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On Λ-fractional variational calculus
Pointing out that Λ-fractional analysis is the unique fractional calculus theory including mathematically acceptable fractional derivatives, variational calculus for Λ-fractional analysis is established. Since Λ-fractional analysis is a non-local procedure, global extremals are only accepted. That means the extremals should satisfy not only the Euler–Lagrange equation but also the additional Weierstrass-Erdmann corner conditions. Hence non-local stability criteria are introduced. The proposed variational procedure is applied to any branch of physics, mechanics, biomechanics, etc. The present analysis is applied to the Λ-fractional refraction of light. </p
Biomonitoring of aquatic habitat using Apodu Dam in Malete, Moro local government area of Kwara state Nigeria as a case study
Water bodies such as dams are an essential part of the ecosystems and the Apodu dam, a Local Government Area of Kwara State supplies water for the populace of Malete. The water is used for both domestic and agricultural purposes. Given the proposed rural development in the catchment area of the Apodu dam, it becomes imperative therefore to do extensive biomonitoring of the dam before the development begins so as to determine the likely source of pollution in the dam as well as determine the health of the dam. Ten samples of both water and plants were collected at different sampling points designated as A-J. The samples collected were digested and analyzed using standard techniques. Data generated from the research were subjected to T-test to determine whether there is a significant variation in the two sets of data. The parameters examined fall within the permissible level of standards set by the Federal Environmental Protection Agency (FEPA) and the World Health Organisation (WHO). Total hardness (TH) was 88.00-128.80 mg/l, pH 6.60-6.80, Total dissolved solids (TDSS) 242.00-420.00 mg/l, Electrical conductivity 102.32-103.39 µs cm, Biological Oxygen Demand (BOD) 3.47-3.53 mg/l, Chemical Oxygen Demand (COD) 104.00-168.00 mg/l and Dissolved oxygen (DO) 3.47- 3.53 mg/l. The lower concentration of DO is an indication of high water quality and this is advantageous for aquatic life as it suggests that there is less decomposition of foreign materials. In conclusion, high potential for an increasingly detrimental impact on the water quality resulting from increased anthropogenic activities especially if the proposed developments commence is imminent. </p
Oceans’ surface pH-value as an example of a reversible natural response to an anthropogenic perturbation
The anthropogenic emission of carbon dioxide (CO2) has influenced the pH values of the oceans’ surface. Observations show that for several decades, the surface pH value is declining with a simultaneously rising CO2 concentration. It is an important question to understand to what extent this process is reversible. Hence, in this study, the atmospheric carbon dioxide (CO2) partial pressure from 1850 to 2020 is derived from the chemical composition of the seawater, the mass action law, Henry’s law, and published literature data on the relevant equilibrium constants. A single exponential relaxation or equilibration time τ = 52 ± 10 years (or half-time of 36 ± 7 years) accounts for the anthropogenic perturbation due to emissions. The model is based on reversible mechanisms and simultaneously represents the atmospheric CO2 volume fraction with a standard deviation of 7 ppm and the oceans’ surface pH values. Projections until 2100 for various emissions include the possibility of recovery within decades. </p
The clinical role of probiotic and prebiotic supplementations in preterm infants
Background: For over two decades we have been trying to study and demonstrate the role of the gut microbiota in the onset of cardiovascular, autoimmune, infectious and neurobiological diseases and more generally the clinical efficacy. Aims: To study the clinical efficacy of the integrative use of prebiotics and probiotics in the prenatal population.Materials and methods: All clinical trials and randomized controlled trials were selected through January 6, 2023, for a useful total of 32 studies and a cohort of more than 37,000 infants, of which just under half are term infants in the control groups.Results: In the neonatal literature, studies on the clinical use of prebiotics and probiotics focus on specific topics of investigation, starting from the intestinal microbial composition and then extending the object of analysis to the effects of antibiotics on the microbiota, to the biochemical integration of these products, the use of breast milk or artificial or donor milk, the alleged claim to intervene on pathological processes arising from opportunistic infections of the respiratory tract, and also in relation to autoimmune, gastrointestinal and dermatological pathologies, up to food intolerances.Conclusions: Significant evidence emerges in the literature that supports the therapeutic use for clinical purposes of prebiotics and probiotics even in neonatology; however, most of the published studies have structural and functional criticalities that often invalidate the research design and therefore the outcome obtained and published, risking to affect negatively the significance eventually detected. Further studies are needed that can confirm and expand scientific knowledge in this particular area.</p
Effect of tryptophan and glutamic acid on morphological traits of Iranian and Afghan saffron
