13109 research outputs found
Sort by
Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes
Full text linkAcute myeloid leukemia (AML) is an aggressive, heterogeneous disease with genomic subtypes that are increasingly treated differently. There is a growing interest in going beyond mutations and cytogenetics to stratify AML. Recent work has combined proteomics,1 signaling,2,3 or immunophenotypes4 with integrated genomic-transcriptomic measurements to improve AML risk classifications.5 Although invaluable as resources, such approaches can neither extend retroactively to existing repositories nor prospectively to new AML cases lacking these data types. We sought to develop a more extensible approach involving sphingolipids (Figure 1A), a family of bioactive molecules implicated in AML pathogenesis and therapeutic resistance6,7 that differentially regulate cell proliferation,8 differentiation,9 autophagy,10 apoptosis,11 and immune cell activation.12 Sphingolipid abundances in AML vary heterogeneously and ratiometrically,13 prompting us to ask whether systematic sphingolipidomic profiling could meaningfully stratify patients with AML and common AML cell lines.National Institutes of Health. National Cancer Institute. National Science Foundation.Letter to the editor -- Acknowledgements -- Contribution -- Conflict-of-interest disclosure -- Correspondence -- ReferencesYe
Alaska Earthquake Center Quarterly Technical Report January-March 2024
Full text linkThis series of technical quarterly reports from the Alaska Earthquake Center (AEC) includes detailed summaries and updates on Alaska seismicity, the AEC seismic network and stations, fieldwork, and our online presence, and lists publications and presentations by AEC staff. Multiple AEC staff members contribute to this report. It is issued in the following month after the completion of each quarter Q1: January-March, Q2: April-June, Q3: July-September, and Q4: October-December. The first report was published for January-March, 2021.1. Introduction
2. Seismicity
3. Alaska Geophysical Network
4. Data quality assurance
4.1 Seismic data
4.2 Environmental data
5. Real-time earthquake detection system
6. Computer systems
6.1 Computer resources
6.2 Waveform storage
6.3 Metadata
6.4 Software development
7. Fieldwork
8. Social media and outreach
8.1 Website
8.2 Twitter/X
8.3 Facebook and Instagram
8.4 LinkedIn
8.5 K–12 and community outreach
9. Publications and presentations
9.1 Publications
9.2 Public presentations
9.3 GI Geoscience lunch seminar talks
10. References
Appendix A: Data availability for broadband stations from the AK network.
Appendix B: Gaps for broadband stations from the AK network
Immersion Tour for Local Native Alaska Students
Full text linkA Project Submitted in Partial Fulfillment of the Requirements
for the Degree of
MASTER OF SCIENCE
in
Project ManagementRecent initiatives by the Department of Defense directed greater outreach to local Native Alaska students due to lack of representation. To bridge this gap, the "Immersion Tour for Local Native Alaska Students" is an impactful initiative aimed at providing a unique educational experience to underserved students residing in remote areas of Alaska. This project serves as a vital component of Air Force outreach, fostering connections with local communities and inspiring the next generation of leaders.
The primary objective of this project is to expose students from remote Alaskan villages, often referred to as "the bush," to opportunities and career paths they may not have access to otherwise. By doing so, it not only enriches their educational journey but also empowers them to envision a brighter future for themselves and their communities. This will be a one day execution event for the immersion tour on Joint Base Elmendorf Richardson, Alaska. Additionally, this project aims to permanently set up an office or set up as a function of an office to carry out this endeavor so this effort may continue as part of the organization.
In summary, the "Immersion Tour for Local Native Alaska Students" is a project with a far-reaching impact, designed to bridge educational gaps, foster community connections, and inspire future leaders within the Alaska Air National Guard. It underscores the Air Force's commitment to outreach and engagement while offering students the chance to explore a world of possibilities.
