GreenPrints Institutional repository of De La Salle Medical and Health Sciences Institut
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    6526 research outputs found

    C-Reactive Protein–based Screening of People with Tuberculosis Symptoms: A Diagnostic Accuracy Study

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    Rationale: C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV. However, its performance among people without HIV and in diverse settings is unknown. Objectives: In a multicountry study, we aimed to determine whether CRP meets the minimum accuracy targets (sensitivity \u3e 90%, specificity \u3e 70%) for an effective TB screening test. Methods: Consecutive outpatient adults with cough \u3e2 weeks from five TB endemic countries in Africa and Asia had baseline blood collected for point-of-care CRP testing and HIV and diabetes screening. Sputum samples were collected for Xpert MTB/RIF Ultra (Xpert) testing and culture. CRP sensitivity and specificity (5 mg/L cut-point) was determined in reference to sputum test results and compared by country, sex, and HIV and diabetes status. Variables affecting CRP performance were identified using a multivariate receiver operating curve regression model. Measurements and Main Results: Among 2,904 participants, of whom 613 (21%) had microbiologically confirmed TB, CRP sensitivity was 84% (95% confidence interval [CI], 81–87%) and specificity was 61% (95% CI, 59–63%). CRP accuracy varied geographically, with higher sensitivity in African countries (\u3e91%) than Asian countries (64–82%). Sensitivity was higher among men than women (86% vs. 78%; difference, 18%; 95% CI, 1–15%) and specificity was lower among people with HIV than people without HIV (64% vs. 45%; difference, 119%; 95% CI, 13–25%). Receiver operating curve regression identified country and measures of TB disease severity as predictors of CRP performance. Conclusions: Overall, CRP did not achieve the minimum accuracy targets, and its performance varied by setting and in some subgroups, likely reflecting population differences in mycobacterial load

    Functional and mobility status of children with neurodevelopmental conditions: a retrospective chart review (preliminary phase)

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    This study aimed to describe the profile of children with Neurodevelopmental Conditions (NDC) in terms of their demographics, anthropometric profile, and clinical profile in terms of diagnosis and NDC type. It described the functional and mobility status of children with NDC and utilized correlation tests to determine significant relationships between profile variables. It also determined significant differences in status based on diagnosis and NDC type. This quantitative research employed a retrospective chart review and utilized purposive and consecutive sampling techniques. Thus, 129 eligible case records were reviewed which qualified in the screening process based on predetermined criteria. Data were collected using a structured Data Extraction Form and analyzed using descriptive statistics and Pearson chi-square. The results concluded that most children with NDCs were young males from financially capable families aged one to five years. A discrepancy in physical growth was evident, with many children falling below-normal height and weight compared to typically developing peers. Moreover, most children with NDC predominantly have severe functional status, however, the results of this study showed otherwise– most only mild mobility limitations. Furthermore, the demographic variables showed no significant relationship with functional status. However, physical attributes were significantly related to both functional and mobility status, and age also showed a significant relationship with mobility status. The study concluded that functional and mobility status significantly differed based on diagnosis and NDC type. Overall, the results underscored the importance of considering clinical and physical characteristics over demographic factors when assessing functional and mobility outcomes in patients

    An analysis of focus and productivity in different learning environments: a survey of home, library, and coffee shops study habits among College of Medical Laboratory Science students

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    College of Medical Laboratory Science (CMLS) students face a demanding academic workload, and choosing an effective learning environment is essential for academic success. This study aims to analyze and compare CMLS students\u27 levels of focus and productivity in three learning environments (home, library, and coffee shops). A validated Likert-scale questionnaire was distributed to 278 CMLS students at DLSMHSI using a quantitative-comparative research design. The data were analyzed using frequency, percentage, mean, and linear regression. According to the findings, the majority of students preferred studying at home since it was more convenient and flexible. However, there were no statistically significant differences in focus or productivity among the three environments. A moderate positive correlation (r = 0.385, p \u3c .001) was found between focus and productivity. These results demonstrate how personal study habits impact the physical environment and provide valuable insights for educators and institutions in developing supportive learning strategies and environments for students

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