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STUDIES ON NEWLY DESIGNED TOOTH SURFACE TREATMENTS FOR ADHESIVE COMPOSITE RESTORATION
Get PDFRecently, problems have occurred frequently such as cervical and exposed dentin surface lesions or root caries and subsequent hypersensitivity because of further increase of the elderly population. This study was projected to devise a proper and simple treatment and materials for the adhesive composite restoration for such lesions. The 10-20Ca (10% citric acid containing 20% calcium chloride) solution was found to be a comparatively mild tooth surface conditioning agent and to be effective with a single application to both dentin and enamel. In addition, the use of the SA primer (3% N-methacryloyl 5-aminosalicylic acid in 80% ethanol) and the LVR (visible light-cured, 33% microfilled low viscous Bis-GMA resin) dramatically improved the adhesion and adaptability of the composite restoration in the saucer cavity at the cervical area.journal articl
A STUDY ON A METHOD TO IDENTIFY THE BORDER BETWEEN MANDIBULAR CORPUS AND RAMUS ON LATERAL CEPHALOMETRIC RADIOGRAPH
Get PDFThe mandible has two major parts, the corpus and the ramus. These two parts must be considered separately because each has its own functional counterpart with the maxilla and the posterior cranial base.
Since the mandible is a single bone, the border of the corpus and the ramus can not be visualized on the conventional two-dimensional lateral cephalometric radiograph. The purpose of this study is to propose a reliable method to distinguish the border between the mandibular corpus and the ramus on the lateral cephalometric radiograph.
In this study, 64 dried skulls in different developmental stages were examined. Metallic markers were placed at the diverging point (point T) on both sides of the dried skulls. From the occlusal view of the mandible, point T was considered to be the lingual border of the corpus and the ramus. Then, the lateral cephalometric radiographs of the dried skulls were taken. On each lateral cephalometric radiograph, a vertical line L was drawn from point Ra (the intersection of the occlusal plane and the anterior border of the ramus) to the mandibular plane. Thus, the distance from the midpoint of point T on each side to the vertical line L was measured.
As a result, over 80% of the midpoints T were found on the vertical line L. Therefore, the vertical line L from point Ra to the mandibular plane can be considered to play the role of a reasonable reference line for distinguishing between the corpus and the ramus on the lateral cephalometric radiograph.journal articl
EFFECTS OF MEALS ON PERIPHERAL BLOOD FLOW REDUCTION BY COLD EXPOSURE IN RABBIT EARS
Get PDFAlthough insulin is known to have various actions on the cardiovascular system, its effects on the microvessels in vivo have not been fully elucidated. This study was aimed to examine the effects of the increased endogenous insulin release after meals on the reflex vasoconstriction induced by cold exposure in the rabbit ears using a laser Doppler flowmeter. A reflex blood flow reduction by cold exposure was tested 3-4 hours after meals in the rabbits with or without pretreatment with a somatostatin analogue (Sandostatin, 100 μg/body). The degrees of the blood flow reduction were decreased after the diet intake compared to the responses in the fasting state. The blood flow reduction after diet intake in the non-treated group was significantly attenuated compared to the treated group (88.4±13.0% in the non-treated group vs. 47.5±13.4% in the treated group at 1 minute of cold exposure; p<0.05, and 87.6±20.2% vs. 40.2±24.8%, respectively, at 5 minutes of cold exposure; p<0.05). The somatostatin-treated rabbits showed a significant suppression of the increase in the serum insulin levels after meals compared to the non-treated control rabbits (17.8±10.2 µU/ml in the treated group vs. 78.6±38.3 µU/ml in the non-treated group, p<0.05). In the somatostatin-treated rabbits, the exogeneously applied insulin caused a decreased response of blood flow to cold exposure. These findings suggest that in the postprandial state the endogenous insulin release may regulate the reactivity of the microvessels to the sympathetic stimuli.journal articl
ULTRASONIC DIAGNOSIS OF ORAL AND NECK MALIGNANT LYMPHOMA
Get PDFA series of 14 patients with nodal and extranodal non-Hodgkin’s lymphoma of the oral and neck region was analyzed by ultrasonogram evaluation. Eight nodal lymphomas and six extranodal lymphomas commonly exhibited almost completely similar ultrasonographic findings, specifically, clear delineation of the boundary echo and a homogeneous, weak internal echo, the so-called pseudo-liquid-like images. The results derived from our study suggest that ultrasonic diagnosis is also helpful in evaluating patients with lymphoma during the initial diagnosis and initial treatment like other diagnostic imaging modalities.journal articl
CYTOGENETIC STUDIES OF HUMAN MALIGNANT MELANOMA CELL LINES
Get PDFCytogenetic studies were performed on six cell lines derived from three patients suffering from malignant melanomas. The modal chromosome numbers were in the hypotriploid to hypertetraploid ranges and both the numerical and structural aberrations of chromosomes were found. Aberrations were most frequently observed in chromosomes 1, 6 and 7. Deletion of 1q was consistently present in all cell lines, while loss of 6q was observed in two cell lines of case l. Translocations t (Y; 6) and t (6; ?) occurred in one cell line from case 3. An increased number of copies of chromosome 7 was a characteristic feature of the cell lines from case 2. Since positive correlation between the expression of EGF receptors and an increased dosage of chromosome 7 has been reported for malignant melanomas and the gene for EGFR has been mapped to band 7pl2-p13, this phenomenon might be of importance for the proliferation of malignant melanoma. The findings of the present study are generally in agreement with the data previously published in the literature, indicating the existence of specific non-random chromosome lesions during melanoma development.journal articl
