17306 research outputs found
Sort by
A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan
Get PDFAppetite, as the internal drive for food intake, is often dysregulated in a broad spectrum of conditions associated with over- and under-nutrition across the lifespan. Appetite regulation is a complex, integrative process comprising psychological and behavioral events, peripheral and metabolic inputs, and central neurotransmitter and metabolic interactions. The microbiota-gut-brain axis has emerged as a critical mediator of multiple physiological processes, including energy metabolism, brain function, and behavior. Therefore, the role of the microbiota-gut-brain axis in appetite and obesity is receiving increased attention. Omics approaches such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics in appetite and weight regulation offer new opportunities for featuring obesity phenotypes. Furthermore, gut-microbiota-targeted approaches such as pre-, pro-, post-, and synbiotic, personalized nutrition, and fecal microbiota transplantation are novel avenues for precision treatments. The aim of this narrative review is 1) to provide an overview of the role of the microbiota-gut-brain axis in appetite regulation across the lifespan and 2) to discuss the potential of omics and gut microbiota-targeted approaches to deepen understanding of appetite regulation and obesity
Merging Hydrogen-Atom-Transfer and the Truce-Smiles Rearrangement for Synthesis of β-Arylethylamines from Unactivated Allylsulfonamides
Get PDFEstado de la cuestión sobre un político de la Restauración: Miguel Villanueva y Gómez (1852-1931)
Get PDFEl objetivo principal de este artículo consiste en elaborar el estado de la cuestión acerca de uno de los prohombres del Partido Liberal más importantes de la Restauración: Miguel Villanueva y Gómez (1852-1931). A lo largo del siglo XX y XXI su figura ha sido poco estudiada por la historiografía, y, realmente, en la actualidad, no disponemos de ninguna biografía en la que Villanueva, presidente del Congreso y ministro en el reinado de Alfonso XIII varias veces, sea el protagonista o el sujeto histórico vertebrador del discurso. En vista del análisis efectuado, concluimos que la mayoría de las obras que lo mencionan o citan adolecen de recurrentes fallos en el ámbito espacial, cronológico y conceptual. Además, no lo han significado como lo que realmente fue: uno de los testigos de primera fila en los procesos clave del reinado de Alfonso XIII. Villanueva así ejerció en la pérdida de Cuba, en la cuestión de Marruecos, en la oposición interna al régimen de Primo de Rivera o en la Dictablanda, al ser miembro destacado y líder del Partido Constitucionalista.The main objective of this article is to elaborate the state of the art of one of the most important figures of the Liberal Party of the Restoration: Miguel Villanueva y Gómez (1852-1931). Throughout the 20th and 21st centuries his figure has been little studied by historiography, and, actually, at present, we do not have any biography in which Villanueva, president of the Congress and minister in the reign of Alfonso XIII several times, is the protagonist. In view of the analysis carried out, we conclude that most of the works that mention or quote him suffer from recurrent failures in the spatial, chronological and conceptual spheres. In addition, they have not described him as what he really was: one of the first-hand witnesses in the key processes of the reign of Alfonso XIII. Villanueva was a key player in the loss of Cuba, in the Moroccan question, in the internal opposition to Primo de Rivera’s regime or in the Dictablanda, as he was a prominent member and leader of the Constitutionalist Part
Artificial intelligence-assisted qualitative analysis of healthcare professionals perception of research in primary care
No full textPerceived barriers and facilitators to family and community nurses’ care for older adults: a descriptive qualitative study
Get PDF
On the Limitations of ROBDDs in Deciding the Evasiveness of Boolean Functions
Get PDFIn this paper, we prove that examining all the Reduced Ordered Binary Decision Diagrams (ROBDDs) of a Boolean monotonefunction is not enough to determine the evasiveness of the function. Working in the framework of simplicial topology, weintroduce the notion of ordered non evasive simplicial complex, corresponding to our ROBDDs quest, and we prove that thereexist non evasive simplicial complexes which are not ordered non evasive
