OPEN Repository (ICM)
Not a member yet
24462 research outputs found
Sort by
Successful reversal of delayed spinal cord ischemia complicating thoracic endovascular aortic repair for type B aortic dissection with hemodynamic optimization and insertion of a lumbar spine drain: a case report.
Full text linkAortic dissection is caused by an intimal tear that results in high-pressure flow of blood between the layers of the aorta, creating true and false lumens. The more widely used Stanford system classifies aortic dissections into type A (involves the ascending aorta) or type B (all other dissections). Complicated type B aortic dissection requires urgent surgical or endovascular intervention. Spinal cord ischemia remains a devastating complication that could happen after both open and endovascular aortic repair. The following case is a 53-year-old man who underwent endovascular repair for complicated type B aortic dissection. His postoperative course was complicated by spinal cord ischemia (paraparesis) that presented on postoperative day 2. Spinal cord ischemia was successfully reversed by prompt recognition and treatment, including cerebrospinal fluid drainage and mean arterial blood pressure augmentation. This case discusses the evolving role of endovascular repair for thoracic aortic dissection, highlights the risk factors for spinal cord ischemia, and emphasizes the importance of close postoperative monitoring and prompt applications of protocols, including cerebrospinal fluid drainage, for early detection and possibly reversal of the devastating complication of spinal cord ischemia
Attenuation Analysis of Polymer Optic Fibres (POF) Manufactured with Different Materials
Full text linkAn overview of the attenuation analysis of producing polymer optical fibres (POF) with different cladding materials but same diameter is given. Based on a systematic literature review, the melt spinning method was applied in practice and different combinations of POF bobbins manufactured. The production methods are described in detail and their attenuation results discussed
Improving quality of life of completely edentulous patient with oral submucous fibrosis and infantile hemangioma
No full textEfficient Solution-Phase Synthesis of Sequence-Defined Oligourethanes with Precise Chirality Control
No full textNature relies on precisely defined macromolecules for complex biochemical processes with exceptional specificity and efficiency. To replicate these properties in synthetic systems, chemists have developed sequence-defined macromolecules—polymers with absolute control over monomer sequence and structure, enabling tailored functions. However, their exploration in material science remains limited due to the challenges of synthesis, which is often low-yielding and time-consuming. To address this, we designed and synthesized Fmoc-assisted stereo-controlled sequence-defined oligourethanes (SDOUs) in the solution phase. Our step-economical synthesis employs a two-step, one-pot strategy, eliminating intermediate purification and achieving an average yield of >85% per step. The optimized protocol, using six modified chiral monomers, enables precise stereochemical and sequence control. Thermal analysis revealed that stereochemistry significantly influences thermal transitions, including glass transition, crystallization, and melting behaviors. Tandem mass spectrometry provided in-depth sequencing analysis. We also demonstrated the post-synthetic modification of the SDOUs with dansyl chloride and explored their photophysical properties, such as solvatochromism and aggregation. Circular dichroism analysis highlighted their unique structural and conformational features. This approach establishes scalable, efficient synthetic routes for stereochemically controlled sequence-defined oligourethanes with diverse functional groups.UMO-2022/44/C/ST4/0006
In pursuit of cytotoxic triterpenoids. Functionalization of lupane, taraxastane, friedelane, and baccharane derivatives via oxidation with selenium reagents
No full textA series of triterpenoids of the lupane, taraxastane, friedelane and baccharane type were oxidized using selenium dioxide (SeO2) and benzeneseleninic anhydride (BSA) under various conditions. Depending on the reaction conditions, different reaction pathways were observed, including dehydrogenation, allylic oxidation, and 1,2-diketone formation. In this way, derivatives functionalized in the triterpene core (especially in rings A, D, and E), difficult to obtain by other methods, can be easily prepared. In some cases, rarely observed α-phenylseleno-ketones were isolated. An unexpected reaction involving the cleavage of the carbon-carbon double bond was observed in the presence of stoichiometric amounts of osmium tetroxide. Further transformations of selected intermediates facilitated the synthesis of new, functionally enriched derivatives. The key reaction pathways were investigated using density functional theory (DFT), focusing on bond length variations and transition states, revealing energetically favored pathways and critical transition structures, including covalent and noncovalent interactions. Solvent and isomerization equilibrium effects were proposed to explain the experimentally observed discrepancies. Cytotoxic activity of selected derivatives was investigated. Derivatives 4 and 38 showed strongest cytotoxicity in cancer cells and fibroblasts (IC50 2.6–26.4 μM); some compounds were selective for G-361 or HeLa cells. These results suggest that they may find application in pharmaceuticals.National Science Centre, Poland 2016/21/B/ST5/02141;
Grant Agency of the Czech Republic 23-05474S
Red-Light-Induced Cysteine Modifications Suitable for Protein Labeling
