31544 research outputs found
Sort by
Psychology Experiment
No full textA man performs an experiment on captive mice in the psychology department, 1962.https://digitalcommons.cwu.edu/john_foster_photos/4114/thumbnail.jp
Microtubule polarity flaws as a treatable driver of neurodegeneration
Get PDFMicrotubule disruption is a common downstream mechanism leading to axonal degeneration in a number of neurological diseases. To date, most studies on this topic have focused on the loss of microtubule mass from the axon, as well as changes in the stability properties of the microtubules and/or their tubulin composition. Here we posit corruption of the normal pattern of microtubule polarity orientation as an underappreciated and yet treatable contributor to axonal degeneration. We include computational modeling to fortify the rigor of our considerations. Our simulations demonstrate that even a small deviation from the usual polarity pattern of axonal microtubules is detrimental to motor-based trafficking of organelles and other intracellular cargo. Additional modeling predicts that axons with such deviations will exhibit significantly reduced speed and reliability of organelle transport, and that localized clusters of wrongly oriented microtubules will result in traffic jams of accumulated organelles
Dale Hutseu
No full textDale Hutseu Basketball Player 1962https://digitalcommons.cwu.edu/john_foster_photos/4124/thumbnail.jp
Bob Moawad
No full textBob Moawad Basketball Player 1962https://digitalcommons.cwu.edu/john_foster_photos/4125/thumbnail.jp
Dining Hall - New Commons Kitchen
No full textA woman prepares meals on the portable grills in the new commons kitchen, 1962.https://digitalcommons.cwu.edu/john_foster_photos/4107/thumbnail.jp
Central Washington University 2023-2024 Undergraduate Catalog
Get PDFhttps://digitalcommons.cwu.edu/catalogs/1291/thumbnail.jp
CWU Faculty Senate Minutes 2/01/23
Get PDFThese are the official Central Washington University Faculty Senate minutes for the February 1, 2023, regular meeting
A stochastic approach to the characterization of the seismic sources: a potential method for the assessment of sources of historical and paleo tsunami
No full textInundation, wave arrival and deformation data gathered from measurement campaigns and historical accounts have been used to study past earthquakes and tsunamis, being crucial for magnitude and extension estimations. Nevertheless, the most commonly used methods cannot provide more information about the spatial characteristics of the event’s slip distribution. In this work, we aim to create a methodology for obtaining more realistic, heterogeneous estimations of the slip distribution characteristics of past tsunamigenic earthquakes, by obtaining slip patterns of each earthquake of the same seismic segment, thus establishing a history of the seismic cycle in a rupture zone. To obtain the stochastic characterization of the slip distribution of the seismic source, we combine fault defining parameters using a logic tree structure to generate random slip distributions which are subsequently submitted to successive restrictions to assess their compliance with the available deformation and tsunami data, discarding those that do not satisfy the constraints and using those that do to estimate the most probable seismic source in terms of the data. We test this methodology with synthetic heterogeneous slip fields off the coast of South Central Chile to assess its limitations, data dependence, resolution capabilities and uncertainties. Obtaining a good correlation between the synthetic observations and the locations of the main slip features. Finally, the 9.5 Mw, 1960 Valdivia earthquake is used to benchmark the methodology with real deformation and tsunami data from surveys and historical accounts. This result is then compared to slip distributions obtained with tsunami, seismological and deformation data inversions. This shows that the magnitude of the earthquake could be recovered correctly and the slip distribution is very similar to models calculated from different techniques
Symposium on American Values
No full textPeople browsing an exhibit of paperback books in the Grupe Conference Center during the 2nd Symposium on American Values, April 24-27, 1963.https://digitalcommons.cwu.edu/john_foster_photos/4154/thumbnail.jp
Symposium on American Values
No full textA man speaking at a podium during the 2nd Symposium on American Values, April 24-27, 1963.https://digitalcommons.cwu.edu/john_foster_photos/4179/thumbnail.jp