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The diagnostic and prognostic utility of complete blood count (CBC)-derived indices in dogs with sepsis caused by canine parvoviral infection
No full textThis study aimed to evaluate the diagnostic and prognostic value of complete blood count (CBC)-derived indices incorporating red blood cell (RBC) and platelet (PLT) parameters in dogs that met the criteria for sepsis due to canine parvovirosis (CP). Fifty-two client-owned dogs with CP and ten healthy controls were enrolled in this study. CBC-derived indices, along with serum CRP and albumin concentrations, were evaluated before (T0) and after treatment (T1 and T3). Dogs meeting the criteria for sepsis exhibited statistically significantly higher RDW/L (P 0.949) and MPV/L (AUC: >0.961). In conclusion, CBC-derived indices incorporating RBC and PLT parameters can provide useful information about the diagnosis and prognosis in dogs with sepsis produced by parvovirus. These findings, if corroborated in larger studies, would support their integration into clinical practice to enhance the early detection and risk stratification in canine sepsis
Teaching english and the environment to efl young learners in Turkey
No full textThis paper reports on a part of a larger practitioner research project focused on integrating environmental issues through critical language pedagogy into a young learner's classroom in Turkey. Drawing on Paulo Freire's problem-posing model grounded in critical pedagogy, the authors developed localized materials, and a pedagogic model rooted in six environmental themes derived from the students' lived experiences. The pedagogic model was implemented in a public primary setting with a group of fourth-grade students. Semi-structured interviews were conducted with the students to understand the model's effectiveness in achieving its dual objectives: development of language and critical environmental awareness. The purpose of this paper is to present a theory-driven, practical, pedagogic model for practitioners seeking to develop their context-sensitive environmental ELT pedagogies
A comparison of the thermal and electrical properties of two different battery cells
No full textIn this study, the electrothermal properties of NMC and LFP cells of equal nominal capacity were investigated under constant current and dynamic current profile conditions performed at vehicle level. Experimental studies have been conducted to investigate the effects of current and temperature on battery cells with different chemistries. It has been determined that the parameters of both cells can be analysed with a maximum relative error of approximately 2.5 % under constant current conditions using a numerical model. Furthermore, using the developed ECM-based mathematical model, the performance of two cells with different chemistries was investigated at the vehicle level under driving cycle conditions. The results demonstrated that the NMC cell provided approximately 9 % more power, with an increase in SOC of 3 % at the conclusion of the WLTP driving cycle. It was determined that this contributed to an increase in vehicle range. The heat generation values during the cycle were found to be 2.48 Wand 2.34 W for the LFP and NMC cell, respectively. Consequently, the utilization of NMC cells is recommended when evaluating cell performance at the vehicle level, as they exhibit superior electrical parameters and facilitate the implementation of simpler BTMS designs owing to their lower thermal loads
Macrocytosis as an early pharmacodynamic marker of imatinib efficacy in chronic myeloid leukemia
No full textBackground: Macrocytosis commonly develops during imatinib therapy, but its relationship with cytogenetic and molecular outcomes in chronic myeloid leukemia (CML) remains unclear. We investigated whether increases in mean corpuscular volume (MCV) during imatinib treatment are associated with response depth and treatment persistence. Methods: In this retrospective study, we analyzed 101 adults with chronic-phase CML treated with a stable imatinib dose of 400 mg/day for at least 12 months. Patients with conditions that could confound MCV (hydroxyurea exposure, megaloblastic anemia, hypothyroidism, chronic liver disease, alcoholism) were excluded. Complete cytogenetic response (CCyR) and major molecular response (MMR) were assessed