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Differences and similarities between children and adults with rhupus syndrome
No full textAim: In this study, we aimed to evaluate and compare the characteristics of pediatric and adult rhupus patients. Methods: Thirty pediatric patients with rhupus syndrome and 15 adult patients with rhupus syndrome were included in this study. Similarities and differences between both groups were evaluated. Results: The time elapsed between the diagnosis of juvenile idiopathic arthritis (JIA)/rheumatoid arthritis (RA) and the diagnosis of systemic lupus erythematosus (SLE) was longer in adults than in pediatric patients (p < 0.001). While the most common phenotypes at disease onset were JIA/RA in both adults and children, SLE was more prevalent in pediatric patients and RA in adult patients at the last visit (both p < 0.001). Cutaneous findings, oral ulcers, hematological and renal involvement, hypocomplementemia, and antidouble-stranded DNA positivity were more frequent in pediatric patients, whereas constitutional findings, nonscarring alopecia, neuropsychiatric involvement, and anticyclic citrullinated peptide positivity were more common in adults (all p < 0.001). Asymmetric polyarthritis was more prevalent in pediatric patients, whereas symmetric polyarthritis was more common in adult patients (both p < 0.001). Erosive arthritis was more frequently observed in adult patients (p < 0.001). In the treatment, mycophenolate mofetil was more commonly prescribed to pediatric patients, while rituximab was more frequently used for adult patients in the treatment of SLE compared to pediatric patients (both p < 0.001). Additionally, leflunomide was more commonly used in JIA/RA treatment in adult patients compared to pediatric patients (p < 0.001). Conclusion: This is the first study comparing pediatric and adult patients with rhupus syndrome. Revealing these differences and similarities will contribute significantly to the literature
E7 economies under climate duress: A new framework for assessing socioeconomic impacts
No full textThe Emerging Seven (E7) countries, marked by high emissions and rapid economic transformation, hold a decisive role in the global response to climate change. However, most existing integrated assessment models rely on global averages and exogenous growth assumptions, making them less suitable for capturing the dynamics of emerging economies. This study introduces a new model specifically designed for the E7 context, combining a semi-endogenous growth framework with updated climate and carbon cycle modules drawn from recent advances in the literature. Calibrated using aggregated data from the E7 economies, the model simulates future growth paths, identifies optimal emission reduction strategies, and estimates the social cost of carbon (SCC). By focusing on regionally calibrated economic dynamics under global carbon and temperature feedbacks, the model offers policy-relevant insights specific to the E7 context. The findings reveal an SCC of 122.84 per ton. These results demonstrate the importance of designing climate policy tools that account for region-specific economic conditions while remaining consistent with global physical systems. They underscore the need for tailored carbon pricing mechanisms and provide a policy-relevant framework for balancing near-term economic development with long-term environmental objectives
The effect of adenoid hypertrophy on growth-development level and dental maturation: A 15-year retrospective radiographs study
No full textBackground This study aimed to retrospectively evaluate the effect of adenoid hypertrophy on growth development levels and dental age in pediatric patients aged 7-12 years, using panoramic and lateral cephalometric radiographs. Methods This analytical-archival study assessed radiographs of 348 children aged 7-12 who underwent orthodontic examination at a private oral and dental health polyclinic between 2008 and 2023. Dental ages were estimated using the Nolla methods based on panoramic radiographs. Lateral cephalometric radiographs were analyzed using the Webceph (TM) program. Adenoid hypertrophy was assessed with the McNamara Method, while growth development levels were evaluated using the Baccetti Cervical Vertebral Maturation (CVM) stages. Results Adenoid hypertrophy was identified in 29.8% of the patients (n = 348). SNA, SNB, ramus height, and face height ratio values were significantly higher in the control group (P 0.05). In CS1 and CS3 stages, boys had significantly higher chronological ages than girls (P 0.05). The Baccetti classification stages increased with age in both genders, with a statistically higher rate of increase in girls (P 0.05). Nolla ages were significantly lower in the study group (P < 0.05). Conclusion Adenoid hypertrophy did not significantly affect growth development levels based on cervical vertebral maturation in children aged 7-12. However, Nolla dental ages were significantly delayed in patients with adenoid hypertrophy, suggesting a negative impact on tooth eruption and development. A multidisciplinary approach involving pediatric dentists, orthodontists, ENT specialists, and pediatricians is essential to address the effects of respiratory disorders
The role of cultural capital on the labour force participation of graduated women in Turkey
