Proceedings in Obstetrics and Gynecology
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Obesity as an Epidemic: Causes, Morbidities and Reproductive Performance
Get PDFObesity is an epidemic causing significant morbidity and mortality in United States. It is facilitated by many factors including sedentary life style, abundance of food, and unhealthy dietary habits. This review aims to briefly address causes and conditions associated with obesity, with a special emphasis on reproductive performance for Obstetricians and Gynecologists
Calcium and vitamin D for the reproductive female
Get PDFThe importance of calcium as well as its interdependence upon vitamin D is well established. Vitamin D acts via the vitamin D receptor, which is found in 37 different human tissues. Because of its rather ubiquitous localization, vitamin D is the topic of a great deal of associative research. However, caution must be exercised in interpreting these initial studies until clear evidence for causality becomes available. The purpose of this article is to review some of the known vitamin D and calcium associations as well as the current guidelines for calcium and vitamin D supplementation
Office Hysteroscopy & Healthcare Efficiency
Get PDFCost-efficiency is one of the essential attributes of a highly-performing healthcare system. In this paper, we discuss the inpatient-outpatient transfer of minor gynecological procedures and attempt to suggest solutions for the rampant inefficiency in the healthcare system
Thomas Gellhaus, MD
Get PDFDr. Thomas Gellhaus, the recently appointed Division Director for General Obstetrics and Gynecology, brings to the Department a wealth of clinical experience and passions for teaching, advocacy, and providing care to patients in the developing world
Combination therapy with mTOR and PI3 kinase inhibitors is broadly synergistic in a wide variety of endometrial cancer cells
Get PDFDysregulation of mammalian target of rapamycin (mTOR) signaling has been found in many human tumors, including endometrial cancer, and mTOR inhibitors have been utilized in clinical trials as targeted therapies with only limited success. Herein we identify a viable treatment alternative that overcomes temsirolimus-induced AKT phosphorylation in endometrial cancer. Our data suggest temsirolimus and BEZ235 inhibit different components of the AKT/mTOR signaling pathway to accomplish synergistic pathway inhibition, which is necessary for therapeutic efficacy to abrogate the increased signaling through AKT that occurs with mTOR inhibition alon
