International Journal of Public Health Science (IJPHS)
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Genome mining of secondary metabolites from marine Streptomyces spp. as potent therapeutics for RET-specific non small-cell lung cancer
Get PDFThe rearranged during transfection (RET) gene encodes a tyrosine kinase oncogene implicated in various cancers, including non-small-cell lung cancer (NSCLC). Till now, multiple kinase inhibitors are commonly used to treat RET-positive NSCLC. However, these inhibitors often exhibit significant toxicity and demonstrate reduced efficacy and specificity toward RET. Recently, bioactive compounds derived from marine sources have shown promising anticancer properties. Therefore, this study aimed to identify effective bioactive compounds from marine Streptomyces species using a virtual screening approach to address these limitations. A literature search identified 20 marine Streptomyces species as potential sources of bioactive compounds. The antibiotics and secondary metabolite analysis shell (antiSMASH) online tool were used to analyze the gene clusters of these marine Streptomyces species, revealing 7,251 metabolites. A total of 661 distinct metabolites were analyzed through a comprehensive array of virtual screening methodologies. The molecular docking and pharmacokinetic analysis resulted in the identification of four metabolites with better binding scores and pharmacological properties than pralsetinib. Collectively, we hypothesize that the identified bioactive compounds could be considered as potent leads for further analysis
Home fever management in children: a systematic review
Get PDFFever is a prevalent illness among children. Physical cooling interventions worsen the child’s condition as a result of parents’ anxiety and misconceptions about fever. This study aims to identify parental physical cooling intervention as fever management for feverish children in the scientific literature. The study adhered to the guidelines in the preferred reporting items for systematic reviews and meta-analyses (PRISMA). The investigations were conducted within scientific electronic databases: ProQuest, PubMed, Scopus, EBSCO, Google Scholar, and Cochrane, published in English, from January 2013 to August 2023. Authors screened articles for inclusion. After exclusion, there were ten studies included in the analysis with 15,488 participants. The literature review demonstrated that the physical cooling methods employed for home fever management were taking off excess clothes, providing extra fluid, warm compresses, sponging, showering and environmental measures. Sponging techniques and cold compresses are popular among parents. However, the methods have negative effects and are not recommended. Effective fever management optimizes the body's physiological response by ensuring adequate hydration, nutrition, and a conducive environment. When the fever worsens, parents should consider seeking medical treatment
The experience of COVID-19: assessing the Malaysian counselors in training coping strategies
Get PDFThe COVID-19 pandemic also had a psychological impact on various levels of society including trainee counselors. Therefore, the aim of this study is to explore the coping strategies employed by trainee counselors to overcome their challenges within their internship during COVID-19. This study is a quantitative study and was conducted among 106 final-year trainee counselors enrolled in a bachelor's counseling program at the University Malaysia Terengganu (UMT). There were two instruments used in this study, consisting of a sociodemographic questionnaire and the Malay Brief COPE (MBC) scale. The findings indicate that emotion-focused is mostly used by counselors in training with a mean value of 28.96 (SD=4.891); the mean of problem-focused was 18.08 (SD=3.080); and the mean of avoidance coping was 26.12 (SD=5.341). The study's dataset can be used by counselor educators, the Malaysian Board of Counsellors, clinicians, and academicians to improve the effectiveness and competencies of trainee counselors completing internship during the adverse period
Challenges in implementing dengue surveillance in Bantul District Special Region of Yogyakarta, Indonesia
Get PDFThe surveillance system is a source of information for policymaker to address the dengue outbreak. However, there was a lack of information on the effectiveness of dengue surveillance system in reporting the outbreak. This study aims to assess dengue surveillance activities in Bantul District, Special Region of Yogyakarta, Indonesia, one of the districts with a high burden of dengue, to provide information on current effectiveness and need assessment for further improvement for dengue surveillance system. This qualitative study was conducted in Bantul District, Special Region of Yogyakarta. The assessment approach was based on the input-processoutput-outcome (IPOO) model. The study participants were selected based on purposive sampling. Data were collected through interviews. Eight program holder surveillance were interviewed based on the interview guide. The surveillance system in Bantul Regency already utilizes electronic reporting. Reporting cases of dengue uses the system for surveillance of outbreak events (SISKLB). Analysis and interpretation are done to monitor progress in cases. The follow-up evaluation ceses is vector control to prevent the spread of the case. The incidence of dengue is still higher than the national rate. The case fatality rate (CFR) for dengue is <1%; CFR has hit its target. The larvae-free rate hasn't reached its target yet. Optimizing electronic reporting can improve the quality of information used as a reference in decision-making. SISKLB was created for timely reporting and monitoring of dengue cases. Monitoring available data laboratory can be used as a quick response to take action to prevent an increase in cases
Father involvement as a predictor of early childhood external behaviors in Indonesian
Get PDFThe prevailing patriarchal culture in Indonesia that posits a father only to act as a breadwinner is thought to be the reason for the lack of father involvement in parenting. Therefore, this study aims to analyze father involvement in problematic behavior in children aged 3-4 years by considering the variables of father's socioeconomic status (SES) and child's gender. This study employs a quantitative descriptive approach through a multiple regression model coupled with survey. The selection of respondents was determined through quota sampling technique by considering the ease of access to data collection. With or without control over the SES of fathers and the gender of children, the engagement indicator contributes an impact to the problematic behavior in children, while accessibility does not. The problematic behavior in children is lower with the control over SES of fathers and the gender of children compared to the condition without control over these two variables. Of the two variables, only the father’s age indicator affects the problematic behavior in children. The results of this study can encourage fathers to get actively involved in raising their children in a way that is appropriate to the current cultural context and situation
