Allegheny College DSpace Repository
Not a member yet
38403 research outputs found
Sort by
Development of a multi-group and multi-residue screening method by LC-MS/MS for the detection of veterinary drug residues in pollen, bee bread, propolis, and royal jelly
No full textBu doktora çalışmasında, polen, perga, propolis ve arı sütü gibi farklı arı ürünlerinde veteriner ilaç kalıntılarının belirlenmesine yönelik olarak, LC-MS/MS tekniğine dayalı çoklu grup–çoklu kalıntı tarama analiz yönteminin geliştirilmesi ve analitik olarak doğrulanması amaçlanmıştır. Bu çalışmada bal arısı ürünlerinde antibiyotik taramasına yönelik geliştirilen yöntemin performansı, alkol bazlı propolis, polen, su bazlı propolis, arı sütü ve perga olmak üzere beş farklı matrikste yürütülen validasyon çalışmalarıyla değerlendirilmiştir. Alkol bazlı propoliste 17 analit için boş numune yanıtları (B) 0,046–1,270 μg/kg, eşik seviyeleri (T) 0,145–2,749 ve 10 μg/kg zenginleştirilmiş numunelerde ortalama yanıtlar (M) 9,955–11,468 μg/kg aralığında bulunmuş; Fm değerleri 7,678–10,120 μg/kg olarak hesaplanarak tüm analitlerde Fm>T koşulu sağlanmıştır. Polen matriksinde B 0,020–0,322 μg/kg, T 0,046–0,810, M 8,551– 13,572 μg/kg ve Fm 6,153–9,490 μg/kg aralığında belirlenmiştir. Su bazlı propoliste B değerlerinin 0,000–0,490 μg/kg gibi düşük seviyelerde seyretmesi ve M değerlerinin 8,209–10,506 μg/kg aralığında bulunması yöntemin seçiciliğini göstermiştir. Arı sütünde B 0,011–0,364 μg/kg ve M 9,402–11,170 μg/kg olarak elde edilmiş, yüksek protein ve lipid içeriğine rağmen yeterli duyarlılık sağlanmıştır. Perga matriksinde B 0,039–0,663 μg/kg ve M 9,348–13,861 μg/kg aralığında bulunmuş, kompleks yapıya bağlı olarak bazı analitler kapsam dışı kalmıştır. Genel olarak yöntem, valide edilen analitler için tüm matrikslerde STC seviyesinde kabul edilebilir CCβ değerleri sağlayarak bu çalışmada yer alan ürünlerinde antibiyotik taraması için uygulanabilir bir yaklaşım sunmuştur. Sonuç olarak bu çalışma ile geliştirilen LC-MS/MS tabanlı çoklu kalıntı tarama yöntemi, arı ürünlerinde veteriner ilaç kalıntılarının güvenilir şekilde izlenmesine olanak sağlamakta; gıda güvenliği, halk sağlığının korunması ve ulusal izleme çalışmalarına bilimsel katkı sunmaktadır.In this doctoral study, the development and analytical validation of a multigroup, multi-residue screening method based on LC–MS/MS were aimed for the determination of veterinary drug residues in various apicultural products, including pollen, perga, propolis, and royal jelly. The performance of the developed antibiotic screening method was evaluated through validation studies conducted on five different matrices: alcohol-based propolis, pollen, water-based propolis, royal jelly, and perga. In alcohol-based propolis, blank sample responses (B) for 17 validated analytes ranged from 0.046 to 1.270 μg/kg, threshold values (T) from 0.145 to 2.749 μg/kg, and mean responses (M) of samples fortified at 10 μg/kg from 9.955 to 11.468 μg/kg. Corresponding Fm cut-off values were calculated between 7.678 and 10.120 μg/kg, fulfilling the Fm>T criterion for all analytes. In the pollen matrix, B values ranged from 0.020 to 0.322 μg/kg, T values from 0.046 to 0.810 μg/kg, M values from 8.551 to 13.572 μg/kg, and Fm values from 6.153 to 9.490 μg/kg. In water-based propolis, very low blank responses (0.000–0.490 μg/kg) and fortified sample responses between 8.209 and 10.506 μg/kg demonstrated high selectivity of the method. In royal jelly, B values ranged from 0.011 to 0.364 μg/kg and M values from 9.402 to 11.170 μg/kg, indicating sufficient sensitivity despite the high protein and lipid content of the matrix. In perga, B and M values were found within the ranges of 0.039–0.663 μg/kg and 9.348–13.861 μg/kg, respectively; however, due to pronounced matrix effects, certain analytes could not be validated in this matrix. Overall, the method provided acceptable CCβ values at the screening target concentration (STC) for all validated analytes across the investigated matrices. Consequently, the LC–MS/MS-based multi-residue screening method developed in this study enables reliable monitoring of veterinary drug residues in apicultural products, contributing scientifically to food safety, public health protection, and national residue surveillance programs
