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Reinforcement learning for dynamic optimization of Eco-Driving in smart healthcare transportation networks
No full textClick on the DOI link to access this article at the publishers website (may not be free).Smart transportation networks face increasing demands for efficiency and sustainability. This study presents a reinforcement learning approach that optimizes eco-driving strategies for connected and automated vehicles (CAVs) in urban environments, with a particular application to healthcare logistics. Specifically, we propose a novel approach using reinforcement learning, specifically a twin delayed deep deterministic policy gradient (TD3) algorithm, to dynamically optimize CAV trajectories at signalized intersections. The proposed healthcare eco-driving trajectory optimization (TD3-HETO) model incorporates real-time traffic conditions, signal timing information, and healthcare urgency levels to generate optimal acceleration profiles. The reward function is designed to balance energy efficiency, traffic flow, safety, comfort, and healthcare delivery timeliness. Additionally, the model introduces a dynamic exploration strategy that adapts to healthcare task urgency, enabling efficient balancing between energy consumption and delivery timelines. Experimental results show that TD3-HETO reduces energy consumption by up to 28.7% compared to baseline methods while improving average speeds by 3.7% for urgent healthcare deliveries. The model achieves superior safety performance with 98.7% of time steps showing zero conflicts, compared to 95.3% for the best baseline. TD3-HETO also demonstrates remarkable adaptability to varying traffic demands and signal timings, maintaining consistent performance even at high traffic volumes. This research contributes to developing intelligent transportation systems to enhance environmental sustainability and healthcare accessibility in smart cities, potentially improving patient outcomes and operational efficiency in urban healthcare logistics. © 2000-2011 IEEE
Measurement along the path of unmanned aerial vehicles for best horizontal dilution of precision and geometric dilution of precision
No full textThis is an open access article under the CC BY license.In the zenith-horizon placement for achieving minimum geometric dilution of precision (GDOP), one access node or sensor is positioned along the z-axis, while the remaining nodes are placed symmetrically on a three-dimensional (3D) cone. This configuration yields the minimum GDOP at the cone’s tip, which we term the designated min-GDOP point. However, in practical localization applications, the unknown node is not necessarily located at this designated min-GDOP point; instead, it may be situated anywhere within an area. As a result, evaluating localization accuracy across the entire area, rather than at a single point, is more relevant. Averaged horizontal dilution of precision (HDOP) and GDOP across the region provide more meaningful metrics for system-wide performance than values computed only at a specific location. Although many recent positioning applications leverage multiple unmanned aerial vehicles (UAVs), many established fixed sensor deployments predate the widespread adoption of UAVs. This paper proposes a novel approach with a single UAV working in conjunction with existing fixed access nodes for positioning. This approach offers improved adaptability for fixed infrastructure while circumventing the expense of establishing entirely new UAV systems, thus providing a valuable compromise. We investigate the criteria of average HDOP and GDOP over the given area. The objective is to determine optimal UAV positions along the flight path that minimize the average HDOP and/or GDOP across the area. Due to the analytical complexity, we employ numerical methods. Our simulation results demonstrate that minimizing average HDOP and GDOP often requires different UAV positions, depending on the number of access nodes and the size of the area. Consequently, achieving simultaneous minimization of both metrics with a single UAV trajectory is generally infeasible. When minimizing the average HDOP with a small number of access nodes, aligning the UAV’s XY-plane angle with those of the stationary nodes, offset by (Formula presented.), proves advantageous. This angular alignment becomes less critical as the number of access nodes increases. For scenarios where both HDOP and GDOP are important, UAV placement can be optimized by selecting appropriate trade-offs. Additionally, we quantify how increasing the number of access nodes improves the average HDOP and GDOP over the specified area. © 2025 by the authors.Air Force Research Laboratory, AFRL, (FA9453-22-C-A127); Air Force Research Laboratory, AFRLThis research was funded by Air Force Research Laboratory (AFRL) under Contract No. FA9453-22-C-A127
Genetically encoding ε-N-methacryllysine into proteins in live cells