by conventional karyotyping and the BCR-ABL1 International Scale, respectively. Increased MCV was defined as MCV > 100 fL after six months of therapy, persisting thereafter. Associations between MCV dynamics, response, and switching to second-generation tyrosine kinase inhibitors were evaluated. Results: Twenty patients (20%) developed increased MCV. Overall, 86 patients (85%) achieved CCyR and 70 (69%) achieved MMR. All patients with increased MCV attained CCyR, compared with 66 of 81 (81%) without MCV elevation (p = 0.037), while MMR rates were 90% versus 64% (p = 0.030). During a median follow-up of 69 months, treatment modification was required in 1 of 20 (5%) patients with increased MCV versus 25 of 81 (31%) in the non-increased group (p = 0.018). Conclusions: MCV elevation during imatinib therapy is associated with deeper molecular response and reduced need for treatment modification. MCV dynamics may serve as an inexpensive pharmacodynamic marker to support risk assessment and guide monitoring in chronic-phase CML
Acute effects of flywheel eccentric and traditional strength training on power output in male athletes: Post-activation potentiation approach
No full textBu araştırmanın amacı, flywheel (FW) ve inclened leg press (LP) yüklenmeler sonrası post aktivasyon potansyelinin (PAP) dikey sıçrama, quadriceps kas aktivasyonu ve çeviklik üzerinde akut etkilerini incelemektir. Araştırmaya 18-32 yaş arasında toplam 24 üniversite erkek sporcu öğrencisi gönüllü katıldı. Bu randomize kontrollü çapraz desene dayalı araştırmaya katılanlar en az 72 saat arayla bir alıştırma ve iki farklı deneysel prosedür uygulamışlardır: FW ve LP. Alıştırma oturumunda katılımcılara deneysel prosedürler anlatıldıktan sonra, EGZ A+ cevapladılar, vücut kompozisyonları ve 1 Tekrar Maksimum (1TM) belirlendi. Daha sonra FW, LP, maksimum istemli izometrik kasılma (MVC), dikey sıçrama (CMJ) ve Zig-zag agility testleri katılımcı tarafından uygulandı. İki deneysel oturumlarda ise sırasıyla; ısınma, Pre test: MVC, CMJ, Zig-zag çeviklik testleri, FW veya LP yüklenmesi (3 set x 6 tekrar), Post test: hemen sonra-15 sn (Post_0), 6 dk (Post_6), 12 dk (Post_12) ve 18 dk (Post_18) sonra Pre testleri tekrar uygulandı. Elde edilen verilen karşılaştırılması için Two Way ANOVA tekrarlanan ölçümler için varyans analizi (2 uygulama (FW ve LP) x 5 zaman (Pre, Post_0, Post_6, Post_12, Post 18) testi kullanıldı. İkili karşılaştırmalar için Bonferroni post-hoc testi kullanıldı. Araştırmamızda, iki farklı uygulama (FW ve LP) ile zaman (Pre, Post_0, Post_6, Post_12, Post 18) arasındaki etkileşim açısından CMJ [F(4,68) = 0.092, p = 0.985, 2 = 0.005], Zig-Zag [F(4, 68, p = 0.520, 2 = 0.038], M. Rectus Femoris MVC [F(4, 68) = 1.123, p = 0.353, 2 = 0.062], M. Vastus Lateralis [F(2.755,46.829) = 1.066, p = 0.369, 2 = 0.059], M. Vastus Medialis [F(2.780,47.258) = 0.480, p = 0.683, 2 = 0.027] sEMG değerlendirmelerin istatistiksel olarak anlamlı bir fark gözlenmemiştir. Sonuç olarak, Flywheel ve Incline Leg Pres egzersizleri bacak kaslarında benzer bir PAPE oluşturdukları söylenebilir. Ayrıca bu egzersizler sonrası yapılan 18 dakikaya kadar pasif dinlenmenin bir toparlanma olduğunu ancak her iki uygulamada da etkinin benzer olduğu görüldü.The aim of present study was to investigate the acute effects of post-activation potentiation (PAP) following flywheel (FW) and inclined leg press (LP) loading on vertical jump (CMJ), quadriceps muscle activation, and agility. A total of 24 male university athletes aged 18–32 voluntarily participated. In this randomized controlled crossover design study, participants completed one familiarization and two experimental (FW and LP) sessions, each separated by at least 72 hours. During the familiarization session, after the experimental procedures were explained, participants completed the PAR-Q+, and their body composition and one-repetition maximum (1RM) were assessed. Subsequently, participants performed FW, LP, maximal voluntary isometric contraction (MVC), CMJ, and Zig-zag agility tests. In each of the two experimental sessions, the following protocol was applied: warm-up; pre-tests (MVC, CMJ, Zig-zag agility test); FW or LP loading (3 sets × 6 repetitions); and post-tests conducted immediately after (Post_0), at 6 minutes (Post_6), 12 minutes (Post_12), and 18 minutes (Post_18), repeating the pre-test measures. To compare the