Bezmialem Vakıf Üniversitesi Kurumsal Akademik Arşiv
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Kırmızı Kantoronun Etanolik Ekstresi ve İnfuzyonununFitokimyasal Özelliklerinin Karşılaştırılması ve Mide Kanseri Üzerindeki Anti-Kanser Etkisinin Değerlendirilmesi
No full textOkul Çağı Çocuklarının Sağlık Problemleri: Okul Sağlığı Hemşireliği Perspektifinden Bir Devlet Okulu Örneği
No full textKey stone plasty and asymmetric hump resection in crooked nose deformity
No full text© 2022 Elsevier Inc.Objective: The aim of this study is to propose a new approach in crooked nose deformity with key-stone plasty and asymmetric hump resection. Method: Twelve patients with crooked nose deformities were operated using the open rhinoplasty technique. Our method, unlike other methods, has two different steps. Following asymmetric hump resection, cartilaginous and osseous septum were cut separated at the key stone area or more caudally and fix the septum with sutures again by allowing them to slide over each other in a way that directs the septum to the midline. If there is an inability to reveal the septum, we apply a longer spreader graft to the cartilage septum side. Results: The mean ages were 27.4 years. The mean follow-up time of the patients was 19.1 months. No complications were observed due to this technique. This technique was effective in the treatment of all our patients with crooked nose deformities. Conclusion: A novel surgical approach with key-stone plasty and asymmetric hump resection method was proposed in crooked nose deformity with a video animation
Comparison of Cytokine Hemadsorption as an Immunomodulator Therapy in COVID-19 Patients with and without Bacterial Sepsis
No full text© 2022 Verlag Klinisches Labor GmbH. All rights reserved.Background: In this retrospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in COVID-19 ICU patients with or without sepsis. Methods: The levels of PCT, CRP, and ferritin were determined as indicators of infection/sepsis; the levels of interleukins (IL-6, IL-8 and IL-10, and TNF-α) were determined as indicators of cytokine storm were compared. APACHE score, SOFA score, and mortality rates were compared for the progression of the disease in 23 COVID-19 patients. Results: The therapy was generally successful in reducing the levels of IL-6, IL-8, IL-10, and TNF-α but the levels measured after the procedure did not differ among the patients with or without sepsis, suggesting that the presence of sepsis did not affect the efficacy and function of the cytokine hemadsorption procedure in COVID-19 patients. All parameters were reduced after the procedure except the levels of PCT and ferritin and mortality rates of patients diagnosed with sepsis. The level of PCT was significantly higher in these patients compared with the patients without sepsis while the ferritin and mortality did not show any significant difference between the two groups, suggesting that the cytokine hemadsorption may be safe in the treatment of critical COVID-19 patients. Conclusions: As a result, the progression of sepsis in COVID-19 may be avoided with cytokine hemadsorption applied as an immunomodulator therapy. However, this therapy should be further explored and validated prior to its introduction to everyday clinical practice when the epidemic conditions end
Atopic dermatitis diagnosis and treatment consensus report
No full textAtopik dermatit (AD) kronik, kaşıntılı ve tekrarlayan enflamatuvar bir deri hastalığıdır. Sık görülmesi nedeni ile çocukluk çağı hastalığı olarak bilinen AD, erişkinlerde de önemli bir sağlık problemi olarak karşımıza çıkmaktadır. Her geçen yıl özellikle gelişmiş ülkelerde görülme sıklığı artan AD, yaşla değişen heterojen bir kliniğe sahiptir ve farklı şiddette seyretmektedir. Tedavi, hastaların ihtiyacı belirlenerek topikal veya sistemik ajanlarla sürdürülür. Özellikle son yıllarda patogenezden sorumlu moleküllerin tanımlanması kişiye özel tedavilerin geliştirilmesine olanak tanımıştır. Son yıllarda AD’nin hem hastalık hem de ekonomik yükünün daha iyi anlaşılması ile tanı, tedavi ve yaşam kalitesine ilişkin çalışmalar hız kazanmıştır. Çeşitli ülkelerde olduğu gibi ülkemizde de tanı ve tedavi yaklaşımları içeren kılavuzlar ve uzlaşı raporları yayınlanmaya başlamıştır. Yaşadığımız hızlı bilgi paylaşımı çağında, tüm bilgilerin sık sık yenilenmesine ve daha yararlı hale getirilmesine ihtiyaç vardır. Bu amaçla, Dermatoimmünoloji ve Alerji Derneği öncülüğünde Kozmetoloji ve Dermatoloji Akademisi Derneği, Kayseri Deri ve Zührevi Hastalıkları Derneği ve Manisa Deri ve Zührevi Hastalıklar Derneği’nin katkıları ve AD tanı ve tedavisinde deneyimli öğretim üyelerinin katılımı ile güncel bir uzlaşı kılavuzu hazırlanması planlanmıştır. Öncelikle Aralık 2020’de konu başlıkları ve yazarlar belirlenmiş ve 1980-2021 yılları arasında yayımlanan tüm Medline verileri, güncel AD tanı ve tedavi kılavuzları, meta-analitik çalışmalar ve uzman görüş ve deneyimleri doğrultusunda bölümler yazılmıştır. Tüm yazarların katılımıyla Mart 2021’de gerçekleştirilen toplantıda literatür verileri ve bölüm taslakları değerlendirilmiş, tartışılmış ve elektronik posta yazışmaları ile son şekli verilerek uzlaşı raporu olarak sunulmuştu
Bolton Analizi: Invisalign Sistem ile Dijital ve Konvansiyonel Metodun Karşılaştırılması
No full textReal-life analysis of treatment approaches and the role of inflammatory markers on survival in patients with advanced biliary tract cancer
No full text© 2022 Informa UK Limited, trading as Taylor & Francis Group.Objectives: Advanced-stage biliary tract cancers (BTC) are rare malignancies with poor prognosis. There are few prospective trials, but several retrospective studies regarding treatment options. In this study, we aimed to investigate the role of systemic inflammatory parameters (SIP) and other possible independent factors that may affect survival and treatment approaches and to determine the benefit of later-line treatments in these patients. Methods: A total of 284 patients, initially diagnosed with advanced stage or progressed after curative treatment of BTC, from different oncology centers in Turkey were included in this retrospective study. The prognostic significance of clinicopathological factors, SIPs and treatment options was analyzed. Results: At a median follow-up of 13 months, the median progression-free survival (PFS) was 6.1 months (95% CI:5.51–6.82), and the median overall survival (OS) time was 16.8 months (95% CI: 13.9–19.6). Treatment choice (p <.001 HR:0.70 CI95% 0.55–0.9), performance status (p <.001 HR:2.74 CI 95% 2.12–3.54) and neutrophil-to-lymphocyte ratio (NLR) (p =.02 HR:1.38 CI 95% 1.03–1.84) were independent prognostic factors for PFS. For OS, the independent prognostic indicators were determined as The Eastern Cooperative Oncology Group Performance Status (ECOG PS) (p <.001 HR:1.78 CI 95% 1.5–2.3), Systemic Immune-inflammation Index (SII) (p <.001 HR:0.51 CI95% 0.36–0.73) and stage at diagnosis (p =.002 HR:1.79 CI 95% 1.24–2.59). Furthermore, second and third line treatments significantly prolonged OS in advanced BTC (p <.001 HR:0.55 CI 95% 0.38–0.79; p =.007 HR:0.51 CI95% 0.31–0.83, respectively). Conclusion: SII and NLR are useful prognostic factors and may be helpful in making treatment decisions. Additionally, second and later-line treatments in advanced BTC have a significant impact on survival under real-life conditions
