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Spindle Cell Sarcoma on a Rare Site
Get PDFSpindle cell sarcoma is a rare tumor. This study reports a case of male patient with large pelvic mass. Examination and MRI confirmed the presence of exophytic mass. Resection of the mass was done. Histopathology showed spindle cell sarcoma
Comparative Study of 3 Different Brands of Glimperide
Get PDFGlimepiride is an antidiabetic agent used for lowering blood glucose levels. It induces the activity of peroxisome proliferator-activated receptor-gamma (PPAR gamma). It lowers blood glucose levels by binding to ATP-sensitive potassium channel receptors on the surface of pancreatic cells. The purpose of this study was to perform a comparative analysis of different physicochemical parameters (weight variation, hardness, thickness, friability, disintegration time, and dissolution time) of 3 different commercially available brands of glimepiride in the market. Statistical analysis revealed minor variations in the results. It was found that GETRYL showed the highest % dissolution among all the 3 brands whereas AMARYL took the least time to disintegrate. According to the results of the friability test, Diabold shows the highest stability in the friabilator. However, all 3 brands complied with the official pharmacopoeial limits. The quality of the drug largely influences its therapeutic activity. Hence, owing to the similar physicochemical profile, all the 3 brands can be interchangeably used
Prevalence of Pulmonary Tuberculosis among the Elderly- An Observation from a Rural Province of Thailand
Get PDFTuberculosis is an important clinical problem worldwide in many countries in Asia. A high incidence of tuberculosis exists in Indochina. Some specific populations including the elderly, have a higher probability of getting infected. The aim of this study was to determine the prevalence of tuberculosis among elderly population in rural district of Thailand, a tropical country in Indochina. According to the study, all 22,033 Thai elderly in this area were screened for tuberculosis. Of these cases, there were 39 infected cases (prevalence rate = 0.18%, 95% CI: 0.13% - 0.24%). In conclusion, tuberculosis is common among Thai elderly in this setting
Tele-health during Covid-19 Pandemic Lockdown in Pakistan - Experience of a Tertiary Care Hospital
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Evaluation of Cardiovascular Responses Using Cold Presser Test as a Possible Future Risk for Hypertension in Normotensive Healthy Young Subjects
Get PDFHypertension is a major public health challenge and an emerging factor for cardiovascular co-morbidities globally. Exaggerated cardiovascular response to stress has been possible evidence to be a future risk for the development of hypertension and cardiac disorders. This cross-sectional study was done to evaluate cardiovascular responses using a cold presser test as a possible future risk for hypertension in normotensive healthy young students. A total of 70 healthy medical students of first-year MBBS, of both genders with ages between 18-22 years were included in the study. About 68.6% of students were found to be normal and were included in the normal response group. They showed no significant increase in heart rate, systolic or diastolic blood pressure. The participants showing a rise of systolic BP ≥25 mmHg or diastolic BP ≥20 mmHg were included in the hyper-response group. The overall mean age group in both male and female students was 20±1.56 years. In conclusion, 31.4% of normotensive medical students showed exaggerated cardiovascular responses to cold pressor tests which can be a possible risk for hypertension in these young normotensive individuals. Early interventions in their lifestyle modification can prevent them from developing hypertension in the future
Recently Described Polyphenotypic Tumor: Uterine Tumor Resembling Ovarian Sex Cord Tumor (Utrosct), A Case Report
Get PDFUterine tumors resembling ovarian sex cord-like tumors (UTROST) are rarely encountered mesenchymal type of uterine tumors with unknown etiology. They usually exhibit nodular and polypoidal growth pattern and are commonly observed in the 4th to 6th decade. UTROSCTs behave benignly however limited data is available to date. Recently these tumors show a novel recurrent gene fusion involving the NCOA2/3 gene. Hysterectomy with bilateral salpingo-oophorectomy or tumor resection is a treatment option. We report a case of a 35 years old female who presented with dysfunctional uterine bleeding. The diagnosis was initially rendered on endometrial curetting’s and further confirmed on the hysterectomy specimen after application of immunohistochemistry