collected data, a Two-Way Repeated Measures ANOVA (2 conditions: FW and LP × 5 time points: Pre, Post_0, Post_6, Post_12, Post_18) was used. Bonferroni post-hoc tests were applied for pairwise comparisons. The results showed no statistically significant interaction between condition (FW vs. LP) and time (Pre, Post_0, Post_6, Post_12, Post_18) for CMJ [F(4,68) = 0.092, p = 0.985, 2 = 0.005], Zig-zag agility [F(4,68), p = 0.520, 2= 0.038], M. Rectus Femoris MVC [F(4,68) = 1.123, p = 0.353, 2= 0.062], M. Vastus Lateralis [F(2.755,46.829) = 1.066, p = 0.369, 2 = 0.059], and M. Vastus Medialis [F(2.780,47.258) = 0.480, p = 0.683, 2= 0.027] sEMG measurements. In conclusion, both Flywheel and Incline Leg Press exercises appear to induce similar PAPE responses in the leg muscles. Furthermore, passive rest periods of up to 18 minutes following these exercises seem to support recovery, with both methods producing comparable effects
Exact analytical solutions of the modified complex ginzburg-landau equation: Multi-waves, bright and dark solitons via systematic integration approaches
No full textIn this study, we present the derivation of exact solutions for the modified complex Ginzburg-Landau (mCGL) equation. This equation is one of the models in plasmas, optical systems and spatially extended nonequilibrium media. Pursuing the Kumar-Malik ansatz, multi-wave expansion and dynamical phase-space analysis, we systematically construct many families of solutions. The Kumar-Malik method furnishes Jacobi elliptic solutions and hyperbolic and trigonometric forms. In this regard, we capture soliton solutions, including singular periodic, bright, dark, kink, anti-kink and singular waveforms. On the other hand, the multi-wave approach presents a rational solution that defines wave interaction, while dynamical analysis reveals bright and dark solitons through Hamiltonian phase portraits. 3-D, density and time plot profiles demonstrate the physical meanings of the exact solutions. With the examined analytic techniques, other nonlinear phenomena in diverse physical systems, such as optical communications, Bose-Einstein condensates and ultrafast laser systems can be investigated
Assessment of the oil release and insect repellent activity of spray-dried gum arabic/citronella oil microcapsules
No full textEssential oils are natural insect repellents, which can be microencapsulated and protected by wall materials to provide prolonged protection against insects. The protection and release of these repellents depend on various parameters, including morphology and production conditions. Herein, twenty-seven gum arabic/citronella essential oil (GA/CEO) spray-dried microcapsules were produced by using three wall-to-core ratios (3:1, 4:1, 6:1), three inlet temperatures (120, 150, 180 degrees C), and three feed rates (1, 2.5, 5 mL/min). The morphology, particle size, encapsulation efficiency, and release rates were evaluated. The insect repellent activity of microcapsules (0.25, 0.5, and 1 g) against Drosophila melanogaster flies was tested. A systematic process optimization was carried out by evaluating the effects of both emulsion concentration and process parameters on the release rates. Microcapsules with smooth surfaces and homogeneous particle sizes were produced. Encapsulation efficiency reached 90% by increasing the inlet temperature and feed rate. Slower release rates (approximately 40%) were achieved with higher concentrations of the wall material and temperatures, generally. Optimal process conditions were determined as a wall-to-core ratio of 4:1, temperatures exceeding 150 degrees C, and feed rates above 2.5 mL/min. The highest repellent activity achieved was 95%, indicating effectiveness of GA/CEO microcapsules as insect repellent materials
Hybrid learning-driven golden jackal optimizer for reliable parameter estimation of nonlinear memristive chaotic systems
