Bezmialem Vakıf Üniversitesi Kurumsal Akademik Arşiv
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ANTİ-IL-17 TEDAVİSİNE BAĞLI FASYAL PALSİ VE YENİ BAŞLANGIÇ ÜLSERATİF KOLİT: PSORİAZİSLİ İKİ OLGU
No full textGİRİŞSecukinumab ve ixekizumab interlökin (IL) -17A\"yı seçici olarak nötralize eden monoklonal antikorlardır. (1) Bell paralizisinin etiyolojisi bilinmemektedir, gizli bir virüsün otoimmün reaksiyonu tetikleyebileceği ve fasiyal sinirde demiyelinizasyona neden olabileceği öne sürülmüştür. (2) IL-17 inhibisyonu ile inflamatuar bağırsak hastalığı (IBD) gelişim mekanizması belirsizdir. (3) Secukinumab tedavisinden sonra gelişen bir fasiyal paralizi ve ixekizumab tedavisinden sonra yeni başlayan bir ülseratif kolit olgusu sunuyoruz.OLGU 110 yıldır kronik plak psoriazisi olan secukinumab tedavisi alan 31 yaş erkek hastada 5 haftalık indüksiyon aşamasını tamamladıktan birkaç gün sonra, dilde ve başının arkasında uyuşma gelişti. Secukinumab tedavisi sonlandırıldı. Hastanın bilateral karotis ve vertebral renkli doppler ultrason muayenesi normaldi. İki gün sonra yüzün sol tarafında uyuşma ile başvurdu ve muayene sırasında sol tarafta azalmış yüz hareketleri tespit edildi. Elektromiyografide, sol fasiyal sinirin amplitüdü sağdan %22 daha düşüktü. Hastanın diğer nörolojik muayenesi normaldi. Diğer infeksiyöz ve otoimmün hastalıklar tespit edilmedi ve hastanın başka bir sistemik hastalığı yoktu. Şikayetleri üç hafta içinde metilprednizolon tedavisi ile geriledi. İki aylık takipte nüks gözlenmedi.OLGU 25 yıl boyunca kronik plak tip ve şiddetli tırnak psoriazisi olan ve ixekizumab tedavisi alan 27 yaşında bir erkek hastada tedavinin 28. haftasından itibaren tekrarlayan karın ağrısı ve kanlı ishal atakları gelişti. Kolonoskopi ve intestinal biyopsinin histopatolojik bulguları ülseratif kolit ile uyumluydu. Ixekizumab tedavisi sonlandırıldı. Kolit atakları metilprednizolon, azatiyoprin ve mesalazin tedavisi ile kontrol edildi. 8 aydır psoriazis için tedavi almayan hastanın psoriatik lezyonları ve tırnak bulguları yeniden ortaya çıktı ve hasta için anti-IL23 biyolojik tedavi planlanıyor. Hastalardan yayın izni için bilgilendirilmiş onam alındı.TARTIŞMAPsoriazis ve psoriatik artrit için secukinumab kullanan 306 hastanın çalışmasında, tek bir fasiyal paralizi olgusu bildirilmiştir. (1) Şimdiye kadar, ixekizumab tedavisinden sonra 3 IBD geliştiği bildirilen 5 vaka raporu ve secukinumab ile tedaviden sonra IBD geliştiren 3 vaka serisi olmuştur. (4) Anti-IL-17 ajanlarına başlamadan önce, hastalardan IBD açısından ayrıntılı bir kişisel ve aile öyküsü alınlamalıdır. Hastalar bu ilişki hakkında bilgilendirilmeli ve gastrointestinal semptomlarını izlemeleri istenmelidir.Anahtar Kelimeler: psoriazis, biyolojikler, anti IL17A, fasiyal paralizi, ülseratif koli
Dynapenic abdominal obesity and incident multimorbidity: findings from the English longitudinal study on ageing.
