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Comparison of the Ventral Nerve Cords of Plectus sambesii and Caenorhabditis elegans
No full textMicroscopic worms known as nematodes are used widely in studies. C. elegans, the most widely known nematode, has its nervous system mapped, serving as a model system. P. sambesii is placed earlier in the phylogenetic tree, while C. elegans diverged later in time. Research Question: What structural differences is there in neurons between P. sambesii and C. elegans
William Albert Noyes Jr. and a Systemic Study of the Near Ultraviolet Photochemical Decomposition of Acetone
No full textPrior Knowledge Chemists observed that acetone vapor decomposes under UV light producing CO and hydrocarbons. The problem with their data was that it was inconsistent due to uncontrolled experimental variables (Herr and Noyes 2052–2053). Quantum yield data varied widely, pressure, temperature, and light intensity had never been systematically analyzed (Herr and Noyes 2052–2053). Noyes and Herr wanted to create a quantitative, controlled measurements to clarify the mechanisms of acetone photolysis (Herr and Noyes 2052–2053).
Importance of Acetone IV Serves as a fundamental model for photochemical bond cleavage (Journal of the American Chemical Society). Tests core photochemical laws (absorption → excitation → reaction (Journal of the American Chemical Society). Provides measurable data for understanding energy transfer, bond-breaking, and reaction pathways (Journal of the American Chemical Society)
JoAnne Stubbe and the Mechanistic Study of Ribonucleotide Reductases
No full textTo catalyze the formation of deoxyribonucleotides from ribonucleotides, the enzyme has to remove an hydroxyl from the ribose sugar part of the molecule (circled in in green) (“Ribonucleotide Reductase”).
The problem is that hydroxyl doesn’t naturally want to break from the base it is attached to, leaving many researchers unable to discern the chemical process going on inside these enzymes that make the bond break possible (Strauss)
Development of Optogenetic Inhibition of the ERK Pathway in Mammalian Cells
No full textThe Ras/ERK pathway controls key processes like cell growth, differentiation, and survival. Since its overactivation is linked to cancer and neurological disorders, optogenetic inhibition could complement existing tools for bidirectional control of this pathway
