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The effect of synthetics kavalactones on sarcoplasmic reticulum Ca²⁺ release in healthy and molecular models of diseased cardiomyocytes.
No full textIon channels in the heart generate electrical currents that initiate contraction through changes in intracellular calcium concentration [Ca²⁺]. The ryanodine receptor type 2 (RyR2) mediates Ca²⁺ release from the sarcoplasmic reticulum (SR), and its dysregulation can lead to arrhythmias. Quantifying SR Ca²⁺ release events, such as sparks and waves, reveals mechanisms of RyR2 activity. This study used isolated, permeabilized mouse cardiomyocytes and leveraged mavacamten and SparkMaster 2 to assess RyR2 function under varying free [Ca²⁺] conditions. Kavalactones, bioactive compounds from Piper methysticum, were evaluated for their effects on SR Ca²⁺ release. A synthetic mixture was tested under physiological and pathological conditions, including calmodulin presence, RyR2 hyperphosphorylation by Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), and ATP depletion. Findings show that kavalactones modulate RyR2-mediated Ca²⁺ dynamics, affecting both normal and disease-mimicking states. These results offer insight into potential regulatory roles of natural products on cardiac calcium signaling and RyR2 function, relevant to cardiac health and therapeutic exploration
Incorporating in-situ wave energy data into a shoreline management model for Biloxi Back Bay, MS
No full textThis study aims to determine if in-situ based wave energy inputs change the output recommendations of a fetch-based shoreline management model (SMM) differently in river sites and bay sites. To collect wave data, gauges were deployed in two-week increments for five months at 12 sites in Biloxi Back Bay, MS. Average wave height (Havg), significant wave height (Hs), and cumulative wave power per day (Pc) were calculated from the gauge data and used to characterize each site’s wave energy. The SMM was run once with fetch-based inputs and once with each of the in-situ inputs (Havg, Hs, and Pc). Each metric caused a change in recommendation from the fetch-based model, but only Hs caused a change that was statistically significant between river and bay sites. The overall change in recommendations due to each metric supports the need for shoreline managers to make management decisions based on comprehensive in-situ data
Interatomic potential of multiphase materials using modified embedded atom method (MEAM) and artificial neural network (RANN)
No full textThere is a significant need for computer simulations to explore multiphase materials because of their significance in both industry and research. These simulations are both more efficient and less expensive than many experimental approaches, making them an ideal choice for this purpose. It is possible to use molecular dynamics simulations that make use of the MEAM and RANN interatomic potentials in order to comprehend and characterize the properties, performance, and behavior of materials at the atomic scale of different material phases. In the realms of elements, alloys, and impurities, MEAM can be utilized in a wide variety of applications. Through the utilization of fingerprints and angular screening, RANN is able to reduce the complexity of computational tasks without compromising the accuracy of MEAM. In the present moment, RANN has successfully forecasted a number of materials that have been challenging to model using classical interatomic potentials such as MEAM. The MEAM potential that was produced for bismuth is beneficial for studying the material and mechanical behavior of the pure material under a variety of situations. Additionally, it paves the way for the development of interatomic potentials for bismuth alloys or other bismuth compounds. Within the context of the electric field, the MEAM+ESP (Electrostatics) potential for bismuth ferrite (BiFeO3) has been developed for the purpose of investigating the shape memory effect of the material. Utilizing the Zinc RANN potential allowed for the investigation of the plasticity of pure zinc on an atomic scale
Drought resilience of cowpea during vegetative and reproductive stages