No full textThis is an open access article under the CC BY license.Lysine acylation is a ubiquitous post-translational modification (PTM) that plays pivotal roles in various cellular processes, such as transcription, metabolism, protein localization and folding. Thousands of lysine acylation sites have been identified based on advances in antibody enrichment strategies, highly sensitive analysis by mass spectrometry (MS), and bioinformatics. However, only 27 lysine methacrylation (Kmea) sites have been identified exclusively in histone proteins. It is hard to separate, purify and differentiate the Kmea modification from its structural isomer lysine crotonylation (Kcr) using general biochemical approaches. Here, we identify Kmea sites on a non-histone protein, Cyclophillin A (CypA). To investigate the functions of Kmea in CypA, we develop a general genetic code expansion approach to incorporate a non-canonical amino acid (ncAA) ε-N-Methacryllysine (MeaK) into target proteins and identify interacting proteins of methacrylated CypA using affinity-purification MS. We find that Kmea at CypA site 125 regulates cellular redox homeostasis, and HDAC1 is the regulator of Kmea on CypA. Moreover, we discover that genetically encode Kmea can be further methylated to ε-N-methyl-ε-N-methacrylation (Kmemea) in live cells. © The Author(s) 2025.Zhejiang University, ZJU; Life Sciences Institute, LSI; outstanding youth fund of Zhejiang Province, (LR20B050001); Chinesisch-Deutsche Zentrum für Wissenschaftsförderung, CDZ, (C-0023); Chinesisch-Deutsche Zentrum für Wissenschaftsförderung, CDZ; National Key Research and Development Program of China, NKRDPC, (2022YFF0608402); National Key Research and Development Program of China, NKRDPC; State Key Laboratory of Robotics, (SKLPO201806); State Key Laboratory of Robotics; Chinese National Natural Science Funds, (22374128, 91953103, 22074132)We thank technical assistance from LSI core facility, Life Sciences Institute (LSI), Zhejiang University. This work was supported by the Chinese National Natural Science Funds (22374128, 22074132 and 91953103 to B.Y.), the National Key R&D Program of China (2022YFF0608402 to B.Y.), the outstanding youth fund of Zhejiang Province (LR20B050001 to B.Y.), the special COVID-19 program of the Sino-German Center for Research Promotion (C-0023 to B.Y.), Open Project Program of the State Key Laboratory of Proteomics (SKLPO201806 to B.Y.)
Advanced Education Program in General Dentistry graduates 2022-2023
No full textSchool composite: students included in composite: Caleb Murray, Kiera Powell, McKay Jensen, Tyler Powell.
Group photo: from left to right: Dr. Elledge, Tyler Powell, Kiera Powell, McKay Jensen, Caleb Murray.Digitized by University Libraries' Technical Services Institutional Repository & Digitization group.Personal and non-profit use only. Contact [email protected] if you have any questions
Aberrant neural activation during inhibitory control in girls with fragile X syndrome
No full textClick on the DOI link to access this article at the publishers website (may not be free).Fragile X syndrome (FXS) is a genetic condition associated with risk for deficits in executive function, especially response inhibition. Under a clinical setting, this study employs a mobile neuroimaging technique, functional near-infrared spectroscopy (fNIRS), to examine differences in inhibition-elicited neural activation between girls with FXS and a control group matched for age, cognitive function, and clinical symptoms. fNIRS data were collected from 42 girls with FXS and 31 controls during a go/nogo task, with valid data available from 35 and 30 respectively. Relative to the control group, girls with FXS showed higher brain activation (NoGo>Go) in the right dorsolateral prefrontal cortex (DLPFC), angular gyrus, precentral gyrus, and left frontal pole, and lower activation in the right ventrolateral prefrontal cortex, frontal pole, precentral cortex, middle temporal cortex, parietal lobe, and left superior temporal cortex. A significant positive correlation was found between DLPFC activation and response inhibition deficits in girls with FXS. Girls with FXS show abnormal neural activation in response to inhibitory stimulus. Aberrant neural activation in DLPFC in girls with FXS is associated with executive function deficits. fNIRS is established to allow participants to engage in a task in relatively more "real world"conditions compared to the scanner environment. © 2025 The Author(s). Published by Oxford University Press. All rights reserved.K elvin Foundation; Canel Family Fund; Kelvin Foundation; National Institute of Mental Health, NIMH, (R01MH050047); National Institute of Mental Health, NIMHFunding text 1: We thank the families who participated in this study and many members of the laboratory who assisted with this project. The authors report no biomedical financial interests or potentialcon-flicts of interest. This work was supported by the National Institute of Mental Health (Grant Nos.R01MH050047 [to ALR]),the K elvin Foundation (toALR), and the Canel Family Fund (toALR).; Funding text 2: This work was supported by the National Institute of Mental Health (Grant Nos. R01MH050047 [to ALR]), the Kelvin Foundation (to ALR), and the Canel Family Fund (to ALR)
Faculty Senate meeting, April 28, 2025
No full textAgenda: (Approval of Minutes): April 14, 2025 -- (Informal Statements) / Jay Price -- (President’s Report) / Mathew Muether -- (Committee Reports): Rules Committee Report / Chris Stone -- Planning and Budget Committee Report -- Mathew Muether – (Old Business): Summary of Proposals – Senate Standing Committee structure proposal – 2nd read – Sunset and Student Success – discussions/ questions – Planning and Budget Committee – discussion and questions -- (New Business): SEAS Report / Dr. Brett Bruner, Dr. Ashlie Jack – Budget Discussion / David Miller, Lyndsay Pletcher – PIAC Report, tabled to next meetin