No full textKadınların iş gücüne katılımı pek çok açıdan eşit değildir ve çeşitli unsurlar kadınların iş gücüne katılımında hayati bir rol oynamaktadır. Çalışma bu bağlamda eşitsizlikleri Bourdieu’nun kültürel sermaye kavramı ile ele almış olup kültürel sermayenin, yüksek öğrenim mezunu kadınların işgücüne katılımında oynadığı rol, çeşitli belirleyicilerle birlikte, iş arama teorisi çerçevesinde incelenmiştir. Kültürel sermayenin iş gücüne katılımdaki rolü çoklu doğrusal hiyerarşik regresyon analizi ile doğrulanmış olup hipotezlerin doğruluğu kanıtlanmıştır. Kültürel sermaye, kadın iş gücünde, eğitim başta olmak üzere pek çok olgu ile birlikte önemli bir yer tutmaktadır. Kadınların tercihlerinden beğenilerine kadar her alanda kendini gösteren kültürel sermaye, pek çok olguyla ilişkilidir ve iş arama faaliyetinde hayati bir öneme sahiptir.Women’s labor force participation is unequal in many respects and various factors play a vital role in women’s labor force participation. In this context, the study addresses inequalities with Bourdieu’s concept of cultural capital and examines the role of cultural capital in the labor force participation of female higher education graduates, along with various determinants, within the framework of job search theory. The role of cultural capital in labor force participation is confirmed by hierarchical multiple linear regression analysis and the hypotheses are proved to be correct. Cultural capital has an important place in the female labor force along with many other phenomena, especially education. Cultural capital, which manifests itself in every field from women’s preferences to their tastes, is associated with many phenomena and has a vital importance in job search activities
Energy and nutritional content of lunch menus in turkish universities: The impact on ecological footprint
No full textThe aim of this study was to evaluate the relationship between ecological footprints and the nutritional contents of lunch menus in universities. One-month lunch menus were evaluated from 70 state universities in seven geographic regions in T & uuml;rkiye. The mean protein, carbohydrate, and fat of the menus were 44.1 +/- 2.7 g, 113.7 +/- 7.4 g, and 80.9 +/- 6.3 g, respectively. Regional differences were observed in the nutrient composition of university lunch menus. The Black Sea region had the highest plant-based protein, while animal-based protein was highest in Eastern/Southeastern Anatolia (p < 0.05). The Mediterranean region had the highest vitamin B-6, and sodium content was highest in the Marmara region (p < 0.05). The average carbon and water footprints of the menus were 2.26 +/- 0.24 CO2 eq/kg and 2.14 +/- 0.16 m(3)/ton. A positive correlation was observed between menus' energy, saturated fat, vitamin B-12, sodium, and iron contents and their carbon footprints (p < 0.05). Water footprints of menus were positively related to energy, total protein, animal-based protein, saturated fat, cholesterol, vitamin B-12, sodium, and iron, and negatively associated with thiamine and zinc (p < 0.05). While a one-unit increase in saturated fat resulted in a 0.829-unit increase in carbon footprint, menus that increased by a unit in saturated fat increased their water footprint by 0.795 units. When evaluating menus, it is essential to consider nutritional content and environmental impacts together. Universities can design more sustainable and nutritious menus by prioritizing fruits, vegetables, legumes, nuts, seeds, and whole grains while moderately reducing red meat consumption, ultimately lowering ecological footprints and improving students' and staff's dietary quality
Rationale for long-acting growth hormone therapy and future aspects
No full textRecombinant growth hormone (GH) is administered as daily subcutaneous injections. Daily treatment can be challenging for children/ adolescents, as well as for parents and/or caregivers, such as legal representatives or guardians of children in institutional care. Challenges associated with daily treatment may result in missing several doses but non-adherence with treatment leads to inadequate growth response. As an inadequate growth response does not meet criteria for continuing treatment, payers (commercial or public) may decide to end reimbursement. Novel long-acting GH (LAGH) formulations with extended half-life may be administered less frequently and aim to improve patient convenience and consequently to improve adherence and responses to treatment. LAGH formulations can restore growth velocity and body composition as effectively as daily treatment, without unexpected adverse effects, as reported in randomized clinical trials
Rethinking the role of education in the digital age: Philosophical perspectives on technology in modern pedagogy
No full textThis article examines the changes taking place in education in accordance with the digital age, with specific emphasis on incorporating technology into contemporary pedagogy from a philosophical point of view. It discusses how technological changes influence educational decisions and also pose questions relating to conventional beliefs about acquisition of knowledge, pedagogy, and learner involvement. Technology's pedagogical promise to encourage adaptive learning and instructional strategies is stressed by philosophical views such as constructivism, critical pedagogy, and postmodernism. The purpose of this article is to provide teachers with an inclusive model for addressing complexities associated with digital union, while maintaining student-centred pedagogical practices in the twenty-first century