In order to investigate the effect of amino acids tryptophan and glutamic acid on the morphological traits of the saffron medicinal plant, a factorial experiment was conducted in the form of a randomized complete block design in three replications in 2018 in the research farm of Zanjan University. The experimental treatments include three genotypes (Iranian, Afghani 1, and Afghani 2) as the main treatment and tryptophan amino acid at two levels (1 and 2 mM) and glutamic acid at two levels (1 and 2 mM) as secondary treatments. They were considered as testify. The results showed that tryptophan and glutamic acid treatments had a significant effect (p ≤ 0.01) on most of the studied traits including the number of flowers, dry weight of flowers, and vegetative body. The highest content of the number of flowers and dry weight of flowers were observed, respectively, 34.6 and 37.36 mg of dry weight. Also, the performance characteristics of the fresh weight of the flower and the dry weight of the stigma showed a significant difference (p ≤ 0.05) under the treatment of two amino acids. In total, different levels of tryptophan and glutamic acid can have an effective role in improving the morphological traits and production of this product. The use of 1 mM glutamic acid to produce the maximum vegetative body of the plant, the treatment of 1 and 2 mM of both amino acids to improve morphological indicators, and 1 mM of glutamic acid for the performance of secondary metabolites is desirable and recommended for the purpose.</p
Use limitation on soil water resource by red plum apricot
Since 1995, the yield, benefits, and plantation area of red plum apricot have increased dramatically. But as red plum apricot trees’ canopy and roots grew, soil drying appeared and sometimes become severe in a wet year. The severe soil drying influence the yield, quality and benefits of red plum apricot because precipitation is small and with a big season change. At this time, the plant-water relationship has to be regulated on Soil Water Resource Use Limitation by Plant and Soil Moisture Vegetation Carrying Capacity. However, there are few studies on the utilization limit of soil water resources by red plum apricot forest land. In this study, daily precipitation, and soil water suctions at different soil water content are measured, and the maximal infiltration depth and the soil water resource use limitation by red plum apricot were estimated. The results show that wilting coefficient varies with soil depth from 7.98 in surface soil to 7.1% in 240 cm soil depth, the maximal infiltration depth is 290 cm and the Use Limit of Soil Water Resources by red plum apricot is 212.7 mm. When the soil water resource in the maximal infiltration depth is lower than the limit, the regulation of the plant-water relationship must be considered. </p
Alopecia areata
Alopecia areata, which is a condition with characteristic regional hair loss on the top of the head, is quite common in outpatient departments and clinics. The hair loss is rather rapid during the acute phase and the development into a severe form of alopecia may be related to the younger onset, along with nail changes, family history of atopic dermatitis, allergic rhinitis, asthmatic bronchitis, etc., or other autoimmune diseases. Physically, a large area of hair loss can be observed, as well as other typical features, including broken hair roots and exclamation mark hairs. The classic histopathological sign is the infiltration of lymphocytes around the hair follicles. Moreover, alopecia is not limited to the scalp, and hairs on any part of the body are subjected to the effect of this disease. </p
Exosome-driven epigenetic modulation of histone proteins: Pioneering anti-oncogenic and skin health applications
This article explores the use of exosomes in skin care and their potential for modifying epigenetic changes in fibroblasts and other immune regulatory cells of the skin. Exosomes are nanosized extracellular vesicles that play a vital role in intercellular communication by transporting various biomolecules such as proteins, lipids, and nucleic acids between cells. They are released by skin cells and contain various molecules that are essential for skin health, such as growth factors, cytokines, and extracellular matrix proteins. Recent studies have shown that exosomes can modify epigenetic changes in skin cells, particularly histones, and they have the potential to be used as a therapeutic agent in various skin disorders. This article discusses the use of exosomes in skin care and their potential for modulating epigenetic changes in skin cells in response to environmental factors, with a focus on histone modifications. </p
Overview of research on adhesion reduction and desorption technology of soil-contact construction equipment
Earthmoving machinery is prone to adhesion problems when working against soil media, resulting in a decline in construction efficiency and quality. This paper summarizes the development of soil adhesion mechanisms, describes the research progress of experts and scholars in various countries in the field of adhesion and desorption, and prospects the research on adhesion and desorption of soil contacting components of construction machinery.</p
The human gut fungiome: Role in physiology and detoxification
The intestinal microbiota is an ecosystem where bacteria, archaea, viruses, and protists, are entangled, but not alone. We take microbiota as the bacterial community because, in many historical papers, the probes to detect other organisms in the intestine were rarely used. But in addition, unicellular fungi or yeasts do exist in microbiota, their assembly is called the mycome or fungiome, and it can reach the size and number of our human cells. The bacteria are far more numerous. For a long time, the whole was taken for a nest of pathogens, but in fact, yeasts adapted and evolved as symbiotic cells helping not only our digestion, but also angiogenesis, tissue growth, vitamin synthesis, and our nervous, endocrine, immune systems and even our detoxification system. Much of what we swallow is or will become fermented, like bread, cheese, or wine. Since the beginning of agriculture, our food is eaten lightly by microbiota including yeasts first in plants not treated by pesticides. Natural yeasts still unknown are in hundreds of types or species at the very least, bringing in particular during their work of fermentation a multiplicity of aromas that play a role in the famous detoxification; but the usual diet only provides a few strains of these yeasts. In yeasts like in all cells, ubiquitous cytochrome P450 detoxifying enzymes form a vast family also involved in cell respiration, which is stimulated to some extent by the aromas and other signals secreted. Yeasts could attract and coordinate bacteria to eliminate in part chemical pollutants.</p