Ufuk Universitesi Akademik Acikerisim Sistemi
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Children with Multiple Sclerosis and Nursing Care Approach
No full textMultiple sclerosis is a chronic and progressive disease proceeding with inflammation, demy elination, and degeneration in the central nervous system. Multiple sclerosis is rarely seen in childhood, but it can occur more frequently than it is known in early childhood. Children with multiple sclerosis disease may reach disability levels at an earlier age than adults. Therefore, early diagnosis, optimal treatment, and care management of multiple sclerosis emerging in childhood are important. The goals of this treatment and care management are similar to those of adult multiple sclerosis; however, there are some specific concerns related to pediatric multiple sclerosis. The concerns related to the efficacy and safety of immuno modulatory treatments used by pediatric multiple sclerosis patients, the continuation of the neurodevelopmental process in children, the pharmacokinetic and pharmacodynamic differ ences between pediatric and adult multiple sclerosis patients, the interruption of school life of children, and anticipatory anxiety of children and their families are among the major con cerns. In this traumatic and challenging process, meeting the physical, emotional, cognitive, and social needs of children and their families is very important for disease management and for the adaptation of children to the disease. In light of this information, the aim of our review article is to give information related to multiple sclerosis disease in childhood and to explain the nursing approach to this disease
Evaluating the Correlation of Mortality and Biochemical Parameters in Community-acquired and Hospital-acquired Pneumonia
No full textObjective: The associations of inflammation and immunity of host lead to higher mortality in both community-acquired and hospitalacquired pneumonia patients. Therefore, several inflammatory and immunological biomarkers are essential for diagnosis, prognosis, and survival. Among these inflammatory markers, such as older age, and higher blood urea nitrogen, creatinine, procalcitonin and C-reactive protein, and lower albumin levels have been shown to have strong correlations with worse outcomes and high mortality, especially in community-acquired pneumonia patients. In this study, we investigated the correlation between several biochemical markers, which are mostly involved in inflammation, and mortality in not only community-acquired but also hospital-acquired pneumonia patients. Material and Methods: This was a retrospective study of hospitalized community-acquired and hospital-acquired pneumonia patients in a third degree university hospital. In their initial blood tests (also used for diagnosis), blood urea nitrogen, creatinine, procalcitonin, C-reactive protein and albumin levels, and white blood cell, lymphocyte, neutrophil, platelet and erythrocyte counts, red blood cell distribution width and hemoglobin levels were measured. The outcome variable was mortality at 30 days. Statistical analysis included univariate comparisons of continuous variables between deceased and survivor groups, subject to mortality analysis and logistic regression in both community-acquired and hospital-acquired pneumonia patients. Results: 272 hospitalized community-acquired and 80 hospital-acquired pneumonia patients were included. Patients who died during follow-up had older age and higher levels of procalcitonin, blood urea nitrogen, creatinine, and red blood cell distribution width in community-acquired pneumonia group. Remarkably, logistic regression analysis showed a significant relationship between creatinine and mortality, regardless of age, severity of community-acquired pneumonia and comorbidities. Creatinine is a strong independent prognostic factor, subject to mortality in community-acquired pneumonia group. Conclusions: Older age, higher procalcitonin, blood urea nitrogen, creatinine and red blood cell distribution width levels are significant biomarkers for prediction of higher mortality in hospitalized communityacquired pneumonia patients
A Case of Multiple Sclerosis Presenting with Thoracic Lhermitte’s Sign
No full textLhermitte’s sign (LS) is a transient symptom consisting of an electric shock-like sensation radiating ascending along the spinal cord during forward flexion of the neck. It may be associated with sensory complaints such as hypo or hyperesthesia. Although it ismore common in cervical lesions, it can also be seen less frequently in thoracic lesions. LS is classified as one of the paroxysmal pain syndromes of multiple scle- rosis (MS). It can also be seen in cervical spondylosis, disc herniation, trauma, spinal cord malignancies, vitamin B12 deficie ncy, cisplatin tox- icity and radiation myelotoxicity. In cases of thoracic myelitis, LS should be considered and confirmed by neuroradiological an d neurophysiological examinations. In this article, we aimed to present a case of MS with Lhermitte sign due to a lesion in the thoracic spinal cord, as a rare but possible example of spinal cord pathology in the thoracic region
Serum galectin-3 and ?-1-acid glycoprotein levels in diagnosis and prognosis of idiopathic sudden sensorineural hearing loss