Hypertensive patients: self-care experience in rural community
Get PDFHypertension is a chronic disease that often occurs in the world. Individual involvement in self-care is very important, in controlling blood pressure. The inability to carry out treatment will increase the risk and complications. The aim study is to explore the experiences and behavior of self-management and self-care of hypertension patients. The study is qualitative research with a phenomenological approach. The technique for taking participants was a purposive sampling of ten hypertensive patients. Data was collected using semi-structured interviews and then analyzed thematically based on the methodological framework of constructivist basic theory. Participant statements describing patient experiences in self-care include six themes, namely the cause of recurrences, emotional response, social support, self-care behavior, barriers to self-care, access to health facilities. The support factors of social support from family, health workers, and affordability of health services greatly influence self-care. An adequate support system, especially from nurses, is needed by patients because it will increase active participation so that patients will try to improve their care and skills in self-care
Stress, stressors, and stress management practices among public-school teachers
Get PDFStress manifests differently among individuals in various circumstances, stemming from multiple sources. Teachers, in particular, encounter many stressors from personal and work-related domains. This study examines the stress levels of elementary, junior high school, and senior high school public school teachers within Congressional District IV of the Division Office of Nueva Ecija, focusing on everyday life stressors. Additionally, it investigates the stress management practices they employ for coping. The personal metrics of these teachers were analyzed to ascertain their significant relationship with stress levels. Data were randomly collected from 273 respondents through a questionnaire developed by Villamayor. The study unveils that public-school teacher experience slight stress levels and utilize diverse stress management techniques to tackle these stressors. However, the personal metrics of respondents were found to have an insignificant relationship with their stress levels. Nevertheless, the findings of this study pave the way for developing a comprehensive stress management plan to assist public school teachers
Addressing the challenges of overweight and obesity: strategies for promoting a healthier future
Get PDFThe prevalence of overweight and obesity among over 1 billion people worldwide constitutes a major public health concern. There is an increased risk for the onset of noncommunicable diseases such as type 2 diabetes, cardiovascular diseases, and various types of cancer, while productivity and life quality are diminished. The social, environmental, and behavioral influences on obesity and overweight can be mitigated through targeted interventions, as these conditions are largely avoidable. This study explores the latest findings on the causes, consequences, and remedies for overweight and obesity, with a global perspective. Additionally, it outlines several effective measures and strategies that have been put into place or are being considered in various contexts, including financial constraints, marketing limits, primary healthcare options, and school-based initiatives. To change the obesity epidemic and promote healthy eating and active living for everyone, the research calls for immediate action and a useful strategy that promotes healthy eating and diet, increased physical exercise, and modifications to environmental elements
Enhancing self-care adherence in tuberculosis patients through family support: a systematic review
Get PDFTuberculosis (TB) is a persistent and widespread chronic disease, posing a significant global health challenge and ranking as a leading cause of mortality worldwide. Indonesia, in particular, bears the fourth-highest TB burden globally, especially within the South-East Asia (SEA) region. Alarmingly, TB incidence rates increased by 13% from 2020 to 2021. This research utilized a systematic review methodology, sourcing data from four reputable English databases: PubMed, Google Scholar, OpenAlex, and Dimensions. Both quantitative and qualitative studies published in the last five years (2019-2023) were included. A comprehensive search strategy across the specified databases yielded a total of 1,201 articles. These articles underwent meticulous screening, resulting in six articles being deemed relevant for inclusion in the review. The inclusion criteria focused on studies examining the association between family support and self-care adherence among TB patients. The systematic review identified and analyzed these six pertinent articles, highlighting the pivotal role of family support in influencing TB patients’ adherence to self-care during treatment. Enhanced family support was found to correlate positively with improved adherence levels among TB sufferers. In summary, this literature review underscores the critical importance of family support in enhancing self-care adherence for individuals undergoing tuberculosis treatment. The positive correlation between robust family support and improved adherence levels emphasizes the influential role of the family unit in the overall well-being and treatment outcomes of TB patients
Demographic determinants of patronage of medicine hawkers by commercial vehicle passengers in Ghana
Get PDFMedicine hawking is one of the major public health problems of the global south. This present study examined the demographic determinants of patronage of the services of medicine hawkers among commercial vehicle passengers in Kumasi, Ghana. A cross-sectional study was carried out from February 2022 to March 2022 at major bus terminals in Kumasi. Data were descriptively and inferentially analysed. The survey revealed that 55% of the respondents had bought medicines from medicine hawkers before. There was a significant relationship between having bought from a medicine hawker before and the intention to buy from them again in the future. Also, age, religion and education contributed significantly to patronising the services of medicine hawkers. We recommend that government intensifies its public health education on the implications of seeking health care services from these medicine hawkers