Modelling of groundwater salt pollution in semi-arid watershed disturbed by agricultural activities: Lake tuz (Salt Lake) basin, Turkey
No full textThis paper aimed at modelling and investigating a groundwater salt pollution/contamination in the Lake Tuz (Salt Lake) Basin (29,425 km2, Central Anatolia, Turkey), in which intensive agricultural activities have been applied throughout the years, in addition to the natural resources (salty lakes). MT3DMS was used by utilizing the groundwater flow model of Eryigit (2025) to simulate the groundwater salt pollution of the watershed under transient conditions. The input files of MT3DMS were generated by GMS groundwater simulator. The model was yearly simulated for 19 years from 2000 to 2018. Model calibration and validation were carried out by using groundwater quality observation data of 2000-2012 and 2013-2018, respectively. Electrical conductivity (mu S/ cm) data were converted to Total Dissolved Solids (g/l) for representing a salinity (as a salt concentration). To improve parameter estimations, the groundwater model parameters were calibrated by the modified Clonal Selection Algorithm (a class of Artificial Immune Systems) linked with MT3DMS in MATLAB. Recharge concentration was calibrated based on the land use/cover (30 different types) while other parameters (porosity, longitudinal dispersivity, sorption) were calibrated depending on the aquifer lithology (23 aquifers). Furthermore, the groundwater contaminant transport model was run to estimate groundwater salt concentrations within the scenario based on increasing agricultural activities in the future. Owing to/thanks to the model, predictions of the groundwater salt pollution depending on both anthropogenic (agriculture) and natural (lakes) factors were performed in the Lake Tuz watershed for the first time as a largest scaled spatiotemporal groundwater quality (salinity) model with a long simulation period (19 years) in Turkey.Bolu Abant Izzet Baysal University Coordination Unit of Scientific Research Projects
2023-BDP-6.12.54-000
A bio-inspired approach to sustainable building design optimization: Multi-objective flow direction algorithm with one-hot encoding
No full textThe urgent need for sustainable building design calls for advanced optimization methods that simultaneously address economic and environmental objectives, particularly those involving mixed discrete-continuous variables such as insulation material, heating source, and insulation thickness. While nature-inspired metaheuristics have shown promise in engineering optimization, their application to building envelope design remains limited, especially in handling discrete choices efficiently within a multi-objective framework. Inspired by the natural process of rainwater runoff and drainage basin dynamics, this study presents a novel hybrid approach integrating the Multi-Purpose Flow Direction Algorithm (MOFDA) with One-Hot Encoding to optimize external wall insulation. This bio-inspired algorithm mimics how water seeks optimal paths across terrain, enabling effective navigation of complex design spaces with both categorical and continuous variables. The model aims to minimize total lifecycle costs and CO2 emissions across T & uuml;rkiye's six updated climatic regions. Pareto-optimal solutions are created using MOFDA, after which the Complex Proportional Assessment (COPRAS) method, weighted by Shannon Entropy, selects the most balanced designs. The results reveal significant climate-dependent variations: in the warmest region, the cost-optimal thickness is 3.3 cm (Rock Wool), while the emission-optimal reaches 17.3 cm (Glass Wool). In colder regions, emission-driven scenarios consistently require up to 40 cm insulation, indicating a practical limit of current materials. Under balanced weighting, fuel preferences shift from LPG in milder climates to Fuel Oil in harsher climates. Notably, Shannon Entropy assigned a weight of 88-92% to emissions due to their wider variability across the Pareto front, underscoring the environmental priority in data-driven decisions. This study demonstrates that the bio-inspired MOFDA framework, enhanced with One-Hot Encoding, effectively handles mixed discrete-continuous optimization and provides a robust, climate-aware decision tool for sustainable building design, reinforcing the value of translating natural flow processes into engineering solutions