No full textIdiopathic sudden sensorineural hearing loss (ISSNHL) is an otological emergency in which etiopathogenesis remains unclear. A number of disorders is considered as the cause; therefore, different treatment modalities are used without certainty of a cure. The present study aimed to analyse the potential correlation between serum alpha-1-acid glycoprotein (AGP) and galectin-3 levels with ISSNHL, and to investigate markers for guidance of treatment. A total of 55 patients with ISSNHL [29 (52.7%) female, 26 male, mean age, 46.76 +/- 17.68 years] and 47 healthy volunteers [25 (53.2%) female, 21 male, mean age, 43.95 +/- 12.96 years) were included in the study. The complete blood count, erythrocyte sedimentation rate, C-reactive protein, serum galectin-3 and AGP levels were evaluated. The audiological investigation included pure tone average and speech discrimination scores were also recorded before and after corticosteroid treatment. Serum AGP levels in the study group vs. the control group were 64.08 +/- 25.10 and 67.01 +/- 21.59 mg/dl (P=0.53), respectively. Galectin-3 levels were 16.80 +/- 4.55 in the study group and 15.15 +/- 3.74 ng/ml in the control group (P=0.05). Serum galectin-3 levels were significantly correlated with unresponsiveness to treatment (P < 0.001). Galectin-3 is an important biomarker for patients with ISSNHL. Patients with high serum galectin-3 levels may be unresponsive to standard therapy
Examining The Rater Drift in The Assessment of Presentation Skills in Secondary School Context
No full textThe alternative assessment, including peer assessment, helps students develop metacognition among the subcategories of assessment types. Despite the advantage of alternative assessment, reliability and validity issues are the most significant problems in alternative assessment. This study investigated the rater drift, one of the rater effects, in peer assessment. The performance of 8 oral presentations based on group work in the Science and Technology course was scored by 7th-grade students (N=28) using the rubric researchers developed. The presentations lasted for four days, with two presentations each day. While examining the time-dependent drift in rater severity in peer assessment, the many-Facet Rasch Measurement model was used. Two indexes (interaction term and standardized differences) were calculated with many-facet Rasch measurement to determine the raters who made rater drift either individually or as a group. The analysis examined the variance of scores in the following days compared to the first day's scores. Accordingly, the two methods used to determine rater drift gave similar results, and some raters at the individual level tended to be more severe or lenient over time. However, no significant rater drift at the group level showed that drifts had no specific models
The effect of ACE2 receptor, IFN-?, and TNF-? polymorphisms on the severity and prognosis of the disease in SARS-CoV-2 infection
No full textTo investigate the effect of genetic variations in the angiotensin converting enzyme (ACE), interferon (IFNG) and tumor necrosis factor (TNF-alpha) genes on the severity of coronavirus disease (COVID-19). Between September and December 2021, 33 patients with COVID-19 were included in this prospective study. The patients were classified and compared according to disease severity: mild&moderate (n = 26) vs severe&critical (n = 7). These groups were evaluated to assess possible relationships with ACE, TNF-alpha and IFNG gene variations using univariate and multivariable analyses. The median age of the mild&moderate group was 45.5 (22-73), and that of the severe&critical group was 58 (49-80) years (p = 0.014). Seventeen (65.4%) of the mild&moderate patients and 3 (42.9%) of severe&critical patients were female (p = 0.393). According to results of univariate analysis, the percentage of patients with the c.418-70C>G variant of the ACE gene was significantly higher in the mild&moderate group (p = 0.027). The ACE gene polymorphisms, c.2312C>T, c.3490G>A, c.3801C>T, and c.731A>G, were each only seen in separate patients with critical disease. The following variants were observed more frequently in the mild&moderate group: c.582C>T, c.3836G>A, c.511+66A>G, c.1488-58T>C, c.3281+25C>T, c.1710-90G>C, c.2193A> G, c.3387T>C for ACE; c.115-3delT for IFNG; and c.27C>T for TNF. It can be expected that patients carrying the ACE gene c.418-70C>G variant may present with a mild clinical manifestation of COVID-19. Several genetic polymorphisms may be associated with pathophysiology, as they appear to help predict COVID-19 severity and enable early identification of the patients requiring aggressive treatment.Turkiye Modern Cerrahi Egitim ve Arasxtirma Dernegi; Turkiye Solunum Arasxtirmalari Dernegi [ADF/17]The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research received support from two organizations(Turkiye Modern Cerrahi Egitim ve Arasxtirma Dernegi, Turkiye Solunum Arasxtirmalari Dernegi (ADF/17)
'Impaired Autonomy and Performance' Predicts Instagram Addiction Among Instagram Users: A Cross-Sectional Study
