, as well as outpatient and inpatient surgeries. Special clinical initiatives include our minimally-invasive surgery program for urinary incontinence and prolapse, including outpatient slings and robotic hysterectomy and sacrocolpopexy
