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Artwork 062: Surgere
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Please call (046) 481-8000 or (02) 8988-3100 local 1525, email us at [email protected], or message us on our Facebook page: https://www.facebook.com/rpamdafscgallery.https://greenprints.dlshsi.edu.ph/painting/1061/thumbnail.jp
Artwork 096: Fishing
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Please call (046) 481-8000 or (02) 8988-3100 local 1525, email us at [email protected], or message us on our Facebook page: https://www.facebook.com/rpamdafscgallery.https://greenprints.dlshsi.edu.ph/painting/1095/thumbnail.jp
Non-Inferiority of Subcutaneous Efepoetin Alfa Compared to Methoxy Polyethylene Glycol-Epoetin Beta in Stage 3 or 4 CKD Patients: Insights From a Phase 3 Trial
No full textAim: Efepoetin alfa, a novel long-acting erythropoietin (EPO)-hybrid Fc fusion protein, represents a promising erythropoiesis-stimulating agent (ESA) for addressing anaemia in chronic kidney disease (CKD) patients. This Phase 3 trial was to assess the efficacy and tolerability of subcutaneous efepoetin alfa in comparison to subcutaneous methoxy polyethylene glycol-epoetin beta in stage 3 or 4 CKD patients. Methods: A randomised, multicentre, open-label Phase 3 trial enrolled 391 CKD stage 3 or stage 4 patients. Subjects underwent a 20-week correction period followed by an 8-week evaluation period. Responders continued treatment for an extra 24-week extension to evaluate long-term safety, maintenance effectiveness, and the longer treatment interval. Results: In the efepoetin alfa Q2W (every 2 weeks) group, the response rate was 75.6%; while in the methoxy polyethylene glycol-epoetin beta Q2W group, the response rate was 69.3%. The difference in the response rate was 6.3% with 95% CI (confidence interval) –3.1% to 15.5%. The lower limit of the 95% CI was above the prespecified non-inferiority margin of −9.0%. Adverse event rates were comparable between the treatment groups. Conclusion: Efepoetin alfa demonstrated non-inferiority to methoxy polyethylene glycol-epoetin beta in correcting anaemia and maintaining haemoglobin (Hb) levels among stage 3 and 4 CKD patients. Moreover, the safety profile of efepoetin alfa was comparable to methoxy polyethylene glycol-epoetin beta
Acceptability of a clofazimine tablet in children with rifampicin-resistant TB in three high-burden countries
No full textBACKGROUND: Rifampicin-resistant TB (RR-TB) in children is frequently treated with clofazimine (CFZ), widely available as a 100mg gel capsule. This formulation is challenging to administer and is poorly acceptable to children and caregivers. Poor acceptability may negatively impact adherence and treatment outcomes. We describe the acceptability of a novel 50mg CFZ tablet formulation among children in South Africa, India, and the Philippines. METHODS: Mixed methods assessments were completed in a moxifloxacin and CFZ safety and pharmacokinetics trial in children with RR-TB. Quantitative data were collected from 36 participants at 4 timepoints. A subsample of 26 child/caregiver dyads participated in ~4 qualitative interviews. Descriptive statistics and thematic analysis were employed. FINDINGS: The median age of n¼36 participants (South Africa n¼20; India n¼6; the Philippines n¼10) was 4.9 years. The majority (29/36) received a CFZ gel capsule prior to switching to the tablet formulation. The 50mg tablet had better acceptability scores for taste (p¼0.035), smell (p¼0.035), and ease of swallowing (p¼0.02) compared to gel capsules. Participants described the tablet formulation as easier to administer/take without a lingering smell or taste. Limited concerns were noted on staining. CONCLUSION: The novel 50mg CFZ tablet has better acceptability and should be prioritised for children wherever possible
Safety practices in clinical laboratories in Maragondon, Cavite: a mixed method study
No full textMedical technologists in clinical laboratories play a major role in providing information that aids physicians in diagnosing and treating patients. However, due to the limitations in resources, the safety of the laboratory workers must be evaluated. Thus, this study focuses on the grand tour question: “What are your experiences about the safety of clinical laboratory procedures with limited resources? This mixed-method study utilized a concurrent triangulation approach with a questionnaire adapted from the World Health Organization and interviews conducted with seven medical technologists in Maragondon, Cavite. The data analysis revealed two themes supported by the quantitative and qualitative data: Challenges in Resources and Working Conditions: Unveiling the Untold Stories of Clinical Laboratories and Resilience in Clinical Laboratory: Fostering an Adaptive and Sustainable Environment
Anthelmintic activity of Peperomia pellucida (pansit-pansitan) leaves against Caenorhabditis elegans
No full textParasitic helminths in the Philippines are known to cause significant pain and disease, especially among children and the immunocompromised. Despite the implementation of Mass Drug Administration, the prevalence of helminth infections remains high. This research investigates the anthelmintic activity of phytochemical compounds in Peperomia pellucida against Caenorhabditis elegans, a model organism for parasitic nematodes. The P. pellucida was macerated in ethanol, extracted using a rotary evaporator, and then subjected to phytochemical analysis. The analysis confirmed the presence of alkaloids, carbohydrates, saponins, tannins, flavonoids, steroids, and triterpenoids. Anthelmintic activity was evaluated using three bioassays: mortality, motility, and egg- laying inhibition. The optimal concentrations of the extract are 15%, 20%, and 25% for both mortality and motility assays. For inhibiting egg laying, the optimal concentration is 25%. Moreover, a significant difference in worm mortality and motility was observed between albendazole and P. pellucida extract at concentrations of 15%, 20%, and 25%. This indicates that higher concentrations of P. pellucida exhibit stronger anthelmintic activity than albendazole. Conversely, results from the egg-laying assay showed no significant difference between albendazole and P. pellucida extract, indicating similar effects between albendazole and the 25% concentration of P. pellucida in reducing C. elegans\u27 ability to lay eggs. These findings support the potential of P. pellucida as a promising plant-based alternative for helminth control, particularly in low-resource settings. The study also emphasizes the relevance of natural product-based therapeutics in combating drug-resistant helminthic infections
Perceived effects of biological, psychological, and social factors influencing the academic performance of College of Medical Laboratory Science students from De La Salle Medical and Health Sciences Institute
No full textThis descriptive quantitative study examined the perceived effects of biological, psychological, and social factors on the academic performance of the College of Medical Laboratory Science students at De La Salle Medical and Health Sciences Institute. Using stratified random sampling, 267 students completed a validated survey assessed through a five-point Likert scale. Data were analyzed using Spearman’s rho and tests of independence. Results revealed that motivation, physical health, per and familial relationships were the most influential factors in their respective domains. Significant relationships were found between biopsychosocial factors and academic performance (p \u3c 0.05), indicating that these interrelated factors collectively affect student achievement. The study highlights the importance of addressing biopsychosocial factors to enhance academic success and student well-being
Jewelry egg box 16
No full text1819-RPA-079https://greenprints.dlshsi.edu.ph/collections_3d/1020/thumbnail.jp
Group of Angels
No full text1819-RPA-095https://greenprints.dlshsi.edu.ph/collections_3d/1035/thumbnail.jp