No full textObjective: This study aims to investigate the effects of early maladaptive schemas on Instagram addiction, as a more specific, controversial, and new field, in terms of the four-factor model developed by Bach et al. Methods: Participants over the age of 18 who have Instagram accounts were evaluated with the sociodemographic data form, Instagram Addiction Scale (IAS), Young Schema Scale - Short Form 3. Participants were divided into two groups according to their addiction scale scores; socio-demographic characteristics and early maladaptive schemas (according to the latest four-factor model) were compared. A multiple linear regression model was created to determine the factors predicting Instagram addiction. Results: The group with a high score on the Instagram Addiction Scale consisted of statistically significantly younger participants (t:4.44, p<.001) than the other group, the rate of being single was higher (X2=6.703, p=.010), Disconnection Rejection (t:-5.36, p<.001), Impaired Autonomy and Performance (t:-6.22, p<.001), Excessive Responsibility and Standards (t:-4.96, p <.001) and Impaired Limits (t:-5.30, p<.001) scales were found to have statistically significantly higher scores. In addition, age (beta=-0.27, p=.004) and scores from Impaired Autonomy and Performance (beta=0.39, p<.001) were found to have a statistically significant predictive effect on IAS scores in the linear regression model. Conclusion: Instagram addiction has been shown to be associated with early maladaptive schemas. Thus, evaluation and understanding of the clients' schemas and interventions for this are/become important in psychotherapy programs for individuals with Instagram addiction. Prospective studies with more participants are needed on Instagram addiction and other social network addictions
A novel prenatal index predicting the probability of neonatal intensive care in pregnants: amnion progesterone receptor to alfa fetoprotein rate
No full textIntroduction: Amniocentesis (AC) is the most used interventional procedure for prenatal diagnosis. The study aims to evaluate the pregnancy outcomes undergoing AC and the potential of amnion progesterone receptor (aPR) to alfa fetoprotein (AFP) rate for predicting the probability of neonatal intensive care unit (NICU). Material and methods:This prospective cross-sectional study population consisted of 85 pregnant women who underwent mid-trimester AC. All cases were screened by ultrasound before AC. Maternal venous and amniotic samples were obtained simultaneously to evaluate the serum progesterone (sPRG), aPR, and aAFP and analyzed with patient results. Results: Unlike sPRG and aAFP, aPR showed a positive correlation with NICU and a negative correlation with parity. In linear regression, the aPR-AFP rate showed strong linearity with NICU and parity. In an aPR-AFP rate analysis, we saw a strong predictivity for NICU compared to the other three parameters. It presented 73.4% specificity and 79% sensitivity at 0.0075 cut-off (AUC: 0.78; p = 0.003; 95% CI: 0.608-0.914). Conclusions: Evaluating the PR either alone or in a rational combination with AFP will provide physicians with valuable information about the advanced process of pregnancy and postpartum complications. The physicians might use the aPR-AFP rate to predict NICU potential for pregnancy and need further studies to make more vital predictions on postpartum complications
Test-Retest Reliability and External Validity of Canadian Diabetes Risk Questionnaire - Turkish
No full textObjectives: The aim of the study was to examine the test-retest reliability and external validity of the Canadian Diabetes Risk Questionnaire (CanRisk). Materials and Methods: Individuals over 40 years of age without any disease were included in the study. Participants were administered the CanRisk, Nottingham Health Profile (NHP), and Visual Analog Scale (VAS). CanRisk test-retest validity was calculated with the interclass correlation coefficient (ICC), and external validity was calculated with the Pearson correlation coefficient. Results: The study included 1349 participants, 549 men and 755 women (mean age 50.03 ± 8.05 years). CanRisk test-retest validity was found to be excellent (0.99). Its external validity was evaluated by examining its correlation with NHP, and it was found that there was a statistically significant, positive weak correlation (p<0.05, r= 0.23). Conclusion: CanRisk -TR was found to be a reliable and valid questionnaire to predict diabetes risk
AN INVESTIGATION OF UNIVERSITY PREPARATORY CLASS TEACHERS’ ATTITUDES TOWARDS ENGLISH LANGUAGE TEACHING IN DISTANCE
No full textThe purpose of this study is to reveal university preparatory class teachers’ attitudes towards distance English language teaching in Turkey. The study has a mixed methods research design combining qualitative and quantitative methods. The participants were 50 instructors from 6 different universities. The general attitudes of participants towards distance English language teaching were investigated via a questionnaire and their more personal attitudes via a semi-structured interview. The results of the study revealed that distance English language teaching is advantageous especially in time management, accessibility, e-facilities, and implementing various productive teaching/learning methods. But, it has serious instructional disadvantages including lack of interaction, participation, motivation, focus, and self-discipline. Difficulties in teaching the four skills, hardness in working on phonology, deterioration of communication skills, difficulties in classroom management, various technical, technological and health problems are some further disadvantages. The results also suggest that distance English language teaching could be made more effective by taking some instructional, technical, technological, and digital precautions, and through training and guidance