No full textAccurate identification of parameters in chaotic and nonlinear systems is essential for ensuring precise modeling, control, and prediction of complex dynamical behaviors. However, conventional metaheuristic algorithms often struggle to maintain an effective balance between exploration and exploitation, leading to premature convergence and estimation inaccuracies. To address these challenges, this study proposes an enhanced golden jackal optimizer (en-GJO) that integrates three complementary mechanisms (Laplacian crossover learning, elite group learning, and opposition repair learning). These hybrid strategies collectively strengthen population diversity, accelerate convergence, and prevent stagnation, thereby improving both the global search capability and local refinement accuracy of the original GJO. The effectiveness of the en-GJO is first validated through extensive benchmarking on twenty-three standard test functions, including unimodal, multimodal, and fixed-dimensional multimodal problems. Comparative results against nine well-established metaheuristics (such as SSA, SCA, HHO, AEO, EO, GBO, RUN, and ARO) demonstrate that en-GJO achieves superior convergence precision and robustness, consistently yielding the lowest mean and standard-deviation values across all categories. To further verify its real-world applicability, the en-GJO is applied to the parameter identification of a memristive chaotic system, formulated as a nonlinear optimization problem using a least-squares-based objective function. Simulation results reveal that the proposed method attains the most accurate estimates of the system parameters \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}\end{document}, with negligible deviation from their true values. Statistical analyses and convergence profiles confirm that en-GJO not only converges faster but also delivers more stable and repeatable performance than competing algorithms. In comparative evaluations with reported techniques such as PSO, ABC, SPSSA, GWO, POA, and FPPOA, the en-GJO achieves the smallest cost value (1.3850 x 10-13) and with a mean fitness of 1.0507 x 10-9 and a standard deviation of 2.5392 x 10-9, outperforming all compared algorithms by several orders of magnitude. The estimated system parameters converge to their true values with error rates below 0.001%, confirming the high accuracy, stability, and repeatability of the proposed approach. In summary, the proposed en-GJO offers a highly accurate, stable, and computationally efficient solution for parameter estimation in nonlinear and chaotic systems
The trend of monthly mean streamflow values and regimes in the Susurluk basin (Türkiye) with mountain and semi-arid climates
No full textThis study diagnoses monthly trends in streamflow magnitude and regime for the Susurluk Basin (T & uuml;rkiye), which spans semi-arid and mountainous sub-climates. Monthly records from 1990 to 2019 were analyzed at 14 stream gauges and nine precipitation stations. Trends are assessed with the Mann-Kendall (MK) test alongside recent graphical approaches, Improved Visualization for Innovative Trend Analyses (IV-ITA) to resolve value class-based (low/high) behavior, and Innovative Polygon Trend Analysis (IPTA) with the Star Concept to quantify intra-annual transitions. Before the trend analyses, the stations were tested to determine whether their values were homogeneous, and any inhomogeneous stations were excluded from the study. The consistency between the trends of nine precipitation stations and the streamflow data in the basin was analyzed. Across the basin, the average streamflow increased by approximately 40-60% between January and March at many measurement points. However, it then decreased by around 80% in April, albeit at a more moderate rate in December. This suggests significant rebalancing occurred during the December-April period, when most of the annual streamflow occurs. IV-ITA exhibits broadly similar trends for both low and high streamflow classes, with notable exceptions in January-February. Precipitation-streamflow trend directions are largely consistent in the high-flow season (December-April), supporting the notion that climatic control influences the detected shifts. To contextualize these signals, basin-wide land-use/land-cover shifts (1990-2018), notably urban growth, forest expansion, and cropland reconfiguration, provide process context, indicating that a larger fraction of rainfall is routed as fast surface runoff while infiltration and base streamflow recharge decline, alongside seasonally modified water demand. Collectively, the MK+IV-ITA+IPTA framework reveals class-specific and intra-annual dynamics that are obscured by monolithic tests alone and provides decision-relevant evidence for allocation, drought-flood risk, and operations in an intensively managed basin