Clinical characteristics and quality of life in children with pfapa syndrome and Behçet's disease
No full textObjective Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome and Beh & ccedil;et's disease (BD) are non-monogenic autoinflammatory disorders with common clinical characteristics and genetic features. We aimed to review both patients' clinical characteristics and quality of life. Methods Retrospective data were collected on patients' clinical and laboratory characteristics with PFAPA and BD between 2019 and 2022. The quality of life questionnaire (Pediatric Quality of Life Inventory) form was completed by the parents of all patients and the control group. Results The study included 150 cases aged between 2 and 18, including 60 with PFAPA, 30 BD patients and 60 healthy volunteers. The duration of attacks in males with PFAPA was longer than that in females (P = 0.015). During attacks, the mean acute phase reactants of PFAPA patients were higher than those of BD (P = 0.010). In addition, there was a statistically significant relationship between the use of colchicine and a decrease in attack frequency in BD patients at 89.29% (P = 0.001 < 0.05) and in PFAPA patients at 88% (P = 0.001 < 0.05). Precisely, 61.67% of PFAPA (n = 37) and 73.33% of BD patients (n = 22) exhibited poor quality of life regarding daily activities and school attendance. Conclusion Limited data on the quality of life of paediatric BD and PFAPA syndrome are available. During the attacks of patients with PFAPA and BD, acute-phase reactants were higher in PFAPA patients. Colchicine is an effective medication in reducing attacks in both groups. Effective and timely treatment is indispensable to improve quality of life
Unlocking the potential of elderberry (sambucus nigra l.) fruit leather: Optimization of production and evaluation of bioactive content and bioaccessibility using response surface methodology
No full textElderberry fruit leather was produced using RSM to evaluate the effects of hot air drying (60, 65, 70 degrees C), sucrose concentration (12, 14, 16 %), and thickness (2, 3, 4 mm) on total phenolic content (TPC), total antioxidant capacity (TAC) via DPPH, CUPRAC, FRAP and total monomeric anthocyanin (TMA) during in-vitro gastrointestinal digestion. Samples exhibited a decrease in TPC, TAC (except-DPPH), and TMA after-digestion. Increased sucrose enhanced TAC-DPPH in post-gastric and post-intestinal phases, while higher temperature boosted TAC in undigested samples but reduced TPC. Elderberry phenolics (UPLC-ESI-MS/MS) (mg/kg) included protocatechuic acid (7.02), p-salicylic acid (3.39), rutin (2.72), and gallic acid (1.66). Main anthocyanins were cyanidin-3glucoside (110.79), cyanidin-3-sophoroside (8.09), and pelargonidin-3-glucoside (1.31). Processing improved L* and hue degrees, while decreasing a*, b*, Chroma. Optimum conditions were 70 degrees C, 15.5 % sucrose, and 4 mm. Elderberry was transformed into a non-seasonal functional snack with enhanced nutritional properties and high market potential
Open versus percutaneous short-segment posterior instrumentation in thoracolumbar junction burst fractures
No full textBACKGROUND: This research aimed to compare the surgical data and the clinical and radiological results of patients who underwent open posterior versus percutaneous posterior instrumentation for burst-type spinal fractures in the thoracolumbar junction. METHODS: This study included 73 patients; 43 underwent open posterior instrumentation, and 30 underwent percutaneous posterior instrumentation. Perioperative parameters included the time between fracture and surgery, duration of surgery, perioperative blood loss, fluoroscopy duration, and total length of hospital stay. Clinical evaluation was performed using the Visual Analogue Scale (VAS) and the Oswestry Disability Index (ODI). Preoperative, postoperative, 7th-day, and last follow-up values were analyzed. Radiological evaluation included the anterior vertebral body height ratio (AVBHR) and Cobb angle. RESULTS: Fluoroscopy time was significantly longer in the percutaneous surgery group than in the open surgery group (12.77 +/- 1.89 minutes vs. 4.33 +/- 1.24 minutes; p<0.001). Hospitalization time was significantly longer in the open surgery group (3.79 +/- 1.53 days vs. 2.13 +/- 0.76 days; p<0.001). VAS scores differed significantly between the open and percutaneous surgery groups on the 7th postoperative day (p=0.02) and at the last follow-up (p=0.02). Similarly, lower ODI scores were observed in the percutaneous group compared to the open surgery group on the 7th postoperative day and at the last follow-up (p<0.001). Regarding radiological outcomes, significant postoperative improvements were achieved in both groups in terms of AVBHR, but differences in the Cobb angle in the sagittal plane were not statistically significant (p=0.07). CONCLUSION: According to the results of this study, the percutaneous surgery group showed significantly better improvement in VAS and ODI scores on postoperative day 7 and at the final follow-up. Similar postoperative improvements were achieved in both groups in terms of AVBHR and sagittal Cobb angle