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NCES Trends in International Mathematics and Science Study (TIMSS)
No full textTIMSS Advanced available for 1995 and 2015. Grade
4 and 8 SAS Control files, Codebooks available.
eTIMSS and bridgeTIMSS available for 201
Myo10 and Me
No full textUsing the power of comics, I have illustrated why I am studying Myosin 10, a protein that helps cells form finger-like protrusions. In these thin protrusions crowded with many molecules, Myosin 10 needs to work with different partners to carry out important cellular functions like movement and growth. How does Myosin 10 do this? It is first important to understand that proteins sometimes have a defined shape, and other times it can be floppy like a noodle. Most proteins contain both structure and undefined noodle-behavior. In my project, I observe that Myosin 10 and its partners partially change their shapes when they form interactions with one another, such as transitioning from a noodle into a defined structure once it contacts its partner
Academic Copaganda
Get PDFHow does social science insulate police from social movements’ demand for abolition? We explore this through a content analysis of policing social science research funded by Arnold Ventures, the MacArthur Foundation, and the National Institute of Justice published from 2011 to 2022 (N = 143 studies). Our mixed method content analysis revealed what we call “Academic Copaganda,” or studies contesting social movement claims by authors (1) masking their conflicts of interest, or (2) espousing police epistemology. Although Academic Copaganda comprised 20% of studies in the sample, they received most media mentions after the 2020 police killing of George Floyd. We conclude by discussing our contributions to legal scholarship on police legitimacy and empirical critical race theory
Actions of nilpotent groups on nilpotent groups
Get PDFFor finite nilpotent groups J and N, suppose J acts on N via automorphisms. We exhibit a decomposition of the first cohomology set in terms of the first cohomologies of the Sylow p-subgroups of J that mirrors the primary decomposition of H1(J, N) for abelian N. We then show that if N ⋊ J acts on some non-empty set Ω, where the action of N is transitive and for each prime p a Sylowp-subgroup of J fixes an element of Ω, then J fixes an element of Ω
Ilkhanid Sources in the Mamluk Sultanate: The Use of Juvaynī’s Tārīkh-i Jahāngushā by al-ʿUmarī and Ibn Kathīr
Get PDFIn the Mamluk Sultanate there was clearly not only an elaborate interest in the Mongols, but an active exchange of ideas and information between the sultanate and Mongol territories, especially the Ilkhanate. Although many of these exchanges appear to have been through oral informants, it is not always exactly clear how information reached the sultanate. Two Mamluk-era historians—al-ʿUmarī and Ibn Kathīr—appear to have independently used the same (or very similar) version(s) of Juvaynī’s Tārīkh-i Jahāngushā, which contained some conspicuous differences in both content and structure compared to the Persian text as we have it today. From a Mamlukist’s point of view, this is relevant first because it allows for a thorough comparison of al-ʿUmarī’s and Ibn Kathīr’s respective utilizations of the text. Such a comparison reveals their differing intentions in their representation of the Yasa—that vague “something” that was clearly important to the Mongols and in which many Mamluk-era authors took an interest
The King of the Tatar in Jerusalem: A Note in Hebrew on the Mongol Advance South
Get PDFAn examination of Mongol troop movements using Mamluk roads in Gaza, using a fourteenth century Hebrew text, which is here translated into English
Hair Removal and Hair Dyeing: Cosmetics in the Medieval Middle East, between Pharmacy and Hadith
Get PDFIn the Islamic world, both men and women are required to deal with their hair in specific ways, such as covering the head or wearing a beard. This paper will not be dealing with these but with two topics that appear not only in religious literature but also in pharmacological writings: the removal of body hair and the dyeing of the hair of one’s head (including the beard) using hadith collections and pharmacopoeia. Previous studies of hair and hair care in Islamic societies have largely focused on legal texts; the purpose of this paper is to add the recipes for hair dyes and depilatory pastes to the conversation, asking: how did people actually color or remove hair? The pharmacological material at my disposal is limited; given the later texts’ extensive quotation of earlier ones, I will be moving back and forth between Abbasid Baghdad and Mamluk Cairo in my citation of hadith and recipes alike. The topic of dyeing the hair of the head and beards seems to have not yet received an actual academic discussion, at least not a historicizing one
