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The Falling-out of Nuclear Suppliers: U.S-France-Canada Negotiations and Debates on the ROK Nuclear Program
No full textMicroglial O-GlcNAcylati on Regulates Inhibitory Tone in the Hippocampus via the Kv1.3 Channel
No full textO- GlcNAcylati on is a post-translati onal modifi cati on criti cal for various cellular functi ons including transcripti on, translati on, signal transducti on, andprotein homeostasis. Notably, it has been shown that O-GlcNAcylati on modulates neuronal functi ons through "on-demand" protein modifi cati on.Despite this fact, it remains to be determined whether O-GlcNAcylati on is essenti al for glial cells such as microglia and astrocytes. In this study, wegenerated microglia-specifi c O-GlcNAc transferase (OGT) knockout (KO) mice to reveal the physiological roles of microglial O-GlcNAcylati on in thebrain. We found that the loss of O-GlcNAcylati on in microglia alters microglial morphology, lysosomal contents, and innate electrophysiologicalproperti es. Interesti ngly, the potassium channel Kv1.3, which is known to be O-GlcNAcylated, exhibited an elevated expression level and channelconductance in the microglia located in the hippocampus of the OGT conditi onal KO mice. We also found that these Kv1.3 abundant microgliaspecifi cally modulate hippocampal GABAergic synapses and inhibitory tone, causing a shift in E/I balance. Collecti vely, these data demonstrate thatmicroglia are important for tuning inhibitory tone in the hippocampus via O-GlcNAcylati on of the microglial proteins including the Kv1.3 channel
Charge breeding experiment of stable ion beams in EBIS charge breeder for RAON facility
No full textThe Electron Beam Ion Source (EBIS) charge breeder is used to produce highly charged ions in the Isotope Separation On-Line (ISOL) system of the Rare isotope Accelerator complex for ON-line experiments (RAON). Beam tests of the EBIS are performed using stable Cs and Sn ion beams. Cs-133(1+) ions from a test ion source were injected into the EBIS to measure the breeding effect with the electron beam. The resulting relative abundance of Cs-133(27+) was 25.0%, and the extraction energy was 49.3 keV/q. A charge breeding test of the Sn-120 ions from the Target Ion Source (TIS) of the ISOL system was also carried out. The charge fraction of Sn-120(24+) was 23.0%, and the energy was 50 keV/q. These results fulfilled the input beam condition of the RFQ accelerator (A/q < 6 and 10 keV/u). Additionally, Cs-133(27+) ions were extracted with a pulse length up to 10 ms (FWHM) by the preliminary pulse-stretching experiment
TAOD-Net: Near-Ophthalmologist Level Active Thyroid-Associated Orbitopathy Detection on Frontal Eye Photographs with Deep Learning
No full textRecyclable organic flexible electronics with an eco-friendly and economical approach to sustainable wearable technologies
No full textOptimal treatment condition of solidification auxiliary agent for stable solidification of radioactive sludge
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A flexible and scalable Li-ion conducting film using a sacrificial template for high-voltage all-solid-state batteries
No full textTo improve the safety concerns of lithium-ion batteries, a flexible scalable composite electrolyte film (FSCEF) was fabricated based on a fiber-shaped ceramic and polymer support. Ceramic fibers of Li1.3Ti1.7Al0.3(PO4)(3) (LATP) were prepared by sintering the precursor-coated sacrificial template and then infiltrated with a polyethylene oxide (PEO) polymer to obtain the FSCEF. The LATP fibers induced continuous Li+ ion channels, allowing the FSCEF to show an ionic conductivity exceeding 10(-4) S cm(-1) at 60 degrees C. The synergistic action of the ceramic frameworks and supportive PEO resulted in enhanced mechanical flexibility. Furthermore, the possibility of using a FSCEF in all-solid-state batteries was confirmed by conducting electrochemical performance tests on a Li/FSCEF/LCO (LiCoO2) cell. We expect that the herein reported findings will contribute to the synthesis of thin and flexible solid-state electrolyte films with manufacturing scalability for promising high-voltage all-solid-state batteries