eCommons at Roseman University
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635 research outputs found
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Exercise Blocks Ethanol-Induced Kappa Opioid Receptor Sensitization in Nucleus Accumbens and Ventral Tegmental Area
Get PDFExercise has been increasingly used as an adjunctive therapy in the treatment of alcohol use disorder (AUD). Despite this, the mechanism by which it influences the mesolimbic circuitry changes underlying alcohol addiction is not well understood. Previous studies have shown alcohol dependence to lead to upregulation of the Dynorphin-Kappa Opioid Receptor (KOR) system, making it a potential target for therapeutics. Thus, gaining a better understanding of these pathways will help develop evidence-based guidelines for integrating exercise into therapies for the treatment of AUD
Identifying Barriers to Effective Clinical Decision Support Use in Preventing Medical Errors: The Pharmacy’s Perspective
Get PDFThe purpose of this research is to understand the perceptions of pharmacy personnel in community and hospital settings concerning their workflows, the Clinical Decision Support (CDS) alerts they interact with, and how their interpretation of these alerts influences patient care. This research aims to begin to investigate pharmacy personnel-voiced factors that influence high rates of alert dismissal. The project also aims to qualify what design factors contribute to more effective CDS Alerts from the pharmacy’s perspective
Effect of Plant Based Nutritional Education on A1C Levels in Type 2 Diabetic Adults
Get PDFType 2 diabetic adults are those with a condition that prevents production of enough insulin and are also resistant to the effects of insulin itself (American Diabetes Association, 2018). According to the U.S. Department of Health and Human Services, “diabetes mellitus affects an estimated 29.1 million people in the United States, and is the 7th leading cause of death,” (Office of Disease Prevention and Health Promotion, 2022, section 3). Risk factors that affect type 2 diabetic adults include being overweight, aged 45 or older, high blood pressure, and high level of triglycerides (National Institute of Diabetes and Digestive and Kidney Diseases, 2016). This particular population commonly presents with comorbidities such as obesity, cardiovascular disease, and a sedentary lifestyle (Mohammadi et al., 2018). Due to poorer access to education, healthcare services, and quality foods, type 2 diabetic adults face many challenges in their management of their disease
Microsporidiosis: Reviewing clinical presentation and treatment strategies
Get PDFMicrosporidiosis is an opportunistic infection caused by obligate intracellular pathogens within the taxon Microsporidia. Infection is zoonotic and has been associated with patients experiencing immunodeficiency, though incidence is increasing among other populations. Most commonly, the disease is gastrointestinal, typically by Enterocytozoon bieneusi and less commonly by Encephalitozoon intestinalis. Symptoms present with diarrhea and vomiting, and severe cases can lead to wasting and mortality. While the incorporation of anti-retroviral therapy for HIV patients has significantly decreased mortality in a subset of the vulnerable populations, treatment for microsporidiosis is still not standardized or well explored. Resistance to first-line treatment albendazole is increasing, and another antiparasitic fumagillin is not approved as a systemic treatment in the US. Given that microsporidiosis is an emerging disease that affects the global population, there is an increasing need to educate clinicians about clinical presentation and to review treatment strategies and opportunities
Assessing the Prevalence of Computer Vision Syndrome at an Osteopathic Medical School with an Electronic Content Delivery Model
Get PDFTo determine the overall prevalence of computer vision syndrome (CVS) among students, faculty, and staff while promoting awareness. CVS is caused by extended screen exposure that can lead to eye discomfort and vision changes which can affect quality of life and educational performance. Our institution is a new Osteopathic medical school that aims to create an innovative approach to medical education delivery via employment of modern technology that is already prevalent. Implementation of pre-recorded lecture materials in the curriculum requires 4-6 additional electronic screen exposure hours. Members of our institution are potentially at increased risk for CVS stemming from the curriculum delivery style and the accelerated use of technology
Impact of simulated toothbrushing and dentifrice abrasiveness on the surface roughness, gloss, and microhardness of CAD/CAM hybrid restorative materials
Get PDFThis study aimed to investigate the impact of toothpaste abrasiveness on the surface roughness, gloss, and microhardness of resin composite and CAD/CAM hybrid materials
Investigating the Role of Chaos in Minimizing Tumor Growth
Get PDFChaos is a type of motion found in mathematical systems that is highly sensitive to initial conditions. While many biological systems described in literature have been analyzed for the presence of chaotic dynamics, there are still many that are yet to be discovered. The goal of this project is to reassess Itik and Banks’ discovery of chaotic behavior in their population dynamics model of cancer growth. Once chaotic behavior is confirmed, we want to investigate how chaos could possibly be controlled to minimize tumor growth and discover novel treatments for cancer patients
Assessment of Condylar volume changes in Class II Division 2 patients treated with proclination of maxillary incisors, overbite reduction and dentoalveolar expansion using Invisalign Clear Aligners
Get PDFTo assess the possible three-dimensional changes in condylar volume in Class II Division 2 growing patients following the use of Invisalign clear aligners to “unlock” the mandible. Unlocking the mandible was done through proclining the maxillary incisors, correcting the overbite, and expanding the maxillary arch