This project successfully resulted in 28 students enjoying a military base immersion tour and in creating a repository of best practices for future tours to use for continuously improved processes. This repository will be used as the basis for turnover to a future office for primary responsibility in supporting outreach tours.Abstract / List of Figures / List of Appendices / Glossary / Scope Statement / Background / Research Methods and Approach / Research / Work Breakdown Schedule / Project Schedule Management / Communications Management Plan / Budget Management Plan / Risk Management Plan / Quality Management Plan / Procurement Management Plan / Integration Management Plan / References / Appendi
Business Plan Development for an Automotive Restoration Company
Full text linkA Project Submitted in Partial Fulfillment of the Requirements for the Degree of
MASTER OF SCIENCE
in
Project ManagementThe Auto Restoration Business Plan Development project arises from a pressing problem and a
compelling opportunity within the auto restoration industry. With a resurgence in interest in classic and
vintage vehicles, there is a growing demand for professional auto restoration services and a need for
entrepreneurs to navigate this intricate landscape. This project aims to address the lack of comprehensive
business planning resources tailored to the unique requirements of auto restoration ventures, thereby
fostering successful startups, and enhancing the industry's overall quality.
The importance of this endeavor is underscored by the transformative impact it can have on aspiring auto
restoration business owners. By delivering a meticulously crafted business plan template, industryspecific
insights, and a roadmap for financial success, this project empowers entrepreneurs to enter the
market with confidence. It not only mitigates common challenges but also enables businesses to thrive
and contribute to the preservation of automotive heritage.
The objectives of this project therefore encompass equipping entrepreneurs with the knowledge and tools
needed to launch sustainable and profitable auto restoration businesses, thus fostering economic growth
within the industry. The purpose being to deliver a comprehensive and accessible resource that catalyzes
innovation, professionalism, and excellence within the auto restoration sector, ensuring its continued
relevance and vibrancy in the years to come.
The outcomes of this project include a personalized business plan for an automotive restoration company
as well as a formatted and defined example to be distributed to prospective business creators. The
research conducted informed the basis of these products for business planning and incorporated project
management principles for an auto restoration business planner. To maintain a widely useful product the
research focused on potential customer segmentation using nationwide discovery and survey participants.
These outcomes therefore give a potential business creator the requirements and guidelines needed for
their business plan to be successful when adding input of their locality and own strengths and weaknesses.Executive Summary / Situation Analysis / Marketing / Operations / Technology Strategy / Management / Growth Strategy / Finance / Risk and Mitigation Pla
Koniag Energy & Water Master Schedule Development Project
Full text linkA Project Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE
in
Project ManagementIn September of 2022, the companies Dowland-Bach Corp. and TecPro, which are both subsidiaries of Koniag Energy & Water, were relocated to a new fabrication facility in Wasilla, Alaska. They are now being asked by their parent company to work together to manage and complete projects.
Being required to share human resources has created a need to be able to efficiently track multiple projects across the two companies from a single platform. This includes accurate tracking of project cost and schedule variance from estimate. The tool identified to address these tasks is the software program Microsoft Project.
The planned outcome of this project was the development of a master schedule template, a new job template, material cost tracking, labor cost tracking, a schedule performance index, resource tracking, a resource pool, and a user tutorial on how to operate these tools to derive the required business objectives.
Structured in this Project Report are the results of the research and analysis performed during the execution of this project. Review on researched literature, as well as methodology and approach are captured. Results from the project as well as key aspects and takeaways are provided as well. Upon its successful completion the results of this project have now been made available to both Koniag employees as well as UAA’s Project Management Program. This contribution to the Project Management Body of Knowledge helps Koniag project managers better execute their work and provides a tool kit for students at UAA’s MSPM program to bring with them to the workforce.Title Page / Table of Contents / List of Exhibits / List of Appendices / Abstract and Keywords / Research Sources / Introduction / Literature Review Results / Research Method Approach / Analysis / Results-Products of Project / Key aspects of Application of Project Management Approaches / Conclusions / Recommendations for Further Research / Resources / Appendice
Pedestrian Safety Analysis using Computer Vision
