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Optimal you
No full textHonors thesis (HB)-- Wichita State University, Dorothy and Bill Cohen Honors College.Accepted in partial fulfillment of the requirements for the degree of Honors Baccalaureate with concentrations in Wellness, Innovation Design, and Digital Marketing.This thesis project can be found here: https://adamkey500.wixsite.com/optimal-youOptimal You is a wellness platform designed to help individuals and organizations enhance their health and performance through evidence-based protocols, corporate retreats, and digital resources. Combining innovation design, digital marketing, and wellness, the platform offers fitness, recovery, mindfulness, and nutrition programs. With a focus on accessibility and community engagement, Optimal You empowers users to optimize their well-being through expert guidance and interactive wellness experiences
The effect of glioma extracellular matrix components on tumor cell migration
No full textThesis (M.S.)-- Wichita State University, College of Liberal Arts and Sciences, Dept. of Biological SciencesAggressive primary brain tumors starting from glial cells in the central nervous system are called gliomas. With collagen and hyaluronic acid as main components, the extracellular matrix (ECM) is vital in controlling tumor cell behavior. While hyaluronic acid offers a hydrated, elastic environment and signals by CD44 and RHAMM receptors to promote cytoskeletal reorganization, proliferation, and invasion, collagen acts as a structural scaffold and influences signaling pathways via integrin-mediated interactions. On collagen, hyaluronic acid, and collagen-hyaluronic acid composite substrates, this work examined the migratory and proliferative responses of U87 glioma cells and primary glioma cells. Results revealed that glioma cells show higher migration speed and proliferation rate on collagen-coated surfaces compared with hyaluronan coated surface. Combining hyaluronic acid with collagen produced an intermediary phenotype. High doses of ascorbic acid were investigated in relation to glioma cell behavior. As an antioxidant, ascorbic acid worked at low dosages to lower reactive oxygen species (ROS) levels, so promoting cell survival. High concentrations, however, had a prooxidant effect that caused cytotoxicity, interfered with mitochondrial function, and resulted in death. These results have important consequences for the design of anti-glioma treatments since they imply that aiming at ECM-cell interactions or changing ECM stiffness and composition could lower tumor invasiveness
SPIRSS impact on rural high-need LEA's
No full textPresented to the 21st Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Rhatigan Student Center, Wichita State University, April 11, 2025.Research completed in the Department of Intervention Services & Leadership in Education, College of Applied Studies.INTRODUCTION: The field of school psychology has grown in recent years, however, there is still a shortage of school psychologists in rural high-need local education agencies (LEA's) across Kansas. In these districts, there are inadequate resources to address students' mental health needs. This study evaluates the impact of the School Psychology Partnerships to Increase Rural School-Based Services (SPIRSS) initiative. Under SPIRSS, graduate students deliver evidence-based mental health services to students in rural high-need LEA's as part of their field experience semester. Funded by the U.S Department of Education and now in its third year, SPIRSS has made significant strides towards reducing the mental health needs of children across rural Kansas.
PURPOSE: To increase the quantity of mental health service providers and address the mental health crisis in high-need rural LEA's across Kansas.
METHODS: The study included 47 participants aged 8 to 15 years old, with a gender distribution of 17 females and 30 males. Participants completed the Behavior Assessment System for Children, Third Edition (BASC-3) Self-Report to evaluate Anxiety, Depression, and Internalizing Problems scales at two time points: pre-intervention and post-intervention. Scores were recorded withing three tiers to reflect severity levels. Data were analyzed to assess changes between pre- and post-test scores using paired t-tests, effect size calculations (Cohen's d), and subgroup analysis based on gender differences.
