Himalayan Journal of Health Sciences (HJHS)
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Role of Kayachikitsa an Ayurveda Modality towards the Geriatric Care: A Review
Get PDFThe system for the management of health evolved through the history of civilization and Ayurveda is one such oldest system that comprises different branches for specific health purpose, Kayachikitsa is one them. The Kayachikitsa involves general principles and approaches related to the treatment procedure and use of internal medicine. The treatment of body (Kaya) by virtue of Ayurveda medication and principle is general aim of branch Kayachikitsa. The ageing or problems related to old age also need to be care and in this regards Ayurveda mentioned different approaches for geriatric care including use of internal medicine. The use of natural rugs along with general principles of Ayurveda offers health benefits in case of ageing or geriatric health issues. Considering this point here we summarizes an Ayurveda aspect towards geriatric care W.S.R. to Kayachikitsa
Panchkarma and its Modality towards the Management of Pain and Related Disorders
Get PDFAyurveda the science of healing and health restoration encompasses various therapeutic modalities for the treatment of disease and health management, Panchkarma is one such approach of Ayurveda that provides health benefits in many ailments including joint pain. The incidences of pain related diseases increases now a days due to the disturbed pattern of daily regimen and sedentary life style thus it is prerequisite to explore an approach that offers beneficial effects in these conditions without severe side effects and Panchkarma can provide therapeutic response in conditions like; osteoarthritis, sports injuries, rheumatoid arthritis, spondylosis, sciatica, myalgia, muscle cramps, sprain and low back ache, etc. Present article summarizes health benefits of Panchkarma in conditions related to pain or joint pain
Cucurbitacins and its Anticancer property: A Review
Get PDFCucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on this unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds show their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins
Breast cancer treatment: survival facts and associated side effects
Get PDFIn the world the cancer is a prevailing disease therefore some rational and effective therapy required. The breast cancer is one of the most common cancers in a woman and now a day’s patients are increase. Therefore, development and research are ongoing on the effective treatment on breast cancer. The breast cancer treatment is depending on the cancer stage disease and risk, based on this therapeutic agent should be employed in the patients to protect the breast cancer disease. Such treatments are reducing the mortality and morbidity but constant monitoring of drug adverse effect. Moreover, it has been seen that the survival rates in breast cancer is rising that is good news for science but on the other side the side effects of the treatments bring new challenges. The early stage diagnosis of the breast cancer can survive the effective or healthy patient life because of long-term and various treatment can be employed on the cancer disease otherwise breast cancer is life threatening illness. Survivors of breast cancer have not only the side effects issues of the cancer therapy treatment but also, they have many other issues of previous treatments therefore it is challenging job for the researchers. Consequently, this review article is dealing with the breast cancer effective treatments and side effects of it. Moreover, it includes the other long-term medical issues after breast cancer diagnosis and treatment. This review will help to the researchers for better understanding of the long-term medical issues in the breast cancer
Ayurveda: The Conventional Indian Medicine System and its Global practice
Get PDFThe word "Ayurveda" meaning knowledge of life and longevity.
Rather than frequent usage of Medicines in common disorders, Ayurvdic medicines are as good as food which serve role of the nutritional needs. Because of the changing in life style and carelessness towards sickness with respect to time as well as money, people are growing modernization some traditional ways. Now a days, There has been increased global interest in traditional medicine.
In this dissertation, attempted to brief history along with worldwide concepts of Ayurveda and availability of Ayurvedic medicines which play roles in medical emergency, surgical emergency and traditional one as nutrition supplement. Moreover, WHO contribution in global acceptance of Ayurveda reflected in this paper reveals worldwide usage of Ayurveda medicines.