No full textThe naturally low abundance of cysteine in proteins, combined with its propensity to undergo thiol–ene reactions, makes it a preferred amino acid for various bioconjugations. However, most of these methods rely on the use of UV radiation, radical initiators, or heavy-metal-based photocatalysts, which limits their applicability in complex biological environments. Herein, we report a photocatalyzed thiol–ene radical reaction that overcomes these limitations by employing a porphyrin-based photocatalyst and low-energy red light. This method operates under mild reaction conditions and can be expanded to a cysteinyl desulfurization reaction. As this approach proceeds in aqueous media and facilitates selective transformations of both simple free cysteine and cysteine residues within complex protein, it significantly expands the existing toolbox for cysteine bioconjugation.National Science Centre Poland (MAESTRO UMO-2020/38/A/ST4/00185);
European Union’s Horizon 2020 research and innovation programme under the Maria Skłodowska-Curie grant agreement no. 956070
Vitamin B12 and Micellar Solution Enable Regioselective Ring Opening of Epoxides and Aziridines with Electrophilic Olefins
No full textVitamin B12, a water-soluble cobalt complex, is inherently predisposed to catalyze reactions under aqueous conditions. Despite its potential, adopting this strategy for transformations of hydrophobic reagents has been challenging, because of their low aqueous solubility. Here, we demonstrate that vitamin B12 promotes the reaction of epoxides and aziridines with electrophilic olefins in a micellar system. The desired products are obtained efficiently in a fully regioselective manner. This green catalytic approach further advances the use of vitamin B12 in sustainable catalysis providing a valuable method to synthesize important intermediates.National Science Centre, Poland (MAESTRO UMO-2020/38/A/ST4/00185)
Dark Web and Blockchain Security in Focus: Introduction to the Cybercrime Minitrack
Full text linkThis year’s Cybercrime minitrack highlights innovative approaches to tackling the complexities of cybercrime, with a special focus on the dark web and the role of blockchain. The three featured papers explore topics ranging from malware proliferation in darknet environments to the impact of blockchain security breaches on crypto token valuation. Together, they offer practical, innovative methodologies for analyzing and combating cybercriminal behavior, enhancing cyber-threat intelligence, and providing actionable insights.This research is supported by the Polish National Science Centre, Poland (Narodowe Centrum Nauki) grant: 2021/43/B/HS6/00710
Strengthening the services sector in rural areas of Lower Silesia in the context of implementation of European Union funds
Full text linkDostępność usług stanowi istotny wyznacznik rozwoju obszarów wiejskich i jest wypadkową szeregu czynników endo- i egzogenicznych. Jednym z najważniejszych bodźców wzmocnienia sektora usług jest dostępność zewnętrznych źródeł finansowania, przede wszystkim w ramach funduszy unijnych. Celem podjętych badań była próba wieloaspektowej oceny zróżnicowania przestrzennego poziomu absorpcji środków UE ukierunkowanych na wsparcie szeroko rozumianego sektora usług jako istotnego akceleratora ich rozwoju. Empiryczna operacjonalizacja i analiza absorbcji i zróżnicowania przestrzennego środków UE została przeprowadzona przy użyciu zestawu wskaźników i spójnej procedury badawczej, według autorskiej koncepcji agregacji projektów zgodnych z klasyfikacją obszarów wsparcia na podstawie kodów kategorii interwencji wynikających z Rozporządzenia Wykonawczego Komisji Europejskiej. Badaniem objęto obszary wiejskie województwa dolnośląskiego w agregacji gminnej. Wyniki wskazują na dużą dywersyfikację alokacji środków oraz zróżnicowanie przestrzenne wdrażania działań związanych z poprawą dostępności usług. Potwierdzono również, że dostępność środków unijnych jest istotnym bodźcem wzmocnienia sektora usług na obszarach wiejskich.Access to services is an important determinant of rural development and is the result of a number of endogenous and exogenous factors. One of the most important factors in strengthening the service sector is the availability of external sources of financing, primarily within the framework of EU funds. The aim of the research undertaken was to attempt a multi-aspect assessment of the spatial differentiation of the level of absorption of EU funds aimed at supporting the service sector, as a significant accelerator of their development. Empirical operationalization and analysis of the absorption and spatial differentiation of EU funds was carried out using a set of indicators and a coherent research procedure. A proprietary concept of aggregation of projects was used, consistent with the classification of support areas based on the intervention category codes resulting from the Implementing Regulation of the European Commission. The research covered rural areas of the Lower Silesian Voivodeship in the aggregation of municipalities. The results indicate the diversification of the allocation of EU funds and the spatial differentiation of the implementation of activities improving access to services. It was also confirmed that the availability of EU funds is an important factor in strengthening the service sector in rural areas
The hermeneutical clue to the blinding of Saul on the road to Damascus
No full textArtykuł analizuje nawrócenie Saula pod Damaszkiem i przedstawia je jako jeden z kluczowych momentów w historii chrześcijaństwa. Uwzględnia hermeneutyczne i teologiczne aspekty tego wydarzenia oraz ich wpływ na współczesną interpretację biblijną
Data sources:
Access Repository Dashboard
Do you manage OPEN Repository (ICM)? Access insider analytics, issue reports and manage access to outputs from your repository in the CORE Repository Dashboard!