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Correlation between Standardized Uptake Values and Ki-67 in Different Cancers
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Correlation between Standardized Uptake Values and Ki-67 on PET Scan in Different Cancers
Introduction:
Cancer is a leading cause of morbidity and mortality worldwide. Accurate assessment of tumor aggressiveness is crucial for prognosis and treatment planning. Two widely used markers are Ki-67, a nuclear protein indicating cellular proliferation, and Standardized Uptake Value (SUV) derived from FDG-PET scans, which reflects tumor metabolic activity. This study aims to evaluate the correlation between SUV and Ki-67 across different cancers to determine whether SUV can serve as a non-invasive surrogate marker for tumor proliferation.
Objectives:
• To determine the correlation between SUV on PET scan and Ki-67 expression in different types of cancers.
• To assess whether SUV can predict tumor proliferative index (Ki-67).
• To explore the influence of demographic variables such as age and gender on SUV and Ki-67 correlation.
Methodology:
A cross-sectional study was conducted at Jinnah Postgraduate Medical Center, Karachi, from [Oct 2024 to march 2025]. A total of 94 patients with histologically confirmed malignancies who underwent FDG-PET scans and Ki-67 immunohistochemistry were included. Patients who had received prior chemotherapy or radiotherapy were excluded. Data on age, gender, SUV (max), and Ki-67 index were collected. Correlation and regression analyses were performed using SPSS version 25.
Results:
A statistically significant positive correlation was found between SUV and Ki-67 index (p < 0.05), with the strongest association observed in breast Cancer, lung cancer, B Cell lymphoma. Multivariate regression revealed that Ki-67 and age significantly predicted SUV values. Female patients, particularly those with breast cancer, showed a stronger SUV–Ki-67 correlation compared to males.
Conclusion:
SUV on PET scan shows a significant correlation with Ki-67 index, suggesting its potential as a non-invasive marker of tumor proliferation. Incorporating SUV into clinica
Frequency of Hyponatremia in Children with Bronchiolitis from 1 Month up to 2 Years in a Tertiary Care Hospital
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Determination of Skin Cancer Types with Deep Learning Methods and Patient Management
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Prevalence of Metabolic Syndrome in Pre and Postmenopausal Women in Mogadishu-A Cross-Sectional Study
Full text linkThis study aims to assess the prevalence of metabolic syndrome in women living in Mogadishu, Somalia, pre and post-menopause. A cross-sectional study was conducted on a sample of 138 women who were receiving medical care in internal medicine clinics in three hospitals located in Mogadishu, Somalia. The sample consisted of women who were both pre- and postmenopausal. Participants were assessed for metabolic syndrome according to the criteria established by the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III). The occurrence of metabolic syndrome in premenopausal women was 34% (47 out of 138), but in postmenopausal women, it was 100% (91 out of 91) (P<0.001). Postmenopausal women diagnosed with metabolic syndrome exhibited a notable rise in waist circumference, fasting blood glucose, blood pressure, and lipid levels.
Conversely, their levels of HDL cholesterol experienced a significant reduction (P<0.001). Metabolic syndrome is often seen among women in Mogadishu, Somalia, both before and after menopause. Nevertheless, there is an increased probability of developing this condition in women who have reached menopause. Additional investigation is necessary to elucidate the underlying mechanisms that lead to the increased prevalence of metabolic syndrome in this particular population
Glycogen Storage Disease IXc with PHKG2 Mutation and Psoriatic-Like Lesions: A Rare Case
Full text linkGlycogen storage diseases (GSDs) cause glycogen metabolism disorders in the human body and are genetically determined metabolic illnesses. Due to sufficient glycogen or its diseased states, glycogen is accumulated in the human body tissues due to the enzymatic defect during glycogenolysis/glycogenesis. Pathogenic transformations in the PHKG2 are related to a very unusual ailment called GSD-IXc distinguished by serious complications of the liver. Here, a case report of a patient is presented with no clinical history given but with obvious hepatomegaly and fatty infiltrations along with psoriasis-like lesions. Genetic testing revealed c.431T>C variant which is expected to cause substitution in an amino acid p.Leu144Pro. The results upturn the gene spectrum and accord with elucidating the clinical presentation of PHKG2 transformations. Special attention to this case should be given due to the sturdy link between lactose dehydrogenase-A deficiency (GSD type XI) that validates several skin wounds associated with the ailment e.g. pustular psoriasis-like lesions, desquamating erythematous-squamous lesions, etc
Ethics and Patient Safety in Home Healthcare: Upholding Quality and Standards
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Thyroid Lymphoma: A Rare but Aggressive Disorder
Full text linkThyroid lymphoma is an uncommon insistent malignancy, often presenting unique diagnostic and therapeutic challenges in clinical practice. This case report describes a 49-year-old male with a previously unremarkable medical history, who presented in the surgical OPD with a progressively enlarging neck mass for approximately four to six months. Initially, there was an associated fever, which soon subsided. Upon clinical examination, a diffusely enlarged thyroid was observed with the enlargement predominantly involving the right lobe. Additionally, imaging revealed a 7x5 cm heterogeneous nodule. While the initial fine-needle aspiration cytology (FNAC) was inconclusive, subsequent cytology detected atypical cells. Due to the increasing discomfort, the patient opted for a right lobectomy but suffered intraoperative complications leading to his demise. Histopathological evaluation of the excised gland confirmed a diagnosis of diffuse large B-cell lymphoma, characterized by sheets of atypical lymphoid cells and extensive necrosis. This case highlights the aggressive nature of thyroid lymphoma and the need for timely diagnosis and management