CLINICAL ASSESSMENT OF THE KNOWLEDGE BASE OF AN EXPERT SYSTEM FOR DATA ANALYSIS IN LABORATORY MEDICINE
Get PDFDespite the apparent demand for a consultation system, only a few expert systems have been developed for laboratory medicine. Some studies on the diagnostic precision of such systems have been reported, but the efficiency of their knowledge bases has not yet been investigated. An expert system, named BLOOD, for data analysis in a hematology laboratory, which is written in C-Prolog and runs on VAX-station, has already been reported to have excellent diagnostic reliability and ability to cope with the fuzziness involved in clinical diagnostic procedures. A quantitative examination of the knowledge base of BLOOD using real laboratory data from 58 patients diagnosed as having iron deficiency anemia clearly revealed the verbosity of the knowledge base, and proved that it was effective for obtaining a group of essential diagnostic rules.journal articl
RELIABILITY OF DOPPLER ECHOCARDIOGRAPHIC STROKE VOLUME MEASUREMENT
Get PDFTo evaluate the accuracy and utility of the echocardiographic Doppler method of determining the stroke volume, the stroke volume was measured in 64 instances in 15 patients and compared to the simultaneous thermodilution stroke volume determinations. Stroke volume, varied by atrial pacing at various heart rates, was calculated noninvasively by the product of the cross-sectional area of the aortic orifice determined by echocardiography and the flow velocity integral measured by continuous wave Doppler. While the cardiac output was increased moderately by atrial pacing, the stroke volume was decreased in relation to the increase in the heart rate. The stroke volume calculated by the echo-Doppler method exhibited a significant linear relationship to the stroke volume determined by thermodilution (r=0.84) and to the cardiac output (r=0.75, p<0.01). Inter-observer and intra-observer variability was 7±4% and 5±4%, respectively. The noninvasive echo-Doppler method of estimating the stroke volume is concluded to be accurate, specifically, to be comparable to the values obtained by thermodilution and with a low inter- and intra-observer variability.journal articl
ENTEROCOLITIS DUE TO METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS - REPORT OF TWO CASES
Get PDFTwo cases of postoperative enterocolitis due to methicillin-resistant Staphylococcus aureus (MRSA) after gastrectomy were experienced. Case 1: A 59-year-old male underwent subtotal gastrectomy for advanced gastric cancer. Diffuse peritonitis progressed after the first operation, so reoperation for drainage was required. Two days after the second operation, a profuse watery diarrhea developed. Case 2: A 46-year-old male underwent total gastrectomy for early gastric cancer. On the fourth postoperative day, frequent vomiting and cholera-like diarrhea started, followed by profound shock several hours later. Both cases were treated successfully by the administration of vancomycin.
Stool cultures of both cases revealed MRSA and it had the same minimal inhibitory concentration, coagulase type and enterotoxin type, so that nosocomial infection was indicated.journal articl
NEW RESTORATION AND DIRECT PULP CAPPING SYSTEMS USING ADHESIVE COMPOSITE RESIN
Get PDFThere have been many arguments on the irritating mechanisms of the composite resin on the dental pulp. While the direct irritative effect of the resin has been prefered, some authors considered that the marginal microleakage and the resulting bacterial infection play a more important role in inducing the complicating pulp irritation. We developed a new filling technique, called the direct inlay restoration method, which could prevent the marginal leakage associated with the polymerization shrinkage of the adhesive composite resin.
In this study, we tried to apply our method clinically. None of the 440 cases which were filled with the adhesive composite resin and 60 cases out of 64 cases in which the pulps were directly capped with the adhesive composite resin developed any signs and symptoms of pulp irritation . The other 4 cases developed signs of pulp irritation. Two of those 4 cases were pulpectomized due to spontaneous pain and the other 2 cases turned out to be well after re-restoration. With the informed consent of the patients, the direct pulp capping using the adhesive composite resin was experimentally performed on 6 caries-free 3rd molars and the histopathological examination of these capped molars revealed that neither significant degenerative nor inflammatory changes were brought about in the dental pulp.
These clinical and histopathological observations suggest that the dental pulp irritation after resin filling is not induced by the composite resin itself.journal articl
STUDY ON CHOLESTERYL ESTER TRANSFER ACTIVITY IN CORONARY HEART DISEASE
Get PDFThe net cholesterol transfer activity from high density lipoprotein (HDL) to low density lipoprotein (LDL) was determined in the patients with coronary heart disease (CHD) to examine its effect on the pathogenesis of arteriosclerosis. Furthermore, in the CHD patients with high HDL cholesterolemia (more than 60 mg/dl), the HDL particle size was measured by high performance liquid chromatography. A significant cholesteryl ester transfer activity (P<0.02) was noted in the CHD patients with low HDL cholesterolemia (less than 60 mg/di). The rate of cholesteryl ester transfer activity (cholesteryl ester transfer activity/hour) inversely correlated with the serum HDL cholesterol value (r=-0.483, P=0.096) in the patients with CHD. These results suggest that an increase of CETA caused a low HDL cholesterol value in the CHD patients with low HDL cholesterolemia and it may have the risk of causing CHD. However, an increase of the CETA was not found in the CHD patients with high HDL cholesterolemia compared to the normal subjects, the HDL particle size beings significantly greater than that in the normal subjects. In the CHD patients with high HDL cholesterolemia, the large size of HDL may have the risk of causing CHD.journal articl