Himalayan Journal of Health Sciences (HJHS)
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The Cancer Treatment by Using Liposome as Drug Delivery Systems and Its Applications: An Extensive Review
Get PDFCancer is a leading cause of death in many countries around the world. However, the efficacy of current standard treatments for a variety of cancers is suboptimal. In the development of cancer chemotherapy, besides the discovery of new anticancer drugs, a variety of nanocarrier systems for the delivery of previously developed and new chemotherapeutic drugs have currently been explored. Liposome is one of the most studied nanocarrier systems because of its biodegradability, simple preparation method, high efficacy and low toxicity. To make the best use of this vehicle, a number of multifunctionalized liposomal formulations have been investigated. This review will be including the development of liposomes for cancer therapy, liposomal formulation of various anticancer drugs that are commercially available, recent progress in liposome technology for the treatment of cancer, and the next generation of lipid-based nanoparticles., recent progress in liposome technology for the treatment of cancer, and the next generation of lipid-based nanoparticles
Homeopathic approaches for the management of Psoriasis: A Review
Get PDFPsoriasis is a chronic autoimmune disease which not only affects physical but also disturbs psychological and social life of patient. The exact cause of Psoriasis is unknown but it is believed that stress plays a major role in disease pathogenesis. Environmental and genetic factors also contribute towards disease pathogenesis along with disturbed pattern of life style. Psoriasis not only affects health of an individual but also imparts economic burden. It may increase the risk of developing other pathological conditions like heart diseases and diabetes. The science of homeopathy offers various approaches for the management of Psoriasis without any side effect.
Present article explored role of homeopathy in the treatment of Psoriasis as a safer therapeutic option
A Targeted Drug Delivery System for Cancer Treatment a Novel Approach: A Review
Get PDFIn the recent scenario of the world there are millions of the people are suffering from the various types of cancer. To cure the cancer immunotherapy, radiation therapy, chemotherapy, surgery and hormonal therapy treatments are used. In treatment of cancer the convectional approaches are used which can adversely affect to normal cells on the body. Also, the side effects of this treatments are damage the immune system of the patient. To overcome such problems with the conventional treatment of the cancer the targeted drug delivery system is developed, in such oral delivery of drug at the particular location of tumor at perfect time with specific dosage. This review includes the development of the new targeted drug delivery system and its limitations
Carica papaya leaves: One of dynamic plant parts having multiple therapeutic activities
Get PDFIntroduction: Papaya (Carica papaya Linn.) belongs to the Caricaceae family. Papaya is well known around the world for its medicinal and nutritional properties. Various parts of the plant like, fruits, roots, bark, peel, seeds and pulp are known to have medicinal properties and scientifically established for the various properties. Since the ancient times, part of plants has been utilized for their medicinal values. The plant contains high amount of vitamins A, B and C as well as proteolytic enzyme such as papain and chymopapain. Due to such type of versatile phytoconstituents, the plants show lots of pharmacological application. In this review article we summarized the information regarding the various pharmacological activities of papaya leaf such as anticancer, anti-inflammatory, antidiabetic, antispasmodic, antifungal, antisickling, antioxidant, antimicrobial, antimalarial, as well as helps in proper digestion, hair growth, skin related problems and relief in menstrual pain.
Methods: All information presented in this review article regarding the beneficial application of Carica papaya leaf extract has been acquired by imminent various electronic databases including Scopus, Google scholar, Science Direct, Web of science, and PubMed.
Result: The papaya plant, including fruit, leaves, seed, bark, latex and its ingredients, plays an important part in the management of progressive illness. The papaya leaf contains active ingredients such as alkaloids, glycosides, phenols, tannins, saponins and the flavonoids responsible for the basketful therapeutic function.