Multi-layered diaspora experiences: A qualitative study with third-generation Turks living in Berlin
No full textAlmanya’daki Türk diasporası, Avrupa’da en yoğun nüfusa sahip diasporik topluluklardan biridir. Türkiye’den Almanya’ya son yıllarda artan göç hareketliliği, yerleşik Türk toplumu ile yeni gelenler arasındaki ilişkileri ve karşılıklı algıları daha görünür hale getirmekte; bu karşılaşmaların diaspora içi ilişkileri anlamak açısından incelenmesi önem kazanmaktadır. Bu çalışmanın amacı, Berlin’de yaşayan ve Almanya’da doğup büyümüş üçüncü kuşak Türk bireylerin kimlik/aidiyet deneyimlerini ve diasporanın içsel dinamiklerini anlamaktır. Bununla birlikte, çalışmanın bir diğer amacı, üçüncü kuşağın son yıllarda Türkiye’den Almanya’ya göç eden yeni dalga Türk göçmenlere dair yaklaşımlarını ve Türk toplumuyla ilişkilerini keşfetmektir. Anlamak ve keşfetmek temel amaç olduğu için, bu araştırma, temel nitel araştırma deseni doğrultusunda tasarlanmıştır. Amaçlı örneklemle Berlin’de yaşayan, 18 yaş üstü üçüncü kuşak 12 katılımcıyla Haziran–Eylül 2025 döneminde yarıyapılandırılmış derinlemesine görüşmeler yapılmış; veriler içerik analiziyle çözümlenmiştir. Sonuçlar, diasporanın iç dinamiklerine, üçüncü kuşağın kimlik algılarına, yeni gelen Türk göçmenlere yönelik yaklaşımlarına ve Türk toplumuyla ilişkilerine ilişkin kodlar ve temalar üzerinden şekillenmiştir. Bulgular, üçüncü kuşak Türk bireylerin kimlik ve aidiyet deneyimlerinin tek bir eksende sabitlenmediğini; Almanya ile Türkiye arasında bağlamsal olarak değişen, ilişkisel ve çok katmanlı biçimde kurulduğunu göstermektedir. Ayrıca yeni dalga Türk göçmenlere ve Türkiye’de yaşayan Türklerle ilişkilere dair anlatılar, diaspora içinde benzerlik kadar mesafe ve sınır üretimlerinin de bulunduğuna işaret etmektedir.The Turkish diaspora in Germany is one of the diasporic communities with the densest population in Europe. The increased migration mobility from Turkey to Germany in recent years makes the relationships and mutual perceptions between the established Turkish community and newcomers more visible; examining these encounters in terms of understanding intra-diaspora relations is gaining importance. The aim of this study is to understand the identity/belonging experiences of third-generation Turkish individuals living in Berlin and who were born and raised in Germany, and the internal dynamics of the diaspora. In addition, another aim of the study is to explore the third generation’s approaches toward the new wave of Turkish migrants who have migrated from Turkey to Germany in recent years and their relationships with the Turkish community. Since understanding and exploring are the main aims, this research was designed in line with the basic qualitative research design. With purposive sampling, semi-structured in-depth interviews were conducted with 12 third-generation participants living in Berlin and over the age of 18 during the period June–September 2025; the data were analyzed using the content analysis technique. The results were shaped through codes and themes regarding the diaspora’s internal dynamics, the third generation’s perceptions of identity, their approaches toward newly arrived Turkish migrants, and their relationships with the Turkish community. The findings show that the identity and belonging experiences of third-generation Turkish individuals are not fixed on a single axis; they are constructed in a context-dependent, relational, and multi-layered manner between Germany and Turkey. In addition, narratives regarding the new wave of Turkish migrants and relations with Turks living in Turkey indicate that there are distance and boundary productions within the diaspora as much as similarity
Short and long term seizure outcomes in functional/dissociative seizures: A single center cohort study with 1-10 years of follow up from Türkiye