No full textEvaluation of Graduate Student And Supervisor Satisfaction at Bezmialem Vakıf University Institute Of Health Sciences
No full textExamination of nursing students individual values and perceptions of individualized care
No full textBackground/Aims: This study was conducted to determine the relationship between nursing students’ values and perceptions of individualized care (IC).Methods: This descriptive and correlational study consisted of all nursing students (n=205) studying at a foundation university in the 2021-2022 academic year, and 194 students selected by using the G* Power (3.1.9.2) program to determine the sample number were included in the study. Data were collected using a Student Information Form, the Portrait Values Questionnaire (PVQ), and the Individualized Care Scale-Nurse Version and analyzed on the SPSS 24 software package.Results: The mean age of the participants was 20.37±1.23, 91.8% were female and 28.3% were second-grade students. It was seen that the participants got a total score average of 4.97±0.43 from the PVQ, and the highest score from the sub-dimensions of universality, respectively. It was determined that the mean ICS-A total score was 4.33±0.74, and the decision-making scores of the patient were high (4.40±0.78). While a positive relationship was determined between the ICS-A sub- dimensions and the PVQ sub-dimensions, there was a statistically significant difference, especially in the mean scores of the PVQ and ICS-A sub-dimensions of the PVQ and ICS-A scales for girls compared to boys (p<0.05).Conclusion: It was found that participants got the highest scores on the universality sub-dimension of the PVQ. This value emphasizes equality and justice in the provision and maintenance of care. Fair and equitable distribution of resources to all individuals is the basic principle in individualized care. These results are important as they show that nursing students, the nurses of the future, can provide individualized nursing care.Keywords: Individual values, Individualized nursing care, Nursing studen
NORMAL İŞİTMEYE SAHİP BİREYLERDE EFFERENT VE AFFERENT İŞİTSEL YOLAK ARASINDAKİ İLİŞKİNİN DEĞERLENDİRİLMESİ
No full textGiriş ve Amaç: İnsan işitme sistemi; kokleadan işitsel kortekse kadar bilgi taşıyan Afferent ve Efferent yollardan oluşmaktadır. Efferent Olivokoklear sistem Superior Olivari Kompleksten (SOC) köken alan ve kokleaya uzanan iki alt sistemden oluşur. Otoakustik Emisyonla Kontralateral Supresyon testi ise kokleadan gelen uyaranlar sonucu oluşan medial olivary kompleks refleksi (MOK) ve efferent sistemi değerlendirir. Böylece, kontralateral supresyonlu OAE, efferent sisteminin koklear inervasyonlarının incelenmesine olanak sağlamaktadır. İşitsel Beyin Sapı Cevabı (ABR), işitme siniri ve beyin sapındaki elektriksel akımın senkronize aktivitesini kaydedip, afferent işitsel yolağı değerlendiren elektrofizyolojik bir test yöntemidir. Elde edilen dalgalar işitsel yolların farklı bölgelerinden elde edilen nöral aktivasyonu yansıtır. Çalışmanın amacı; Efferent işitsel yol ve Afferent işitsel yolakta ortak nokta olan SOC’in anatomik ve fizyolojik ilişkisini Transient Otoakustik Emisyonla Kontralateral Supresyon ve İşitsel Beyin Sapı Cevabı (ABR) test yöntemleri ile araştırmaktır. Yöntem: Çalışmaya 18-40 yaş aralığında, odyolojik ve immitansmetrik değerlendirme sonuçları normal sınırlarda olan sağlıklı bireyler dahil edilmiştir. Katılımcılara Otoakustik Emisyonla Kontralateral Supresyon testi 60 dB SL geniş bant gürültü varlığında 75 ±4 dB peSPL’de lineer click uyaran ile kaydedilmiş olup en az üç frekansta 1 dB ve üzeri azalma supresyon varlığı olarak kabul edilmiştir. Supresyon elde edilen 26, elde edilmeyen 35 kulak çalışmaya dahil edilmiştir. ABR testinde 80 dB nHL şiddetinde Click uyaran ve 21.1 rate ile ölçüm yapılmıştır. Supresyon olan ve olmayan kulakların I, III ve V. Dalgaların amplitüd ve latans değerleri karşılaştırılmıştır.Bulgular: Otoakustik Emisyonla Kontralateral Supresyon testinde supresyon cevabı elde edilen ve edilmeyen kulaklarda I, III, V. dalga mutlak latansı, dalgalar arası latans ve dalga amplitüdü değerleri arasında anlamlı farklılık gözlenmemiştir (p>0.05). Sonuç: Supresyon cevabı elde edilen ve edilmeyen kulaklarda ABR sonuçlarında farklılık gözlenmemesi; Otoakustik Emisyonla Kontralateral Supresyon testi ile yapılan değerlendirme sonucu belirlenen efferent sistemdeki olası bir bozukluğun ABR testinin değerlendirmiş olduğu afferent işitme sistemi üzerindeki bir patolojik durumla ilişkili olmadığını göstermiş olup, iki yolun birbiri üzerine bağımlı bir etkisi olmadığını düşündürmüştü
Effect of STAT3 status on RAS & RAF mutation in patients with metastatic colon carcinoma
No full textEmodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
