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Meta-Narrative Review of Possible Impacts of Genetic Screening on Treatment of Breast Cancer
Get PDFObjective: To examine the impacts of genetic screening on the treatment of breast cancer, in relation to differences, outcomes and decisions in treatment plans or surgery in patients that performed genetic screening versus those that did not.
Background: Genetic screening technology has become commercially available, yet standard preventative care for breast cancer has no genetic screening involved. Genetic screening in breast cancer treatment is performed, but its usage is not standardized.
Methods: Findings were synthesized using the meta-narrative review style to examine articles retrieved from searches of digital databases PubMed and the M.D. Anderson Scholarly Library.
Discussion: Articles were selected using a series of limiting criteria, with 12 final articles examined for the synthesized findings. Data regarding the usage of genetic screening in breast cancer treatment specifically, comparisons between genetically screened patients and non-screened patients, effects of genetic screening on patients, and any accessibility barriers to genetic screening were gathered.
Conclusion: A gap in the literature was found due to only 1 article containing comparative data between patients that performed genetic screening and those that did not. However, several barriers to genetic screening have been identified: limiting stages built into the treatment pathway, physician bias in genetic counseling recommendation, and socioeconomic barriers to genetic screening. Future research can be directed towards generating comparative data and reducing barriers to genetic screening.https://openworks.mdanderson.org/rmps/1000/thumbnail.jp
Understanding the Efficacy and Safety of Stem Cell Therapy and CAR T-cell Therapy in Leukemia Patients
Get PDFCAR T-cell therapy and Stem cell therapy are effective treatments with varying benefits, efficacy, and safety for patients with recurrent leukemia. CAR T-cell therapy and Stem cell therapy are both effective immunotherapies that use engineered cells to combat cancers. The implications of this study allow patients to understand the benefits and disadvantages of both therapies and paves the way for future advancement within immunotherapy. This review selected studies from reputable medical journals, clinical trials and peer-reviewed research published within the last five years obtained from multiple databases including PubMed, Wiley Online Library, and Google Scholar. We compared the efficacy and safety of CAR T-Cell therapy to Stem cell therapy in patients with leukemia using meta narrative principles to synthesize relevant information. Here we show that CAR T-cell therapy is a safer treatment option since its side effects such as cytokine release syndrome (CRS), neurotoxicity, and infections can be managed with secondary treatment. These treatment approaches include corticosteroids and supportive care aid in patient recovery within two weeks to a month. Compared to CAR T-cell therapy, Stem cell therapy has a higher risk of graft vs. host disease, suggesting that it is less effective for patients with recurrent leukemia. Furthermore, our results indicate that CAR T-cell therapy is a safer and more effective treatment for patients with relapsing leukemia. However, the combination of CAR T-cell therapy with Stem Cell therapy has shown to be the most effective method of treatment for patients with refractory leukemia.https://openworks.mdanderson.org/rmps/1009/thumbnail.jp
Hematopoietic Stem Cell Transplant: Remotely Supporting Our Caregivers
No full textJessica Osburn pictured.https://openworks.mdanderson.org/aprn-week-23/1015/thumbnail.jp
Immunotherapy-Induced Encephalitis: A Case of a Rare but Serious Complication of Anti-PD-1 Treatment
Get PDFSon Linda Soy pictured.https://openworks.mdanderson.org/aprn-week-23/1023/thumbnail.jp
Chromatin Organization Analysis of EGFR in Various Human Cancer Samples
Get PDFhttps://openworks.mdanderson.org/sumexp23/1026/thumbnail.jp
LINAC-Based Stereotactic Body Radiation Therapy for Benign Tumors of the Skull Base
Get PDFhttps://openworks.mdanderson.org/sumexp23/1072/thumbnail.jp
Fabrication of radiopaque, drug loaded resorbable inferior vena cava filters
Get PDFhttps://openworks.mdanderson.org/sumexp23/1073/thumbnail.jp
Novel Computer-Aided Detection of Respiratory Misregistration Artifacts in PET/CT
Get PDFhttps://openworks.mdanderson.org/sumexp23/1083/thumbnail.jp
Use of ATR-PARP inhibitor combination therapy to treat and generate an immune response in PARP inhibitor resistant breast cancer is questioned
Get PDFhttps://openworks.mdanderson.org/sumexp23/1019/thumbnail.jp
Improving LGBTQ+ Cancer Care Through Staff Education and Data Collection
No full textFirst Place in Poster Competitionhttps://openworks.mdanderson.org/edwk23/1004/thumbnail.jp