Proceedings in Obstetrics and Gynecology
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University of Iowa Dept. of Obstetrics and Gynecology partners with Preeclampsia Foundation
Get PDFThe Preeclampsia Foundation is the only national 501(c)(3) not-for-profit patient advocacy organization serving the 5-8% of pregnant women - 300,000 women each year in the U.S. - who are affected by hypertensive disorders of pregnancy such as preeclampsia (formerly known as toxemia), eclampsia and HELLP syndrome. Their mission is to reduce maternal and infant illness and death due to preeclampsia, HELLP syndrome, and other hypertensive disorders of pregnancy by providing patient support and education, raising public awareness, catalyzing research and improving healthcare practices.The Preeclampsia Foundation and the Department of Obstetrics and Gynecology of the University of Iowa will be co-hosting a continuing medical education course on October 18, 2013, “Controversies in the Care of Women with Preeclampsia: A National Debate.” For additional information, contact CME Division, University of Iowa Carver College of Medicine at 319-335-8599
Defining normal IgG changes throughout pregnancy
Get PDFImmunoglobulin G (IgG) is the major serum immunoglobulin, accounting for roughly 75% of all immunoglobulin. IgG is the only class of immunoglobulin that crosses the placenta and it serves as the main immunologic barrier between the fetus and external environments. There has not been a clear consensus on what the normal values of IgG are throughout pregnancy. The aim of this study is to measure serum immunoglobulin G in each trimester of the pregnant female to determine a normal IgG profile throughout all trimesters in normal pregnancy
Giant endometrial polyp protruding from the external cervical os in a postmenopausal woman: magnetic resonance imaging and hysteroscopic findings
Get PDFEndometrial polyps are most commonly seen in the postmenopausal women with uterine bleeding, although the giant polyps which originate from the uterine cavity and protruding from the cervical os are rare. Several cases which have been described in the literature are usually developed secondary to tamoxifen use, and the polyps do not extend or protrude from the external cervical os. Most of the polyps protruded from the cervical os can mimic a cervical neoplasia or endocervical polyp. We report the case of a giant endometrial polyp (8x4x3 cm in size) which was protruding from the external cervical os and that developed spontaneously without tamoxifen use in a multiparous 73 -year-old woman presenting with vaginal bleeding. Hysteroscopic polypectomy was performed and no recurrence was seen at 6 months after surgery. Diagnosis, management and outcome of this rare entity have been discussed according to the literature
Gynecologic Oncology Group Study 229C: Personal Reflection
Get PDFI heard the statistician say, “The drug does not have sufficient activity to study further in this population.” It was my co-investigator on GOG study 229C, Gefitinib in the Treatment of Advanced and Recurrent Endometrial Cancer (see related extended abstract in this issue*), calling from Roswell Park in Buffalo. He had just completed the analysis of data from 26 women treated on our study – a study which had been five years in the making from concept to clinical trial
Obstetrics and Gynecology at the University of Iowa: Three leaders and 51 years
Get PDFIn his history of the Department of Obstetrics and Gynecology of the University of Iowa College of Medicine, William C. Keettel traced the evolution of the department from its origin in 1870 until 1980. This article will focus on a particular segment of the department’s history, that from 1926 to 1977, in which the department grew and developed to a position of national stature. During this 51-year period, departmental leadership was provided by three individuals, E. D. Plass (1926-1951), John H. Randall (1952-1959), and William C. Keettel (1959-1977) and this paper will consider these three men and their contributions to the department’s growth and development. The 1980 department history provided most of the basis of the article, although a small amount of the Randall section and a substantial amount of the Keettel section reflect my personal perspective and recollections
Malignant phyllodes tumor in a patient with hereditary retinoblastoma: a case report and literature review
Get PDFPatients with hereditary retinoblastoma are at increased risk for second malignancies, most notably sarcomas, particularly after treatment with radiation. Malignant phyllodes tumor is a rare secondary malignancy in these patients. We present a review of the literature and report of a patient with hereditary retinoblastoma who developed two secondary malignancies, including malignant phyllodes tumor. The patient’s phyllodes tumor presented as a palpable breast mass with suspicious findings on mammogram and ultrasound. The mass was shown to be at least a borderline phyllodes tumor via sonographic percutaneous biopsy and confirmed malignant phyllodes tumor on final surgical excision
Persistent postoperative granulation tissue following vaginal prolapse repair
Get PDFTo report rates and risk factors for persistent postoperative granulation tissue (GT) in women undergoing reconstructive vaginal prolapse surgery
The effect of weight-based chemotherapy dosing in a cohort of gynecologic oncology patients
Get PDFThe American Society of Clinical Oncology recommends that full weight-based doses of chemotherapy be used to treat obese patients with cancer. However, many oncologists limit the dose of chemotherapy based on ideal body weight or a maximum body surface area (BSA) of m2. The objective of our study is to determine how weight-based chemotherapy dosing affects toxicity, treatment delays, and laboratory values in a cohort of obese gynecologic cancer patients at our institution. We hypothesize that full weight-based dosing in obese patients does not increase adverse chemotherapy outcomes
Ethics issues identified by obstetrics and gynecology learners
Get PDFThis study evaluated a specific ethics and professionalism curriculum whereby medical students and residents provided a written assessment on various ethical issues encountered during their Ob/Gyn rotations. Our goal with this study was to retrospectively evaluate the content of reflections written by medical students and resident physicians and compare content and issues identified by each learner level. Our ultimate goal is to use these data to refine and improve the ethics and professionalism curriculum for Ob/Gyn medical learners
Flow mediated vasodilation predicts the development of gestational diabetes mellitus
Get PDFTo prospectively measure flow mediated vasodilation (FMD) in a cohort of women with risk factors for preeclampsia and to identify poor obstetrical outcomes associated with changes in FMD