Full text linkThe goal of this research project was to explore the capabilities of computer vision for pedestrian safety analysis. Computer vision, an AI application in image processing, tracks the movement of cars, bikes, and pedestrians, offering superior information about speed, trajectory, and count data for various transportation modes. The University of Idaho acquired two computer vision sensors from the startup Numina. This project funded the installation and one year of data access. In collaboration with the City of Moscow, we identified a test location, but the sensors failed to provide the necessary data. Consequently, we pivoted to the open-source computer vision package YOLOv8. Our research then focused on YOLOv8’s capabilities for pedestrian safety analysis. The first task tested detection accuracy, and the second compared different model sizes, or “brain sizes,” of YOLOv8, which range from smaller, faster models to larger, more accurate ones. Accuracy tests compared average detection confidence across various zones and times of day, revealing that cars in high daylight had the highest confidence levels, while objects closer to the camera and oriented perpendicularly were detected more accurately. In contrast, objects at skewed angles and farther distances had lower confidence levels. The model size comparison showed that larger models, despite requiring more time and storage, produced significantly higher-quality detections
Synthesis, characterization and cytotoxicities of novel organoplatinum(IV) complexes
Full text linkThesis (M.S.) University of Alaska Fairbanks, 2024Breast cancer is the most common form of cancer in the world. In 2023, nearly 300,000 new cases of breast cancer were projected in the U.S. alone. When treating breast cancer, several therapies are utilized, often including chemotherapy. Organoplatinum(IV) complexes are among the newer chemotherapy drugs being developed as an alternative to cisplatin, the first platinumbased anticancer drug. Two novel organoplatinum(IV) complexes: [Pt(CH₃)₂X₂{bipy-(CO₂H)₂}] (X = Br, I) have been isolated and structurally characterized by single-crystal X-ray diffraction. Nuclear magnetic resonance and infrared spectroscopic data were also collected to confirm these new compounds and provide useful reference values. The anticancer potential of each compound was assessed via in vitro 3-4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assays using human breast cancer cells (cell line ZR-75-1). EC₅₀ values were determined as 3020 μM, for Pt(CH₃)₂Br₂{bipy-(CO₂H)₂} and 86.0 μM, for Pt(CH₃)₂I₂{bipy-(CO₂H)₂}; for comparison, the EC₅₀ value for cisplatin against the ZR 75-1 cells was 16.4 μM. While these compounds were not as effective as cisplatin, the single-crystal X-ray diffraction data showed evidence of intermolecular π-π interactions within the unit cell which suggest that the bipyridyl ligands can potentially interact with tumor DNA nucleobases in the DNA double helix.UAF Department of Chemistry and Biochemistry, National Science Foundation (DUE-9850731, CHE-0619638), US Army Medical Research and Material Command (05178001), Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health grant number P20GM103395, National Science Foundation’s Major Research Instrumentation (1827313
Exploring teacher emotions in a university ESL writing classroom
Full text linkThesis (M.A.) University of Alaska Fairbanks, 2024Second language acquisition research has been steadily moving towards recognizing the importance of emotions as they relate to language teaching and learning. Indeed, the language classroom - especially in the context of English as a Second Language (ESL) instruction - is often an intensely emotional place for both teachers and students. This study explores the following question: As a university ESL teacher in a writing classroom, what emotions do I experience in the classroom, and what emotional work do I put in to address these emotions? Using autoethnographic methods in my own classroom, including reflexive journals, classroom observations, and student artifacts, I examined my own emotional journey throughout a semester teaching university ESL students. Guided by both emotion labor and emotion regulation theories, I used a grounded theory approach to analyze data. In doing so, I found that the majority of negative emotions I experienced stemmed from expectations I placed on myself. In addition, I also discovered that my emotions are influenced by my reactions to my students' behaviors, and various external factors outside the classroom. I also documented the emotional work I performed in response, discovering a wide range of behaviors and reactions. The study concludes with a teacher action plan to help future ESL teachers map out their own emotions and create a successful classroom environment for their students
An intertaxon dissimilarity for level-1 phylogenetic networks from rooted triples
Full text linkThesis (M.S.) University of Alaska Fairbanks, 2024An important problem in evolutionary biology is how to infer the evolutionary history of a set of taxa in the presence of hybridization. In this work, we present an important first step in the establishment of an algorithm for the inference of a level-1 species network under the Network Multispecies Coalescent Model using rooted triples. In particular, we define a new intertaxon dissimilarity, dRT , which can be directly computed from the topology of the rooted triples displayed on a network, and might be estimated from data. In our main result we prove that this dissimilarity is equivalent to an intertaxon splits dissimilarity, dλRT , which can be used to reconstruct a level-1 species network using the NeighborNet and Circular Network Algorithms
Alaska DUI Arrest Rates, by Sex: 1987-2022
No full textThis fact sheet presents data on Alaska DUI arrest rates, by sex, from 1987-2022. Sex-specific DUI arrest rates were calculated as the number of arrests per 100,000 males and 100,000 females in Alaska. Between 2008 and 2014, male and female DUI arrest rates underwent sharp declines. While both male and female DUI arrest rates decreased overall, the effect was much more pronounced for the male arrest rate