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Student Groups
No full textFour students sitting together at a table.https://digitalcommons.cwu.edu/john_foster_photos/2693/thumbnail.jp
Hunting and Fishing
No full textThree men hunting with guns in a field by a mountain range.https://digitalcommons.cwu.edu/john_foster_photos/2721/thumbnail.jp
Registration
No full textStudents registering for classes in 1950.https://digitalcommons.cwu.edu/john_foster_photos/2732/thumbnail.jp
Registration
No full textAn outdoor view of the registration line in 1950.https://digitalcommons.cwu.edu/john_foster_photos/2733/thumbnail.jp
Students at Library
No full textTwo female students standing in front of the library.https://digitalcommons.cwu.edu/john_foster_photos/2745/thumbnail.jp
Kaags
No full textThe Kaags group cleaning a wall on October 26, 1951.https://digitalcommons.cwu.edu/john_foster_photos/2757/thumbnail.jp
Enlands, Lowell
No full textLowell Enlands standing with his family on campus in 1955.https://digitalcommons.cwu.edu/john_foster_photos/2783/thumbnail.jp
Pure as the Driven Snow Play
No full textA stage view of the play Pure as the Driven Snow.https://digitalcommons.cwu.edu/john_foster_photos/2790/thumbnail.jp
Ernie De Rocher
No full textErnie De Rocher posing for a photo in 1958.https://digitalcommons.cwu.edu/john_foster_photos/2812/thumbnail.jp
Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters
Get PDFC-fused γ-lactam-lactones are resident in several bioactive molecules, including anticancer agents such as omuralide. In this embodiment, we report mild conditions for the catalytic halolactonization of lactam-tethered 5-aryl-4(E)-pentenoic acids. The use of dichloromethane as the solvent and Ph3PS as the catalyst led to predominant 6-endo-trig cyclization and furnished the trans-fused-γ-lactam-δ-lactones. The transformation is modular, regioselective, chemoselective, and diastereoselective. The γ-lactam-δ-lactones bear angular quaternary benzylic stereocenters, which is noteworthy since the presence of a quaternary carbon in bioactive small molecules often promotes an element of conformational restriction that imparts potency, selectivity, and metabolic stability. The generated halogen and lactone motifs are important functional handles for late-stage diversification