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The dark proteome of rodent hepatitis E virus: Analysis of intrinsically disordered regions
No full textHepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or Intrinsically Disordered Protein (IDPs) are regions or proteins that are characterized by a lack of definite structure. These regions or proteins play significant roles in a wide range of biological processes, such as cell cycle regulation, control of signaling pathways, etc. IDPRs or IDPs in proteins are associated with the virus’s pathogenicity and infectivity. The occurrence of intrinsic disorder in the proteome of rat HEV remains to be elucidated, which prompted us to explore its dark proteome. In this study, the unstructured/disordered regions of ORF proteins of rat HEV have been examined. We have analyzed the prevalence of intrinsic disorder by using a set of computational predictors. The intrinsic disorder propensity analysis showed that the ORF proteins consisted of a varying fraction of intrinsic disorder. The ORF3 protein was identified with a maximum propensity for intrinsic disorder while the protein ORF6 showed the least propensity for the intrinsic disorder. Further, the analysis revealed ORF6 as highly structured protein (ORDP); ORF1 and ORF4 as moderately disordered proteins (IDPRs); and ORF3 and ORF5 as highly disordered proteins, categorizing them as ordered protein (ORDP), a protein having Intrinsically Disordered Region (IDPR) and Intrinsically Disordered Proteins (IDP) respectively. Such disordered regions may play several important roles in the pathogenesis and replication of viruses. Collectively, this comprehensive study data from our investigation suggested ORF protein’s role in the regulation and pathogenesis of rat herpesvirus.</p
Ultrasound Precautions during COVID-19 Pandemic
No full textAn epidemic that travels throughout the world is called a pandemic [1]. There have been several pandemics that have impacted the world. One example of a pandemic that became global is Spanish influenza. This pandemic was very severe and attacked more than 30% of the world population. Approximately 50 million people died from the first outbreak. </p
A rare case report of piloleiomyomas
No full textLeiomyoma is a rare benign tumor of smooth muscle. In the word leiomyomas, “Leio” means “smooth”, “myo” means ‘muscle’, and “oma” means ‘tumor’. It may arise from smooth muscles of the skin, uterus, bladder, urethra. Depending upon the origin of skin smooth muscles cutaneous leiomyomas are of three main types: 1. Piloleiomyoma or leiomyoma cutis or pilar leiomyoma derived from arrector pili muscle; 2. Genital leiomyoma or dartoic myoma is derived from smooth muscle of the scrotum, vulva, and areola of the nipple, and 3. Angioleiomyoma is derived from the media of blood vessels. We report one such rare case of multiple piloleiomyomas. </p
Reflectance study of soil silt using proximal sensing in Northern Iran
No full textThe study of silt fractions using the traditional methods, especially on large scales, is time-consuming, laborious, and costly. The present work intends to investigate the spectral behaviors of the soil silt fraction using reflectance spectroscopy technology. Accordingly, 128 soil samples were collected from 20cm of soil surface of Mazandaran province, northern Iran. First, the sample set was subdivided into calibration and validation subsets. Spectral signatures of silt components were detected utilizing the PLSR algorithm and Cross-Validation technique. The final model with 4 LFs was calibrated with these specs: Rc: 0.55, RMSEc: 8.31%, RPDc: 1.20, and RPIQc:1.71 and was eventually selected as the best model for studying the soil silt of Mazandaran province. The obtained spectral wavebands with the highest correlation coefficients (R(CCmax)) indicate the high impact as the independent predictors in the processes of modeling. Finally, the capability of the proximal sensing technology (VNIR-PS) was proved in examining the silt content of Mazandaran province. Also, the most influential spectral domains and ranges were detected and recognized. Our findings can be used as a basis for studying silt content on a large scale by applying the upscaling process via airborne/satellite hyperspectral data.Subject classification codes: Soil Conservation, Proximal Soil Sensing, Soil Spectral Modeling</p
Rapid diagnosis in thyroid tumors by using touch cytology
No full textThe study aims to assess the role of imprint cytology in the diagnosis of thyroid nodules and compare it with paraffin Section in the diagnosis of thyroid lesions.It included 40 patients who visited Private Hospitals in Aleppo during the period from April to December 2021. The results indicated that there were 19 patients with thyroid cancer, representing 47.5%, of whom 14 were diagnosed with Papillary Carcinoma, with a percentage of 35%, and 5 cases with Follicular Carcinoma, with a percentage of 12.5%, while the remaining cases included 21 patients with Benign Adenomas at a rate of 52.5%, including 11 cases of Hashimoto’s disease at a rate of 27.5% and 10 cases of Benign Follicular Tumors at a rate of 25%. These results were compared with Paraffin Sections and reached sensitivity, specificity, and accuracy in diagnosis for this technology, 94.73%, 95.23% and 95%, respectively, and the positive predictive value was 94.73%, while the negative predictive value was 95.23%. The results also indicated that this technology is fast in determining the Histologic Grading of Tumor Differentiation, but it does not determine the Histological Type. It also indicated that there was a significant association between gender and the incidence of thyroid tumors, while no significant statistical evidence was observed between age and the possibility of thyroid cancers.</p
Health effects of organic farming, review of literature since 2005-Revision