Department of Dental Hygiene Class of 2006
No full textFirst row (left to right): Kelly Brackeen, SADHA President 2005-2006; Camala Gates, SADHA Vice Presdent 2004-2005; Stephanie Bright, SADHA Secretary 2004-2006; Celeste McCabe, SADHA Treasurer 2004-2005, SADHA Class Representative 2005-2006; Jennifer Feil, SADHA Class Representative 2004-2006; Jennifer Heineken, SADHA Class Representative 2004-2005Second row (left to right): Tammy Amspacker, Melinda Boynton, Vanessa D'Angelo, Marla Dattilo, Stephanie Diane Ewertz, Emily Lynn Fisher, Neely Fortner, Kayla Lynn HarrisThird row (left to right): My Phuong T Hoang, Amanda Kanngiesser, Amanda Kippenberger, Amber Renee' Koester, Allyson Metzinger, Ambur Miller, Ngoc Nguyen, Laura PhillipsFourth row (left to right): Michon Rylant, Holly Spellman, Kelsey Stevens, Jenae Nicole Tippin, Julie Walters, Maranda E. Wass, Havilah WilcoxDigitized by University Libraries' Technical Services Institutional Repository & Digitization group.Personal and non-profit use only
Laminated nanocomposites and nano-reinforced adhesively bonded joints with improved mechanical performance and adhesion
No full textClick on the DOI link to access this article at the publishers website (may not be free).Composite laminates and bonded joint assemblies have several advantages, and they are widely used in structural applications, because of their lightweight, high strength and stiffness, corrosion resistance, tailorable properties, damage tolerance, reduced maintenance, design flexibility, and tunable thermal and electrical properties. Despite having these superior properties and advantages over traditional materials, composite laminates and joints do have several disadvantages including poor interlaminar properties, difficulty to adhesively bond and repair, sensitivity to UV radiation and moisture, and limited impact resistance and through-the-thickness properties. One of the most promising solutions that can address some of the shortcomings is to incorporate nanomaterials, e.g., carbon nanotubes (CNTs), as a nanoscale reinforcement between the traditional microfiber reinforcements and within the resin system to improve the interlaminar and through-the-thickness properties of the composite laminates and bonded joints assemblies. Our prior studies demonstrated that helical CNTs (HCNTs) perform better than the straight CNTs (SCNTs), due to their unique helical geometries that can provide a nanoscale interlocking mechanisms between the reinforcements and within the solidified resin. In this study, composite and HCNTs reinforced nanocomposite panels with varying weight percentages of HCNTs inclusion (i.e., 0wt%, 0.025wt%, and 0.05wt%) were prepared, cut, and prepared for mechanical testing and analysis, as per ASTM standards (i.e., ASTM D790-17, ASTM D2344/2344M-16, ASTM D3039/D3039M-17, and ASTM D5868-01). The test results for flexural strength, short-beam strength, tensile strength, and single-lap shear strength for the nanocomposite samples with HCNTs reinforcements were compared to those without nano-reinforcements and promising results were obtained. © 2025 Soc. for the Advancement of Material and Process Engineering. All rights reserved
Faculty Senate meeting, May 12, 2025
No full textAgenda (2024-2025): (Approval of Minutes): April 28, 2025 -- (Committee Reports): Rules Committee Report / Victoria Sherif – PIAC Report / Bayram Yildirim - Ombuds Report / Carolyn Shaw – Standing Committee Annual Reports – (New Business): Discussion of State Proviso and Compliance Implementation / Mathew Muether, Monica Lounsbery -- Pass the Gavel / Muether
Agenda (2025-2026): Call to order / Chris Stone – (President’s Report) / Chris Stone: Welcome to New Senators and University Committee members – (Election of Officers): 2025-2026 Slate of Officers for Executive Committe
“You will believe what you believe”: A thematic analysis of (un)believability in law & order: Special victims unit
No full textThesis (M.A.)-- Wichita State University, College of Liberal Arts and Sciences, Elliott School of CommunicationVictim-survivors of sexual assault face several obstacles when disclosing their experience, especially to law enforcement. Their believability is often doubted because of their subjectivity or performance as a victim-survivor. This dynamic is present in primetime dramas depicting sexual violence. This study employs a thematic analysis under the framework of Cultivation Theory and Framing Theory to analyze themes of (un)believability in the hit primetime show Law & Order: Special Victims Unit. This research found themes power, the victim-survivor's subjectivity, the assailant’s subjectivity, nonideal performance by the victim-survivor were present. dispelling sexual violence myths (SVMs) and an ideal performance by the victim-survivor. These themes show that there are negative characterizations of victim-survivors based on their subjectivity and performance. To counterbalance this, the shows often juxtapose SVMs with correction. It is possible SVU cultivates a negative or positive reality towards believability in the minds of its heavy viewers