OpenWorks @ MD Anderson
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Liposomal Nanoparticle Mediated Gene Modulation for the Treatment of Melanoma in the Murine Model
Get PDFThis study evaluated the efficacy of liposomal nanoparticles (LNPs) in delivering Wnt/β-catenin-inhibiting mIR-124 plasmids to melanomas. In vitro, LNPs with mIR-124 were applied to B16N2 melanoma cells. In vivo, LNPs were injected into B16N2 tumors in mice. Delivery success was confirmed via flow cytometry and RT-PCR, assessing GFP expression, tumor transition markers, and Wnt/β-catenin signaling. Overall, the findings suggested that LNP-mediated delivery of Wnt/β-catenin inhibitors holds promise as a therapeutic strategy for melanoma, with trends indicating a reversal of epithelial-mesenchymal transition (EMT) and slowed melanoma progression.https://openworks.mdanderson.org/soar24/1008/thumbnail.jp
Targeting CDK2 in p16 Deficient Head and Neck Squamous Cell Carcinoma
No full textIn this study, we explored the therapeutic vulnerability of head and neck squamous cell carcinoma (HNSCC) cell lines to a novel CDK2 inhibitor, Tagtociclib.https://openworks.mdanderson.org/soar24/1011/thumbnail.jp
Plasma Protein Binding (PPB) & Tissue Binding as High-Throughput Assays to Quantify the Free Fraction of Novel Cancer Therapeutics
Get PDFhttps://openworks.mdanderson.org/catalyst24/1010/thumbnail.jp
SpongeBob the Scientist, 2024, close-up
No full textArtist: Heidy E. Lozano
Materials: Styrofoam, cardboard, and absorbent mats.
SpongeBob SquarePants is an animated character. A cheerful and optimistic sea sponge who lives in a pineapple under the sea, in the fictional underwater city of Bikini Bottom. Its impact on children has been significant, with its messages of friendship, perseverance, and imagination resonating with young viewers worldwide. The materials used in this sculpture is Styrofoam, cardboard, and absorbent mats.https://openworks.mdanderson.org/recycledart2024/1020/thumbnail.jp
Development and Clinical Implementation of a Digital Workflow Utilizing 3D-Printed Oral Stents for Patients with Head and Neck Cancer Receiving Radiotherapy
No full textDevelopment and clinical implementation of a digital workflow utilizing 3D-printed oral stents for patients with head and neck cancer receiving radiotherapy.https://openworks.mdanderson.org/aprn-week-24/1002/thumbnail.jp
Technology Enabling Strategic Moves to End Cancer, 2024
No full textArtist: Cade Farmer
Materials: Recycled computer parts, acrylic
Technology underpins much of our everyday lives and much of what we do as employees to advance our mission to end cancer, just as a chess board is the foundation of the classic game of strategy. But it is the thoughtful and strategic moves that we, as people, make upon that foundation—guided by our core values—that positively impacts our patients’ lives and consistently earns us #1 rankings. This chess board incorporates recycled computer and keyboard components set in leftover acrylic that was destined for a landfill. Thirty-two handcrafted acrylic chess pieces complete the playable set.https://openworks.mdanderson.org/recycledart2024/1006/thumbnail.jp
Library News December 2024
Get PDFAuthorship Considerations for Biomedical Research Papers The Significance and Innovation Sections of NIH Research Grant Applications Why Does My Editor Leave Some Abbreviations but Recommend Spelling Out Others? Top 10 Tool Time Tuesday Videos Best and Worst Reads of 2024https://openworks.mdanderson.org/rmlnews24/1011/thumbnail.jp
We are Chain Linked, 2023
No full textArtist: Mercedes A. Geaslin
Materials: Metal bottle caps with gluehttps://openworks.mdanderson.org/recycledart2023/1004/thumbnail.jp
Krak des Chevaliers, 2024, drawbridge
No full textArtist: Habib Chamoun-Farah
Materials: Blue sponges, tape, glue, and cardboard boxhttps://openworks.mdanderson.org/recycledart2024/1024/thumbnail.jp
Interventional Radiology Expansion of Transperineal Hydrogel Placement for patients with prostate cancer in the Woodlands
No full texthttps://openworks.mdanderson.org/acif24/1014/thumbnail.jp