No full textIn 2005, a study was carried out with chicks fed either organic feed or conventional feed. The aim of the trial was to see whether there was a difference in health between organic and non-organic fed chickens, as a stepping stone to a study in pigs and ultimately in humans. Thus, the final goal was to see whether organic food has positive health effects on humans. In the study, it appeared that animals fed organic feed showed a stronger immune response after a challenge than animals not fed organic feed. However, the researchers found that no firm conclusions could be drawn about the health status of organically fed animals. Based on these results, it was decided not to commission a follow-up study because the differences would be too small. The current knowledge and insights may give new reasons for follow-up research. For this purpose, a report was published with a summary of the original research and subsequent publications, as well as results from literature since 2005 on the health effects of organic feed for animals and organic products for humans. After the 2005 study, no comparable animal studies were carried out with organic and conventional feed. It is precisely in the case of animals that only the feed can differ, which can provide valuable insight into the effects of using only organic nutrition. Research has been done on the differences in composition between conventional and organic products. Human cohort studies have also been conducted on the effects of organic food on health parameters and the occurrence of various types of cancer. Although most researchers are very cautious about concluding the health effects of organic food, there are several relevant findings on differences in the composition of products, most of which are related to the organic production method. These include no synthetic chemical crop protection agents and fewer biocides as compared to conventional production, more antioxidants, and phenols and fewer antibiotic-resistant germs than conventional food. Moreover, milk has a more beneficial fatty acid pattern. There are some indications that eating organic food lowers the risk of developing certain conditions, such as allergies, metabolic syndrome and obesity, and certain cancers.</p
Antioxidant activity assay and determination of phenolic and flavonoid content of Libho (Ficus Septica Burm. F) fruits
No full textBackground: One of the plants used in Indonesian traditional medicine Libho (Ficus Septica Burm. F) is traditionally used to treat some diseases, including malaria, diarrhea, diabetes, analgesic, antifungal, dysentery, anthelmintic, antioxidant, hemostatic and anti-inflammatory. Purpose: The purpose of the study is to investigate the potential in vitro antioxidant activity assay and phytochemical content of Libho fruits. Methods: Libho leaves powder was extracted with the maceration method Antioxidant activity was evaluated using ABTS cation and CUPRAC radicals. Total phenolic content was determined using the Folin-Ciocalteau method. Meanwhile, the total flavonoid content was determined using the aluminum chloride complex colorimetric method; Results: Extract and fraction of Ficus Septica Burm. F fruits have the strongest antioxidant potential. The ethyl acetate fraction showed the strongest antioxidant activity on both ABTS and CUPRAC radicals with IC50 values of 6.33 ± 0.01 µg/mL and 11.64 ± 0.28 µg/mL, respectively. Ethyl acetate fraction also showed high phenolic and flavonoid content with values of 28 ± 0.05 mg GAE/100 mg sample and 43.08 ± 0.48 mg QE/100 mg sample, respectively. Conclusion: Ethyl acetate fraction has the potential to be used as a source of natural antioxidants and has the potential to be used as a nutraceutical.</p
Normal left pulmonary inferior lobe in abnormal systemic circulation arterial supply
No full textNormal left pulmonary inferior lobe in abnormal systemic circulation arterial supply without sequestration is a rare malformation of congenital lung vascular. Multi-Detector Computed Tomography (MDCT) and it’s Three-Dimensional (3D) reconstruction can display clearly the signs of the abnormal systemic circulation arterial supply to the lung lobe and the imaging changes of the left pulmonary inferior lobe associated with this disorder, it can provide detailed information for the clinician to make the treatment planning. </p
Evaluation of the cookies formulated with finger millet plant material for antidiabetic property
No full textCookies are the most popular bakery food consumed worldwide. The development of reduced-sugar soft cookies by using Finger Millet, Syzygium cumini L. (Jamun) and stevia extract was investigated. In addition to it, Buttermilk powder was used as a bulking agent to improve the flavor, color and texture of the cookies along with other ingredients like flour, margarine, salt, sodium bicarbonate, and water. The creamery method of production was used for cookie preparation. Amounts of water, stevia, and buttermilk powder and baking duration for each formulation were determined by preliminary experiments. Different formulations use different ratios to find out the best composition for cookies on the basis of palatability. After the selection of the best composition, cookies were prepared for the physiochemical, sensory and nutritional analysis. Sensory analysis was evaluated based on organoleptic properties: color, taste, aroma and overall acceptability on the basis of a 9-point hedonic scale. The physiochemical evaluation included total ash value, total water, and alcoholic extraction, and total moisture content. On the basis of nutritional value comparison, it was found that protein content is higher in our formulation than in other marketed products. Due to the high antioxidant potential and phenolic content of the Finger Millet cookie, it can be used as a therapeutic or functional food source for the treatment of overweight, obesity, and diabetes.</p
Brown fat and a short circuit make warm and slim
No full textIt is not widely known that the body contains a mechanism that protects against cold and at the same time leads to normal body weight. It is brown fat, combined with a special protein called thermogenin/UCP1. Though there are several UnCoupled Proteins, the main one for the brown tissue is UCP1. It switches ATP production towards heat production. Good oils and cool outside temperatures help in this process.</p