RESULTS: A paired-samples t-test was conducted to compare Tier 3 pre-test and post-test scores for Depression, Anxiety and Internalizing Problems. The results indicated a statistically significant decrease in Tier 3 scores from pre-test (M = 13.67, SD = 4.16) to post-test (M = 6.00, SD = 2.00), [t(2) = 4.35, p = .049, d = 4.35]. These findings suggest that the intervention had a significant effect on the most affected individuals (Tier 3), as evidenced by a large effect size (Cohen's d = 4.35), which indicated a very strong practical impact. Analyses of Tier 2 data set yielded no statistically significant results between pre-test and post-test scores. To explore gender-based differences in the intervention's effectiveness, estimated Tier 3 change scores were analyzed separately for females (n = 17) and males (n = 30). The results suggested that males experienced greater reductions in symptoms across all categories:
Scale Females Males
Depression M = 2.53 M = 4.47
Anxiety M = 1.81 M = 3.19
Internalizing Problems M = 3.98 M = 7.02
CONCLUSION: The SPIRSS initiative has shown promising results in reducing mental health challenges among students in rural, high need LEAs throughout Kansas. Further expansion of the SPIRSS program could prove to further address the mental health crisis amid rural districts across Kansas.Graduate School, Academic Affairs, University Librarie
Monte Carlo method for constructing confidence intervals with unconstrained and constrained nuisance parameters in the NOvA experiment
No full textThis is an open access article under the CC BY license.Measuring observables to constrain models using maximum-likelihood estimation is fundamental to many physics experiments. Wilks' theorem provides a simple way to construct confidence intervals on model parameters, but it only applies under certain conditions. These conditions, such as nested hypotheses and unbounded parameters, are often violated in neutrino oscillation measurements and other experimental scenarios. Monte Carlo methods can address these issues, albeit at increased computational cost. In the presence of nuisance parameters, however, the best way to implement a Monte Carlo method is ambiguous. This paper documents the method selected by the NOvA experiment, the profile construction. It presents the toy studies that informed the choice of method, details of its implementation, and tests performed to validate it. It also includes some practical considerations which may be of use to others choosing to use the profile construction. © 2025 IOP Publishing Ltd and Sissa Medialab. All rights, including for text and data mining, AI training, and similar technologies, are reserved
An initial study of language preferences and ableism: Interviews of autistic adolescents and young adults
No full textPresented to the 21st Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Rhatigan Student Center, Wichita State University, April 11, 2025.Research completed in the Department of Communication Sciences and Disorders, College of Health Professions.INTRODUCTION: The language used by educational and medical professionals can assist in providing the best care; alternatively, words can create barriers between professionals and the individuals they serve. A broad range of terms are acceptable to use with autistic individuals with the two most common being identity first language (IFL) or person first language (PFL). There is evidence documenting that some autistic adults in the U.S. prefer IFL. However, individuals from some European countries prefer PFL for linguistic reasons. It is vital for professionals to use the language preferred by the individual to provide person-centered care.
PURPOSE: While previous research has queried autistic individuals about their preferences through surveys, a gap exists in exploring the actual impact language has on autistic adults. The current study examined the impact language has on autistic adolescents and young adults.
METHOD: Autistic adolescents and young adults (N = 12) participated in semi-structured interviews using a set of questions regarding their preferences for PFL or IFL and what they want professionals to know about autism and ableism. This was part of a larger study exploring autistic individuals' use of various linguistic features.
RESULTS: Significant statements in the interview transcripts were identified. The authors will review transcripts for codes and thematic analysis will be conducted.?
CONCLUSION: Many participants did not share that PFL or IFL had an impact on them while Taboas et al. (2023) indicated the impact of identifying language needed further examination. Clinical implications and suggestions for future research will be shared.Graduate School, Academic Affairs, University Librarie
Superior differential ion mobility spectrometry of pendular macromolecules using low-frequency rectangular waveforms
No full textClick on the DOI link to access this article at the publishers website (may not be free).Ion mobility spectrometry (IMS) can delineate gas-phase ions and probe their geometries. Coupling with electrospray ionization and MS has brought IMS to structural biology, revealing the macromolecular folding and subunit connectivity. However, the orientational averaging of ion-molecule collision cross sections (Ω) in the linear and field asymmetric waveform IMS (FAIMS) diminishes the resolution and structural specificity. In the novel low-field differential (LOD) IMS, a field too weak for ion heating (and thus FAIMS) aligns strong macrodipoles, capturing their magnitudes and directional Ω across the dipole (Ω⊥). However, the bisinusoidal waveforms (from FAIMS) have compromised the resolution, measurement accuracy, and correlation to the ion properties. Large ions amenable to LODIMS have low mobility and diffuse slowly, allowing the waveform frequencies down to ∼10 kHz. The low field and frequency permit generating the ideal rectangular waveforms with a flexible frequency and duty cycle by direct switching (impractical for FAIMS) in a miniature low-power format. This new IMS stage is evaluated for the exemplary large protein albumin (66 kDa) previously studied using the bisinusoidal waveform. The flat voltages and greater form factor initiate the differential IMS effect at lower fields, expand the separation space, and enable the quantification of Ω⊥ values by varying the duty cycle. © 2025 American Chemical Society.National Science Foundation, NSF, (CHE-2105182); National Science Foundation, NSFThis research was supported by NSF (CHE-2105182)