Opportunity and challenges with global perspective of Ayurvedic medicine and gold time for modernization presented in this concept paper gives idea about market value for herbal medicines
A case of endometrial tuberculosis leading to infertility in a young woman
Get PDFThe morbidity and mortality due to tuberculosis (TB) is high worldwide, and the burden of disease among women is significant, especially in developing countries. Mycobacterium tuberculosis bacilli reach the genital tract primarily by haematogenous spread and dissemination from foci outside the genitalia with lungs as the common primary focus. Genital TB in females is a chronic disease with low-grade symptoms. The fallopian tubes are affected in almost all cases of genital TB, and along with endometrial involvement, it causes infertility in patients. A case report is presented herewith where a woman suffering from endometrial tuberculosis resulted in blockage of the fallopian tube and eventually in damaged uterus. A result of which she could not conceive even after three transfers of in vitro Fertilization
Simultaneous estimation of Amino acids by using HPLC
Get PDFVarious methods for the individual as well as simultaneous estimation of amino acids using various techniques like HPLC and other way outs like electrophoresis have been described in this review paper. The amino acid determination by using HPLC can either be done by using pre-column or post column derivatization. The amino acid is first derivatized into a particular derivative and then is analysed into the column in the case of pre-column derivatization, whereas in the case of post column derivatization, the amino acid is first passed through the column for the sake of separation and then the separated amino acids are derivatized into their such derivatives which can be detected by fluorescence detector. Out of the above two mentioned techniques, pre-column derivatization is used more oftenly than the post column derivatization. Few of the most commonly used derivatization agents are phenylisothiocyanate, o-phthalaldehyde+2-mercaptoethanol, dansyl chloride, phenylthiohydantoin etc
Formulation development and Stability Studies of Meropenem Extended-Release matrix Tablets
Get PDFThe aim of this research was to develop a new hydrophilic matrix system containing meropenem (MEX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxyl propyl methyl cellulose or poly (ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75± 5% relative humidity), and the film-coating process is recommended to avoid MEX photo-degradation. The dissolution profiles demonstrated an extended-release of MEX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo
Effect of life style abnormality in adolescent age group
Get PDFA complete urinalysis includes physical, chemical and microscopic examinations. Midstream clean catch collection is acceptable in most situations, but the specimen should be examined within two hours of collection. Cloudy urine often is a result of precipitated phosphate crystals in alkaline urine, but pyuria also can be the cause. A strong odour may be the result of a concentrated specimen rather than a urinary tract infection. Dipstick urinalysis is convenient, but false-positive and false-negative results can occur. Specific gravity provides a reliable assessment of the patient’s hydration status. Glomerular, renal and urologic causes of microhaematuria often can be differentiated by other elements of the urinalysis. Although transient proteinuria typically is a benign condition, persistent proteinuria requires further work-up
Design and Evaluation of Chitosan films for Transdermal delivery of Glimepiride
Get PDFGlimepiride is a third generation oral antidiabetic sulphonylurea drug frequently prescribed to patients of type 2 diabetes. However, its oral therapy is encountered with bioavailability problems due to its poor solubility leading to irreproducible clinical response, in addition to adverse effects like dizziness and gastric disturbances. As a potential for convenient, safe and effective antidiabetic therapy, the rationale of this study was to develop a transdermal delivery system for glimepiride. Chitosan polymer was utilized in developing transdermal films for glimepiride. Chitosan has film forming ability, bioadhesive and absorption enhancing properties. Aiming at optimizing the drug delivery and circumventing the skin barrier function, inclusion complexation of glimepiride with beta-cyclodextrin (β-CyD) as well as the use of several conventional penetration enhancers were monitored for augmenting the drug flux. The physical and mechanical properties of the prepared films were investigated using tensile testing, IR spectroscopy and X-ray diffractometry. Release studies revealed adequate release rates from chitosan films. Permeation studies through full thickness rat abdominal skin were conducted. High flux values were obtained from films comprising a combination of the drug with limonene and ethanol as well as from films containing glimepiride-β-CyD complex. In vivo studies on diabetic rats for selected formulae revealed a marked therapeutic efficacy sustained for about 48 hours. The above-mentioned results shed light on feasibility of utilizing chitosan as an effective, safe transdermal delivery system for glimepiride characterized by increased patient compliance and better control of the disease