Conclusion: The main findings showed that papaya leaf extract has strong medicinal properties. The leaves of papaya may also useful in cosmetic applications
Research on analytical methods of analysis of Ranolazine: A Review
Get PDFNew antianginal drugs examines are focusing on promising concentrations in order to develop new prescription contenders. Fundamental and biochemical strategy feeble connection between seriousness of torment and level of oxygen hardship in the heart muscle, for instance at times, angina can be very extreme, and in the mid twentieth century this was a known indication of looming demise, can accept an essential activity in the distinctive evidence of these goals. Compounding angina assaults, abrupt beginning angina very still, and angina enduring over 15 minutes are indications of flimsy angina (normally gathered with comparative conditions as the intense coronary disorder). As these may go before a respiratory failure, they require critical clinical consideration and are, all in all, rewarded in comparative design to myocardial localized necrosis. The pharmaceutical undertakings are centered around new drug improvement due to the overall affirmation of this unsafe security from the correct now available antianginal treatment. The HPLC, UV and HPTLC methods are available for the assessment of Ranolazine the starting late used prescription for intestinal sickness are studied in this articles
Psidium Guajava Leaves: Phytochemical study and Pharmacognostic evaluation
Get PDFPsidium guajava known as Guava is a medicinal plant belonging to the family Myrtaceae. P. guajava is a well-known traditional medicinal plant used in various indigenous systems of medicine. P. guajava leaves are green to dull green colour with characteristic taste and having ovate-elliptic shape. The chief constituents like essential oil, poly phenols, tannin, pinene, gallic acid, isoflavonoid, catechin, rutin, ascorbic acid, beta carotene, terpenoid and triterpene shows pharmacological importance against several disorders like antibacterial, anti-inflammatory, antispasmodic, diarrhoea, diabeties, colic, cough, pain, high cholesterol, heart disease, cancer and weight loss.The extract of guava leaves also have antimicrobial and antioxidant activity. P. guajava also contain ascorbic acid beneficial for skin and effective against oxidation and act as antioxidant. The present study reveals the pharmacognostical, physicochemical and phytochemical study of leaves P. guajava which are useful in laying down standardization and pharmacopoeial parameters
Classical presentation of Shaarira Rachana w.s.r. to Vedas, Samhitas and other ancient literatures
Get PDFAyurveda is considered as traditional Indian medical system which encompasses great knowledge about human anatomy and physiology. Acharya Susruta presented several aspects related to human anatomy along with utility of dissection process. The ancient Acharya of Indian system emphasizes structural organization of human body. Susruta has described anatomical aspects of body in Sharira sthana; this section emphasizes that origin of universe can be correlated with physical and metaphysical state of body. The ancient Acharya presented human body as an extension of the embryo. The classical texts presented several concepts related to the human anatomy (Rachana Shaarira) and this article elaborated same
Recent advances in Raktamokshana w.s.r. to modification in Shastra used for Raktamokshana
Get PDFRaktamokshana in other words, bloodletting is a kind of Para surgery directed for the treatment of specifically Raktaja roga. It is considered as the important and prime process of blood detoxification. It is derived from two words ie; Rakt which means blood & Mokshana which means leave. So the meaning of Raktamokshana is to let the blood out. The blood is expelled out from the body to reduce the toxic substances and this process helps in Raktaja vikara. The process of Raktamokshana can be traced back to the Vedic period only and not beyond that. Sushruta, father of Indian surgery, has given all the information regarding bloodletting in detail in his treatise, "Sushruta Samhita". Sira Vedhan, Sringa Avacharana, Alabu Aavacharana, Jalauka Avacharana, Pracchanna Karma, Ghati Yantra Avacharana and Suchi Avacharana are approaches utilized for blood detoxification. Bloodletting as a method of treatment is indicated in gouty arthritis, filariasis, herpes, tumors, various skin disorders, genital infections, abscess, inflammatory condition, cellulitis, painful ulcers, chronic ulcers resulting from snake bite, etc
In-Vitro Anticoagulant Study of Leaf Extract of Couropita Guianensis
Get PDFAnticoagulant activity of different extract of cannon ball tree was evaluated in-vitro. Medicinal plant acts as a metabolic bio factory, which can be accessed as therapeutic potential with lesser side effects. The phyto constituents of various medicinal plants can be correlated with pharmacological study. In vitro study was carried out with a vision to setup standards that could be beneficial for detecting authenticity of this medicinal plant. Numerical standards reported in this work could be useful for the compilation of suitable monograph of Couropita guianensis. Various phyto constituents such as alkaloids, tannins, saponnins and glycosides are producing a better opportunity for testing various pharmacological activities. The results obtained from this research revealed that that the plant contains bioactive agents which are connected with anticoagulant activity in plants
Comparative study on the efficacy of Cinnamomum zeylanicum capsule and infusion on serum cholesterol level of subjects with type 2 diabetes
Get PDFThere are health claims that liquid forms are better absorbed and they function rapidly than capsules, as the body need not break down a liquid extract, allowing more of the medicinal properties to be absorbed into the system. The present study was carried out to find the efficacy of cinnamon capsules over infusions on serum cholesterol levels of type 2 diabetes subjects sixty type 2 diabetes mellitus subjects were supplemented with one gram of Cinnamomum zeylanicum capsule and 75 mL of infusion. The effectiveness of the supplements to decrease serum cholesterol levels after a period of 45 days was investigated. Total cholesterol, serum HDL, serum LDL, serum triglycerides and serum VLDL were assessed. Results indicated that there was a significant difference in serum cholesterol level between the capsule ingested group and infusion ingested group indicating that consumption of cinnamon capsule had a positive effect. As capsules are easy to swallow, does not require preparation time and the exact dosage can be consumed, capsules of Cinnamomum zeylanicum when consumed regularly at effective levels, had a good impact on serum cholesterol levels in subjects with type 2 diabetes