Enhancing service delivery efficiency through inter-local collaboration: A network analysis in water service context
No full textClick on the DOI link to access this article at the publishers website (may not be free).Fragmentation among local governments often leads to inefficiencies in public service delivery. This challenge is particularly salient in delivering services for small communities. This study applies the Institutional Collective Action (ICA) framework and network analysis to examine how inter-local collaborative agreements can improve cost efficiency in water and wastewater services in Iowa. Integrating the theories of economies of scale and transaction costs, this study provides a nuanced understanding of how inter-local collaborative networks lower costs in service delivery. The findings reveal that while collaboration is widely considered a means to achieve economies of scale, local actor's network structure could play a more significant role in shaping actual efficiency gains. Specifically, in water services, cities in more tightly clustered networks experience lower efficiency. Conversely, in wastewater services, clustering is associated with higher efficiency by fostering resource sharing and enforcement mechanisms, but network centrality is associated with lower efficiency. These results suggest the importance of strategic management of collaborative ties to balance the benefits of economies of scale with the transaction costs of collaboration. The findings provide implications for policymakers aiming to improve public service efficiency through inter-local collaboration
University Staff Senate meeting, May 20, 2025
No full textAgenda: (Call to Order) -- (Guest) -- (Discussion and New Business) -- (Senate Committee Updates) -- (Campus/University Business Updates & Discussions) -- (Adjourn/Upcoming Meetings and Events/Shoutouts)
Minutes: (Call to Order): Approval of minutes -- (Guest): Budget Updates – David Miller -- Federal Agency & Legislative Actions – General Counsel -- (Discussion and New Business): Staff Senate Internal Awards and Recognition -- At-Large Senator Appointments -- Executive Team Elections -- (Senate Committee Updates): Awards and recognition -- Communications and website -- Elections -- Policy review -- Professional development and service -- Scholarships – Shocker STRIVE -- (Campus/University Business Updates & Discussions): Academic forum -- Budget Advisory Committee -- Human Resources (Joint with Faculty Senate) -- Legislative update + KBOR briefing -- Parking appeals + traffic appeals -- President’s meetings -- RSC Board of Directors -- UPS/USS Presidents Council (KBOR) -- Human Resources (Joint with Faculty Senate) -- Legislative update + KBOR briefing -- (Adjourn/Upcoming Meetings and Events/Shoutouts): June Senate Meeting: Tuesday, June 17, 2025 -- Check the Events Calendar for upcoming events on campus -- Morning of Tuesday June 3rd, sculpture tour, sign up will be shared through WSU Today soon.
Attachments contain Senate meeting minutes with Vietnamese translation
Educating undergraduate students about swallowing pretreatment for head and neck cancer patients
No full textThird place winner of poster presentations for Applied Sciences at the 24th Annual Undergraduate Research and Creative Activity Forum (URCAF) held in the Woolsey Hall, Wichita State University, April 25, 2025.Most patients with head and neck cancer receive chemoradiation that often results in long-term severe swallowing deficits. Research shows that swallowing pretreatment provided by a speech-language pathologist can counteract these deficits if patients are referred for swallowing intervention early enough in their treatment plan. A recent interprofessional education project showed that a one-hour presentation increased nurse practitioner students' and physician associate students' knowledge of these issues. The current project investigates the following research question: Will Communication Sciences and Disorders undergraduate students demonstrate increased knowledge of swallowing pretreatment for patients with head and neck cancer from a similar educational presentation? A pretest will be given to gather information on the students' prior knowledge. Then, the undergraduate students will listen to a presentation based on the aforementioned interprofessional education project. A post-test will follow to measure if the students' knowledge has increased. The pretest and post-test data will be analyzed statistically to determine whether the increases are significant. The changes in students' scores will be reported and the implications for the research question will be discussed. If students' knowledge increases significantly following the education module, it adds to the evidence that this is an effective method of teaching students about this vital issue. Improved awareness of the benefits of swallowing pretreatment may strengthen referrals for swallowing intervention. This study is a component of a larger project aiming to improve long-term swallowing outcomes for head and neck cancer patients
Department of Dental Hygiene Class of 2018
No full textFirst row (left to right): Huynhmy Phan, SADHA President; Jenna Harpstrite, SADHA Secretary; Kaitlyn Flanagin, SADHA Treasurer; Danielle Gomez, SADHA Class Representative; Stormi Leyba, SADHA Class RepresentativeSecond row (left to right): Mohammed Alshawi, Katie Burgess, Danni Chilcott, Mandy Cockrell, Nelly Conde, Lauren Copp, Jamie Decker, Anna Dunn, Maile FeikertThird row (left to right): Chelsea Hermann, Yetong Koh, Maeghen Law, Courtney Lies, Lauren Mellinger, Carly Metcalf, Linda Namvong, Sierra Osborne, Carlie Phillis, Kara ReimerFourth row (left to right): Constance Roe, Bryce Schroeder, Lacey Schwartz, Madison Silknitter, Lisa Smithyman, Courtney Supernaw, Dale Maxwell Thompson, Kylie Thompson, Amberlyn Westney, Meagan WilliamsDigitized by University Libraries' Technical Services Institutional Repository & Digitization group.Personal and non-profit use only