DR-NTU (Data) (Nanyang Technological University)
DR-NTU (Data) (Nanyang Technological University)Not a member yet
1955 research outputs found
Sort by
Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model
No full textMacrophages accumulate lipid droplets (LD) under stress and inflammatory conditions. Despite the presence of LD-loaded macrophages in many tissues, including the brain, their contribution to neurodegenerative disorders remains elusive. This study investigated the role of lipid metabolism in Alzheimer’s disease (AD) by assessing the contribution of LD-loaded brain macrophages, including microglia and border-associated macrophages (BAMs), in an AD mouse model. In particular, activated CD11c+ microglia, localized proximal to beta-amyloid (Aβ) plaques, had a pronounced lipid-associated gene signature and a higher LD load than other microglial subtypes. Having observed that elevated intracellular LD content correlated inversely with microglial phagocytic activities, we subsequently inhibited LD formation specifically in CX3CR1+ brain macrophages using an inducible transgenic mouse model. Reducing the lipid load of microglia and CX3CR1+ BAMs improved phagocytic and efferocytic capacities and significantly reduced Aβ deposition in the brain. Therefore, mitigating LD accumulation in microglia and BAMs provides new perspectives for the treatment of AD
Replication Data for: Fundamental scaling laws of water-window X-rays from free electron-driven van der Waals structures
No full textReplication Data for: Fundamental scaling laws of water-window X-rays from free electron-driven van der Waals structure
Replication Data for : Efficiency enhancement and doping type inversion in Cu₂CdSnS₄ solar cells by Ag substitution
No full textReplication Data for : Efficiency enhancement and doping type inversion in Cu₂CdSnS₄ solar cells by Ag substitutio
MMDetection3D
No full textMMDetection3D is an open source object detection toolbox based on PyTorch, towards the next-generation platform for general 3D detection. It is a part of the OpenMMLab project
Data and Codes for: Exploring earthquake kinematics and physics using high-frequency seismic waves
No full textThe material provides necessary codes and data to reproduce results in the theis, Exploring earthquake kinematics and physics using high-frequency seismic wave
Prism Figures
No full textThis dataset contains the experimental data for characterization of impedance based bioanalysis of cell quality attributes (biomass, viability, differentiation) in 3D cell culture systems (microcarriers, hydrogel microparticles, cellular aggregates). The experimental data showing the sorting based on impedance signatures for cell yield and quality improvement are also included
Performative Documentary Filmmaking
No full textThis research provides an in-depth survey of the aesthetic significance of the performative documentary film. Unlike conventional documentary approaches, which prioritize facts and straightforward reporting, the performative documentary engages with reality through dynamic "play." This concept of play encompasses multiple meanings, including theatrical performance, improvisation, and the linguistic idea of the speech act. Play Life refers to the performativity embedded within the documentary form, where reality is reimagined and interpreted through creative acts
Co-incidence of BA.1 and BA.2 at the start of Singapore's Omicron wave revealed by Community and University Campus wastewater surveillance
No full textWastewater surveillance (WWS) has been globally recognised to be a useful tool in quantifying SARS-CoV-2 RNA at the community and residential levels without biases associated with case-reporting. The emergence of variants of concern (VOCs) have given rise to an unprecedented number of infections even though populations are increasingly vaccinated. This is because VOCs have been reported to possess higher transmissibility and can evade host immune responses. Results in this study corroborate clinical incidence of the Omicron lineages in Singapore and indicate minimal silent circulation prior to January 2022. The subsequent simultaneous spread of both variant lineages followed strategic relaxation of safe management measures upon meeting nationwide vaccination goals
Related data for: Evaluating a polymicrobial biofilm model for structural components by co-culturing Komagataeibacter hansenii produced bacterial cellulose with Pseudomonas aeruginosa PAO1
No full textRaw data for biofilms
Related Data for: Performance Analysis of Optical Reflecting Surface-Assisted Optical Space Shift Keying-Based MIMO-FSO System
No full textThis paper proposes an optical reflecting surface (ORS)-assisted free space optics (FSO) communication system based on the optical space shift keying (OSSK) technique. Closed-form expressions for the probability density function (PDF) and moment generating function (MGF) of the system's signal-to-noise ratio (SNR) are derived using the Malaga turbulence model. Upper bounds for the average bit error rate (BER) and lower bounds for ergodic capacity are also obtained, with diversity gain calculated through asymptotic BER.
The given codes will produce Bit error rate and ergodic capacity plots for the above pape