No full textObjective: Functional/Dissociative Seizures (FDS) are episodic events resembling epileptic seizures but stemming from psychological origins. They often result in misdiagnosis and suboptimal treatment, significantly impairing patients' quality of life. This study aimed to investigate the clinical and demographic factors associated with short and long term prognosis in FDS. Methods: The primary variables of interest were seizure outcomes at two horizons: short term (status at 6 months after discharge) and long term (status during the last 12 months within 1-10 years post-diagnosis). We defined seizure outcomes as remission vs persistence and change in seizure frequency from baseline, ascertained from VEM records and standardized clinic/telephone follow up. Results: The cohort included 147 patients; short term seizure outcomes were available for 144 and long term seizure outcomes for 138 (median follow-up 6 years; range 1-10). At 6 months, 6.9 % were seizure free; at long term follow up, 37.7 % were seizure free. In short term analysis, only early diagnosis (= 5 min) were associated with a more favorable long term seizure outcome (p = 0.027), whereas family related stressors continued to independently predict poorer prognosis (p = 0.002). Conclusions: FDS outcomes are shaped by identifiable psychosocial and clinical factors. Early diagnosis and older age at onset predict favorable short term remission, whereas family related stressors consistently predict poorer outcomes across both time horizons. These findings highlight the prognostic value of early detection and the need to address sustained family related stress in treatment planning
The introduction of the sociology of science in Turkey: The case of Prof. Dr. Hüsamettin Arslan
No full textElinizdeki çalışmanın amacı, hem bilim sosyolojisinin serencamını tarihsel, politik ve sosyolojik kontekstte incelemek, hem de sözü edilen disiplinin Türkiye’deki gelişimini Prof. Dr. Hüsamettin Arslan örneğinde somutlaştırarak özgün bir katkı sunmaktır. Tez, bahsi geçen kontekstte iki düzlemli bir analiz sunmaktadır: birincisi, bilimin ve bilim sosyolojisinin doğasına dair teorik çözümleme; ikincisi ise bu çözümlemelerin Türkiye kontekstinde nasıl bir düşünsel zemin üzerinde geliştiğine dair yerel bir inceleme. Bahsi geçen ikili yapı, bilimsel bilginin yalnızca epistemolojik sınırlarını değil, aynı zamanda tarihsel, politik ve sosyolojik boyutlarının da olduğunu ortaya koymayı hedeflemektedir. Elinizdeki tez, yalnızca bilim sosyolojisinin Türkiye kontekstindeki gelişimini incelemekle kalmayıp, Prof. Dr. Hüsamettin Arslan’ın düşünsel mirasını sistematik biçimde ele alan ilk akademik çalışma olma özelliğini taşımaktadır. Bugüne kadar Arslan’ın “epistemik cemaat” kavramı ve bilimsel bilgiye dair özgün yaklaşımları, çoğunlukla dağınık alıntılar ve sınırlı değerlendirmelerle gündeme gelmiş; ancak bütünlüklü bir teorik çerçeve içerisinde akademik düzeyde analiz edilmemiştir. Bahsi geçen kontekstte tez, hem bilim sosyolojisi literatürüne yerli bir figür üzerinden katkı sağlamakta, hem de Arslan’ın düşüncesini bir vaka olarak ele alarak Türkiye’de bilim sosyolojisinin gelişimine dair yeni bir tartışma alanı açmaktadır. Tezin özgünlüğü, yalnızca ele aldığı konu itibarıyla değil; aynı zamanda bu konuyu ele alış biçimi, teorik kavramlar arasında kurduğu bağlantılar ve metodolojik yaklaşımı itibarıyla da kendini göstermektedir.The primary aim of this study is to examine the evolution of the sociology of science within a historical and theoretical framework, while also providing an original contribution by concretizing the development of this discipline in Turkey through the case of Prof. Dr. Hüsamettin Arslan. In this context, the thesis presents a two-dimensional analysis: first, a theoretical examination of the nature of science and the sociology of science; second, a localized analysis of how these examinations have developed within the intellectual landscape of Turkey. This dual structure aims to reveal not only the epistemological boundaries of scientific knowledge but also its sociological, ideological, and political dimensions. This thesis holds the distinction of being the first academic work to systematically address both the development of the sociology of science in Turkey and the intellectual legacy of