Center for Disease Control (CDC) National Environmental Public Health Tracking Network Data
No full textAll datasets needed to run the CDC's National Environmental Public Health Tracking Network Dat
N-SUMHSS Opioid and Mental Health Facilities
No full textThe National Substance Use and Mental Health Services Survey (N-SUMHSS) is an annual, voluntary survey conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA). It aims to collect comprehensive data on substance use and mental health treatment facilities across the United States, including U.S. territories and the District of Columbia. The survey provides a detailed "snapshot" of the services offered, facility characteristics, and client demographics as of a specific reference date. The dataset includes annual data from 2021 through 2023, with each year's data accompanied by a codebook and questionnaire detailing the variables and methodology used
Elucidating the Role of ALKBH1 in Arsenic-Induced Skin Tumorigenesis
No full textSkin cancer is the most common form of cancer in the U.S and is commonly driven by exposure to environmental factors. A major environmental risk factor for skin cancer development is through chronic arsenic exposure. Arsenic is a metalloid that is found naturally within the Earth’s crust. Arsenic can leach into neighboring bodies of water and lead to their contamination. As such, the major mechanism by which people are exposed to arsenic is through ingestion of contaminated drinking water. However, the mechanisms of that underlie arsenic tumorigenicity remain incompletely understood. With the threat of climate change, overirrigation, and unpredictable weather patterns, arsenic levels may continue to rise and pose a sizable public health risk. Increasing our understanding of the mechanisms that underlie arsenic tumorigenicity remains paramount. Here, I present my doctoral research, which unveils novel insights into arsenic-induced skin tumorigenicity, arsenic biochemistry, and RNA epitranscriptomics. Here, we establish that ALKBH1 is an oncogene that promotes arsenic-induced skin cancer. Using a model of in vitro arsenic-induced skin transformation, we find that ALKBH1 protein levels are up-regulated in arsenic-transformed keratinocytes, as compared to normal keratinocytes, and that ALKBH1 is up-regulated at early stages in the arsenic-induced transformation process. We identify that arsenic promotes ALKBH1 protein stability through complex mechanisms, including regulation by the proteasome and autophagy. Furthermore, we establish that knockdown of ALKBH1 in arsenic-transformed keratinocytes leads to decreased tumorigenicity, as evidenced by decreased cell proliferation, colony formation, growth in soft agar, and tumor growth in nude mice. Our findings establish that ALKBH1 is highly oncogenic and suggest that ALKBH1 may be a novel therapeutic target for the treatment of arsenic-induced skin cancer, as well as other ALKBH1-driven cancers. We also identify that arsenic can bind to the human ALKBH1 protein at cysteine residues. Our findings highlight that the binding between ALKBH1 and arsenic may be critical for ALKBH1’s oncogenic function and may also be required in regulating the substrate specificity of ALKBH1. Overall, our findings unveil a novel and complex interaction between arsenic and ALKBH1. Furthermore, we establish that ALKBH1, a demethylase with broad substrate specificity, may be induced to demethylate N6-methyladenosine (m6A) in mRNA in the presence of arsenic. We find that knockdown of ALKBH1 in arsenic-transformed keratinocytes leads to increases in m6A in mRNA and does not affect the expression of other m6A modifiers. Using a cell-free system, we identified that this apparent change in substrate specificity is directly due to arsenic, which we hypothesize promotes a re-wiring of the ALKBH1 protein functionality. Mechanistically, we also identify NR2C2 as an m6A-dependent target of ALKBH1 that functions as a tumor suppressor and a promotes changes in global mTOR-mediated translation