No full textCowpea (Vigna unguiculata (L.) Walp.) is an important leguminous crop. Exposure to drought can lead to significant reductions in yield and quality. Designing strategies to mitigate the effects of drought requires a comprehensive understanding of how trait variability influences resilience at various crop growth stages. Three experiments were conducted to assess the response and resilience of various cowpea genotypes under control (100% irrigation) and drought (50% irrigation of control for 14 days) conditions during the vegetative (nodulation initiation - V2, and peak branching - V4) and reproductive (flowering - R1, and seed fill - R4) stages. The short-term drought impacted physiology and biomass, resulting in a significant reduction in 46% yield during R1, followed by R4 (35%), V2 (33%), and V4 (27%). Phenotyping of diverse genotypes at V2 revealed that deep-rooted genotypes exhibited greater drought tolerance compared to shallow-rooted ones. However, drought at R1 severely impacted the genetic potential of traits, leading to reduced gas exchange, a 4.6°C increase in canopy temperature, and a 47% yield decrease due to poor seed set compared to the control. The reproductive stage is more sensitive to drought than the vegetative stages. Deep-rooted genotypes maintained a cooler canopy during different growth stages, making this combination of traits valuable for enhancing yield potential in drought conditions
Harnessing the potential of biostimulants to mitigate drought and heat in soybeans
No full textDrought and heat stresses during vegetative and reproductive stages cause yield losses up to 50% in soybeans. Biostimulants have potential to improve stress tolerance and enhance crop resilience, but selecting an effective product remains challenging due to the wide range of commercial options. This study aimed to identify suitable biostimulants that alleviate drought and heat stress during vegetative and reproductive stages. There was 64% and 76% reduction in stomatal conductance under vegetative and reproductive stage drought stress, respectively. Drought and heat stress during reproductive stages resulted in 44% and 36% reduction in total seed weight, respectively. Among biostimulants, treated check (T2) and Trevo (T14) increased total seed weight by 32% under drought stress and the combination of BioWake and Biofriendly increased total seed weight by 11% under heat stress compared to untreated check (T1). Biostimulants showed non-significant effects on soybeans across growth stages in soybeans under drought and heat stress
Portrait of Boyce and Windell Bailey, undated
No full textThis black and white photograph features two young boys, one in dark clothing and the other in a white gown and seated in a wicker chair. The back of the photograph identifies the boys as Boyce and Windell Bailey,https://scholarsjunction.msstate.edu/mss-lampton-images-misc/1034/thumbnail.jp
Stereograph of Union Dead at Gettysburg, 1865
No full textA number of dead Union soldiers lying in an open field at Gettysburg are pictured on this 1861--photographic history--1865 stereograph card. The back of the card describes the photograph\u27s history, the series of original photographs in the Photographic History set and an explanation of prices.https://scholarsjunction.msstate.edu/mss-lampton-images-misc/1038/thumbnail.jp
U. S. S. Mississippi Docked at the Panama Canal
No full textA sepia toned photograph of the U. S. S. Mississippi navy ship at the Panama Canal docks is featured on this postcard. Sailors dressed in white uniforms are pictured on the deck of the ship looking over the railing toward the dock. A man is pictured standing on the platform of the dock near a tall lamp post. The identity and location of the ship is handwritten on the back of the card.https://scholarsjunction.msstate.edu/mss-lampton-images-misc/1040/thumbnail.jp
Elks Home, Greenville, Mississippi
No full textA color photograph of the Elks home/club house in Greenville, Mississippi is featured on this postcard. The building is a two story stone structure with dental molding along the edge of the roofline, round stone columns across the front porch, and a balcony bump out on the left side. Trees are pictured behind the house and a stone elk head is placed in the front gable.https://scholarsjunction.msstate.edu/mss-lampton-images-ms-delta/1360/thumbnail.jp
Charleston High School, Charleston, Mississippi
No full textA black and white photograph of the sanctuary in the interior of the Methodist Church in Winona, Mississippi is featured on this postcard. A row of dark, wooden pews are pictured on either side of the aisle that leads to the alter where the choir stand, the pulpit, and three chairs are located. A pipe organ is pictured behind the choir seats an dark trim lines the ceilings and windows. The title of the card is printed in white along the bottom edge of the image.https://scholarsjunction.msstate.edu/mss-lampton-images-ms-delta/1372/thumbnail.jp