Prof. Dr. Hüsamettin Arslan. Until now, Arslan's concept of the "epistemic community" and his original approaches to scientific knowledge have mostly been referenced in fragmented citations and limited evaluations. However, they have not been analyzed within a comprehensive theoretical framework at an academic level. In this regard, the thesis contributes to the literature on the sociology of science through the lens of a local figure, while also opening a new field of discussion on the development of the sociology of science in Turkey by treating Arslan's thought as a case study. The originality of the thesis lies not only in the subject it addresses but also in its approach, the connections it establishes between theoretical concepts, and its methodological perspective
Enhanced emi shielding of ag-polymer composites via tib 2 reinforcement in the 2-4 ghz range
No full textDue to its exceptional electrical conductivity, high thermal stability, and mechanical hardness, titanium diboride (TiB2) has emerged as a critical reinforcement material for high performance electromagnetic interference (EMI) shielding. Despite its potential, achieving a synergistic balance between filler dispersion and high shielding efficiency within polymer matrices remains a significant challenge in current research. This study investigates the performance of composite coatings reinforced with TiB2, a conductive ceramic material, for EMI shielding applications in the 2-4 GHz frequency range. TiB2 is incorporated into a commercially available Ag polymer at various weight ratios (10-50 wt%), and the resulting composites are evaluated using a Vector Network Analyzer. The reflection (S-1(1)) and transmission (S-2(1)) parameters are measured to calculate the total shielding effectiveness, which reached a peak of approximately 45 dB at 2.2 GHz. These findings highlight the promise of TiB2-filled composites as effective EMI shielding materials for use in aerospace, defense, and healthcare applications. Future research will aim to optimize the filler composition and assess material stability under elevated temperatures.Mudanya Üniversites
Geophysical and remote sensing monitoring of a snow patch system in barton peninsula shows impacts of warming on low-altitude permafrost
No full textAntarctica, a critical regulator of global climate, faces threats to its permafrost and ecosystems from recent warming. However, a quantitative understanding of subsurface responses remains limited, hindering accurate environmental modeling. This gap hinders accurate modeling of future environmental changes. This study investigates the influence of rising air temperatures on thaw depth and permafrost characteristics by quantifying the links between surface environmental changes and subsurface responses. From 2018 to 2024, we integrated meteorological observations, drone and satellite remote sensing, and geophysical surveys-electrical resistivity tomography (ERT) and ground-penetrating radar (GPR)-to assess atmosphere, surface, and subsurface changes. Our results revealed an overall warming trend during the study period, with the average annual air temperature rising by approximately 1 degrees C and the thaw season extending by up to 50 days. Earlier snowmelt reduced albedo, increasing soil heat absorption and meltwater infiltration. The thaw depth thickened from 1.1 to 1.5 m (maximum) and from 0.65 to 0.85 m (dry sites). ERT indicated reduced resistivity at similar to 1-m depth, reflecting permafrost ice melt, and localized meltwater pooling at similar to 3-m depth. Normalized difference vegetation index data showed increased vegetation activity. Our study shows that even slight warming can drive linked physical and ecological shifts in Antarctica, with implications for global climate feedbacks. Our quantitative analysis of the increasing late-summer thaw depth provides important data that can contribute to the validation and improvement of regional climate models.Korea Polar Research Institute of Marine Research Placement (KOPRI)
PE26080L Global-Learning and Academic Research Institution for Master's, Ph.D. Students, and Postdoctoral (LAMP) Program of the National Research Foundation of Korea (NRF)
RS-2024-0044518
