LNH-Journals
Not a member yet
521 research outputs found
Sort by
Association Between High Triglyceride-Glucose Index and Diabetic Nephropathy in Asian Populations
Full text linkAssociation of high Triglyceride-Glucose (TyG) index with diabetic nephropathy in Asian populations, is gathering attention these days as early predictor of kidney damage. This letter expands the findings of the recently published meta-analysis titled, "Association Between High Triglyceride-Glucose Index and Diabetic Nephropathy in Asian Populations: A Meta-Analysis Perspective", in The Egyptian Journal of Internal Medicine. Here we briefly explain that since TyG, a marker of triglyceride and glucose levels, is increasingly identified as an indicator of insulin resistance, and thereby has a strong association with augmenting diabetic nephropathy risks. Recent studies including a meta-analysis from Zhang et al. (2020) show that the TyG index could be a non-invasive and cost-effective biomarker for early detection, given the silent progression of early nephropathy. We also examine the very specific genetic and dietary factors within Asian populations that further increase their predisposition to insulin resistance and nephropathy. More large-scale prospective studies should therefore be encouraged to evaluate the time relationship between TyG index and nephropathy as well as its value application at various stages of kidney disease. The TyG index certainly has much to offer in improving early diagnosis and intervention for diabetic nephropathy within high-risk populations. Thus, the results will be reflected in better outcomes
Anxiety, Depression, and Coping Strategies among Parents of Children with Autism in Abu Dhabi
Full text linkNot Availabl
Prevalence and Factors Associated with Obesity among High School Children of District Shaheed Benazirabad
Full text linkNot Availabl
Challenges and Adverse Outcomes of Teenage Parenting: A Narrative Review
Full text linkTeenage pregnancy remains a major global public health concern, with significant health and socioeconomic consequences for both young mothers and their children. Young parents face challenges across multiple domains—societal, financial, medical, educational, and employment—that compound their difficulties. This narrative review addresses key gaps in understanding the long-term impacts of early motherhood, focusing on how young women balance childcare with personal aspirations and the resulting implications for their health, education, and employment. Research shows that children of young mothers are at higher risk of delinquency, depression, early parenthood, and school dropout. Adolescent mothers often experience fatigue, social isolation, and difficulty managing academic and job responsibilities. Young fathers, frequently from disadvantaged backgrounds, face high rates of unemployment and criminal involvement. Additionally, relationships among young parents are often unstable, with only half remaining together one year after childbirth. This review highlights the need for targeted prevention and support programs for young families, particularly mothers, to inform effective policy and intervention strategies
Chronic Myeloid Leukemia with an Atypical b2a3 (e13a3) BCR::ABL1 Transcript: A Case Report
Full text linkChronic Myeloid leukemia (CML) is a treatable disorder that is associated with an acquired cytogenetic abnormality resulting in reciprocal translocation between the long arm of chromosome 9 and 22, which generates the BCR::ABL1oncoprotein. In Classic CML, two transcript variants are seen, b2a2 & b3a2. This case study features a 23-year-old Asian female diagnosed with CML exhibiting the rare variant b2a3 (e13a3), which encodes the p203 protein. The diagnosis of this case remained consistent with CML after receiving the patient's complete medical history, peripheral smear findings, bone marrow biopsy, and Philadelphia-positive result on cytogenetics, but the identification of an unknown band on gel other than p210 by real-time PCR did not favor the results. Further molecular analysis was carried out by using the Seeplex BCR::ABL1kit by PCR, on which this infrequent variant b2a3 was detected. This unusual variant is significant because it lacks the a2 exon, which partially encodes the SH3 domain responsible for regulating the STAT pathway. Globally, as the number of these rare cases is escalating, it demands a need for quantitative analysis to measure the disease prognosis and outcome
Frequency and Associated Factors of Dry Eye Among Glaucoma Patients Attending Tertiary Eye Hospital, Karachi
Full text linkNot Availabl
Impact of a Community-Based Intervention on Maternal and Neonatal Health in Flood-Affected Districts of Sindh, Pakistan: A Retrospective Pre- and Post-Intervention Study
Full text linkNot Availabl
Pathological Response Rate with Neoadjuvant Treatment with or without Pertuzumab in Patients with Stage II and III HER2-Positive Breast Cancer: A Single-Center Study
Full text linkNot Availabl