No full textBackground: Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active role in wound healing, is a well-characterized large family of serine/threonine kinases and regulates processes such as proliferation, oncogenesis, differentiation, and inflammation in the cell. The aim of this study is to comparatively elucidate the mechanisms of action of emodin and aloe-emodin, which are potential agents in wound healing. Methods: The mechanism of the effects of emodin and aloe-emodin on cell viability and cell migration was examined using the human skin fibroblast (CCD-1079Sk) cell line. The gene expression levels of the MAP kinases (JNK, P38, ERK) in the skin fibroblast cells along with a molecular docking study analyzing their interaction potential were evaluated. Furthermore, the molecules’ effects on the lifespan of Caenorhabditis elegans were studied. Results: Emodin and aloe-emodin inhibited the ATP content of the cells in a concentration dependent manner and accelerated cell migration at the lower concentrations while inhibiting cell migration in the higher concentration treatment groups. The expressions of JNK and P38 were upregulated at the low concentrations and downregulated at the higher concentrations. The molecular docking studies of the molecules gave high docking scores indicating their interaction potential with JNK and P38. C. elegans lifespan under heat stress was observed longer after 75 µM emodin and was significantly reduced after 150 µM aloe-emodin treatment. Conclusion: Aloe-emodin was found to be more potent on cell viability, cell migration, gene expression levels of the MAP kinases in healthy fibroblastic skin cells, and on the lifespan of C. elegans. This study reveals the functional effects and the biological factors that interact in the wound healing process of emodin and aloe-emodin, and give a possible treatment alternative to shorten the duration of wound care
Standard Water Generating Vials for Lipophilic Compounds
No full textAmerican Chemical Society.The study of non-polar compounds in aqueous environments has always been challenging due to their poor solubility in aqueous media. The low affinity of non-polar compounds toward polar solutions facilitates their attachment to glassware, which results in unstable sample concentrations. To address this challenge, and to enable the preparation of a stable mixture of hydrophobic compounds in an aquatic environment, we introduce an in-vial standard water generating system consisting of a vial containing appropriate aqueous solution and a polydimethylsiloxane thin film spiked with target compounds. In this system, a solution with a stable analyte concentration is attained once equilibrium between the thin-film and aqueous solution has been achieved. The developed standard water system was studied using endocannabinoids and phospholipids as model hydrophobic compounds of biological importance, with results indicating that the concentration of hydrophobic compounds in water can remain stable over multiple days. The results also showed that analytes released from the thin film can compensate for analyte loss due to extractions with solid-phase microextraction fibers, thereby re-establishing equilibrium. Thus, the vial is suitable for the repeatable generation of non-polar standards for routine analysis and quality control. The results of this work show that the developed system is stable and reproducible and therefore appropriate for studies requiring the measurement of free concentrations and accurate quantification
Comparison of the burnout among medical residents before and during the pandemic
No full text© 2022 The AuthorsObjective: This study aims to compare the level of burnout syndrome in medical residents before and during the COVID-19 pandemic and identify potential risk factors. Methods: This cross-sectional study was conducted on medical residents from three different university hospitals in Turkey in March 2021, one year after the pandemic hit Turkey. Burnout is measured by the Maslach Burnout Inventory which assesses three dimensions of it: emotional exhaustion, depersonalization, and personal accomplishment. Collected data were combined and compared with data from a previous study which was held in the same hospitals in December 2019, three months before the pandemic. Results: 412 medical residents from three universities participated. The mean age was 27.8 ± 2.4 and half of them were female. Compared to pre-pandemic levels, no significant differences in emotional exhaustion (pre:19.0 ± 7.6 post:18.8 ± 7.8), depersonalization (pre:7.3 ± 4.3 post:7.2 ± 4.4), and personal accomplishment (pre:20.8 ± 5.1 post:21.1 ± 5) scores were observed one year after pandemic. Adjusting for confounders, multiple linear regression models indicated that who are female, are in surgical specialty, have vulnerable cohabitant, and have more night shifts faces higher emotional exhaustion. Depersonalisation is higher among who spent more years in residency, have more night shifts, or COVID-19 outpatient duty. Females and those who have vulnerable cohabitant has lower levels of Personal Achievement. Conclusion: This study does not support the hypothesis that pandemic increases the burnout levels. Yet it identifies a couple of pandemic related factors that are associated with burnout and confirming the association of several previously known factors